Article
Surgery
Federica Riccio, Mario Costantini, Renato Salvador
Summary: Accurate diagnosis is crucial for successful treatment of achalasia, with barium swallow, upper endoscopy, and high-resolution manometry providing essential information about anatomy, absence of other diseases, and type of achalasia. Prognostic value is also found in high-resolution manometry, with best treatment results obtained in type II achalasia according to the Chicago classification. Additional imaging tests such as abdominal CT scanning and endoscopic ultrasound may be necessary if malignancy is suspected.
WORLD JOURNAL OF SURGERY
(2022)
Editorial Material
Medicine, Research & Experimental
Fernando A. M. Herbella, Leonardo M. Del Grande, Francisco Schlottmann, Marco G. Patti
Summary: The Chicago Classification 4.0 introduces new concepts for the diagnosis of achalasia, potentially reducing unnecessary treatment. Conditions such as esophagogastric junction outflow obstruction, distal esophageal spasm, and hypercontractile esophagus are now considered clinically significant only in certain conditions, leading to a potential decrease in treatment, especially peroral endoscopic myotomy, solely based on manometric diagnosis.
ADVANCES IN THERAPY
(2021)
Article
Gastroenterology & Hepatology
Roberto Penagini, Nicola de Bortoli, Edoardo Savarino, Elena Arsie, Salvatore Tolone, Garrett Greenan, Pierfrancesco Visaggi, Daria Maniero, Aurelio Mauro, Dario Consonni, C. Prakash Gyawali
Summary: RDC during high-resolution manometry is an effective surrogate for TBE in assessing esophageal emptying in treated patients with achalasia.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Mark R. Fox, Rami Sweis, Rena Yadlapati, John Pandolfino, Albis Hani, Claudia Defilippi, Tack Jan, Nathalie Rommel
Summary: The Chicago Classification v4.0 introduces a more rigorous and expansive protocol for identifying esophageal motility disorders through high-resolution manometry testing. Provocative tests aim to increase diagnostic sensitivity and specificity, reducing inconclusive diagnoses and directing effective therapy for patients. The establishment of a standard manometry protocol worldwide also aims to improve procedural consistency, diagnostic reliability, and promote collaborative research.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Hisashi Fukuda, Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Hiroki Okada, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Hironori Yamamoto, Haruhiro Inoue
Summary: This study aimed to investigate the etiology of chest pain in achalasia-related esophageal motility disorders and the frequency of persistent chest pain after POEM. The results showed that age, sex, disease duration, and prior treatment were related to the prevalence and severity of chest pain. POEM had satisfactory efficacy, but residual pain was often observed.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Jin Hee Noh, Kee Wook Jung, In Ja Yoon, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study aimed to compare the diagnostic accuracy and differences between Chicago classification version 3.0 (CC v3.0) and 4.0 (CC v4.0). The results showed that CC v4.0 is more rigorous in diagnosing esophagogastric junction outflow obstruction (EGJOO) and ineffective esophageal motility (IEM) compared to CC v3.0. It also diagnoses achalasia more accurately using provocative tests and functional lumen imaging probe (FLIP). Further studies on treatment outcomes with CC v4.0 diagnosis are needed.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Chemistry, Analytical
Teodora Surdea-Blaga, Gheorghe Sebestyen, Zoltan Czako, Anca Hangan, Dan Lucian Dumitrascu, Abdulrahman Ismaiel, Liliana David, Imre Zsigmond, Giuseppe Chiarioni, Edoardo Savarino, Daniel Corneliu Leucuta, Stefan Lucian Popa
Summary: This paper presents a Machine Learning-based solution to automate the Chicago Classification algorithm for identifying esophageal motility diseases. The proposed solution preprocesses the photos, applies Deep Learning models for precise classification, and combines the results to automate the whole classification and diagnosis process. The solution achieves a top-1 accuracy of 86% without human intervention.
Review
Gastroenterology & Hepatology
Abraham Khan, Rena Yadlapati, Sutep Gonlachanvit, David A. Katzka, Moo In Park, Michael Vaezi, Marcelo Vela, John Pandolfino
Summary: The latest update in the diagnostic criteria for achalasia by Chicago Classification version 4.0 introduced subtypes and definitive/inconclusive diagnostic statements. In cases of inconclusive diagnosis, further testing such as functional lumen imaging probe (FLIP) is recommended for clarification.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Otorhinolaryngology
Moshe Carmel, Daniel L. Cohen, Basem Hijazi, Narges Azzam, Tawfik Khoury, Marta Pagliaro, Marcella Pesce, Amir Mari
Summary: The 4th iteration of the Chicago Classification (CC v4.0) introduces more restrictive criteria for the diagnosis of Ineffective Esophageal Motility (IEM), leading to a decrease in the number of patients diagnosed with IEM. Patients reclassified as normal motility under the new criteria showed better esophageal function and lower acid exposure compared to those retaining an IEM diagnosis.
Article
Gastroenterology & Hepatology
Kazuto Tsuboi, Fumiaki Yano, Nobuo Omura, Masato Hoshino, Se-Ryung Yamamoto, Shunsuke Akimoto, Takahiro Masuda, Yuki Sakashita, Naoko Fukushima, Hideyuki Kashiwagi, Ken Eto
Summary: The subtypes diagnosed by high-resolution manometry are associated with esophagography findings and best reflect esophageal clearance, with no correlation to patient backgrounds and symptoms.
Article
Gastroenterology & Hepatology
Masato Hoshino, Nobuo Omura, Fumiaki Yano, Kazuto Tsuboi, Se Ryung Yamamoto, Shunsuke Akimoto, Takahiro Masuda, Yuki Sakashita, Naoko Fukushima, Hideyuki Kashiwagi
Summary: This study utilized esophageal clearance testing with low-density barium to longitudinally investigate patients with achalasia, revealing that approximately 2.4% of patients exhibited normal esophageal clearance without esophageal dilation. This approach may be helpful in identifying cases of achalasia based on esophageal clearance and esophageal diameter measurements.
Article
Otorhinolaryngology
Daniel L. Cohen, Basem Hijazi, Ali Omari, Anton Bermont, Haim Shirin, Helal Said Ahmad, Narjes Azzam, Fahmi Shibli, Ram Dickman, Amir Mari
Summary: This study compared the demographic, clinical, endoscopic, and manometric findings of achalasia patients between Israeli Arabs and Israeli Jews. It found that Israeli Arab achalasia patients had different clinical symptoms and higher integrated relaxation pressure compared to Israeli Jewish patients.
Review
Gastroenterology & Hepatology
Fernando A. M. Herbella, Francisco Schlottmann, Marco G. Patti
Summary: High-resolution manometry has led to the development of the Chicago classification, the most commonly used system for categorizing esophageal motility disorders. However, there are challenges in accurately interpreting test results, such as distinguishing between different types of disorders.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Sawangpong Jandee, Kasemsak Jandee
Summary: This study evaluated the diagnostic yield of high-resolution manometry in Thai patients, finding the highest yield in dysphagia patients. However, the test was not as beneficial in detecting clinically relevant esophageal motor disorders in patients presenting with non-dysphagia symptoms.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Otorhinolaryngology
C. Prakash Gyawali, Peter J. Kahrilas
Summary: High-resolution esophageal manometry (HRM) combined with pressure topography allows simultaneous observation of the entire esophageal contractility, with advantages of easier recognition and better reproducibility of contractile patterns. Compared to conventional manometry, HRM is more sensitive in detecting impaired relaxation of the esophagogastric junction (EGJ) and subcategorizes achalasia into three clinically relevant subtypes. HRM and the CC process have revolutionized our understanding of esophageal motility and motility disorders.
Article
Gastroenterology & Hepatology
Erika S. Boroff, Molly Disbrow, Michael D. Crowell, Francisco C. Ramirez
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2017)
Letter
Gastroenterology & Hepatology
B. E. Lacy, M. D. Crowell, N. J. Talley
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2013)
Article
Public, Environmental & Occupational Health
Michael J. Cevette, Gaurav N. Pradhan, Daniela Cocco, Michael D. Crowell, Anna M. Galea, Jennifer Bartlett, Jan Stepanek
AVIATION SPACE AND ENVIRONMENTAL MEDICINE
(2014)
Article
Surgery
Rebecca L. Corey, Michael D. Whitaker, Michael D. Crowell, Mira T. Keddis, Bashar Aqel, Vijayan Balan, Thomas Byrne, Elizabeth Carey, David D. Douglas, M. Edwyn Harrison, Hugo E. Vargas, Jorge Rakela
CLINICAL TRANSPLANTATION
(2014)
Article
Gastroenterology & Hepatology
Scott L. Gabbard, Brian E. Lacy, Gary M. Levine, Michael D. Crowell
DIGESTIVE DISEASES AND SCIENCES
(2014)
Article
Gastroenterology & Hepatology
Diana M. Orbelo, Felicity T. Enders, Yvonne Romero, Dawn L. Francis, Sami R. Achem, Tushar S. Dabade, Michael D. Crowell, Debra M. Geno, Ramona S. DeJesus, Vikneswaran Namasivayam, Steven C. Adamson, Amindra S. Arora, Andrew J. Majka, Jeffrey A. Alexander, Joseph A. Murray, Matthew Lohse, Nancy N. Diehl, Mary Fredericksen, Kee Wook Jung, Margaret S. Houston, Angela E. O'Neil, David A. Katzka
DIGESTIVE DISEASES AND SCIENCES
(2015)
Article
Otorhinolaryngology
Shiva K. Ratuapli, Stephanie L. Hansel, Sarah B. Umar, George E. Burdick, Francisco C. Ramirez, David E. Fleischer, Lucinda A. Harris, Brian E. Lacy, John K. DiBaise, Michael D. Crowell
Article
Gastroenterology & Hepatology
L. Rodriguez, P. Rodriguez, B. Gomez, J. C. Ayala, D. Oksenberg, A. Perez-Castilla, M. G. Netto, E. Soffer, M. D. Crowell
Article
Gastroenterology & Hepatology
Ting-Hui Hsieh, Kristin L. Mekeel, Michael D. Crowell, Cuong C. Nguyen, Ananya Das, Bashar A. Aqel, Elizabeth J. Carey, Thomas J. Byrne, Hugo E. Vargas, David D. Douglas, David C. Mulligan, M. Edwyn Harrison
GASTROINTESTINAL ENDOSCOPY
(2013)
Article
Endocrinology & Metabolism
Qing Wu, Wenchun Qu, Michael D. Crowell, Joseph G. Hentz, Keith A. Frey
JOURNAL OF BONE AND MINERAL RESEARCH
(2013)
Article
Gastroenterology & Hepatology
R. S. Choung, G. R. Locke, D. D. Francis, D. Katzka, P. J. Winkle, W. C. Orr, M. D. Crowell, K. Devault, W. S. Harmsen, A. R. Zinsmeister, N. J. Talley
NEUROGASTROENTEROLOGY AND MOTILITY
(2014)
Article
Gastroenterology & Hepatology
Lucinda A. Harris, Stephanie L. Hansel, Elizabeth Rajan, Komandoor Srivathsan, Robert Rea, Michael D. Crowell, David E. Fleischer, Shabana F. Pasha, Suryakanth R. Gurudu, Russell I. Heigh, Arthur D. Shiff, Janice K. Post, Jonathan A. Leighton
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2013)
Editorial Material
Gastroenterology & Hepatology
Michael D. Crowell
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2013)
Article
Rheumatology
Jamie Bering, W. Leroy Griffing, Michael Crowell, Sarah B. Umar
Summary: Research shows that patients with SSc generally demonstrate longitudinal stability or improvement in GI symptoms, but a subset of patients experience worsening of GI symptoms, leading to negative impacts on GI-related quality of life.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Ivana Dzeletovic, Edwyn Harrison, Michael D. Crowell, Rahul Pannala, Cuong C. Nguyen, Qing Wu, Douglas O. Faigel
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2014)