Article
Medicine, General & Internal
Bogdan Silviu Ungureanu, Dan Ionut Gheonea, Dan Nicolae Florescu, Sevastita Iordache, Sergiu Marian Cazacu, Vlad Florin Iovanescu, Ion Rogoveanu, Adina Turcu-Stiolica
Summary: This study developed an Artificial Neural Network (ANN) for the non-endoscopic triage of nonvariceal upper gastrointestinal bleeding (NVUGIB), with mortality as a primary outcome. The machine learning models were more accurate at identifying patients who met the endpoint of mortality than any of the existing risk scores.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Evan S. Dellon, Nirmala Gonsalves, J. Pablo Abonia, Jeffrey A. Alexander, Nicoleta C. Arva, Dan Atkins, Stephen E. Attwood, Marcus K. H. Auth, Dominique D. Bailey, Luc Biederman, Carine Blanchard, Peter A. Bonis, Paroma Bose, Albert J. Bredenoord, Joy W. Chang, Mirna Chehade, Margaret H. Collins, Carlo Di Lorenzo, Jorge Amil Dias, Ranjan Dohil, Christophe Dupont, Gary W. Falk, Cristina T. Ferreira, Adam T. Fox, Robert M. Genta, Thomas Greuter, Sandeep K. Gupta, Ikuo Hirano, Girish S. Hiremath, Jennifer L. Horsley-Silva, Shunji Ishihara, Norihisa Ishimura, Elizabeth T. Jensen, Carolina Gutierrez-Junquera, David A. Katzka, Paneez Khoury, Yoshikazu Kinoshita, Kara L. Kliewer, Sibylle Koletzko, John Leung, Chris A. Liacouras, Alfredo J. Lucendo, Lisa J. Martin, Emily C. McGowan, Calies Menard-Katcher, David C. Metz, Talya L. Miller, Fouad J. Moawad, Amanda B. Muir, Vincent A. Mukkada, Simon Murch, Quan M. Nhu, Ichiro Nomura, Samuel Nurko, Yoshikazu Ohtsuka, Salvatore Oliva, Rok Orel, Alexandra Papadopoulou, Dhyanesh A. Patel, Robert D. Pesek, Kathryn A. Peterson, Hamish Philpott, Philip E. Putnam, Joel E. Richter, Rachel Rosen, Melanie A. Ruffner, Ekaterina Safroneeva, Philipp Schreiner, Alain Schoepfer, Shauna R. Schroeder, Neil Shah, Rhonda F. Souza, Stuart J. Spechler, Jonathan M. Spergel, Alex Straumann, Nicholas J. Talley, Nikhil Thapar, Yvan Vandenplas, Rajitha D. Venkatesh, Mario C. Vieira, Ulrike von Arnim, Marjorie M. Walker, Joshua B. Wechsler, Barry K. Wershil, Benjamin L. Wright, Yoshiyuki Yamada, Guang-Yu Yang, Noam Zevit, Marc E. Rothenberg, Glenn T. Furuta, Seema S. Aceves
Summary: This study achieved an international consensus for standardized EGID nomenclature, providing a unified terminology for eosinophilic gastrointestinal diseases. The umbrella term EGID was preferred, and specific naming conventions were proposed based on the location of gastrointestinal tract involvement.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Iulia Ratiu, Raluca Lupusoru, Alina Popescu, Ioan Sporea, Adrian Goldis, Mirela Danila, Bogdan Miutescu, Tudor Moga, Andreea Barbulescu, Roxana Sirli
Summary: This observational retrospective study aimed to investigate the differences and associated factors between variceal and nonvariceal upper gastrointestinal bleeding (UGIB). The results showed that there was a higher rebleeding rate in patients with variceal bleeding.
Article
Gastroenterology & Hepatology
Tamotsu Matsuhashi, Waku Hatta, Takuto Hikichi, Sho Fukuda, Tatsuya Mikami, Tetsuya Tatsuta, Jun Nakamura, Yasuhiko Abe, Yusuke Onozato, Yohei Ogata, Atsushi Masamune, Motoki Ohyauchi, Hirotaka Ito, Norihiro Hanabata, Yasumitsu Araki, Takumi Yanagita, Hidemichi Imamura, Tsuyotoshi Tsuji, Kae Sugawara, Yohei Horikawa, Shuichi Ohara, Yutaka Kondo, Takahiro Dohmen, Yoichi Kakuta, Tomohiro Nakamura, Katsunori Iijima
Summary: A novel prediction score (CHAMPS-R Score) for in-hospital mortality in nonvariceal UGIB patients was successfully derived and externally validated, showing high discriminative ability in both derivation and validation cohorts. The CHAMPS Score outperformed existing scores such as the Glasgow Blatchford Score, AIMS65, ABC Score, and clinical Rockall Score in predicting mortality.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Eun Jeong Gong, Li-chang Hsing, Hyun Il Seo, Myeongsook Seo, Baek Gyu Jun, Jong Kyu Park, Sang Jin Lee, Koon Hee Han, Young Don Kim, Woo Jin Jeong, Gab Jin Cheon, Min-Ju Kim
Summary: In patients with nonvariceal UGIB, nasogastric lavage is useful for predicting the presence of UGIB, improving the management of patients before endoscopy. However, its clinical utility is limited in high-risk patients with a GBS score of 12 or higher.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Dennis M. Jensen, Thomas Kovacs, Kevin A. Ghassemi, Marc Kaneshiro, Jeffrey Gornbein
Summary: This study aimed to compare the outcomes of using large OTSC versus standard hemostasis in the treatment of NVUGIB. Results showed that OTSC significantly reduced rates of rebleeding, severe complications, and post-randomization red cell transfusions, especially beneficial for patients with major stigmata of hemorrhage.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Surgery
Aryeh Shander, Howard L. Corwin, Jens Meier, Michael Auerbach, Elvira Bisbe, Jeanna Blitz, Jochen Erhard, David Faraoni, Shannon L. Farmer, Steven M. Frank, Domenico Girelli, Tiffany Hall, Jean-Francois Hardy, Axel Hofmann, Cheuk-Kwong Lee, Tsin W. Leung, Sherri Ozawa, Jameela Sathar, Donat R. Spahn, Rosalio Torres, Matthew A. Warner, Manuel Munoz
Summary: Perioperative anemia has been linked to increased risk of red blood cell transfusion, morbidity, and mortality after surgery. However, the optimal approach for diagnosing and managing perioperative anemia is not fully established. Therefore, an international expert panel developed consensus recommendations through evidence review using modified RAND Delphi methodology.
Review
Gastroenterology & Hepatology
Nicolas Chapelle, Myriam Martel, Marc Bardou, Majid Almadi, Alan N. Barkun
Summary: This study systematically reviewed the effectiveness of Doppler endoscopic probe (DEP) in nonvariceal upper gastrointestinal bleeding (NVUGIB) and found that DEP-related information improves prediction of rebleeding and DEP-guided management reduces overall rebleeding, bleeding-related mortality, and need for surgery in NVUGIB patients.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Andrew J. Kruger, Marwan S. Abougergi, Sajid Jalil, Lindsay A. Sobotka, Michael R. Wellner, Kyle M. Porter, Lanla F. Conteh, Sean G. Kelly, Khalid Mumtaz
Summary: This study evaluated hospital outcomes of cirrhosis patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) using the 2014 Nationwide Readmission Database. The results showed that patients with decompensated cirrhosis had higher readmission rates, mortality rates, and healthcare utilization compared to those with compensated cirrhosis and no cirrhosis. Early esophagogastroduodenoscopy was a modifiable factor associated with reduced readmission rates. Early identification of high-risk patients and adherence to guidelines may improve clinical outcomes.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Editorial Material
Medicine, General & Internal
Zahir Kanjee, Akwi W. Asombang, Tyler M. Berzin, Risa B. Burns
Summary: Nonvariceal upper gastrointestinal bleeding is a common, morbid, and potentially fatal condition. Management involves fluid resuscitation, blood transfusion, endoscopy, and individualized proton-pump inhibitor therapy based on patient's risk factors for recurrent bleeding in outpatient setting.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Arunchai Chang, Manus Rugivarodum, Nuttanit Pungpipattrakul, Keerati Akarapatima, Komsai Suwanno, Attapon Rattanasupar, Bancha Ovartlarnporn, Varayu Prachayakul
Summary: The present study aimed to investigate the effects of oral iron supplementation on hemoglobin response and iron storage in patients with anemia secondary to nonvariceal UGIB. The results showed that oral iron supplementation had beneficial effects on anemia and iron storage without significant adverse effects.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
J. Reed McGraw, Ryan M. Kiefer, Amol Shah, Timothy W. I. Clark, Richard D. Shlansky-Goldberg, Gregory J. Nadolski, Stephen J. Hunt, Terence P. Gade
Summary: The purpose of this study is to evaluate the changes in gastric and intestinal mucosa after transarterial embolization (TAE) and its impact on mortality rate. The study found that TAE is a safe and effective intervention for patients with upper gastrointestinal bleeding (UGIB). Most patients showed either stability or improvement in the target lesion after TAE, and only a minority of patients demonstrated adverse mucosal changes.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wenjie Yue, Yi Liu, Weiru Jiang, Jianping Huang, Jie Liu
Summary: This study found that prealbumin and d-dimer are independent predictors for rebleeding in NVUGIB patients, showing superior predictive value compared to traditional scoring systems. They are promising markers for assessing severity and prognosis in NVUGIB practice.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Joerg M. Pollok, Pascale Tinguely, Marina Berenguer, Claus U. Niemann, Dimitri A. Raptis, Michael Spiro
Summary: Enhanced recovery for liver transplant recipients has been controversial. This review aims to summarize current knowledge, identify key components, and establish internationally accepted guidelines. Expert statements were prepared based on systematic literature reviews and a consensus conference, resulting in 80 final recommendations.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Joerg M. Pollok, Pascale Tinguely, Marina Berenguer, Claus U. Niemann, Dimitri A. Raptis, Michael Spiro
Summary: There is significant controversy surrounding enhanced recovery for liver-transplant recipients, and this review aimed to summarize current knowledge, identify key components, and create internationally accepted guidelines. A collaborative effort by the ERAS4OLT.org partnership and specialists from around the world resulted in 80 final recommendations covering various aspects of enhanced recovery for liver transplantation. These guidelines provide a comprehensive overview and can guide the development of enhanced recovery programs globally.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Berbel L. M. Ykema, Lisanne S. Rigter, Manon C. W. Spaander, Leon M. G. Moons, Tanya M. Bisseling, Berthe M. P. Aleman, Evelien Dekker, Wieke H. M. Verbeek, Ernst J. Kuipers, Jan Paul de Boer, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, Richard W. M. van der Maazen, Gerrit A. Meijer, Michael Schaapveld, Flora E. van Leeuwen, Beatriz Carvalho, Petur Snaebjornsson, Monique E. van Leerdam
Summary: The study evaluated clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in Hodgkin's lymphoma (HL) survivors who had undergone abdominal radiotherapy and/or procarbazine treatment. Colorectal neoplasia in HL survivors differs from average-risk controls, with AN primarily classified based on polyp size (>=10 mm) and longer follow-up between HL diagnosis and colonoscopy associated with a higher prevalence of AN.
DIGESTIVE ENDOSCOPY
(2022)
Article
Surgery
Mitchell L. S. Driessen, Leontien M. Sturms, Frank W. Bloemers, Henk Jan ten Duis, Michael J. R. Edwards, Dennis den Hartog, E. J. Kuipers, Peter A. Leenhouts, Martijn Poeze, Inger B. Schipper, Richard W. Spanjersberg, Klaus W. Wendt, Ralph J. de Wit, Stefan W. A. M. van Zutphen, Mariska A. C. de Jongh, Luke P. H. Leenen
Summary: The COVID-19 pandemic has had an adverse effect on the outcome of major trauma patients in the Netherlands. Fewer patients, especially those with less severe traumatic brain injuries, were admitted to the ICU during the peak period, resulting in increased mortality rates for this subgroup.
Article
Oncology
Josephina G. Kuiper, Myrthe P. P. Van Herk-Sukel, Valery E. P. P. Lemmens, Ernst J. Kuipers, Ron M. C. Herings
Summary: The NCR-PHARMO GP cohort, consisting of 135,868 cancer patients, provides rich data on primary care management of cancer, enabling large-scale observational cancer research in the primary care setting. Patient-level linkage allows for long-term follow-up with ongoing annual updates.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Oncology
S. A. Nieuwenburg, M. C. Mommersteeg, L. M. M. Wolters, A. J. van Vuuren, N. Erler, M. P. Peppelenbosch, G. M. Fuhler, M. J. Bruno, E. J. Kuipers, M. C. W. Spaander
Summary: This study found that FIT can be used with high accuracy and sensitivity for the diagnosis of H. pylori, and is considered the most convenient test method. Non-invasive Hp-FIT test shows great promise for combined upper and lower gastrointestinal (pre-) cancerous screening. Further research should explore the clinical implications, benefits, and cost-effectiveness of this approach.
Article
Gastroenterology & Hepatology
Suk Yee Lam, Michiel C. Mommersteeg, Bingting Yu, Linda Broer, Manon C. W. Spaander, Fabian Frost, Stefan Weiss, Henry Voelzke, Markus M. Lerch, Ben Schoettker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C. Wood, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell P. Tracy, Edmond K. Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, Andre Uitterlinden, Ernst J. Kuipers, Gwenny M. Fuhler, Georg Homuth, Maikel P. Peppelenbosch
Summary: The association between anti-H pylori IgG titers and the TLR1/6/10 locus was not replicated across different populations, and the variation at this locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes and neutrophils.
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Sulleman Moreea, Harinder Dhaliwal, Dana C. Moffatt, Krish Ragunath, Terry Ponich, Alan N. Barkun, Ernst J. Kuipers, Robert Bailey, Fergal Donnellan, David Wagner, Keith Sanborn, James Lau
Summary: The study evaluated the safety and effectiveness of Hemospray as a monotherapy for active peptic ulcer bleeding. Results showed that Hemospray was successfully administered in nearly all patients, with a high rate of hemostasis achieved. Recurrent bleeding was observed in a small percentage of patients, but no adverse events were attributed to the use of Hemospray.
GASTROINTESTINAL ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Alexander C. Ford, Evangelos Tsipotis, Yuhong Yuan, Grigorios Leontiadis, Paul Moayyedi
Summary: The study suggests that H. pylori eradication therapy can lead to both cure and improvement of symptoms in patients with functional dyspepsia, although the benefit is modest. Successful eradication of H. pylori is associated with a greater effect, but also with more adverse events.
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Endocrinology & Metabolism
Josephina G. Kuiper, Aline C. Fenneman, Anne H. van der Spek, Elena Rampanelli, Max Nieuwdorp, Myrthe P. P. Van Herk-Sukel, Valery E. P. P. Lemmens, Ernst J. Kuipers, Ron M. C. Herings, Eric Fliers
Summary: This study did not find a reduced risk of colorectal cancer in levothyroxine users. When stratified by tumour subsite, a borderline significant risk reduction of rectal cancer was found, indicating a need for further research.
ENDOCRINE CONNECTIONS
(2022)
Letter
Gastroenterology & Hepatology
Alexander C. Ford, Yuhong Yuan, Paul Moayyedi
Article
Health Care Sciences & Services
Jenna Rines, Kim Daley, Sunny Loo, Kwestan Safari, Deirdre Walsh, Marlyn Gill, Paul Moayyedi, Aida Fernandes, Nancy Marlett, Deborah Marshall
Summary: Food plays a significant role in the psychosocial experiences of young adults with inflammatory bowel diseases (IBDs). Patient-led research reveals challenges in managing diet and the importance of involving patients in healthcare system change to improve outcomes.
HEALTH EXPECTATIONS
(2022)
Review
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Gianluca Ianiro, Judy Nee, Anthony J. Lembo, Paul Moayyedi, Christopher J. Black, Alexander C. Ford
Summary: This study aimed to evaluate the efficacy and safety of peppermint oil in the treatment of IBS. The results showed that peppermint oil was more effective than placebo, but adverse events occurred more frequently.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Siavosh Nasseri-Moghaddam, Amir-Hossein Mousavian, Amir Kasaeian, Takeshi Kanno, Yuhong Yuan, Alexander C. Ford, Paul Moayyedi
Summary: This study evaluated the prevalence of clinically significant endoscopic findings in patients with dyspepsia and found that dyspeptic symptoms cannot accurately predict endoscopic pathology. Among individuals with dyspepsia, 11.0% had erosive esophagitis and 4.4% had peptic ulcer, with a higher likelihood of peptic ulcer in the dyspepsia group. Most endoscopic findings were normal, and the prevalence of gastroesophageal cancer was very low.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Gianluca Ianiro, Judy Nee, Anthony J. Lembo, Paul Moayyedi, Christopher J. Black, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Paul Moayyedi, Neeraj Narula
Summary: Improving racial diversity in IBD clinical trials requires action at multiple levels to increase opportunities for patients of all races to participate in trials, ultimately leading to improved care for diverse patients in clinical practice.
JOURNAL OF CROHNS & COLITIS
(2023)