☆ 4.7 Editorial Material

Green Light from the FDA for New Drug Development in Irritable Bowel Syndrome and Functional Dyspepsia

AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)

Journal

AMERICAN JOURNAL OF GASTROENTEROLOGY

Volume 104, Issue 6, Pages 1339-1341

Publisher

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1038/ajg.2009.295

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Letter: Post- -COVID--19 functional dyspepsia and irritable bowel syndrome

Cong Dai, Yu-Hong Huang, Min Jiang

Summary: This article is connected to the papers of Marasco et al. To access these papers, visit and

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

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Letter Gastroenterology & Hepatology

Letter: Post- -COVID--19 functional dyspepsia and irritable bowel syndrome--Authors' reply

Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara

Summary: This article is connected to Marasco et al papers. To view these articles, visit and...

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

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Article Gastroenterology & Hepatology

Meta-analysis: Post-COVID-19 functional dyspepsia and irritable bowel syndrome

Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara

Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

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Review Gastroenterology & Hepatology

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

Congzhen Wang, Xiucai Fang

Summary: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders that often overlap with each other. The pathogenesis of these disorders is complex, involving various factors, with limited studies focusing on the inflammatory mechanism in patients with overlap syndrome of IBS-FD.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2021)

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Article Gastroenterology & Hepatology

Gender difference in the overlap of irritable bowel syndrome and functional dyspepsia: a prospective nationwide multicenter study in Korea

Kwangwoo Nam, Nayoung Kim, Hyun Joo Song, Gwang Ho Baik, Suck Chei Choi, Hyun Jin Kim, Ju Yup Lee, Kyung Sik Park, Sun-Young Park, Seun Ja Park

Summary: The overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS) is associated with more severe upper gastrointestinal symptoms and depression compared to non-overlap patients. Women with FD-IBS overlap experience more severe gastrointestinal and depression symptoms than men.

JOURNAL OF GASTROENTEROLOGY (2021)

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Review Medicine, General & Internal

Impact of shift work on irritable bowel syndrome and functional dyspepsia A meta-analysis

Nian Wang, Xinghuang Liu, Weixiang Ye, Zhaohong Shi, Tao Bai

Summary: This meta-analysis study explored the association between shift work and irritable bowel syndrome (IBS) and functional dyspepsia (FD). The findings showed that shift workers were more likely to suffer from IBS, but no significant association was observed between shift work and FD.

MEDICINE (2022)

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Article Gastroenterology & Hepatology

Brain activity in response to food images in patients with irritable bowel syndrome and functional dyspepsia

Ryo Katsumata, Takayuki Hosokawa, Noriaki Manabe, Hitoshi Mori, Kenta Wani, Katsunori Ishii, Tomohiro Tanikawa, Noriyo Urata, Maki Ayaki, Ken Nishino, Takahisa Murao, Mitsuhiko Suehiro, Minoru Fujita, Miwa Kawanaka, Ken Haruma, Hirofumi Kawamoto, Toshihiro Takao, Tomoari Kamada

Summary: This study aimed to compare food preference and brain activity when viewing food images between patients with disorders of gut-brain interaction (DGBI) and healthy controls. The results showed that patients with DGBI, especially those with functional dyspepsia (FD), had a lower preference for fatty foods. Increased brain activity in the left prefrontal cortex (PFC) was confirmed in patients with FD.

JOURNAL OF GASTROENTEROLOGY (2023)

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Article Surgery

Functional Dyspepsia and Irritable Bowel Syndrome are Highly Prevalent in Patients With Gallstones and Are Negatively Associated With Outcomes After Cholecystectomy A Prospective, Multicenter, Observational Study (PERFECT-Trial)

Judith J. de Jong, Carmen S. S. Latenstein, Djamila Boerma, Eric J. Hazebroek, David Hirsch, Joost T. Heikens, Joop Konsten, Fatih Polat, Marten A. Lantinga, Cornelis J. H. M. van Laarhoven, Joost P. H. Drenth, Philip R. de Reuver

Summary: This study investigated the prevalence of FD and IBS in patients eligible for cholecystectomy and their association with resolution of biliary colic and pain-free state. The results showed that one third of eligible patients had FD/IBS, and only a few patients experienced biliary colic after cholecystectomy, while nonbiliary abdominal pain persisted in over 40% of patients, especially those with pre-existing FD/IBS.

ANNALS OF SURGERY (2022)

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Article Gastroenterology & Hepatology

Impacts of the COVID-19 pandemic on functional dyspepsia and irritable bowel syndrome: A population-based survey

Tadayuki Oshima, Kewin Tien Ho Siah, Takanori Yoshimoto, Ko Miura, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa

Summary: This study investigated the impact of the COVID-19 pandemic on gastrointestinal and psychological symptoms of functional dyspepsia (FD) and irritable bowel syndrome (IBS). Results showed that during the pandemic, respondents with FD-IBS overlap syndrome had the worst symptoms, followed by IBS-alone and FD-alone respondents. 11.9% reported deterioration and 2.8% reported improvement of gastrointestinal symptoms.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Medicine, General & Internal

Heartburn in children and adolescents in the presence of functional dyspepsia and/or irritable bowel syndrome correlates with the presence of sleep disturbances, anxiety, and depression

Jennifer M. Colombo, Amanda D. Deacy, Jennifer Schurman, Craig A. Friesen

Summary: The study aimed to assess the relationship between heartburn in pediatric patients with functional dyspepsia and irritable bowel syndrome, finding that patients reporting heartburn were more likely to experience gastrointestinal symptoms, sleep disturbances, anxiety, and depression.

MEDICINE (2021)

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Review Psychology, Clinical

Irritable bowel syndrome and functional dyspepsia in patients with eating disorders - a systematic review

Vivien Hanel, Martha A. Schalla, Andreas Stengel

Summary: There is a close relationship between eating disorders and functional gastrointestinal disorders, with patients often experiencing psychological, hormonal, and functional alterations. Further research is needed to understand the underlying mechanisms of this relationship.

EUROPEAN EATING DISORDERS REVIEW (2021)

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Article Gastroenterology & Hepatology

Post COVID-19 irritable bowel syndrome

Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara

Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.

GUT (2023)

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Review Medicine, General & Internal

Misinterpreting Diarrhea-Predominant Irritable Bowel Syndrome and Functional Diarrhea: Pathophysiological Highlights

Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini

Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Gastroenterology & Hepatology

Concomitant Irritable Bowel Syndrome Does Not Influence the Response to Antimicrobial Therapy in Patients with Functional Dyspepsia

Ayesha Shah, Saravana Ruban Gurusamy, Teressa Hansen, Gavin Callaghan, Nicholas J. Talley, Natasha Koloski, Marjorie M. Walker, Michael P. Jones, Mark Morrison, Gerald J. Holtmann

Summary: The study found that in FD patients, antimicrobial therapy with rifaximin is effective in improving symptoms and is not influenced by concomitant IBS symptoms. The effects of the treatment persisted for 6 weeks post-treatment.

DIGESTIVE DISEASES AND SCIENCES (2022)

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Article Gastroenterology & Hepatology

Irritable bowel syndrome: treatment based on pathophysiology and biomarkers

Michael Camilleri, Guy Boeckxstaens

Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.

GUT (2023)

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Review Gastroenterology & Hepatology

Human intestinal spirochetosis, irritable bowel syndrome, and colonic polyps: A systematic review and meta-analysis

Kening Fan, Guy D. Eslick, Prema M. Nair, Grace L. Burns, Marjorie M. Walker, Emily C. Hoedt, Simon Keely, Nicholas J. Talley

Summary: A systematic review and meta-analysis found that human colonic spirochetosis (CS) is significantly associated with diarrhea and irritable bowel syndrome (IBS), but not colonic polyps. CS may be underestimated and could be an overlooked risk factor for a subset of IBS patients with diarrhea.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Editorial Material Medicine, General & Internal

Passing on the Editor-in-Chief baton at the Medical Journal of Australia

Nicholas J. Talley

Summary: This quote highlights the idea that we live in interesting and turbulent times, which are simultaneously dangerous and uncertain, yet also highly creative in the history of mankind.

MEDICAL JOURNAL OF AUSTRALIA (2022)

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Editorial Material Medicine, General & Internal

Educating future clinician academics: the role of medical schools

Diann S. Eley, Wendy Hu, Nicholas J. Talley

MEDICAL JOURNAL OF AUSTRALIA (2022)

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Article Gastroenterology & Hepatology

Diabetes mellitus is an independent risk factor for a greater frequency of early satiation and diarrhea at one and three years: Two prospective longitudinal population-based studies

Natasha A. Koloski, Michael Jones, Marjorie M. Walker, Michael Horowitz, Gerald Holtmann, Nicholas J. Talley

Summary: Diabetes is an independent risk factor for an increased frequency of gastrointestinal symptoms, adjusting for lifestyle and psychological factors.

NEUROGASTROENTEROLOGY AND MOTILITY (2023)

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Review Gastroenterology & Hepatology

Placebo response in pharmacological trials in patients with functional dyspepsia-A systematic review and meta-analysis

Michelle Bosman, Fabienne Smeets, Sigrid Elsenbruch, Jan Tack, Magnus Simren, Nicholas Talley, Bjorn Winkens, Ad Masclee, Daniel Keszthelyi

Summary: This study conducted a systematic review and meta-analysis to investigate the placebo response in pharmacological trials for functional dyspepsia (FD). The study found that the pooled placebo response rate ranged from 35.5% to 39.6% depending on the responder definition used. Lower baseline symptom scores were significantly associated with higher placebo response rates. The study suggests considering entry criteria based on symptom severity and separate reporting of core FD symptoms in future trials.

NEUROGASTROENTEROLOGY AND MOTILITY (2023)

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Article Gastroenterology & Hepatology

Economic living standard and abdominal pain mediate the association between functional gastrointestinal disorders and depression or anxiety

M. H. Simon, P. E. Heenan, C. Frampton, S. Bayer, J. Keenan, de N. K. Boer, N. C. Roy, N. J. Talley, R. B. Gearry

Summary: This study examines the association between functional gastrointestinal disorders (FGIDs) and depression and anxiety, and identifies the covariates influencing this association. The study finds that economic standard of living, pain, and IBS phenotype are significant independent factors associated with depression and anxiety in FGID cases.

NEUROGASTROENTEROLOGY AND MOTILITY (2023)

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Article Gastroenterology & Hepatology

Factors Associated With Placebo Treatment Response in Functional Dyspepsia Clinical Trials

Michael P. Jones, Liam Guthrie-Lyons, Yuri A. Sato, Nicholas J. Talley

Summary: Controlling for placebo effects is crucial for accurately estimating the effect of therapy. This study aimed to identify risk factors and suggest trial design changes to minimize the placebo effect in functional dyspepsia treatment trials.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2023)

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Letter Gastroenterology & Hepatology

High Discovery Rate of Duodenal and Gastric Eosinophilia in Patients With Unexplained Moderate-Severe Abdominal Symptoms: A Prospective US Multisite Study

Nicholas J. Talley, Kathryn A. Peterson, Robert M. Genta, Alan T. Chang, Evan S. Dellon, William J. Sandborn

GASTROENTEROLOGY (2023)

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Editorial Material Medicine, General & Internal

Welcoming the new MJA Editor-in-Chief, and the top ten original research articles in the MJA in 2022

Nicholas J. Talley

MEDICAL JOURNAL OF AUSTRALIA (2023)

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Letter Gastroenterology & Hepatology

Letter: childhood recurrent abdominal pain is associated with increased duodenal eosinophilia independent of Helicobacter pylori infection

Lucas Wauters, Paul R. Harris, Marjorie M. Walker, Carolina A. Serrano, Andrea Villagran, Gurpreet S. Rakhra, Jean E. Crabtree, Nicholas J. Talley

Summary: This article is connected to the paper by Broeders et al. To access this article, visit the provided link.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

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Review Medicine, General & Internal

Weight loss with subcutaneous semaglutide versus other glucagon-like peptide 1 receptor agonists in type 2 diabetes: a systematic review

Brandon Stretton, Joshua Kovoor, Stephen Bacchi, Shantel Chang, Benjamin Ngoi, Tess Murray, Thomas C. Bristow, Jonathan Heng, Aashray Gupta, Christopher Ovenden, Guy Maddern, Campbell H. Thompson, Leonie Heilbronn, Mark Boyd, Christopher Rayner, Nicholas J. Talley, Michael Horowtiz

Summary: This review summarizes the direct comparisons between subcutaneous semaglutide and other GLP-1 RAs in individuals with type 2 diabetes, focusing on their efficacy for inducing weight loss and improving metabolic health markers. Five studies which fulfilled the inclusion criteria were identified. Randomized trials support the superior efficacy of semaglutide over other GLP-1 RAs in terms of weight loss, but tirzepatide is more effective than semaglutide.

INTERNAL MEDICINE JOURNAL (2023)

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Does the microbiome play a role in the pathogenesis of colonic diverticular disease? A systematic review

Raquel Cameron, Kerith Duncanson, Emily C. Hoedt, Guy D. Eslick, Grace L. Burns, Cheenie Nieva, Simon Keely, Marjorie M. Walker, Nicholas J. Talley

Summary: This systematic review assessed the association between the microbiota and metabolome in diverticulosis, symptomatic uncomplicated diverticular disease (SUDD), and diverticulitis pathophysiology. The findings suggest that there is no convincing evidence of microbial dysbiosis in colonic diverticula to suggest that the microbiota contributes to the pathogenesis of diverticulosis, SUDD, or diverticular disease.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2023)

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Article Biochemistry & Molecular Biology

Concentrations of Plasma Amino Acids and Neurotransmitters in Participants with Functional Gut Disorders and Healthy Controls

Shanalee C. James, Karl Fraser, Janine Cooney, Catrin S. Guenther, Wayne Young, Richard B. Gearry, Phoebe E. Heenan, Tania Trower, Jacqueline I. Keenan, Nicholas J. Talley, Warren C. McNabb, Nicole C. Roy

Summary: This study aimed to compare the circulating concentrations of amino acids and neurotransmitters between healthy participants and those with functional gastrointestinal disorders (FGIDs). The results showed significant differences in branched-chain amino acids, ornithine, and alpha-aminobutyric acid between healthy controls and FGID groups. No other significant differences were observed for the neurotransmitters or any other amino acids analyzed.

METABOLITES (2023)

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Article Gastroenterology & Hepatology

Increased mucosal eosinophils in colonic diverticulosis and diverticular disease

Raquel Cameron, Marjorie M. Walker, Michael Jones, Guy D. Eslick, Simon Keely, Peter Pockney, Carolina C. Cosentino, Nicholas J. Talley

Summary: This study examined the changes of eosinophils and other immune cells in the mucosa of colonic diverticula through quantitative histology. The results showed a significant increase in eosinophil counts at the base and neck of the diverticula. These findings provide new clues for understanding the role of eosinophils and chronic inflammation in the pathophysiology of colonic diverticulosis.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2023)

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Review Gastroenterology & Hepatology

Overlap of disorders of gut-brain interaction: a systematic review and

Thomas Fairlie, Ayesha Shah, Nicholas J. Talley, William D. Chey, Natasha Koloski, Yeong Yeh Lee, Kok-Ann Gwee, Michael P. Jones, Gerald Holtmann

Summary: This systematic review and meta-analysis aimed to determine the prevalence of DGBI overlap and compare the overlap in different healthcare settings. It also aimed to assess the severity of psychological comorbidities in DGBI with and without overlap.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2023)

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Green Light from the FDA for New Drug Development in Irritable Bowel Syndrome and Functional Dyspepsia

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LIPPINCOTT WILLIAMS & WILKINS

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