Article
Anesthesiology
Anthony Lembo, John M. Kelley, Judy Nee, Sarah Ballou, Johanna Iturrino, Vivian Cheng, Vikram Rangan, Jesse Katon, William Hirsch, Irving Kirsch, Kathryn Hall, Roger B. Davis, Ted J. Kaptchuk
Summary: In the study on irritable bowel syndrome, open-label placebo (OLP) treatment was found to be superior to no-pill control (NPC) and had similar efficacy to double-blind placebo (DBP).
Article
Gastroenterology & Hepatology
Isabelle Mack, Juliane Schwille-Kiuntke, Nazar Mazurak, Beate Niesler, Kurt Zimmermann, Hubert Moennikes, Paul Enck
Summary: This study investigated the effectiveness of a nonviable probiotic lysate (BL) in the treatment of IBS and found that BL was not effective for all IBS subtypes, but may offer a treatment option for IBS-D which needs further verification through adequately powered drug trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Food Science & Technology
Hee-Young Kim, Eui-Seong Park, Young Sik Choi, Seun Ja Park, Jae Hyun Kim, Hee Kyung Chang, Kun-Young Park
Summary: This study confirms the alleviative effect of kimchi on IBS symptoms. Kimchi intake increases dietary fiber intake, reduces serum inflammatory cytokine levels and harmful fecal enzyme activities, improves typical IBS symptoms and bowel movements, and alters the composition of the gut microbiota.
FOOD & NUTRITION RESEARCH
(2022)
Article
Nutrition & Dietetics
Chiara Ricci, Fernando Rizzello, Maria Chiara Valerii, Enzo Spisni, Paolo Gionchetti, Silvia Turroni, Marco Candela, Federica D'Amico, Renato Spigarelli, Irene Bellocchio, Giovanni Marasco, Giovanni Barbara
Summary: Geraniol, an acyclic monoterpene alcohol, has demonstrated anti-inflammatory and antimicrobial properties and positive effects on gut microbiota in IBS patients. In this study, IBS patients treated with a low-absorbable geraniol food supplement (LAGS) showed a significant reduction in IBS symptoms severity score compared to placebo. Geraniol administration also resulted in changes in gut microbiota composition, with a decrease in Oscillospira and an increase in Faecalibacterium. The findings suggest that LAGS is effective in treating overall IBS symptoms and improving gut microbiota profile, particularly in the IBS mixed subtype.
Article
Nutrition & Dietetics
Matthew Stefan, Matthew Sharp, Raad Gheith, Ryan Lowery, Charlie Ottinger, Jacob Wilson, Shane Durkee, Aouatef Bellamine
Summary: The study indicates that L-carnitine tartrate supplementation can improve short-term recovery among athletes, while longer-term effects in the general population need further research. The experiment found that L-carnitine tartrate supplementation for 5 weeks could enhance perceived recovery and reduce soreness, as well as lower serum creatine kinase levels.
Article
Engineering, Multidisciplinary
Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen
Summary: This study aimed to investigate the IBS-D-alleviating effects of Lactobacillus plantarum CCFM8610, and the results showed that this probiotic significantly alleviated clinical symptoms and gut microbiota dysbiosis.
Article
Psychiatry
Tsuyoshi Sasaki, Kenji Hashimoto, Tomihisa Niitsu, Yutaka Hosoda, Yasunori Oda, Yuki Shiko, Yoshihito Ozawa, Yohei Kawasaki, Nobuhisa Kanahara, Akihiro Shiina, Tasuku Hashimoto, Takaaki Suzuki, Takeshi Sugawara, Hideki Hanaoka, Masaomi Iyo
Summary: This study suggests that ifenprodil tartrate may be a short-term effective and safe alternative treatment for adolescent patients with PTSD, improving symptoms especially in hyperarousal and dissociation.
PSYCHIATRY RESEARCH
(2022)
Article
Nutrition & Dietetics
Kyoungmi Jung, Areum Kim, Ji-Hae Lee, Donghyun Cho, Juyeon Seo, Eun Sung Jung, Hye-ji Kang, Jonghwa Roh, Wangi Kim
Summary: The study demonstrated that Lactiplantibacillus plantarum APsulloc 331261 (GTB1®) is effective in providing relief for patients with diarrhea-predominant irritable bowel syndrome (IBS-D), reducing abdominal pain severity and frequency, improving diarrhea frequency, and enhancing overall quality of life.
Article
Medicine, General & Internal
Robert Croop, Richard B. Lipton, David Kudrow, David A. Stock, Lisa Kamen, Charles M. Conway, Elyse G. Stock, Vladimir Coric, Peter J. Goadsby
Summary: Rimegepant was found to be effective for preventive treatment of migraine compared to placebo, with tolerability similar to that of placebo and no unexpected or serious safety issues noted.
Article
Nutrition & Dietetics
Brenda Hildeliza Camacho-Diaz, Martha Lucia Arenas-Ocampo, Perla Osorio-Diaz, Antonio Ruperto Jimenez-Aparicio, Guadalupe Monserrat Alvarado-Jasso, Eden Valfre Saavedra-Briones, Miguel angel Valdovinos-Diaz, Elisa Gomez-Reyes
Summary: Irritable bowel syndrome has three subtypes: constipation, diarrhea, and mixed. Dietary fiber treatment is used for different subtypes considering the fiber's composition. The low-FODMAPs diet is recommended for IBS-D subtype, while prebiotics and probiotics are suggested for IBS-C subtype. This study assessed the effects of using agave fructans as soluble fiber in a jelly for the IBS-C group, resulting in improved bowel movements, quality of life, and reduced anxiety and depression.
Article
Integrative & Complementary Medicine
Aakash Deep Das, Shubhamoy Ghosh, Chithra Palanisamy, Nilanjana Guha, Sanjukta Mandal, Shukdeb Maiti, Arunava Nath, Navin Kumar Singh, Munmun Koley, Subhranil Saha
Summary: This study aimed to explore the efficacy of individualized homeopathic medicines (IHMs) for irritable bowel syndrome (IBS). Through a double-blind, randomized, placebo-controlled trial, it was found that IHMs were more effective than placebos in the treatment of IBS. The results of this study suggest that homeopathy could be a promising treatment option for IBS.
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
(2023)
Article
Medicine, General & Internal
Anil Kumar Gupta, Chiranjit Maity
Summary: The study evaluated the safety and efficacy of Bacillus coagulans LBSC in irritable bowel syndrome through a rigorous clinical trial, demonstrating that LBSC was effective in alleviating symptoms and improving quality of life for IBS patients.
Article
Gastroenterology & Hepatology
David Gunn, Rabia Topan, Lorna Barnard, Ron Fried, Ivana Holloway, Richard Brindle, Maura Corsetti, Mark Scott, Adam Farmer, Kapil Kapur, David Sanders, Maria Eugenicos, Nigel Trudgill, Peter Whorwell, John Mclaughlin, Ayesha Akbar, Lesley Houghton, Phil G. Dinning, Qasim Aziz, Alexander C. Ford, Amanda J. Farrin, Robin Spiller
Summary: Ondansetron improves stool consistency and reduces the number of days with loose stool and urgency, according to a meta-analysis of this and other similar trials.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Psychiatry
Yongqian Wang, Xufeng Huang, Hongzhen Fan, Huimei An, Ting Ma, Qi Zhang, Wenxuan Zhao, Yajun Yun, Wenshuang Yang, Xiaolu Zhang, Zhiren Wang, Fude Yang
Summary: This study showed that high-dose betahistine can effectively improve cognitive function but not psychiatric symptoms in Chinese Han patients with schizophrenia. Betahistine (72 mg/d) was considered safe for use in these patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Integrative & Complementary Medicine
Ya Zheng, Jessica Ching, Chung Wah Cheng, Wai Ching Lam, Kam Leung Chan, Xuan Zhang, Pui Yan Lam, Xing Yao Wu, Linda L. D. Zhong, Pei Hua Cao, Cho Wing Lo, Pui Kuan Cheong, Zhixiu Lin, Matthew Koh, Justin Wu, Zhao Xiang Bian
Summary: This study aims to evaluate the efficacy and safety of Chinese medicine JCM-16021 for IBS-D through a multi-center, randomized, double-blind, placebo-controlled clinical trial. The research hopes to provide more evidence to support Chinese medicine treatment for IBS-D.
Review
Gastroenterology & Hepatology
Eva Szigethy, Mitchell Knisely, Douglas Drossman
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
L. Vork, D. Keszthelyi, Z. Mujagic, J. W. Kruimel, C. Leue, I. Ponten, H. Tornblom, M. Simren, A. Albu-Soda, Q. Aziz, M. Corsetti, L. Holvoet, J. Tack, S. S. Rao, J. van Os, E. G. Quetglas, D. A. Drossman, A. A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Anesthesiology
Egilius L. H. Spierings, Douglas A. Drossman, Byron Cryer, M. Mazen Jamal, Taryn Losch-Beridon, Shadreck M. Mareya, Martin Wang
Article
Gastroenterology & Hepatology
Douglas A. Drossman, Jan Tack, Alexander C. Ford, Eva Szigethy, Hans Tornblom, Lukas Van Oudenhove
Article
Gastroenterology & Hepatology
Peter B. Cotton, Qi Pauls, Jamila Keith, Andre Thornhill, Douglas Drossman, April Williams, Valerie Durkalski-Mauldin
GASTROINTESTINAL ENDOSCOPY
(2018)
Article
Gastroenterology & Hepatology
Yukari Tanaka, Motoyori Kanazawa, Olafur S. Palsson, Miranda A. Van Tilburg, Lisa M. Gangarosa, Shin Fukudo, Douglas A. Drossman, William E. Whitehead
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Editorial Material
Gastroenterology & Hepatology
Douglas A. Drossman
Review
Gastroenterology & Hepatology
Helen B. Murray, Adrienne S. Juarascio, Carlo Di Lorenzo, Douglas A. Drossman, Jennifer J. Thomas
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Psychology, Clinical
Jim D. Kantidakis, Simon R. Knowles, Antonina Mikocka-Walus, Tiffany H. Taft, Laurie Keefer, Olafur S. Palsson, Douglas A. Drossman
CLINICAL PSYCHOLOGIST
(2019)
Review
Gastroenterology & Hepatology
Douglas A. Drossman, Johannah Ruddy
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Antonina Mikocka-Walus, Alexander C. Ford, Douglas A. Drossman
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Ami D. Sperber, Shrikant Bangdiwala, Douglas A. Drossman, Uday C. Ghoshal, Magnus Simren, Jan Tack, William E. Whitehead, Dan L. Dumitrascu, Xuicai Fang, Shin Fukudo, John Kellow, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Peter Whorwell, Timothy Archampong, Payman Adibi, Viola Andresen, Marc A. Benninga, Bruno Bonaz, Serhat Bor, Luis Bustos Fernandez, Suck Chei Choi, Enrico S. Corazziari, Carlos Francisconi, Albis Hani, Leonid Lazebnik, Yeong Yeh Lee, Agata Mulak, M. Masudur Rahman, Javier Santos, Mashiko Setshedi, Ari Fahrial Syam, Stephen Vanner, Reuben K. Wong, Aurelio Lopez-Colombo, Valeria Costa, Ram Dickman, Motoyori Kanazawa, Ammar Hassanzadeh Keshteli, Rutaba Khatun, Iradj Maleki, Pierre Poitras, Nitesh Pratap, Oksana Stefanyuk, Sandie Thomson, Judith Zeevenhooven, Olafur S. Palsson
Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.
Review
Medicine, General & Internal
Christopher J. Black, Douglas A. Drossman, Nicholas J. Talley, Johannah Ruddy, Alexander C. Ford
Review
Gastroenterology & Hepatology
Jordyn H. Feingold, Douglas A. Drossman
Summary: Stigma is prevalent in healthcare, especially in disorders of gut-brain interaction. These disorders are often wrongly presumed to be psychiatric, leading to emotional distress, medication non-adherence, barriers to care, and worsening symptoms for patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Douglas A. Drossman, Lin Chang, Jill K. Deutsch, Alexander C. Ford, Albena Halpert, Kurt Kroenke, Samuel Nurko, Johannah Ruddy, Julie Snyder, Ami Sperber
Summary: The changes in healthcare have negatively impacted the communication between patients and providers, but evidence shows that communication skills training can improve patient satisfaction and outcomes. More research is needed to confirm these findings and to further explore the role of communication skills in healthcare.