Article
Cardiac & Cardiovascular Systems
Xin-sheng Deng, Xianzhong Meng, David Fullerton, Matthew Stone, James Jaggers
Summary: This study demonstrates that complement induces profibrogenic activities in aortic valve interstitial cells through the activation of ERK1/2-mediated Runx-2 signaling pathways, suggesting a potential therapeutic target to limit the progression of calcific aortic valve disease.
ANNALS OF THORACIC SURGERY
(2021)
Article
Dermatology
Zhenjun Deng, Manon Subilia, Ian L. Chin, Nicole Hortin, Andrew W. Stevenson, Fiona M. Wood, Cecilia M. Prele, Yu Suk Choi, Mark W. Fear
Summary: Keloid fibroblasts (KFs) are stiffer than normal fibroblasts (NFs) with higher levels of nuclear YAP and alpha-SMA expression. In NFs, YAP nuclear translocation is influenced by matrix stiffness and TGF-beta stimulation, while KFs exhibit baseline elevated nuclear YAP levels that are unresponsive to matrix stiffness or TGF-beta stimulation.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Cell Biology
Mengwen Zhang, Hailong Chen, Huan Qian, Chen Wang
Summary: Keloids, a fibroproliferative skin disorder, exhibit cancer-like behaviors and have similar genetic and epigenetic modifications in the keloid microenvironment. The keloid microenvironment consists of keratinocytes, fibroblasts, myofibroblasts, vascular endothelial cells, immune cells, stem cells, and collagen fibers.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Dermatology
Yasuhiro Nanri, Satoshi Nunomura, Yuko Honda, Hironobu Takedomi, Yukie Yamaguchi, Kenji Izuhara
Summary: Systemic sclerosis (SSc) is a chronic, heterogeneous disease characterized by fibrosis, vascular injury, and autoimmunity. TGF-0 and Periostin play important roles in fibrosis, while SOX11 is involved in organ development. The interactions among TGF-0 signals, Periostin, and SOX11 in SSc pathogenesis are still unclear.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Suwen Ou, Haipeng Chen, Hufei Wang, Jinhua Ye, Huidi Liu, Yangbao Tao, Songlin Ran, Xiaoqin Mu, Fangzhou Liu, Shuang Zhu, Kangjia Luo, Zilong Guan, Yinghu Jin, Rui Huang, Yanni Song, Shu-lin Liu
Summary: The study found that Fusobacterium nucleatum (F. nucleatum) can promote migration and metastasis of colorectal cancer (CRC) cells by upregulating Matrix metalloproteinase 7 (MMP7), and F. nucleatum and MMP7 may serve as potential therapeutic targets for suppressing CRC progression and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Tong Guo, Xiuli Liu, Zhikun Zhang, Yiqun Luo, Tong Li, Lan Li, Huixue Wang, Yong Huang, Jian He, Qiaoying Chen, Yongxiang Zhao, Lu Gan, Liping Zhong
Summary: The study on using matrix metalloproteinase to enhance oncolytic virus (NDV-MMP8) spread in tumors showed that in vitro and in vivo experiments, NDV-MMP8 can effectively degrade extracellular matrix, promote virus spread, and reduce tumor growth.
CHINESE CHEMICAL LETTERS
(2021)
Review
Pharmacology & Pharmacy
Fan Feng, Mingying Liu, Lianhong Pan, Jiaqin Wu, Chunli Wang, Li Yang, Wanqian Liu, Wei Xu, Mingxing Lei
Summary: Keloids are a fibroproliferative skin disorder caused by abnormal healing of injured or irritated skin. Mechanical stimulation can lead to excessive fibroblast proliferation, extracellular matrix deposition, and increase of keloid matrix stiffness, while matrix mechanics further activates the fibrotic phenotype. The TGF-beta/Smad signaling pathway, integrin signaling pathway, YAP/TAZ signaling pathway, and calcium ion pathway are involved in keloid formation. Understanding the role of biomechanical factors in keloid formation may facilitate the development of therapeutic interventions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-En Lu, Ying-Jung Chen
Summary: The study revealed that TNF-α-induced p300-mediated p65 acetylation results in the upregulation of MMP-1 and MMP-3 expression, while resveratrol reduces this upregulation by decreasing p300 expression.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Immunology
Yang Li, Min Li, Caijie Qu, Yongxi Li, Zhanli Tang, Zhike Zhou, Zengzhao Yu, Xu Wang, Linlin Xin, Tongxin Shi
Summary: This study systematically clarifies critical biomarkers related to inflammation and immune response affecting keloid formation. Hub genes were screened through protein-protein interactions (PPIs) and significant signaling pathways and genes related to keloid fibrosis were identified. The study also found abnormal immune cell activity in keloid tissue compared to normal skin tissue.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Pegah Rahmati Nezhad, Pilvi Riihila, Minna Piipponen, Markku Kallajoki, Seppo Meri, Liisa Nissinen, Veli-Matti Kahari
Summary: The study investigated the functional role of complement factor I (CFI) in the progression of cutaneous squamous cell carcinoma (cSCC). It was found that CFI regulates genes associated with cell proliferation and growth of malignant tumors, as well as matrix metalloproteinase activity and extracellular matrix components, affecting invasion and metastasis of cSCC. These results suggest CFI as a potential molecular marker for cSCC invasion and metastasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Leqi Qian, Qiang Wang, Chuanyuan Wei, Lu Wang, Yanwen Yang, Xinyi Deng, Jiaqi Liu, Fazhi Qi
Summary: The study revealed that reduced expression of PTP1B in keloid tissues and fibroblasts was associated with enhanced cell proliferation, motility, ECM production, and ERK activity. Overexpression of PTP1B suppressed these bio-behaviors in keloid fibroblasts and promoted their phenotypic switch to normal cells by inhibiting the MAPK/ERK signaling pathway, indicating its potential as an anti-keloid therapy.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Qiuchen Li, Huaxia Chen, Yanxin Liu, Jianhai Bi
Summary: This study investigated the effects of osteomodulin (OMD) on the cell proliferation, migration, and extracellular matrix (ECM) synthesis of keloid-derived fibroblasts (KFs). The results showed that OMD was highly expressed in keloid tissues and was positively correlated with the activation of p38 MAPK signaling pathway. Silencing OMD inhibited the proliferation and migration of TGF-beta 1-treated KFs, as well as the expression of collagen and fibronectin; while overexpression of OMD had the opposite effects. These findings suggest that OMD may promote the hyperproliferation, migration, and excessive ECM synthesis in KFs through regulation of the p38 MAPK signaling pathway.
JOURNAL OF DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Jinsong Wu, Yanzhi Zhao, Yanmei Fu, Shurong Li, Xu Zhang
Summary: The expression and regulation of lumican play an important role in promoting apoptosis of scleral fibroblasts and the development of myopia.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Medicinal
Ilekuttige Priyan Shanura Fernando, Soo-Jin Heo, Mawalle Kankanamge Hasitha Madhawa Dias, Dissanayaka Mudiyanselage Dinesh Madusanka, Eui-Jeong Han, Min-Ju Kim, Kalu Kapuge Asanka Sanjeewa, Kyounghoon Lee, Ginnae Ahn
Summary: The study evaluated the protective effects of HTT isolated from brown algae against UVB-induced skin aging in HDFs. HTT suppressed ROS generation, mitochondrial hyperpolarization, apoptotic body formation, and inflammatory cytokines, as well as downregulated matrix metalloproteinase activity, suggesting its potential for use in UV protective products.
Article
Multidisciplinary Sciences
Alaa M. Altaie, Mohammad G. Mohammad, Mohamed I. Madkour, Mohammed Amjed AlSaegh, Manju Nidagodu Jayakumar, Aghila K. G. Rani, A. R. Samsudin, Rabih Halwani, Rifat A. Hamoudi, Sameh S. M. Soliman
Summary: Recently, 1-nonadecene and l-lactic acid were identified as unique metabolites in radicular cysts and periapical granuloma, respectively. The research aimed to investigate their effects on inflammation and cell behavior. The results showed that 1-nonadecene enhanced inflammation and induced a process called mesenchymal-epithelial transition (MET) in periodontal ligament fibroblasts (PdLFs). It also polarized macrophages to a pro-inflammatory phenotype. On the other hand, l-lactic acid had differential effects, promoting collagen synthesis but inhibiting the release of MMP-1 in PdLFs. These findings provide a better understanding of the roles of 1-nonadecene and l-lactic acid in the periapical area's microenvironment.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
Soomin Kim, Jihee Kim, Young In Lee, Seulgi Jang, Seung Yong Song, Won Jai Lee, Ju Hee Lee
Summary: The study found that PM and UVA radiation can accelerate skin cell aging, leading to increased inflammation and downregulation of collagen. The l-ascorbic acid compound (LAC) can reduce ROS and inflammatory cytokine levels, and decrease signs of aging.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Dohyun Kim, Youngdae Lee, Kwangsook Park, Danbi Park, Won Jai Lee, Tai Suk Roh, Hyungju Cho, Wooyeol Baek
Summary: This study utilized human tonsil-derived mesenchymal stem cells to produce functional biomimetic nanovesicles with anti-senescence properties, demonstrating enhanced cell proliferation, reduced senescence activity, and impacts on the expression of extracellular matrix and antioxidant genes. These findings suggest that TMSC-NVs can be beneficial for skin rejuvenation applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Surgery
Young Chul Suh, Shin Hyun Kim, Woo Yeol Baek, Jong Won Hong, Won Jai Lee, Young Joon Jun
Summary: This study investigated the distance and vector between perforator points in the super-thin ALT flap elevation technique, suggesting its effectiveness with the help of preoperative color duplex ultrasonography.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Surgery
Shin Hyun Kim, Won Jai Lee
Summary: This study described the clinical appearance and surgical complications of children with car-tire friction injuries treated with split-thickness skin grafts. The results showed that 11 out of 15 patients had hypertrophic scars and/or scar contracture after surgery.
ARCHIVES OF PLASTIC SURGERY-APS
(2021)
Article
Surgery
Oh Young Joo, Seung Jin Moon, Dong Won Lee, Dae Hyun Lew, Won Jai Lee, Seung Yong Song
Summary: This study investigated the effect of early exercise on total drainage volume and drain duration in prosthesis-based breast reconstruction patients. The results showed that early exercise can improve shoulder mobility postoperatively and is beneficial for patient recovery.
ARCHIVES OF PLASTIC SURGERY-APS
(2021)
Article
Surgery
Ji Hyuk Jung, Yeo Reum Jeon, Dong Won Lee, Hyung Seok Park, Dae Hyun Lew, Tae Suk Roh, Seung Yong Song
Summary: The use of the da Vinci SP model for creating a DIEP free flap allows for surgery in smaller areas, reducing the risk of complications and promoting faster healing.
ARCHIVES OF PLASTIC SURGERY-APS
(2022)
Article
Biochemistry & Molecular Biology
Bok Ki Jung, Tai Suk Roh, Hyun Roh, Ju Hee Lee, Chae-Ok Yun, Won Jai Lee
Summary: In this study, the role of mortalin in scar formation and its association with interleukin-1 alpha receptor were explored. The results showed that mortalin treatment increased the expression of scar formation-related proteins in human dermal fibroblasts. In a rat incisional wound model, mortalin-specific shRNA significantly reduced scar size and the expression of related proteins. Blocking mortalin could be a potential therapeutic target for scar formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Mijung Kim, Nara Lee, Woohyun Tark, Won Jai Lee, Tai Suk Roh, Wooyeol Baek
Summary: Dual-tunneling method is an effective approach for forehead lifting, reducing relapse and weakening of adhesion. By utilizing a triangular plane and fixing the periosteum, better surgical outcomes can be achieved.
ARCHIVES OF AESTHETIC PLASTIC SURGERY
(2022)
Review
Surgery
Young Woong Mo, Jae Hyeok Choi, Won Jai Lee
Summary: There is no consensus on the use of prophylactic intraoperative wound irrigation (pIOWI) for reducing surgical-site infections (SSIs), particularly surgical incisional wounds, and opinions are divided on whether an antibiotic should be mixed with the solution used for incisional wound irrigation. No large, reliable cohort studies or meta-analyses of pIOWI for surgical incisional wounds were found. Further large, prospective RCTs only limited to incisional SSIs and excluding other variables and biases in the field of plastic surgery are needed.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Polymer Science
Seung-Jun Jwa, Jong-Min Won, Do-Hyun Kim, Ki-Bum Kim, Jung-Bok Lee, Min Heo, Kyu-Sik Shim, Han-Saem Jo, Won-Jai Lee, Tai-Suk Roh, Woo-Yeol Baek
Summary: This study explores the possibility of using a PCL scaffold to repair tissue defects after partial mastectomy. The results demonstrate that in a rat model, implantation of the PCL scaffold leads to restoration of breast tissue, and the PCL scaffold with collagen promotes collagen expression.
Editorial Material
Surgery
Kwan Chul Tark, Eul Sik Yoon, Hak Chang, Won Jai Lee, Joon Pio Hong
ARCHIVES OF PLASTIC SURGERY-APS
(2023)
Article
Emergency Medicine
Young In Lee, Jung Eun Shim, Jihee Kim, Won Jai Lee, Jae Woo Kim, Kee Hyun Nam, Ju Hee Lee
Summary: This study identified a partial mechanism of keloid pathogenesis, which involves intercellular communication via the WNT5A and STAT pathways leading to the occurrence of EMT-like phenomena. Improving our understanding of keloid development and the role of WNT5A in EMT could promote the development of targeted treatments for keloid scars.
Article
Medicine, General & Internal
Jongmin Won, Jong Won Hong, Mi Jung Kim, In-sik Yun, Woo Yeol Baek, Won Jai Lee, Dae Hyun Lew, Yoon Woo Koh, Se-Heon Kim
Summary: This study retrospectively analyzed the methodologies of conventional head and neck reconstruction after robotic surgery. The radial forearm flap was found to be commonly used for this purpose. Ensuring additional space is a key step for successful reconstruction.
YONSEI MEDICAL JOURNAL
(2022)
Article
Surgery
Hong Bae Jeon, Hyun Roh, Hyo Min Ahn, Ju Hee Lee, Chae Ok Yun, Tai Suk Roh, Won Jai Lee
Summary: The study showed that metformin can inhibit the expression of ECM components in TGF-beta-stimulated human dermal fibroblasts and keloid spheroids, indicating its potential as an effective agent for the treatment of keloids.
ANNALS OF PLASTIC SURGERY
(2021)
Article
Surgery
Simon Yang, Jong Won Hong, In Sik Yoon, Dae Hyun Lew, Tai Suk Roh, Won Jai Lee
Summary: The study found that radial forearm free flaps (RFFF) and anterolateral thigh free flaps (ALT) have similar outcomes in reconstruction surgery after removal of head and neck cancer, with no significant differences in donor site morbidity and flap survival rate. ALT can be considered as an option for head and neck reconstruction surgery, especially for patients with large and complex defects.
ARCHIVES OF PLASTIC SURGERY-APS
(2021)