Article
Clinical Neurology
Andrew R. Mayer, Timothy B. Meier, Andrew B. Dodd, David D. Stephenson, Cidney R. Robertson-Benta, Josef M. Ling, Sharvani Pabbathi Reddy, Vadim Zotev, Kishore Vakamudi, Richard A. Campbell, Robert E. Sapien, Erik B. Erhardt, John P. Phillips, Andrei A. Vakhtin
Summary: The study aims to investigate the recovery process after pediatric mild traumatic brain injury (pmTBI) by examining the changes in brain structure and the age-at-injury effects. It is hypothesized that there will be reduced cortical thickness and hippocampal volumes up to 4 months postinjury, and these changes will be influenced by the age at injury.
Article
Clinical Neurology
Andrew R. Mayer, Timothy B. Meier, Andrew B. Dodd, David D. Stephenson, Cidney R. Robertson-Benta, Josef M. Ling, Sharvani Pabbathi Reddy, Vadim Zotev, Kishore Vakamudi, Richard A. Campbell, Robert E. Sapien, Erik B. Erhardt, John P. Phillips, Andrei A. Vakhtin
Summary: This study aimed to examine the structural brain changes and age-at-injury effects in pediatric patients with mild traumatic brain injury (pmTBI). The results showed reduced cortical thickness and hippocampal volumes in pmTBI patients, but these changes were not associated with age at injury. The study also found that postconcussive symptoms and cognitive deficits were observed in these patients.
Article
Clinical Neurology
Ashley L. Ware, Catherine Lebel, Adrian Onicas, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce H. Bjornson, William Craig, Mathieu Dehaes, Quynh Doan, Sylvain Deschenes, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Keith Owen Yeates
Summary: This prospective cohort study investigated the trajectories of brain gray matter macrostructure after pediatric mild traumatic brain injury (mTBI). The study found that mTBI can alter the typical course of cortical gray matter thinning up to 6 months postinjury, even after symptoms typically abate in most children. Therefore, it is important to examine neurobiology in relation to clinical outcomes and within a neurodevelopmental framework.
Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Laura Campbell-Sills, Sonia Jain, Xiaoying Sun, Lauren B. Fisher, Stephanie D. Agtarap, Sureyya Dikmen, Lindsay D. Nelson, Nancy Temkin, Michael McCrea, Esther Yuh, Joseph T. Giacino, Geoffrey T. Manley
Summary: Preinjury psychiatric history and history of prior TBI are predictors for suicidal ideation following mild traumatic brain injury, while post-TBI symptoms are strongly associated with suicidal ideation, mainly driven by co-occurring depression.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)
Article
Rehabilitation
Toril Skandsen, Jonas Stenberg, Turid Follestad, Migle Karaliute, Simen B. Saksvik, Cathrine E. Einarsen, Hanna Lillehaug, Asta K. Haberg, Anne Vik, Alexander Olsen, Grant L. Iverson
Summary: Personal factors play an important role in predicting postconcussion symptoms in patients with mild traumatic brain injury (MTBI). Factors such as work status, preinjury health problems, and gender were found to be predictors of postconcussion symptoms. Intracranial abnormalities on CT scans were also identified as a risk factor for postconcussion symptoms.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Gerard Janez Brett Clarke, Toril Skandsen, Henrik Zetterberg, Cathrine Elisabeth Einarsen, Casper Feyling, Turid Follestad, Anne Vik, Kaj Blennow, Asta Kristine Haberg
Summary: The study showed that GFAP and tau levels were highest in the acute phase, while NFL peaked at 2 weeks and 3 months in patients with mTBI. Patients with concomitant other somatic injuries had the most significant elevations in biomarker levels, and were more likely to be victims of traffic accidents and violence. Acute GFAP concentrations displayed the highest discriminability between patients and controls.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Jennifer N. Belding, Bilal Khokhar, Robyn Martin Englert, Shannon Fitzmaurice, Cynthia J. Thomsen
Summary: This study examined the persistence of concussion-related symptoms following injury as a function of mechanism of injury (high-level blast [HLB] vs impact) and low-level blast (LLB) exposure among Marines. The findings suggest that blast-induced brain injuries may be fundamentally different from impact-induced injuries, and additional screening and symptomatic treatment for blast-exposed patients may be warranted. Probable HLB-induced mTBIs were associated with significantly more neurological symptoms at return from deployment and approximately 6 months later.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)
Article
Clinical Neurology
William C. Walker, Sarah W. Clark, Kaleb Eppich, Elisabeth A. Wilde, Aaron M. Martin, Chelsea M. Allen, Melissa M. Cortez, Mary Jo Pugh, Samuel R. Walton, Kimbra Kenney
Summary: This study analyzed the relationship between lifetime history of mild traumatic brain injury (mTBI) and other factors with headache prevalence and impact among combat-exposed current and former service members. The results showed that regardless of the remoteness of mTBI, participants with positive mTBI history had higher headache prevalence and impact. Blast-related mTBI posed the highest risk and was uniquely associated with elevated headache burden. Other demographic and potentially modifiable risk factors were also identified.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Debbie Y. Madhok, Robert M. Rodriguez, Jason Barber, Nancy R. Temkin, Amy J. Markowitz, Natalie Kreitzer, Geoffrey T. Manley
Summary: This study found that most patients with mild TBI, with a GCS score of 15 and a negative head CT scan, did not fully recover at 2 weeks and 6 months after the injury. Emergency department clinicians should recommend 2-week follow-up visits to identify patients with incomplete recovery and facilitate rehabilitation.
Article
Family Studies
Leanne K. Knobloch, Bryan Abendschein
Summary: Objective: This study aims to differentiate the effects of deployment-acquired traumatic brain injury (TBI) from concurrent postconcussive and PTSD symptoms on relationship distress. Background: Understanding the predictors of relationship distress after TBI is crucial for supporting military marriages. Method: Survey data from the U.S. Army STARRS Pre-Post Deployment Study were used to evaluate predictors of relationship distress in 2,585 married service members. Results: Deployment-acquired TBI was associated with more relationship distress, but its predictive power was overshadowed by concurrent postconcussive and PTSD symptoms. Conclusion: Treating comorbid conditions is essential for supporting military marriages after TBI.
Review
Clinical Neurology
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Summary: This article reviews recent research on neuromodulation for mild traumatic brain injury (mTBI). It suggests that transcranial magnetic stimulation (TMS) shows promise as a potential treatment strategy for post-concussive symptoms, such as depression and headaches, while transcranial direct current stimulation (tDCS) has more mixed results. Further studies are needed to explore new stimulation protocols, personalized approaches, and the role of placebo effects.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Rehabilitation
Umesh M. Venkatesan, Deepa M. Ramanathan-Elion
Summary: This article discusses the theoretical foundations and conceptual framework of psychoeducation in cognitive rehabilitation interventions, and proposes the use of treatment theory and the Rehabilitation Treatment Specification System to personalize educational content and improve health literacy in Service Members and Veterans affected by mild traumatic brain injury.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Ann Scher, James S. McGinley, R. J. Wirth, Richard B. Lipton, Heidi Terrio, Lisa A. Brenner, Wesley R. Cole, Karen Schwab
Summary: The study found that post-traumatic headaches differ from other headaches in terms of symptom complexity, with post-traumatic headache patients more likely to seek medical care for headaches.
Review
Pharmacology & Pharmacy
Steven H. Lamm, Isabella J. Boroje, Hamid Ferdosi, Jaeil Ahn
Summary: Research suggests that models other than the linear no-threshold (LNT) model may better explain human cancer risk from arsenic ingestion at lower exposure levels. Previous epidemiological studies have shown increased cancer risks for bladder, lung, and skin cancers at arsenic exposures of 200 ug/L or higher, while dose-response patterns at lower levels of exposure may differ.
Article
Clinical Neurology
Rosemay A. Remigio-Baker, Ida Babakhanyan, Emma Gregory, Wesley R. Cole, Mark L. Ettenhofer, Therese West, Felicia Qashu, Lynita Mullins, Jason M. Bailie
Summary: The timing between current and previous concussions may influence symptom severity in acutely concussed military Service members. Individuals with a relatively recent previous concussion had worse symptoms within 72 hours and 1 week post-injury compared to those with more remote previous concussion or no history. This relationship was particularly significant for affective and somatosensory symptoms.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)
Article
Immunology
Nusrat J. Epsi, Stephanie A. Richard, Eric D. Laing, Anthony C. Fries, Eugene Millar, Mark P. Simons, Caroline English, Christopher J. Colombo, Rhonda E. Colombo, David A. Lindholm, Anuradha Ganesan, Ryan C. Maves, Nikhil Huprikar, Derek Larson, Katrin Mende, Sharon W. Chi, Cristian Madar, Tahaniyat Lalani, Christopher C. Broder, David Tribble, Brian K. Agan, Timothy H. Burgess, Simon D. Pollett
Summary: Obesity is strongly correlated with COVID-19 severity in US Military Health System beneficiaries, as obese patients may have higher viral loads and stronger immune responses following SARS-CoV-2 infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Clinical Neurology
Hakan Ashina, Anna K. Eigenbrodt, Tad Seifert, Alexandra J. Sinclair, Ann Scher, Henrik W. Schytz, Mi Ji Lee, Roberto De Icco, Alan G. Finkel, Messoud Ashina
Summary: Post-traumatic headache is a common sequela of traumatic brain injury and significant progress has been made in understanding its clinical features and identifying effective therapies. This disorder is increasingly recognized as heterogeneous, with different subphenotypes potentially responding better to specific therapies. More evidence-based research is needed to address the current shortcomings in diagnostic criteria and treatment selection.
Article
Immunology
F. Julian Lantry, Nusrat J. Epsi, Simon D. Pollett, Mark P. Simons, David A. Lindholm, Rhonda E. Colombo, Anthony C. Fries, Ryan C. Maves, Anuradha Ganesan, Gregory C. Utz, Tahaniyat Lalani, Alfred G. Smith, Rupal M. Mody, Christopher J. Colombo, Sharon W. Chi, Cristian Madar, Nikhil Huprikar, Derek T. Larson, Samantha Bazan, Christopher C. Broder, Eric D. Laing, Caroline English, Charlotte Lanteri, Katrin Mende, David R. Tribble, Brian K. Agan, Timothy H. Burgess, Stephanie A. Richard
Summary: This study compared the detection of SARS-CoV-2 in swab samples collected on the same day and found that nasopharyngeal swabs detected the virus more accurately than other swab types. The sensitivity of non-nasopharyngeal swabs decreased over time.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
Stephanie A. Richard, Nusrat J. Epsi, Simon Pollett, David A. Lindholm, Allison M. W. Malloy, Ryan Maves, Gregory C. Utz, Tahaniyat Lalani, Alfred G. Smith, Rupal M. Mody, Anuradha Ganesan, Rhonda E. Colombo, Christopher J. Colombo, Sharon W. Chi, Nikhil Huprikar, Derek T. Larson, Samantha Bazan, Cristian Madar, Charlotte Lanteri, Julia S. Rozman, Caroline English, Katrin Mende, David R. Tribble, Brian K. Agan, Timothy H. Burgess, John H. Powers
Summary: The FLU-PRO Plus instrument was assessed for its measurement properties in individuals with COVID-19, showing good reliability, construct validity, known-groups validity, and responsiveness to change. The study found moderate to high correlations between FLU-PRO Plus scores and disease severity ratings, indicating its effectiveness in assessing symptoms in SARS-CoV-2 infection.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Nusrat J. Epsi, Stephanie A. Richard, David A. Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Anthony C. Fries, Ryan C. Maves, Rhonda E. Colombo, Derek T. Larson, Alfred Smith, Sharon W. Chi, Carlos J. Maldonado, Evan C. Ewers, Milissa U. Jones, Catherine M. Berjohn, Daniel H. Libraty, Margaret Sanchez Edwards, Caroline English, Julia S. Rozman, Rupal M. Mody, Christopher J. Colombo, Emily C. Samuels, Princess Nwachukwu, Marana S. Tso, Ann Scher, Celia Byrne, Jennifer Rusiecki, Mark P. Simons, David Tribble, Christopher C. Broder, Brian K. Agan, Timothy H. Burgess, Eric D. Laing, Simon D. Pollett
Summary: Prior SARS-CoV-2 infection followed by vaccination, or vice versa, leads to a stronger and more enduring IgG response compared to infection or vaccination alone. The timing between infection and vaccination affects the magnitude of post-vaccine immune response.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Clinical Neurology
Ann I. Scher, Lars Bendtsen
Article
Oncology
Julie A. Bytnar, Jie Lin, Brett J. Theeler, Ann Scher, Craig D. Shriver, Kangmin Zhu
Summary: The study suggests that there is a significant association between psychiatric illnesses and subsequent brain cancer diagnosis, which may not be solely due to detection bias. Psychiatric illnesses might serve as an early manifestation of brain cancer.
CANCER CAUSES & CONTROL
(2022)
Article
Medicine, Research & Experimental
Keturah R. Faurot, Wesley R. Cole, Beth A. MacIntosh, Margaret Dunlap, Carol B. Moore, Brittney Roberson, Melissa Guerra, Anthony F. Domenichiello, Olafur Palsson, Wanda Rivera, Ann Nothwehr, Jacques Arrieux, Katie Russell, Cecily Jones, J. Kent Werner, Ruth Clark, Ramon Diaz-Arrastia, Chirayath Suchindran, J. Douglas Mann, Christopher E. Ramsden, Kimbra Kenney
Summary: This study aims to evaluate the clinical effects of dietary modifications on nociceptive lipid mediators and symptoms in patients with post-traumatic headache (PTH). By conducting a prospective randomized controlled trial, researchers will assess the efficacy and safety of targeted dietary interventions in active-duty service members and military healthcare beneficiaries. The study will measure clinical outcomes and biochemical effects to determine the impact of different dietary regimens on PTH.
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Immunology
Stephanie A. Richard, Nusrat J. Epsi, David A. Lindholm, Allison M. W. Malloy, Ryan C. Maves, Catherine M. Berjohn, Tahaniyat Lalani, Alfred G. Smith, Rupal M. Mody, Anuradha Ganesan, Nikhil Huprikar, Rhonda E. Colombo, Christopher J. Colombo, Cristian Madar, Milissa U. Jones, Derek T. Larson, Evan C. Ewers, Samantha Bazan, Anthony C. Fries, Carlos J. Maldonado, Mark P. Simons, Julia S. Rozman, Liana Andronescu, Katrin Mende, David R. Tribble, Brian K. Agan, Timothy H. Burgess, Simon D. Pollett, John H. Powers
Summary: This study found that being fully vaccinated against SARS-CoV-2 is associated with a lower severity of patient-reported symptoms, leading to an earlier return to usual activities. Infection with the Delta variant is associated with higher FLU-PRO Plus scores, even after controlling for vaccination status.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Psychology, Clinical
Brian J. Ivins, Jacques P. Arrieux, Wesley R. Cole
Summary: This study aimed to replicate the results of a new computerized test battery, Brain Gauge (BG), which uses tactile stimulation, for cognitive assessment of patients with mild traumatic brain injury (mTBI). The analysis did not replicate the high level of classification accuracy reported by BG's developers, suggesting limited clinical utility for assessing mTBI patients.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Kjetil Bjornevik, Marianna Cortese, Brian C. Healy, Jens Kuhle, Michael J. Mina, Yumei Leng, Stephen J. Elledge, David W. Niebuhr, Ann Scher, Kassandra L. Munger, Alberto Ascherio
Summary: This study suggests that multiple sclerosis may be caused by Epstein-Barr virus, with no direct association with other viral infections. These findings provide clues to the primary cause of MS.
