Article
Biochemistry & Molecular Biology
K. P. Best, R. A. Gibson, M. Makrides
Summary: Globally, preterm birth is a major cause of child mortality, and increasing maternal intake of omega-3 long chain polyunsaturated fatty acids (LCPUFA) during pregnancy can help prevent it. This statement provides a synthesis of current evidence on the role of omega-3 LCPUFA in preventing preterm birth and offers guidance for medical practitioners, midwives, health services, professional bodies, and policy makers.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2022)
Article
Pediatrics
Karolina Sobczyk, Tomasz Holecki, Joanna Wozniak-Holecka, Mateusz Grajek
Summary: In addition to low birth weight and intrauterine growth restriction, prematurity is a major problem in modern neonatology. This study found that there is a relationship between early pregnancy body mass index (BMI) and the risk of preterm delivery, with overweight and obese women being more likely to have extremely and very preterm births.
Article
Physiology
Andrew A. Bremer, Jagteshwar Grewal, Rohan Hazra, Roberto Romero, Diana W. Bianchi
Summary: Premature birth is a major cause of morbidity and mortality, with research efforts focused on prevention and improved treatment for pre-term infants. Collaboration between intramural and extramural research institutions, including multiple institutes and centers at the National Institutes of Health, is crucial in addressing this issue.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Pediatrics
George Daskalakis, Alexandros Psarris, Antonios Koutras, Zacharias Fasoulakis, Ioannis Prokopakis, Antonia Varthaliti, Christina Karasmani, Thomas Ntounis, Ekaterini Domali, Marianna Theodora, Panos Antsaklis, Kalliopi I. Pappa, Angeliki Papapanagiotou
Summary: Preterm birth, a major public health concern worldwide, is the leading cause of neonatal morbidity and mortality. This review analyzes the association between infections and premature birth. Intrauterine infection/inflammation is commonly associated with spontaneous preterm birth. Inflammation-induced overproduction of prostaglandins can lead to uterine contractions and contribute to preterm delivery. Various pathogens, including Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Actinomyces, Candida spp., and Streptococcus spp., have been implicated in premature delivery, chorioamnionitis, and neonatal sepsis. Further research is needed to develop effective preventive methods and reduce neonatal morbidity.
Article
Nutrition & Dietetics
Mariela Bernabe-Garcia, Philip C. Calder, Raul Villegas-Silva, Maricela Rodriguez-Cruz, Luis Chavez-Sanchez, Leonardo Cruz-Reynoso, Leovigildo Mateos-Sanchez, Gabriel Lara-Flores, Augusto R. Aguilera-Joaquin, Luisa Sanchez-Garcia
Summary: A daily dose of 75 mg/kg body weight of DHA for 14 days may prevent NEC in preterm infants. The study found that infants in the DHA treatment group had lower risk of NEC and lower rate of treatment failure compared to the control group.
Article
Geriatrics & Gerontology
Peter D. Ahiawodzi, Petra Buzkova, Alice H. Lichtenstein, Nirupa R. Matthan, Joachim H. Ix, Jorge R. Kizer, Russell P. Tracy, Alice Arnold, Anne B. Newman, David Siscovick, Luc Djousse, Kenneth J. Mukamal
Summary: This study aimed to investigate the associations between individual NEFAs and disability and mobility limitation. The results showed that higher concentrations of total NEFA and various individual NEFA species were associated with an increased risk of disability and mobility limitation. Specific fatty acids, such as myristic and palmitic acids, were significantly associated with higher risk, while certain types of PUFA were not associated with disability or mobility limitation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Genetics & Heredity
Tracy A. Manuck, Lauren A. Eaves, Julia E. Rager, Rebecca C. Fry
Summary: This study found a link between changes in RNA in mother's blood in early pregnancy and preterm delivery, with combining genetic and clinical information leading to more accurate prediction of premature birth risk.
Article
Medicine, General & Internal
Dvora Kluwgant, Tamar Wainstock, Eyal Sheiner, Gali Pariente
Summary: Placenta previa, multiple gestations, and placental abruption were identified as the strongest risk factors for extreme preterm birth. Risk factors including placental abruption and previa, lack of prenatal care, and recurrent pregnancy loss were observed in sub-populations with multiple gestations, previous PTB, and indicated PTBs. Placental abruption emerged as the most significant risk factor across all groups, with no significant differences observed between sub-populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Brahm Seymour Coler, Oksana Shynlova, Adam Boros-Rausch, Stephen Lye, Stephen McCartney, Kelycia B. Leimert, Wendy Xu, Sylvain Chemtob, David Olson, Miranda Li, Emily Huebner, Anna Curtin, Alisa Kachikis, Leah Savitsky, Jonathan W. Paul, Roger Smith, Kristina M. Adams Waldorf
Summary: Preterm birth remains a significant cause of infant morbidity and mortality, with limited therapeutic options despite 50 years of research. The global need for better tocolytic agents is particularly urgent, with newer therapeutics targeting inflammatory checkpoints for more effective tocolysis. However, regulatory hurdles and a small market for new PTB therapeutics have hindered pharmaceutical interest in this area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Derek Miller, Valeria Garcia-Flores, Marcia Arenas-Hernandez, Andrew D. Winters, Bruce A. Berkowitz, Robert H. Podolsky, Yimin Shen, Tomi Kanninen, Bogdan Panaitescu, Catherine R. Glazier, Roger Pique-Regi, Kevin R. Theis, Nardhy Gomez-Lopez
Summary: This study investigates the role of IL-6 and IL-1 alpha in sterile intra-amniotic inflammation (SIAI) and their impact on preterm birth and neonatal outcomes. The researchers found that IL-6 plays a critical role in the inflammatory response and that IL-1 alpha injection leads to preterm birth and neonatal mortality. Prenatal treatment with an IL-6R blockade shows promising results in preventing preterm birth and improving neonatal outcomes.
Article
Cell Biology
Remi Karadayi, Charlotte Pallot, Stephanie Cabaret, Julie Mazzocco, Pierre-Henry Gabrielle, Denis S. Semama, Corinne Chantegret, Ninon Ternoy, Delphine Martin, Aurelie Donier, Stephane Gregoire, Catherine P. Creuzot-Garcher, Alain M. Bron, Lionel Bretillon, Olivier Berdeaux, Niyazi Acar
Summary: The study suggests that the accumulation of n-6 PUFAs and the decrease of n-3 PUFAs in the blood of preterm infants may be partly due to plasmalogens, which are associated with the development of retinopathy of prematurity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medical Laboratory Technology
Jose Galaz, Kenichiro Motomura, Roberto Romero, Zhenjie Liu, Valeria Garcia-Flores, Li Tao, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Tomi Kanninen, Marcelo Farias-Jofre, Derek Miller, Adi L. Tarca, Nardhy Gomez-Lopez
Summary: Preterm birth is a major cause of neonatal morbidity and mortality worldwide. Sterile intra-amniotic inflammation, triggered by alarmins, is a common condition associated with preterm labor. The NLRP3 inflammasome has been implicated in this process, but its mechanisms are not fully understood. By studying Nlrp3-/- mice, researchers found that NLRP3 deficiency prevents preterm birth and neonatal mortality by inhibiting premature labor activation and reducing inflammation. Furthermore, both maternal and fetal Nlrp3 signaling contribute to alarmin-induced preterm birth. These findings highlight the importance of targeting NLRP3 signaling to prevent adverse perinatal outcomes.
TRANSLATIONAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Chenchen Zhao, Bing Wu, Jinxia Li, Qianming Jiang, Menglin Liu, Linfang Chen, Yiwei Zhu, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Lin Lei, Xinwei Li
Summary: AdipoRon shows positive effects on NEFA-induced lipid accumulation and mitochondrial dysfunction. It alleviates these pathological changes by influencing lipid metabolism and protein expression in mitochondria. In addition, AdipoRon enhances autophagic activity in hepatocytes, suppressing the negative effects of NEFA.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Medicine, General & Internal
Isabelle Marc, Amelie Boutin, Etienne Pronovost, Norma Maria Perez Herrera, Mireille Guillot, Frederic Bergeron, Lynne Moore, Thomas R. Sullivan, Pascal M. Lavoie, Maria Makrides
Summary: This systematic review and meta-analysis examines the association between daily omega-3 docosahexaenoic acid (DHA) supplementation and bronchopulmonary dysplasia (BPD) in preterm infants born at less than 29 weeks' gestation. The study found that high-dose DHA supplementation during the neonatal period was not associated with BPD overall, but was inversely associated with BPD in trials that used a more stringent definition. These findings suggest that high-dose DHA supplementation should not be recommended for the prevention of BPD in very preterm infants.
Article
Multidisciplinary Sciences
Max T. Aung, Pahriya Ashrap, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario, Carmen M. Velez-Vega, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: Maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters were characterized, revealing potential biomarkers for pregnancy outcomes. Fine omics-scale analysis of the maternal lipidome may offer more informative insights compared to whole class level lipid analysis.
SCIENTIFIC REPORTS
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Baiyang Sun, Marnie Bertolet, Cora E. Lewis, Erica P. Gunderson, Janet M. Catov
Editorial Material
Medicine, Research & Experimental
Marnie Bertolet, Maria Mori Brooks, Jeffrey L. Carson
Article
Developmental Biology
Baiyang Sun, W. Tony Parks, Hyagriv N. Simhan, Marnie Bertolet, Janet M. Catov
Article
Obstetrics & Gynecology
Stacy M. Lenger, Megan S. Bradley, Debbie A. Thomas, Marnie H. Bertolet, Jerry L. Lowder, Siobhan Sutcliffe
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Endocrinology & Metabolism
Janet M. Catov, Baiyang Sun, Marnie Bertolet, Gabrielle G. Snyder, Cora E. Lewis, Norrina B. Allen, James M. Shikany, Katherine H. Ingram, Duke Appiah, Erica P. Gunderson
Article
Cardiac & Cardiovascular Systems
Baiyang Sun, Marnie Bertolet, Maria M. Brooks, Carl A. Hubel, Cora E. Lewis, Erica P. Gunderson, Janet M. Catov
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Hematology
Craig D. Seaman, Marnie Bertolet, Jun Zhang, Margaret V. Ragni
Summary: This study aimed to compare the quality of periprocedural care received by patients with von Willebrand disease (VWD) at Haemophilia Treatment Centres (HTCs) and non-HTCs. Results showed that VWD-specific therapy was more frequently used in HTC cases, but there was no difference in periprocedural bleeding outcomes between the two groups.
Article
Endocrinology & Metabolism
Janet M. Catov, Baiyang Sun, Cora E. Lewis, Marnie Bertolet, Erica P. Gunderson
Summary: This study found that weight gain before pregnancy is associated with excessive weight gain during pregnancy, especially among women without overweight or obesity. Assessing pre-pregnancy weight changes can help identify those at risk for high GWG.
Article
Obstetrics & Gynecology
Alexander J. Layden, Marnie Bertolet, W. Tony Parks, James M. Roberts, Jennifer J. Adibi, Janet M. Catov
Summary: Latent class analysis of placental histopathologic data can help distinguish early and late preterm births, and is associated with maternal obesity and neonatal outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Janet M. Catov, Baiyang Sun, Erica P. Gunderson, Samantha Bryan, Marnie Bertolet, Cora E. Lewis, Abbi Lane-Cordova, Sadiya Khan, Stacy Beck
Article
Psychology, Multidisciplinary
Krissy K. Moehling, Mary P. Nowalk, Richard K. Zimmerman, Joyce T. Bromberger, Chyongchiou J. Lin, Samantha E. Ford, Marnie Bertolet
Summary: The study found that spirituality plays a positive role in alleviating the negative impact of depression and stress on frailty among older adults, helping them maintain a healthier state.
PSYCHOLOGY OF RELIGION AND SPIRITUALITY
(2022)
Article
Public, Environmental & Occupational Health
Alexander J. Layden, Marnie Bertolet, W. Tony Parks, Jennifer J. Adibi, James M. Roberts, Janet M. Catov
Summary: This study investigates the association between prepregnancy obesity and histologic placental inflammation, as well as the influence of selection bias on this association. The results suggest that obesity is associated with a lower risk of acute chorioamnionitis and fetal inflammation, and a higher risk of chronic villitis.
ANNALS OF EPIDEMIOLOGY
(2023)
Meeting Abstract
Hematology
Margaret V. Ragni, Frederico Xavier, Craig D. Seaman, Suchitra Acharya, Catherine E. McGuinn, Eric J. Werner, Courtney Elizabeth Lawrence, Allison P. Wheeler, Ulrike Reiss, Irmel Ayala, Erin Cockrell, Cristina Tarango, Amy Dunn, Roshni Kulkarni, Sanjay P. Ahuja, Meera B. Chitlur, Steven W. Pipe, Lynn M. Malec, Vilmarie Rodriguez, Shelley Crary, Deborah Brown, Rosa Diaz, Maria Velez
Article
Hematology
Marnie Bertolet, Maria M. Brooks, Margaret Ragni
Meeting Abstract
Obstetrics & Gynecology
S. Lenger, M. S. Bradley, D. Thomas, M. Bertolet, J. Lowder, S. Sutcliffe
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)