Review
Cell Biology
Farbod Bahreini, Elham Rayzan, Nima Rezaei
Summary: Breast cancer, a multifactorial disease, may have an increased risk due to alterations in microRNA sequences. miR-SNPs are potential biomarkers for early detection of breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Lin Li, Baoqiang Pei, Yanyan Feng
Summary: This study found that the use of exogenous hormones is associated with an increased risk of keratinocyte carcinoma (KC), specifically squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), among women. Oral contraceptives (OC) were found to increase the risk of SCC, while no significant association was observed between hormonal replacement therapy (HRT) and SCC risk. Both OC and HRT use were linked to an increased risk of BCC.
Article
Orthopedics
Ingrid Heuch, Ivar Heuch, Knut Hagen, Kjersti Storheim, John-Anker Zwart
Summary: This study investigated the associations between systemic MHT or OC use and the risk of chronic LBP using a large population-based dataset. The results showed that long-lasting use of systemic MHT, especially therapy based on estrogen only, is associated with an increased risk of chronic LBP. Using OC may slightly increase the risk of chronic LBP.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Oncology
Kyung-Hwak Yoon, Yeshong Park, Eunyoung Kang, Eun-Kyu Kim, Jee Hyun Kim, Se Hyun Kim, Koung Jin Suh, Sun Mi Kim, Mijung Jang, Bo La Yun, So Yeon Park, Hee-Chul Shin
Summary: This study retrospectively analyzed the clinicopathological characteristics, endocrine responsiveness, and five-year recurrence-free survival of breast cancer patients. The results showed that ERlow breast cancer has distinct features, higher recurrence rates, and no significant benefit from hormonal therapy.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Fei Chen, Sungshim L. Park, Lynne R. Wilkens, Peggy Wan, Steven N. Hart, Chunling Hu, Siddhartha Yadav, Fergus J. Couch, David V. Conti, Adam J. de Smith, Christopher A. Haiman
Summary: This multiethnic study found that germline pathogenic variants in BRCA1, BRCA2, and ERCC2 are associated with the development of second primary cancer in breast cancer survivors, providing biological insights and biomarkers for patient monitoring.
Article
Medicine, General & Internal
Bei-Hao Shiu, Ming-Hong Hsieh, Wen-Chien Ting, Ming-Chih Chou, Lun-Ching Chang, Chi-Chou Huang, Shih-Chi Su, Shun-Fa Yang
Summary: This study investigated the impact of FGFR4 gene polymorphisms on the risk and progression of CRC, finding that certain SNPs were associated with a lower likelihood of metastasis in rectal cancer patients. Additionally, analysis using databases showed that a specific SNP may regulate FGFR4 expression, influencing the occurrence and metastasis of colon adenocarcinoma.
Review
Oncology
Laura A. Huppert, Ozge Gumusay, Dame Idossa, Hope S. Rugo
Summary: HR-positive/HER2-negative breast cancer is characterized by the presence of estrogen receptor and/or progesterone receptor and the absence of HER2 gene amplification. It accounts for a significant proportion of breast cancers and is treated with endocrine therapy. Combining endocrine therapy with cyclin-dependent kinase inhibitors has shown promising results in reducing recurrence and improving survival. Chemotherapy is used based on the stage and tumor biology. New therapies, such as novel endocrine agents and antibody-drug conjugates, are changing the treatment landscape.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Hematology
Leslie Skeith, Gregoire Le Gal, Marc A. Rodger
Summary: Exogenous hormone therapies like combined oral contraceptives (COC) and hormone replacement therapy (HRT) can increase blood hypercoagulability and the risk of venous thromboembolism (VTE). Controversy exists on the strength of this provoking risk factor and how it may synergize with other risk factors. Reviewing the latest literature on COC and HRT usage can provide guidance for anticoagulation duration decisions and future research direction.
THROMBOSIS RESEARCH
(2021)
Article
Clinical Neurology
Hyewon Kim, Juhwan Yoo, Kyungdo Han, Dong-Yun Lee, Maurizio Fava, David Mischoulon, Hong Jin Jeon
Summary: This study investigated the association between hormone therapy and the occurrence of dementia in female patients with depression. The findings showed that lifetime oral contraceptive use was associated with a decreased risk of Alzheimer's disease (AD), and hormone replacement therapy after menopause was associated with a decreased risk of AD and vascular dementia (VD) among female patients with depression.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Review
Oncology
Agnieszka Baranska, Joanna Dolar-Szczasny, Wieslaw Kanadys, Wiktoria Kinik, Dorota Ceglarska, Urszula Religioni, Robert Rejdak
Summary: Oral contraceptive use has different effects on the risk of developing various molecular breast cancer subtypes. It may increase the risk of TNBrCa and ER-BrCa, while reducing the risk of ER+BrCa. The impact on HER2+BrCa is minimal.
Article
Oncology
Jiayang Yu, Chun-Guang Wang
Summary: Using a meta-analysis approach, this study found that the G172T polymorphism in the RAD51 gene may be associated with an increased risk of breast cancer, particularly in the Arab population. The association between the XRCC2 R188H polymorphism and breast cancer was not significant. The T241M polymorphism in XRCC3 may be associated with an increased risk of breast cancer, especially in the Asian population.
FRONTIERS IN ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Kelly L. Klump, Alaina M. Di Dio
Summary: Endogenous ovarian hormones may increase the risk of binge eating in females through gene x hormone interactions and hormonally induced increases in genetic influences. Combined oral contraceptives (COCs), which mimic the riskiest hormonal environment for binge eating, are commonly used by women. Preliminary studies suggest that COCs may increase the risk of binge eating and related phenotypes, especially in genetically vulnerable women. Larger and more systematic studies are needed to explore the relationship between COCs and binge eating, with the goal of advancing personalized medicine.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jieun Kim, Boo-Kyung Han, Eun Young Ko, Eun Sook Ko, Ji Soo Choi, Ko Woon Park
Summary: This study investigated the predictability of breast MRI for pathologic complete response (pCR) by molecular subtype in patients with breast cancer receiving neoadjuvant chemotherapy (NAC) and explored the MRI findings that can mimic residual malignancy. The results showed that the diagnostic accuracy of MRI for predicting pCR differed by molecular subtypes, and subtle residual enhancement observed on MRI after NAC was associated with false-negative findings.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Lusine Yaghjyan, Carmen Smotherman, John Heine, Graham A. Colditz, Bernard Rosner, Rulla M. Tamimi
Summary: This study investigated the relationship between oral contraceptives and breast density in premenopausal women, finding that an earlier age at first use of oral contraceptives was associated with a significant increase in a novel density measure (V).
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Obstetrics & Gynecology
Serena Girardelli, Luigi Albano, Giorgia Mangili, Luca Valsecchi, Emanuela Rabaiotti, Paolo Ivo Cavoretto, Pietro Mortini, Massimo Candiani
Summary: The relationship between female hormones and meningiomas should be considered in the treatment of such diseases. Current research lacks unified guidelines, with management methods mostly based on personal strategies. Understanding the biological links between female hormones and meningiomas is crucial for correctly counseling patients.
REPRODUCTIVE SCIENCES
(2022)
Article
Oncology
Songfa Zhang, Chuan Yan, David G. Millar, Qiqi Yang, James M. Heather, Adam Langenbucher, Laura T. Morton, Sean Sepulveda, Eric Alpert, Lauren R. Whelton, Dominique T. Zarrella, Mei Guo, Eleanor Minogue, Michael S. Lawrence, Bo R. Rueda, David R. Spriggs, Weiguo Lu, David M. Langenau, Mark Cobbold
Summary: This study develops a high-throughput preclinical platform to identify patient-specific antibody-peptide epitope conjugates that target cancer cells and demonstrates the potential of this immunotherapy approach for treating ovarian carcinoma.
Article
Biotechnology & Applied Microbiology
XiaoJing Chen, Yite Xue, Lingfang Wang, Yang Weng, Sen Li, Weiguo Lu, Xing Xie, Xiaodong Cheng
Summary: This study aims to explore the function of LGALS3BP in MTX-resistance in choriocarcinoma cells. The results showed that LGALS3BP was up-regulated in MTX-resistant cells and the concentration of LGALS3BP in the serum of MTX-resistant patients was higher than in MTX-sensitive patients. Knocking down LGALS3BP can reverse the MTX-resistance in choriocarcinoma cells.
Article
Biochemistry & Molecular Biology
Yang Weng, Yuanyuan Liu, Chitapa Benjoed, Xiaodong Wu, Sangsang Tang, Xiao Li, Xing Xie, Weiguo Lu
Summary: This study evaluates the efficacy of risk factors in predicting single-agent chemoresistance and explores the feasibility of simplifying the FIGO 2000 scoring system for GTN. The results show that a simplified model with two independent factors performs better in predicting single-agent chemoresistance.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Engineering, Civil
Weiren Zhang, Fan Yang, Siyuan Zhang, Yijie Bian, Peng Wang, S. A. Meguid
Summary: This paper presents a new multicellular design for effective energy absorption. Extensive experiments, simulations, and analysis were conducted to evaluate the performance of this design. The results show that a face centered square layout with an appropriately selected taper angle has excellent energy absorption and crashworthiness properties.
INTERNATIONAL JOURNAL OF STRUCTURAL STABILITY AND DYNAMICS
(2023)
Article
Engineering, Mechanical
Weiping Lu, Wen Cui, Xiaogang Zhang, Yali Zhang, Shu Yang, Jian Pu, Junyan Li, Zhongmin Jin
Summary: The friction and wear behaviors between cartilage replacement materials and articular cartilage are crucial for the function and performance of the replacements. This study investigated the difference between cross-shear motion and reciprocal linear motion on the frictional and wear behaviors of cartilage, as well as the effect of bearing surface roughness. The results showed that there was no significant difference between the two motion types. The water contact angle of the bearing surface affected the friction and wear behaviors for low roughness implants, while the surface roughness of the material affected the behaviors for high roughness implants. PEEK was found to be a suitable material for osteochondral implants.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: The incidence and mortality rates of childhood cancer vary between different countries. This study used data from the Cancer Incidence in Five Continents Time Trends, Nordic Cancer Registries, Surveillance, Epidemiology and End Results, and WHO Mortality databases to extract the Age-Standardised Rates (ASR) of cancer incidence and mortality among children aged 0-14 years old. The country-specific Average Annual Percentage Change (AAPC) and its corresponding 95% confidence interval (CI) were calculated to determine the epidemiological cancer trend. The results showed that low-income countries had the highest mortality and mortality to incidence ratio of childhood cancer. The incidence of childhood cancer showed an overall increasing trend, while the mortality rate decreased over the past decade.
Review
Gastroenterology & Hepatology
Junjie Huang, Don Eliseo Lucero-Prisno III, Lin Zhang, Wanghong Xu, Sunny H. H. Wong, Siew C. C. Ng, Martin C. S. Wong
Summary: Globally, gastrointestinal cancers account for over one-fourth of all cancer incidence and one-third of cancer-related mortality. East Asia has the highest burden of gastrointestinal cancers, including stomach, liver, oesophageal, and gallbladder cancers, which is attributed to population growth, aging, and westernization of lifestyles. The increasing incidence of young-onset colorectal cancer is also observed in East Asia. To effectively reduce the burden of gastrointestinal cancers in this region, efforts should be made to modify unhealthy lifestyles, promote vaccination against hepatitis virus, control infections, increase colorectal cancer screening, enhance early cancer detection, and improve cancer survivorship through organized rehabilitation programs.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Wei-Yuan Yao, Leah Li, Hui-Ru Jiang, Yong-Fu Yu, Wang-Hong Xu
Summary: The aim of this study was to investigate the transgenerational associations between exposure to famine in early life and obesity. The results showed that maternal exposure to famine was associated with higher risk of obesity in children, while paternal exposure was associated with lower risk. Understanding the transgenerational associations is important for reducing obesity risk in future generations.
Article
Nutrition & Dietetics
Wei-Yuan Yao, Yong-Fu Yu, Leah Li, Wang-Hong Xu
Summary: This study aimed to evaluate the associations of fetal and childhood exposure to famine of parents with their offspring's risk of overweight during childhood. The results showed that children with fathers exposed to famine during childhood had a lower risk of overweight, especially male offspring. The association between paternal childhood exposure to famine and lower overweight risk in offspring was more evident in the high paternal education group.
CLINICAL NUTRITION
(2023)
Article
Obstetrics & Gynecology
Junjie Huang, Wing Chung Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: The objective of this study is to evaluate the global distribution, risk factors, and temporal trends of corpus uteri cancer for different countries and age groups. Data from the Global Cancer Observatory database, Cancer Incidence in Five Continents, and the WHO mortality database were analyzed to calculate age-standardized rates and estimate the annual average percent change. The results showed a substantial increasing trend of corpus uteri cancer, with high-income countries having the highest incidence. Intensive lifestyle modifications are needed, especially among younger women.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Jianfeng Pei, Yanyun Li, Yihui Yang, Minna Cheng, Yan Shi, Wang Hong Xu
Summary: The prevalence of diabetes and prediabetes among Chinese adults in Shanghai has been increasing over the years, leading to a heavier disease burden. The study emphasizes the urgent need to strengthen the community healthcare system in China to ensure comprehensive management of diabetes and prediabetes.
JOURNAL OF DIABETES
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Yat Ching Fung, Wing Sze Pang, Fung Yu Mak, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: Vulvar cancer is an uncommon malignancy that poses a public health problem in terms of cost, treatment, and women's health. This study provides a comprehensive analysis of the global burden, risk factors, and temporal incidence trends of vulvar cancer. The incidence of vulvar cancer was higher in Western Europe, Northern America, Northern Europe, Australia and New Zealand, and Eastern Africa. Risk factors such as gross domestic product per capita, Human Development Index, smoking, alcohol drinking, unsafe sex, and HIV infection were associated with higher incidence rates. Overall, the incidence of vulvar cancer is increasing, with different trends observed in older and younger females. The disease burden of vulvar cancer affects women in both developed and developing regions and calls for promotion of smoking cessation, sex education, and HPV vaccination programs. Further studies are needed to explore the reasons behind the increasing trend.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Junjie Huang, Sze Chai Chan, Samantha Ko, Veeleah Lok, Lin Zhang, Xu E. Lin, Don E. Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong, NCD Global Hlth Res Grp, Assoc Pacific Rim Univ APRU
Summary: This study evaluated the global incidence, mortality, risk factors, and temporal trends of lip, oral, and pharyngeal cancer. Results showed that the highest incidence rates were found in Melanesia and South-Central Asia, with mortality rates of 8.2 and 7.5. Risk factors associated with incidence and mortality included HDI, tobacco use, alcohol consumption, poor diet, and chronic health conditions. Overall, global incidence and mortality rates have decreased, but there are significant increases in older age groups and female subjects.
Article
Oncology
Martin C. S. Wong, Eman Yee-man Leung, Sarah T. Y. Yau, Sze Chai Chan, Shaohua Xie, Wanghong Xu, Junjie Huang
Summary: This study devised and validated a simple, accurate, and easy-to-use scoring algorithm to predict the risk of gastric cancer in a large Chinese population. The algorithm has a high discriminatory capability and can prioritize upper digestive tract investigation for individuals suspected of having gastric cancer.
Article
Oncology
Ziyang Wang, Jiaoyue Teng, Weimiao Wu, Jianming Dou, Martin C. S. Wong, Yangming Gong, Junjie Huang, Kai Gu, Wanghong Xu
Summary: This study evaluated the accuracy of FIT and RA in the Shanghai CRC screening program and conducted a systematic review of relevant evaluations worldwide. The results indicate that using only FIT as an initial screening test has limitations in the Chinese population, and highlight the higher sensitivity of parallel use of RA and FIT.
