Article
Radiology, Nuclear Medicine & Medical Imaging
Hao Xu, Jieke Liu, Zhe Chen, Chunhua Wang, Yuanyuan Liu, Min Wang, Peng Zhou, Hongbing Luo, Jing Ren
Summary: The study developed and validated radiomic models based on DCE-MRI to predict intraductal component in invasive breast cancer (IBC-IC) before surgery. The models showed good diagnostic performance and could facilitate individualized surgical planning for breast cancer patients undergoing breast-conserving surgery.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Roxanne A. W. Ploumen, Cornelis M. de Mooij, Suzanne Gommers, Kristien B. M. I. Keymeulen, Marjolein L. Smidt, Thiemo J. A. van Nijnatten
Summary: This study aimed to summarize and examine the literature on imaging findings for different modalities evaluating DCIS response to NST. Results showed that mammography, breast MRI, and contrast-enhanced mammography are accurate and specific in evaluating DCIS. Calcifications are related to DCIS and can persist despite complete response.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liping Wang, Ping Wang, Huafei Shao, Jun Li, Qinglin Yang
Summary: This study compared the use of contrast-enhanced mammography (CEM) and magnetic resonance imaging (MRI) in the preoperative diagnosis of ductal carcinoma in situ (DCIS). The results showed that CEM had similar sensitivity to MRI in diagnosing DCIS, and was significantly more sensitive than low-energy image alone. Additionally, CEM had the advantage of simultaneous comparison of calcifications with enhancements and showed high sensitivity for noncalcified DCIS.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristien B. I. M. Keymeulen, Sandra M. E. Geurts, Loes F. S. Kooreman, Lucien E. M. Duijm, Sanne Engelen, Sigrid Vanwetswinkel, Ernest Luiten, Sabine Siesling, Adri C. Voogd, Vivianne C. G. Tjan-Heijnen
Summary: Breast MRI at primary DCIS diagnosis can detect additional synchronous cDCIS and cIBC, and is associated with a higher rate of metachronous cDCIS without decreasing the rate of metachronous cIBC. This finding is most evident in younger patients.
EUROPEAN RADIOLOGY
(2023)
Article
Surgery
Giovanni Tomasicchio, Arcangelo Picciariello, Luigia S. Stucci, Annunziata Panebianco, Alda E. Montanaro, Alfredo Cirilli, Clelia Punzo
Summary: Ductal carcinoma in situ (DCIS) is usually treated with breast conserving surgery (BCS) followed by adjuvant radiotherapy and/or endocrine therapy. This study found that margin status, multifocality, hormone receptor status, and HER-2/Basal-like subtype were identified as reliable risk factors for the progression of the disease.
Article
Oncology
Tiffany Sin Hui Bong, Jun Kiat Thaddaeus Tan, Juliana Teng Swan Ho, Puay Hoon Tan, Wing Sze Lau, Tuan Meng Tan, Jill Su Lin Wong, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Preetha Madhukumar, Wei Sean Yong, Sue Zann Lim, Chow Yin Wong, Kong Wee Ong, Yirong Sim
Summary: This study identified factors predicting malignant upgrade for atypical ductal hyperplasia (ADH) diagnosed on core-needle biopsy (CNB) and developed a nomogram to facilitate decision making. The nomogram showed good discrimination of breast cancer risk prediction and identified a subset of low-risk women who may avoid surgical excision following a CNB diagnosis of ADH.
JOURNAL OF BREAST CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carla Darras, Marcela Uchida
Summary: The upgrade rate of percutaneously diagnosed radial scar (RS) and complex sclerosing lesions (CSL) is low, and the presence of other atypical proliferative lesions can be easily missed at biopsy. During follow-up, two cases developed malignancy in a different quadrant, and other atypical proliferative lesions were present on biopsy.
EUROPEAN RADIOLOGY
(2023)
Article
Instruments & Instrumentation
Firas Al-Zubaydi, Dayuan Gao, Dipti Kakkar, Shike Li, Jennifer Holloway, Zoltan Szekely, Nancy Chan, Shicha Kumar, Hatem E. Sabaawy, Susan Love, Patrick J. Sinko
Summary: The intraductal administration of Ciclopirox nanoformulations showed significant anti-tumor efficacy in treating DCIS, demonstrating a new potential strategy for dose de-escalation while maintaining effectiveness.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Manuel Gentiluomo, Chiara Corradi, Paolo Giorgio Arcidiacono, Stefano Crippa, Massimo Falconi, Giulio Belfiori, Riccardo Farinella, Laura Apadula, Gaetano Lauri, Niccolo Bina, Cosmeri Rizzato, Federico Canzian, Luca Morelli, Gabriele Capurso, Daniele Campa
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with limited treatment options and late diagnosis. Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of PDAC, and identifying high-risk IPMN patients can help improve survival rates. This study investigated both genetic and non-genetic risk factors in a cohort of IPMN patients and found potential associations with smoking status and obesity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Tamami Morisaki, Masatsune Shibutani, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira
Summary: This study found that current smoking status is an independent risk factor for the progression from DCIS to invasive ductal carcinoma, while the number of pack-years is not.
ANTICANCER RESEARCH
(2022)
Article
Obstetrics & Gynecology
Michael D. Sandak, Katherine A. Chandler, Samuel P. Goberdhan, William F. Willett, Charles S. Scarborough
Summary: The article reports a successful treatment of ductal carcinoma in situ found in ectopic breast tissue of the vulva using wide-excision biopsy and anastrozole.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Kang Wang, Zhuyue Li, Xingxing Chen, Jianjun Zhang, Yongfu Xiong, Guochao Zhong, Yang Shi, Qing Li, Xiang Zhang, Hongyuan Li, Tingxiu Xiang, Theodoros Foukakis, Tomas Radivoyevitch, Guosheng Ren
Summary: The risk of developing secondary hematologic malignancies (SHM) is increased in patients with ductal carcinoma in situ (DCIS) of the breast treated with external beam radiotherapy (RT), especially for low/intermediate-risk subsets. Surveillance for SHM after DCIS diagnosis is recommended to ensure long-term survival.
Article
Oncology
Jia-Qiang Zhang, Tsai-Mu Cheng, Wei-Chun Lin, Kuo-Chin Chiu, Szu-Yuan Wu
Summary: The study found that smoking-related COPD is not an independent risk factor for all-cause mortality in women with IDC receiving standard treatments, while being hospitalized for COPDAE at least once within one year before breast surgery is associated with higher mortality.
Article
Oncology
Xiaoling Zhuge, Hao Zhou, Liming Chen, Hui Chen, Xiao Chen, Chuangen Guo
Summary: This study demonstrated that elevated serum ferritin levels are associated with malignant IPMNs, and may serve as a useful marker for identifying malignancy in IPMNs. Serum ferritin outperformed CEA and CA19-9 in identifying malignant IPMNs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jessie D. Kang, Sharon E. Clarke, Andreu F. Costa
Summary: Recognizing pitfalls of PDAC detection and interpretation, including intrinsic tumor features, secondary signs, technical factors, and cognitive biases, can assist radiologists in making an early and accurate diagnosis.
EUROPEAN RADIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Michael J. LaMonte, Joshua H. Gordon, Patricia Diaz-Moreno, Christopher A. Andrews, Daichi Shimbo, Kathleen M. Hovey, Michael J. Buck, J. Wactawski-Wende
Summary: There is an association between oral microbiota and blood pressure regulation as well as development of hypertension in postmenopausal women, suggesting that specific oral bacteria may be related to the risk of hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Oncology
Kathy Pan, Aaron K. Aragaki, Yvonne Michael, Cynthia A. Thomson, Linda G. Snetselaar, Jean Wactawski-Wende, David O. Garcia, Christina M. Dieli-Conwright, Aladdin H. Shadyab, Nazmus Saquib, Rowan T. Chlebowski
Summary: This study found that women participating in the Women's Health Initiative dietary modification randomized trial had a lower rate of physical inactivity and spent more time in recreational physical activity compared to the control group.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Obstetrics & Gynecology
Edwina H. Yeung, Pauline Mendola, Rajeshwari Sundaram, Tzu-Chun Lin, Miranda M. Broadney, Diane L. Putnick, Sonia L. Robinson, Kristen J. Polinski, Jean Wactawski-Wende, Akhgar Ghassabian, Thomas G. O'Connor, Robert E. Gore -Langton, Judy E. Stern, Erin Bell
Summary: The study aimed to evaluate whether children conceived using assisted reproductive technology (ART) or ovulation induction (OI) have greater cardiometabolic risk compared to children conceived without treatment. The results showed that at 9 years of age, children conceived using ART or OI did not have greater cardiometabolic risk compared to children conceived without treatment.
FERTILITY AND STERILITY
(2022)
Article
Oncology
Tarah J. Ballinger, Zora Djuric, Sagar Sardesai, Kathleen M. Hovey, Chris A. Andrews, Theodore M. Brasky, Jian Ting Zhang, Thomas E. Rohan, Nazmus Saquib, Aladdin H. Shadyab, Michael Simon, Jean Wactawski-Wende, Robert Wallace, Ikuko Kato
Summary: This study found that the use of PPI was inversely associated with the risk of colorectal cancer, while the use of H2RA showed no such association. This relationship is consistent with the preclinical data showing the preventive effect of FASN inhibition on colon cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Surgery
Elizabeth L. Chou, Mary Pettinger, Bernhard Haring, Matthew A. Allison, Matthew W. Mell, Mark A. Hlatky, Jean Wactawski-Wende, Robert A. Wild, Aladdin H. Shadyab, Robert B. Wallace, Linda G. Snetselaar, Tracy E. Madsen, Matthew J. Eagleton, Mark F. Conrad, Simin Liu
Summary: This study finds that premature menopause may be an important risk factor for AAA in women with significant smoking history. There was no significant association between premature menopause and risk of AAA amongst women who have never smoked.
Meeting Abstract
Clinical Neurology
Galit Dunietz, Kerby Shedden, Kara Michels, Ronald Chervin, Xiru Lyu, Joshua Freeman, Ana Baylin, Louise O'Brien, Jean Wactawski-Wende, Enrique Schisterman, Sunni Mumford