Article
Environmental Sciences
Lauren M. Hurwitz, Laura E. Beane Freeman, Gabriella Andreotti, Jonathan N. Hofmann, Christine G. Parks, Dale P. Sandler, Jay H. Lubin, Jia Liu, Kristine Jones, Sonja I. Berndt, Stella Koutros
Summary: The study found that there is an interaction between pesticides, specific organic compounds, and genetic variants in relation to prostate cancer risk. Farmers exposed to certain organophosphate and organochlorine insecticides have an increased risk of prostate cancer. Additionally, there is a suggestion of interaction between pesticides and genetic variants occurring in regions associated with DNA damage response and variants related to altered androgen receptor-driven transcriptional programs critical for prostate cancer.
ENVIRONMENTAL RESEARCH
(2023)
Article
Agronomy
Ethan Menke, M. Habib Widyawan, Nicole Bachleda, James Buck, Zack Shearin, H. Roger Boerma, Zenglu Li
Summary: This study investigated the genetic characteristics of soybean PI 398469, which exhibits resistance to southern stem canker (SSC). Two populations, F-2:3 and F-5-derived recombinant inbred lines (RILs), were developed through crosses with the susceptible breeding line G81-2057. The qRdm_14 locus on chromosome 14 was identified as a major quantitative trait locus (QTL) for SSC resistance. The findings provide useful information for breeding lines with resistance to SSC.
Editorial Material
Gastroenterology & Hepatology
Selena Z. Kuo, Rohit Loomba
Summary: This article is linked to the papers by Kuo et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biology
Marie Loh, Weihua Zhang, Hong Kiat Ng, Katharina Schmid, Amel Lamri, Lin Tong, Meraj Ahmad, Jung-Jin Lee, Maggie C. Y. Ng, Lauren E. Petty, Cassandra N. Spracklen, Fumihiko Takeuchi, Md Tariqul Islam, Farzana Jasmine, Anuradhani Kasturiratne, Muhammad Kibriya, Karen L. Mohlke, Guillaume Pare, Gauri Prasad, Mohammad Shahriar, Miao Ling Chee, H. Janaka de Silva, James C. Engert, Hertzel C. Gerstein, K. Radha Mani, Charumathi Sabanayagam, Marijana Vujkovic, Ananda R. Wickremasinghe, Tien Yin Wong, Chittaranjan S. Yajnik, Salim Yusuf, Habibul Ahsan, Dwaipayan Bharadwaj, Sonia S. Anand, Jennifer E. Below, Michael Boehnke, Donald W. Bowden, Giriraj R. Chandak, Ching-Yu Cheng, Norihiro Kato, Anubha Mahajan, Xueling Sim, Mark McCarthy, Andrew P. Morris, Jaspal S. Kooner, Danish Saleheen, John C. Chambers
Summary: South Asians have a higher risk of developing type 2 diabetes (T2D). Through a genomewide association meta-analysis, researchers identified 21 novel genetic loci associated with T2D, which are linked to adiposity and glucose metabolism. A polygenic risk score based on South Asian-derived summary statistics can predict T2D risk.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan Hong, Petra B. Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe Muilwijk, Marieke T. Blom, Leen M. T. Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
Summary: The application of multiple omics technologies in biomedical cohorts can reveal patient-level disease characteristics and individualized response to treatment. We developed a deep-learning-based framework, MOVE, to integrate and analyze multi-omics data from a cohort of newly diagnosed type 2 diabetes patients. By using in silico perturbations, we identified drug-omics associations in the multi-modal datasets with higher sensitivity than univariate statistical tests.
NATURE BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Luyi Li, Jialin Xu, Wenlou Zhang, Zhaokun Wang, Shan Liu, Lei Jin, Qi Wang, Shaowei Wu, Xuejun Shang, Xinbiao Guo, Qingyu Huang, Furong Deng
Summary: This study aimed to investigate the association between metal mixture during early pregnancy and the risk of gestational diabetes mellitus (GDM), as well as identify the key metals within the mixture associated with GDM. The results showed that nickel (Ni) was associated with a decreased risk of GDM, while strontium (Sr) and antimony (Sb) were associated with an increased risk of GDM. Interestingly, Ni was identified as a key metal within the mixture associated with a decreased risk of GDM.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sarah ElHajj Chehadeh, Noura S. Sayed, Hanin S. Abdelsamad, Wael Almahmeed, Ahsan H. Khandoker, Herbert F. Jelinek, Habiba S. Alsafar
Summary: This study investigated genetic variations and Single Nucleotide Polymorphisms (SNPs) associated with microvascular complications (DR, DNp, DPN) among T2DM patients of Arab origin. The findings revealed significant associations between certain SNPs and the complications, with stronger associations observed when multiple complications were present.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Rafael Paternostro, Mathias Jachs, Thomas Reiberger, Mattias Mandorfer
Summary: This article is linked to the papers by Paternostro et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Xiaoying Kang, Shengxin Liu, Jonas F. Ludvigsson
Summary: This article is related to the papers by Kang et al. To access these articles, please visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Tzu-Wei Wu, Chao-Liang Chou, Chun-Fang Cheng, Shu-Xin Lu, Yih-Jer Wu, Li-Yu Wang
Summary: This study identified 9 diabetes-related SNPs that are associated with carotid atherosclerosis, suggesting that these SNPs can be used as biomarkers for high-risk individuals.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Carlos Antonio Fernandes Santos, Soniane Rodrigues da Costa, Leonardo Silva Boiteux, Dario Grattapaglia, Orzenil Bonfim Silva-Junior
Summary: This study successfully assembled the genome of Psidium guajava and transferred genes to detect genomic loci linked to resistance. The findings suggest that the resistance may be regulated by mineral nutrients and phytohormone homeostasis or signaling. These findings contribute to the development of improved guava cultivars and hybrid rootstocks.
Article
Geriatrics & Gerontology
Zsofia Flora Nagy, Margit Pal, Andras Salamon, Gloria Kafui Esi Zodanu, Dalma Fustos, Peter Klivenyi, Marta Szell
Summary: This study aimed to investigate the role of 14 ALS-related genes in a Hungarian ALS population. The research confirmed the association of repeat expansions in the C9orf72, ATXN1, and ATXN2 genes with ALS risk in the cohort. The study also identified a pathogenic mutation in the SOD1 gene and suggested its founder effect.
NEUROBIOLOGY OF AGING
(2022)
Review
Nutrition & Dietetics
Ninna Karsbaek Senftleber, Maria Overvad, Inger Katrine Dahl-Petersen, Peter Bjerregaard, Marit Eika Jorgensen
Summary: In recent years, dramatic lifestyle changes among the Inuit in Greenland have led to a rapid increase in obesity, metabolic disturbances, and the prevalence of diabetes. Research indicates that both lifestyle changes and potential gene-lifestyle interactions play a significant role in these health issues.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yimin Zhao, Yueying Li, Zhenhuang Zhuang, Zimin Song, Wenxiu Wang, Ninghao Huang, Xue Dong, Wendi Xiao, Jinzhu Jia, Zhonghua Liu, Duo Li, Tao Huang
Summary: This study found an association between cumulative social risks and incident type 2 diabetes. Adherence to a healthy lifestyle can reduce the risk of diabetes caused by social vulnerability. Genetic susceptibility and disadvantaged social status may interact synergistically, leading to additional risks for type 2 diabetes.
Review
Genetics & Heredity
Xi Cheng, Fengzhou Du, Xiao Long, Jiuzuo Huang
Summary: This article provides an overview of the genetic inheritance model of non-syndromic cleft lip with or without palate (NSCL/P), including both monogenic and polygenic perspectives. Representative genes and regions are presented, along with existing association studies and corresponding loci in the Chinese population. The potential of using polygenic risk scores for risk stratification of NSCL/P is highlighted, offering promising avenues for improved risk assessment and personalized interventions.
