Article
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Ahmed Ali Alfawzan, Fatema Akhter, Haytham Jamil Alswairki, Prabhat Kumar Chaudhari
Summary: This study investigated the variation between non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to lip morphology (LM) and nasolabial angle (NLA). The results showed significant disparities in LM-1 and NLA between NSCLP and NC individuals.
APPLIED SCIENCES-BASEL
(2022)
Review
Dentistry, Oral Surgery & Medicine
Robert Frederick, Amy Claire Hogan, Natalie Seabolt, Rose Mary S. Stocks
Summary: This article emphasizes the benefits of a multidisciplinary team approach in the systemic management of patients with cleft lip and cleft palate, and suggests the addition of a registered dietitian to the care team. An ideal cleft palate care team should focus on a comprehensive, collaborative, and family-centered approach. While care teams may vary depending on context and location, there are still some key principles.
Article
Medicine, General & Internal
Yohan Guichoud, Oumama El Ezzi, Anthony de Buys Roessingh
Summary: The precision of antenatal diagnosis for cleft lip and/or palate plays a crucial role in providing appropriate counseling, neonatal care, surgical strategies, and psychological support for affected families. This study aimed to evaluate the accuracy of antenatal diagnosis and the detection rate of cleft lip and/or palate using routine morphologic ultrasonography. A retrospective observational study comparing antenatal and postnatal diagnosis was conducted on 233 patients. The overall detection rate of facial clefts was 44.6%, with an accuracy of 62.5% at birth.
Article
Chemistry, Multidisciplinary
Natalia Kaczorowska, Marcin Mikulewicz
Summary: This paper examines cephalometric parameters in patients with cleft lip and palate and cleft lip, and compares the differences between these patient groups. The results show that cleft palate surgery has an effect on the forward growth of the maxilla.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Xiaofeng Li, Yu Tian, Ling Qiu, Shu Lou, Guirong Zhu, Yue Gao, Lan Ma, Yongchu Pan
Summary: This study utilized an expression quantitative trait locus (eQTL) dataset to identify multiple associations with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). Functional annotation analysis showed that these risk loci were significantly enriched in transcription regulation and chromatin open regions on the genome. Additionally, these susceptible genes were closely related to cell fate determination, the pluripotency of stem cells, and Wnt signaling pathways.
Review
Genetics & Heredity
Arwa Babai, Melita Irving
Summary: Orofacial clefting is a common birth defect worldwide, presenting as cleft lip only, isolated cleft palate or cleft lip and palate. It has a diverse genetic background influenced by gene-gene and gene-environment interaction, resulting in syndromic and nonsyndromic orofacial clefts. Orofacial clefts cause significant physiological difficulties, impacting feeding, speech and language development, and other developmental aspects, leading to increased social and financial burden. The management of orofacial clefts requires a multidisciplinary team approach.
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article provides an overview of characteristics of unilateral cleft lip and nasal deformity, as well as its management options including presurgical orthopedics, operative techniques, and postsurgical care. Specific surgical techniques such as rotation-advancement and straightline repairs are discussed in detail, along with current concepts in primary cleft nose repair.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Health Care Sciences & Services
Chin-Han Chang, Chi-Hua Chang, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: This study investigated the prevalence of tooth agenesis, tooth malformation, and eruption patterns of upper canines/first premolars in Taiwanese children. The results suggest a strong correlation between the patterns of dental anomalies and the cleft sites in cleft lip and cleft palate patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Chihiro Iwaya, Akiko Suzuki, Junichi Iwata
Summary: Cleft lip and palate is a common congenital birth defect with varied causes. Recent studies suggest that non-coding RNAs, specifically microRNAs, may play a role in the development of cleft lip and palate. This review examines the potential of microRNAs as causative mechanisms in humans and mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
David O'Neil Danis, Kevin Bachrach, Jacquelyn Piraquive, Alexander P. Marston, Jessica R. Levi
Summary: The study found an association between neonatal abstinence syndrome (NAS) and cleft lip and/or cleft palate (CLP), specifically isolated cleft palate, suggesting that prenatal exposure to opioids may be an environmental risk factor in the development of CLP.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Genetics & Heredity
Benjamin L. Green, Grace-Ann Fasaye, Sarah G. Samaranayake, Anna Duemler, Lauren A. Gamble, Jeremy L. Davis
Summary: Pathogenic and likely pathogenic variants in the CDH1 gene are associated with increased risk of gastric and breast cancers, as well as hereditary cleft lip and palate (CLP). This study aimed to determine the prevalence of CLP in families with these variants. The results showed a high prevalence of CLP in families carrying CDH1 variants, with no clear genotype-phenotype pattern. Genetic testing for CDH1 should be considered in families with CLP and a history of gastric or lobular breast cancer.
FRONTIERS IN GENETICS
(2022)
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article describes the characteristics and management of bilateral cleft lip and nasal deformity, including presurgical orthopedics, operative techniques, and postsurgical care.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Anne M. Sescleifer, Caitlin A. Francoisse, Tamara A. Osborn, Jeffrey D. Rector, Alexander Y. Lin
Summary: By modifying patients' postoperative photographs, the study found that lip angle has a smaller impact on appearance ratings compared to scar severity. Although families are more concerned about scarring, clinically, the angle of the cleft lip repair is more likely to influence the perception of the surgical result.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Immunology
Elizabeth Gershater, Yuan Liu, Binglan Xue, Min Kyung Shin, Hyun Koo, Zhong Zheng, Chenshuang Li
Summary: Orofacial cleft disorders, particularly cleft lip and/or palate (CL/P), are common congenital disorders worldwide. This review examines the differences in microbiota between CL/P patients and healthy individuals at various anatomical locations. Pathogenic bacterial and fungal species were found to be prevalently and/or specifically detected in CL/P patients, which may aid in the development of CL/P-specific microbiota management strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
M. J. Faaij, N. C. W. van der Kaaij, M. A. Disse, J. P. W. Don Griot, C. Vermeij-Keers, E. M. Bronkhorst, E. M. Ongkosuwito
Summary: This study aimed to assess the relationship between different subphenotypes of bilateral oral clefts and dentition patterns of the lateral incisor. The results showed a positive correlation between the severity of the cleft and abnormal patterns of the dentition.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Environmental Sciences
Ana K. Rosen Vollmar, Caroline H. Johnson, Clarice R. Weinberg, Nicole C. Deziel, Donna D. Baird, Allen J. Wilcox, Anne Marie Z. Jukic
Summary: This study investigates the impact of pregnancy on creatinine excretion and its implications for biomarker measurement in assessing environmental exposures. The findings suggest that pregnancy leads to a decrease in urinary creatinine concentration, which may introduce errors in exposure assessment. While there is a small underestimation in analyte concentrations when using pooled creatinine adjustment, overall agreement between pooled and individually-adjusted assessments is good.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Psychiatry
Maria C. Magnus, Alexandra Havdahl, Nils-Halvdan Morken, Knut-Arne Wensaas, Allen J. Wilcox, Siri E. Haberg
Summary: Studies have shown that women diagnosed with psychiatric disorders have an increased risk of miscarriage, with various psychiatric diagnoses associated with different levels of risk. This highlights the importance of awareness and surveillance in antenatal care for this particular risk group.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Maria C. Magnus, Allen J. Wilcox, Elin A. Fadum, Hakon K. Gjessing, Signe Opdahl, Petur B. Juliusson, Liv Bente Romundstad, Siri E. Haberg
Summary: Children conceived by ART are shorter and lighter at birth, but experience more rapid growth and surpass naturally conceived children in height and weight by age 3. However, by age 17, there are no significant differences in height and weight between ART and naturally conceived children.
HUMAN REPRODUCTION
(2021)
Article
Pediatrics
Laura L. Oakley, Annette K. Regan, Deshayne B. Fell, Sarah Spruin, Inger Johanne Bakken, Jeffrey C. Kwong, Gavin Pereira, Natasha Nassar, Kari M. Aaberg, Allen J. Wilcox, Siri E. Haberg
Summary: This study found that maternal influenza infection during pregnancy may increase the risk of childhood seizures, particularly febrile seizures. Children exposed to influenza infection in utero had a higher risk of seizures in the second and third trimester of pregnancy.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Letter
Medicine, General & Internal
Lauren H. Zauche, Bailey Wallace, Ashley N. Smoots, Christine K. Olson, Titilope Oduyebo, Shin Y. Kim, Emily E. Petersen, Jun Ju, Jennifer Beauregard, Allen J. Wilcox, Charles E. Rose, Dana M. Meaney-Delman, Sascha R. Ellington
Summary: The risk of spontaneous abortion in early pregnancy after receiving mRNA Covid-19 vaccination is consistent with historical data.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Nutrition & Dietetics
Jonathan Groot, Tanja G. Petersen, Pal Suren, Anne Lise Brantsoeter, Peter Uldall, Torben Martinussen, Charlotta Granstrom, Sjurdur F. Olsen, Allen J. Wilcox, Katrine Strandberg-Larsen
Summary: The study found that periconceptional folate supplementation was not associated with cerebral palsy (CP), while supplementation during gestational weeks 9-12 was linked to a reduced risk of CP. Midpregnancy supplementation or dietary folate alone did not show a significant association with CP. Strong inverse associations were observed with low gross motor function impairment, suggesting potential benefits of folate intake during gestational weeks 9-12 for reducing the risk of CP.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Obstetrics & Gynecology
Shruthi Mahalingaiah, Victoria Fruh, Erika Rodriguez, Sai Charan Konanki, Jukka-Pekka Onnela, Alexis de Figueiredo Veiga, Genevieve Lyons, Rowana Ahmed, Huichu Li, Nicola Gallagher, Anne Marie Z. Jukic, Kelly K. Ferguson, Donna D. Baird, Allen J. Wilcox, Christine L. Curry, Sanaa Suharwardy, Tyler Fischer-Colbrie, Gracee Agrawal, Brent A. Coull, Russ Hauser, Michelle A. Williams
Summary: The Apple Women's Health Study aims to gain a better understanding of the relationship between menstrual cycles, health, and behavior. The first 10,000 participants in this study were diverse in demographic characteristics and all used Apple iPhones.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Allen J. Wilcox, Marianna Cortese, D. Robert McConnaughey, Dag Moster, Olga Basso
Summary: The study found that birthweight percentiles performed poorly in identifying high-risk infants, while gestational age was effective. The results in Norway and the United States were virtually identical, suggesting this trend is robust across populations.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Obstetrics & Gynecology
Lise A. Arge, Siri E. Haberg, Allen J. Wilcox, Oyvind Naess, Olga Basso, Maria C. Magnus
Summary: History of miscarriage is associated with decreased fecundability, while subfertility is linked to higher risk of miscarriage in subsequent pregnancies.
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
Ellen O. Carlsen, Quaker Harmon, Maria C. Magnus, Helle M. Meltzer, Iris Erlund, Lars C. Stene, Siri E. Haberg, Allen J. Wilcox
Summary: This study found that among women without a history of diabetes, higher HbA1c levels at 18 weeks of pregnancy were associated with important perinatal outcomes, including birth weight, large-for-gestational age, preterm delivery, and preeclampsia.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jenna Nobles, Lindsay Cannon, Allen J. Wilcox
Summary: US state legislatures have proposed laws to ban abortion once the earliest embryonic electrical activity is detectable, affecting specific population subgroups who may face difficulties in detecting pregnancy early due to irregular menstrual cycles and common health conditions. Individual physiological limitations may impact the ability to detect pregnancy before fetal cardiac activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Public, Environmental & Occupational Health
Allen Wilcox, Olga Basso
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Maria C. Magnus, Alexandra Havdahl, Allen J. Wilcox, Alice Goisis
Summary: Parental time-to-pregnancy is modestly but robustly associated with neurodevelopmental delays and difficulties in offspring, with no additional impact of assisted reproductive technologies.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Editorial Material
Public, Environmental & Occupational Health
Allen J. Wilcox, Rolv Skjaerven
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2022)
Article
Obstetrics & Gynecology
Ana K. Rosen Vollmar, Clarice R. Weinberg, Donna D. Baird, Allen J. Wilcox, Antonia M. Calafat, Nicole C. Deziel, Caroline H. Johnson, Anne Marie Z. Jukic
Summary: Urinary phenol concentrations of 2,5-dichlorophenol were associated with an increased odds of early pregnancy loss, while higher concentrations of butylparaben and triclosan were associated with an increase in fecundability. This study is the first to investigate the associations between phenol exposure and fecundability and early pregnancy loss using repeated pooled measures, providing important insights for future research on reproductive health.
HUMAN REPRODUCTION
(2023)