Article
Urology & Nephrology
Maohe Wang, Singh Prince, Yong Tang, Xiang Zhong, Shasha Chen, Guisen Li, Li Wang, Wei Wang
Summary: The study found that macroscopic hematuria after wasp sting may indicate a deteriorating clinical outcome, especially in patients with this symptom or elevated serum LDH levels, the risk of acute kidney injury significantly increases, necessitating consideration for hemodialysis treatment. The Poisoning Severity Score is helpful in assessing the severity of wasp sting patients early on.
Article
Cell Biology
Ying Lv, Li Lu, Fanglin Yu, Zhao Gao, Hai Yuan, Fengqi Hu
Summary: The STING signaling pathway plays a critical role in the inflammatory responses associated with wasp venom-induced acute kidney injury (AKI), as evidenced by in vivo and in vitro studies. Inhibition of this pathway could be a potential therapeutic target for managing wasp venom-induced AKI.
INFLAMMATION RESEARCH
(2023)
Article
Urology & Nephrology
Yong Liu, Hongmei Shu, Youlin Long, Xiaoqin Nie, Hongfu Tang, Lang Tu, Hao Zhang, Gang Qiu, Daihua He, Qiang Huang, Qi Zhang, Shuang Qing, Donglin Xu, Hongtao Xia
Summary: The incidence of wasp sting has been increasing in China, resulting in organ damage and high mortality. This study identified risk factors for severe cases of wasp sting and developed a severity scoring system, WSS. The WSS score of >= 3 can indicate the need for blood purification and reduce mortality.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biology
Xesus Feas, Carmen Vidal, Susana Remesar
Summary: This study provides data on fatalities due to stinging insects in 32 European countries over a 23-year period. Male adults were the most common group to be fatally injured. More epidemiological data at the regional level is needed to understand the incidence of insect-sting mortality.
Article
Pharmacology & Pharmacy
Rui Wang, Dan Gao, Fanglin Yu, Jiamin Han, Hai Yuan, Fengqi Hu
Summary: This study demonstrates the potential of varespladib as a therapeutic agent for wasp sting-induced acute kidney injury. The results show that varespladib significantly inhibits wasp venom PLA(2) activity, reducing rhabdomyolysis and hemolysis markers and improving kidney pathology.
Article
Cell Biology
Lulu Zhang, Xubiao Wei, Zhimeng Wang, Peiyuan Liu, Yanfei Hou, Yifang Xu, Huili Su, Matthew D. Koci, Hang Yin, Conggang Zhang
Summary: NF-KB pathway activation enhances STING signaling by regulating microtubule-mediated STING trafficking, leading to robust host antiviral defense and amplified interferon response.
Article
Biochemistry & Molecular Biology
Kyungpyo Son, Seokhwan Jeong, Eunchong Eom, Dohyeong Kwon, Suk-Jo Kang
Summary: Researchers have discovered that the mitochondrial ubiquitin ligase MARCH5 enhances STING activation by ubiquitinating it. However, a prolonged deficiency of MARCH5 leads to the production of reactive oxygen species, which promotes the formation of inactive STING polymers. These findings highlight the important role of MARCH5 in regulating STING activity.
Article
Nanoscience & Nanotechnology
My Thi Ngoc Nguyen, Ha Le Bao Tran
Summary: The study reported the heparinization of bovine pericardial scaffolds using the Layer-by-Layer self-assembly technique, which significantly improved the anticoagulant properties of the scaffolds, showing potential applications in the cardiovascular field.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2022)
Article
Engineering, Chemical
Ilka I. Rose, Michael Kather, Hannah Roth, Hannah Duenkelberg, Lukas Rein, Sascha N. Klimosch, Manfred Schmolz, Matthias Wessling
Summary: This study presents a facile method using chitosan for heparinization of membranes. The resulting membranes show significant charge differences and increased pure water permeance. They also exhibit strong antifouling properties and excellent hemocompatibility.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Editorial Material
Cell Biology
Sonia Assil, Soren R. Paludan
Summary: A recent study reveals that the deactivation of the immune adaptor protein STING is mediated by the encapsulation of STING-carrying vesicles by lysosomal compartments through microautophagy.
NATURE CELL BIOLOGY
(2023)
Article
Virology
Huifang Zhu, Rongzhao Zhang, Li Yi, Yan-Dong Tang, Chunfu Zheng
Summary: This study demonstrates that UNC93B1 acts as a crucial regulator of STING, attenuating its signaling pathway through autophagy-lysosome degradation, and provides novel insights into UNC93B1's function in antiviral innate immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiamin Han, Long Cui, Fanglin Yu, Rui Wang, Hai Yuan, Fengqi Hu
Summary: The study demonstrated that cilastatin attenuated wasp sting-induced AKI in rats by reducing oxidative stress and apoptosis, thus improving kidney injury.
Article
Hematology
Fugang Li, Li Liu, Dezheng Chen, Yong Zhang, Mingli Wang, Dongmei Zhou, Li Peng, Wujun Lin
Summary: This study aimed to explore the therapeutic effects of 3 renal replacement therapy modalities on acute kidney injury caused by wasp stings. Results showed that early RRT was effective in treating AKI caused by wasp stings, with CVVHDF + HP and CVVHDF modalities showing better clearance of toxins and recovery of renal function compared to the IHD + HP group.
BLOOD PURIFICATION
(2022)
Article
Chemistry, Multidisciplinary
Dan Lu, Liying Wang, Liping Wang, Liwei An, Minfeng Huo, Huixiong Xu, Jianlin Shi
Summary: This study reports the engineering of a sonosensitizer onto bifidobacterium for targeted tumor treatment by sonodynamic therapy. It also employs an immune agonist to enhance the immunological responses against tumors, resulting in improved anti-tumor immunity.
Article
Biochemistry & Molecular Biology
Souvik Dey, Huan-Xiang Zhou
Summary: Human WASP and N-WASP are homologous proteins that require the binding of multiple regulators, including PIP2 and Cdc42, to relieve autoinhibition. In the absence of Cdc42, both proteins associate with PIP2-containing membranes through their basic region. Cdc42 binding compromises the ability of the basic region in WASP, but not N-WASP, to bind PIP2.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)