Article
Dermatology
Raniah Al Amri, Danielle De Stefano, Qian Wang, Claudia M. Salgado, Ana M. Gomez, Eduardo Zambrano, Miguel Reyes-Mugica
Summary: This study reviewed the clinical and pathological features of RMH in pediatric patients, emphasizing the importance of recognizing these characteristics to avoid misdiagnosis. The study found that RMH predominantly occurs in the head and neck regions.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Dermatology
Yu-Hua Lee, Xiao-Feng Yao, Yu-Hung Wu
Summary: Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare benign tumor composed of skeletal muscle fibers and other mesenchymal-derived cells. It typically presents as solitary skin tag lesions in children or adults, with a distinct clinical manifestation on the chin.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2021)
Review
Dermatology
Ivan A. Gonzalez, Louis P. Dehner
Summary: Smooth muscle hamartoma (SMH) and striated muscle hamartoma (STH) are anomalous proliferations of smooth muscle or striated muscle in anatomic sites where these tissues are normally present. The study found that SMH cases were more commonly located in the torso and extremities, while STH were more commonly located in the head and neck area. It suggests the importance of obtaining clean margins for these lesions.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Article
Dermatology
Lisa M. Marinelli, Wendi E. Wohltmann, Kevin D. Myers, Geoffrey T. Sasaki
Summary: Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital malformation commonly found in midline sites of the head and neck region. While most cases are diagnosed in newborns or young children, some may not present until later in life. Differential diagnosis should include RMH and other lesions containing dermal striated muscle and/or adipose tissue.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ioana Bratoiu, Alexandra Maria Burlui, Anca Cardoneanu, Luana Andreea Macovei, Patricia Richter, Gabriela Rusu-Zota, Ciprian Rezus, Minerva Codruta Badescu, Andreea Szalontay, Elena Rezus
Summary: Systemic sclerosis (SSc) is a complex autoimmune disease characterized by heterogeneous changes involving multiple organs and systems. Muscle injury is widespread in SSc and leads to significant clinical manifestations. Heart involvement in SSc is heterogeneous, with the majority of patients experiencing asymptomatic cardiac disease. Further research is needed to fully understand the mechanisms and implications of muscle involvement in scleroderma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ramesh Venkatesh, Sameeksha Agrawal, Nikitha Gurram Reddy, Rubble Mangla, Naresh Kumar Yadav, Jay Chhablani
Summary: This study reported on a type of choroidal lesion that was not noticeable on clinical examination or conventional color fundus images, but could be detected using multi-color imaging and optical coherence tomography (OCT). After comparing the features with other known entities, it was concluded that this lesion is a distinct clinical entity, which is named as 'choroidal melanocytic hamartoma'. Longer follow-up is needed to confirm its benign nature.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Haiwen Li, Lingqiang Zhang, Lei Zhang, Renzhi Han
Summary: This article summarizes the link between autophagy and cardiac and skeletal muscle defects, as well as discusses potential interventions to regulate autophagy activities in treating muscle diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Dermatology
Omid Zargari, Masih Asadi, Seyyede Zeinab Azimi, Alireza Mesbah
Summary: Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital malformation of the dermis and subcutaneous tissue, commonly occurring in the midline of the face and neck region. While more common in neonatal period or young children, RMH should be considered in older adults as well as part of a differential diagnosis.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tamaki Kurosawa, Keitaro Minato, Madoka Ikemoto-Uezumi, Jun Hino, Kunihiro Tsuchida, Akiyoshi Uezumi
Summary: Transgenic expression of Bmp3b in mesenchymal progenitors alleviates age-related muscle deterioration, including maintaining muscle weight, myofiber cross-sectional areas, decreasing fibrosis, and preserving neuromuscular junctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dentistry, Oral Surgery & Medicine
Maria Eduarda Perez-de-Oliveira, Liam Robinson, Jose Narciso Rosa Assuncao Junior, Aline Correa Abrahao, Mario Jose Romanach, Paulo Victor Mendes Penafort, Luan Cesar da Silva, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Willie F. P. van Heerden, Pablo Agustin Vargas
Summary: This study reports 9 additional tongue hamartomas in children paired with a literature review. The posterior dorsum tongue was the most affected site, and salivary gland tissue was the most common predominant component. When masses are found in the posterior dorsum tongue of children, the possibility of tongue hamartomas should be considered.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yoshitaka Iso, Sayaka Usui, Hiroshi Suzuki
Summary: The aim of this study was to investigate the pro-angiogenic potential of skeletal muscle mesenchymal stem/stromal cells (mMSCs). The results showed that PDGFR-alpha positive mMSCs secreted VEGF and hepatocyte growth factor, inducing endothelial tube formation and promoting capillary growth. Epo stimulation enhanced phosphorylation and cellular proliferation in mMSCs, leading to improved perfusion recovery and capillary growth in the ischemic limbs.
Article
Biotechnology & Applied Microbiology
Aline Goncalves Lio Copola, Iria Gabriela Dias dos Santos, Luiz Lehmann Coutinho, Luiz Eduardo Vieira Del-Bem, Paulo Henrique de Almeida Campos-Junior, Izabela Mamede Costa Andrade da Conceicao, Julia Meireles Nogueira, Alinne do Carmo Costa, Gerluza Aparecida Borges Silva, Erika Cristina Jorge
Summary: This study reports the global transcription expression profile of RGMa-treated C2C12 myoblasts during differentiation, revealing the modulation of transcript expression, involvement in RNA splicing and degradation, induction of nuclei accretion and muscle hypertrophy mechanisms, and promotion of skeletal muscle structural protein expression.
Article
Cell Biology
Kyung-Ah Cho, Da-Won Choi, Yu-Hee Kim, Jungwoo Kim, Kyung-Ha Ryu, So-Youn Woo
Summary: This study investigated the role of T-MSC exosomes in recovery of body weight and skeletal muscle mass in chemotherapy-treated mice. The results showed that T-MSC exosomes rescued muscle atrophy both in vivo and in vitro via a miR-145-5p dependent manner, suggesting therapeutic potential in maintaining or improving skeletal muscle mass under various activin A elevated pathologic conditions.
Review
Biochemistry & Molecular Biology
Elancheleyen Mahindran, Wan Safwani Wan Kamarul Zaman, Khairul Bariah Ahmad Amin Noordin, Yuen-Fen Tan, Fazlina Nordin
Summary: Population ageing is increasing globally due to advancements in medical treatments and technologies. This leads to a higher prevalence of age-related diseases, such as muscle loss, among the older population. Current interventions only slow down and control symptoms, and there is no treatment to prevent or reverse age-related muscle frailty. Mesenchymal stem cell-derived extracellular vesicle (MSC-EV) therapy shows promise in attenuating age-related muscle frailty, but further studies, including large-scale clinical trials, are needed to determine its effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yusuke Kono, Junya Takegaki, Takeshi Ohba, Koji Matsuda, Ryosuke Negoro, Satoshi Fujita, Takuya Fujita
Summary: The study demonstrated that magnetized mesenchymal stem cells (MSCs) have the potential to effectively treat sarcopenia by promoting myogenic cell differentiation and suppressing inflammation. The results showed that magnetized MSCs had a high retention efficiency in inflamed skeletal muscle and could regulate the expression of inflammatory factors through paracrine effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
