Journal
AMERICAN JOURNAL OF DERMATOPATHOLOGY
Volume 30, Issue 4, Pages 381-384Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DAD.0b013e31817532c4
Keywords
glioblastoma metastasis; scalp metastasis; subcutaneous metastasis; extracranial glioblastoma
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Despite an aggressive clinical course, glioblastorna multiforme (GBM) rarely develops extracranial metastasis, with only 6 cases of skin involvement reported in the literature. We report 2 cases of GBM that spread to the scalp. Both patients presented with a firm nodule adjacent to their original craniotomy site. Histologic examination revealed highly anaplastic tumor cells invading the subcutaneous tissues. Immunohistochemistry was positive for vimentin, S-100, and glial fibrillary acidic protein in the malignant cells. Although it is possible that these cases represent true metastatic GBM, the close proximity of the nodules to suture lines suggests extension of GBM to the skin through surgical sites or seeding of tumor cells. It is important to have an accurate clinical history when evaluating scalp nodules in patients with GBM, so that a diagnosis of GBM is not overlooked.
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