Article
Hematology
Jorn Gerritsma, Vera Bongaerts, Corien Eckhardt, Harriet Heijboer, Erfan Nur, Bart Biemond, Ellen van der Schoot, Karin Fijnvandraat
Summary: Delayed haemolytic transfusion reaction (DHTR) is a potentially life-threatening complication of red blood cell (RBC) transfusions in sickle cell disease (SCD), with a high incidence rate despite extended donor RBC matching. Early diagnosis is crucial for improving outcomes.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, General & Internal
Siti Zaleha S. Abdullah, Mohd Nazri Hassan, Marini Ramli, Marne Abdullah, Noor Haslina Mohd Noor
Summary: Red blood cell (RBC) alloimmunization is a significant complication of blood transfusion, with variation in prevalence among different patient populations. This study aimed to determine the prevalence and factors associated with RBC alloimmunization among chronic liver disease (CLD) patients. A total of 441 CLD patients were included, and the overall prevalence of RBC alloimmunization was 5.4%, with higher rates in females and patients with autoimmune hepatitis. The most common alloantibodies were from the Rh blood group. There was no significant factor associated with RBC alloimmunization among CLD patients. Therefore, it is recommended to provide Rh blood group phenotype matching for CLD patients requiring blood transfusions to prevent RBC alloimmunization.
Article
Medicine, General & Internal
Salome Conrath, Vincent Vantilcke, Mickael Parisot, Francoise Maire, Pierre Selles, Narcisse Elenga
Summary: This study aimed to describe the prevalence of alloimmunization in patients with sickle cell disease who were monitored at Cayenne Hospital in 2016. It found that 23% of the patients had detectable RBC alloantibodies, and 19% of those patients developed a delayed hemolytic transfusion reaction. Differences between donors from France vs. recipients from French Guiana may explain the high prevalence of alloimmunization and further reduction strategies are needed.
FRONTIERS IN MEDICINE
(2021)
Article
Hematology
Stacey Uter, Hyun Hyung An, Grace E. Linder, Stephan Kadauke, Deborah Sesok-Pizzini, Haewon C. Kim, David F. Friedman, Stella T. Chou
Summary: The study successfully reduced the number of red blood cell units required by patients undergoing chronic red cell exchange during the COVID-19 pandemic by implementing two measures, maintaining pretransfusion HbS% target goals and minimizing iron accumulation.
Editorial Material
Hematology
France Pirenne
Summary: The study demonstrates that heme released during hemolysis inhibits human plasma B-cell differentiation, but this pathway is inhibited in B cells from alloimmunized patients with sickle cell disease. Insensitivity to heme inhibition in B cells may pose a potential alloimmunization risk factor.
Review
Medicine, General & Internal
Julie Carrara, Anoosha Habibi, Alexandra Benachi, Geoffrey Cheminet
Summary: Pregnancy is a high-risk period for patients with sickle cell disease, requiring planning and close monitoring. Physiological changes during pregnancy increase the risk of various complications, such as vaso-occlusive crises, acute chest syndrome, venous thromboembolic events, and infections. Before planning pregnancy, parents should be informed about the risk of disease transmission and treatment plans should be adjusted.
Article
Hematology
Yan Zheng, Jeffrey M. Gossett, Pei-Lin Chen, Martha Barton, Missy Ryan, Jing Yu, Guolian Kang, Jane S. Hankins, Stella T. Chou
Summary: This study found that the inflammatory state of transfusion recipients affects the risk of red blood cell alloimmunization, which is not modified by hydroxyurea (HU) therapy. Judicious use of transfusion during proinflammatory events is critical for preventing alloimmunization.
Article
Multidisciplinary Sciences
Fahad M. Aldakheel, Bader H. Alali, Shatha A. Alduraywish, Ayesha Mateen, Rabbani Syed
Summary: Alloantibodies, formed against various blood components, are commonly associated with transfusions. This study examined the clinical factors related to red blood cell transfusion and the impact of Rh-Kell antigen matching on alloimmunization in sickle cell anemia patients. The results indicated that advancing age and multiple transfusion episodes were associated with an increased risk of alloantibody development after transfusion in SCA patients.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Parisa Ebrahimisadr, Zahra Bakhshandeh, Hamidreza Majidiani
Summary: The study revealed that about 63% of beta-thalassemia patients referred to Tehran Regional Blood Transfusion Center had alloimmunization, with anti-K (Kell system), anti-D, and anti-E (Rhesus system) being the most abundant alloantibody variants. Regular RBC antigen phenotyping and receiving compatible blood for Kell and RH subgroups are suggested for all cases of transfusion-dependent thalassemia to address the issue of alloantibody production.
Article
Hematology
Shu Min Wong, Tanya Cawthorne, Peta M. Dennington, Frank S. Hong
Summary: This study evaluated the risk of acute hemolytic transfusion reactions in recipients with preformed anti-Yt(a) receiving Yt(a+) donor RBCs, indicating that there is no significant risk in cases of weak antibody reactions. It suggests that incompatible crossmatched RBCs can be considered for transfusion in patients with weak antibody reactions.
Article
Medical Laboratory Technology
Muhammad Saboor, Saeed Ahmed
Summary: The study found a prevalence rate of 2.8% for red cell alloantibodies in un-transfused multiparous women, including clinically significant and cold type antibodies. It is recommended to screen and identify antibodies during pregnancy to prevent fatal complications of HDFN.
CLINICAL LABORATORY
(2021)
Review
Hematology
Eric A. Gehrie, Bipin N. Savani, Garrett S. Booth
Summary: Advancements in laboratory testing, pathogen reduction, and donor qualification have significantly reduced the risk of infection from blood transfusions. However, the prevention and recognition of hemolytic reactions, particularly due to donor-recipient incompatibility, have seen little recent progress. The article discusses the role of compatibility testing and transfusion practices in acute hemolysis, emphasizing clinical scenarios with increased risk and outlining initial clinical management for severe hemolytic reactions.
Article
Hematology
Margo R. Rollins, Stella T. Chou
Summary: This review discusses the specific adverse events that may occur during blood transfusion in patients with sickle cell disease, including alloimmunization, hemolytic transfusion reactions, hyper-viscosity, and transfusion-associated iron overload, and provides corresponding risk factors, mitigation strategies, and management recommendations.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Medical Laboratory Technology
Hui Ni, Xiaoye Sun, Hui Cong
Summary: This study analyzed the specificity of red blood cell irregular antibodies in inpatients. Among the 778 cases of irregular antibody positive samples, 214 were from males and 564 from females. History of blood transfusion accounted for 13.1% of the total. A total of 131 antibodies were identified, including 68 Rh systematic antibodies, 6 MNS systematic antibodies, 6 Lewis systematic antibodies, 2 Kidd systematic antibodies, 10 autoantibodies, and 39 antibodies of uncertain specificity.
LABORATORY MEDICINE
(2023)
Article
Hematology
Chiara Moriconi, Monika Dzieciatkowska, Micaela Roy, Angelo D'Alessandro, Philippe Roingeard, June Young Lee, David R. Gibb, Maria Tredicine, Marlon A. McGill, Annie Qiu, Francesca La Carpia, Richard O. Francis, Eldad A. Hod, Tiffany Thomas, Martin Picard, Imo J. Akpan, Chance John Luckey, James C. Zimring, Steven L. Spitalnik, Krystalyn E. Hudson
Summary: This study found that patients with sickle cell disease (SCD) have actively functioning mitochondria in their red blood cells, which can elicit immune responses and may play a role in disease complications and alloimmunization risk.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
