Review
Medicine, General & Internal
Alexander J. Howie, Mared P. Owen-Casey
Summary: This article presents a systematic review of recent papers on the appearance of Congo red-stained amyloid under a microscope, revealing that not all images show green birefringence as commonly believed. The study also highlights the widespread inaccuracies in reporting and emphasizes the need for more accurate descriptions.
ANNALS OF MEDICINE
(2022)
Article
Oncology
Sandip Bartakke, Umesh Lukade, Shrividya Sethuratnam
Summary: Cytopenias are common in neonates in NICU, and although bone marrow aspirations are often performed for diagnostic purposes, trephine bone marrow biopsies have not been reported in living neonates. This study describes trephine BMB from PSIC using 18-gauge BMA needle for the first time, aiding in understanding the underlying mechanisms and diagnosis of cytopenias in neonates.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yoshie Haratake, Kohei Sano, Miki Tsuchiya, Kaori Minaki, Masayuki Munekane, Toshihide Yamasaki, Masayori Hagimori, Takahiro Mukai
Summary: This study designed and synthesized a novel radiolabeled amyloid imaging probe, demonstrating its potential for diagnosing amyloidosis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Rahul Nadda, Ramjee Repaka, Nabhajit Mallik, Ashish Kumar Sahani
Summary: Trephine bone marrow biopsy is a useful technique for diagnosing hematological malignancies in patients of different ages. A survey was conducted on Indian patients to assess the procedure's difficulties and diagnostic outcomes. Pain was the main complication, with different degrees reported by the patients. Additionally, the patients' anxiety levels and bone texture were found to impact the biopsy process.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Hematology
Shruti Mishra, Somanath Padhi, Sonali Mohapatra, Ashutosh Panigrahi, Prabodha Kumar Das, Amit Kumar Adhya, Susama Patra, Pritinanda Mishra, Biswajit Bhuyan
Summary: This study demonstrates the utility of immunohistochemistry in characterizing malignancy-associated myelonecrosis on bone marrow trephine biopsies. It shows that tumor antigenicity may be retained in myelonecrosis, and immunohistochemistry with a selected panel of antibodies can aid in early presumptive diagnosis and decision making.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Pathology
Sorina-Dana Mihailescu, Pauline Jaselme, Marie-Laure Fontoura, Lamia Feddag-Hannachi, Elena-Liana Veresezan, Fanny Drieux, Vincent Camus, Florian Bouclet, Herve Tilly, Nathalie Cardinae, Fabrice Jardin
Summary: The study aimed to compare the quality of BMB obtained from manual BMB vs. drill-powered BMB, and to evaluate patient's pain and anxiety, as well as the haematologist's perceived difficulty in performing BMB. The results showed significant differences in trephine length and number of interosseous spaces between the two procedures.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Review
Urology & Nephrology
Maria M. Picken
Summary: Amyloidoses are rare diseases in which treatment depends on the type of amyloid protein, and delays in diagnosis lead to poor prognosis.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Article
Engineering, Environmental
Chao Liang, Shuzhen Qin, Hao Ai, Shasha Li, Kaifeng Du
Summary: A novel biosorbent with superadsorption ability for Congo red removal, porous lysozyme skeletons, was successfully prepared using an enhanced amyloidal denaturation protocol. The as-prepared superadsorbent showed rapid kinetics and high capacity for CR adsorption, as well as selectivity and recyclability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Medical Laboratory Technology
Ahmed Shehabeldin, Caroline Hussey, Roaa Aggad, Luan Truong
Summary: Traditionally, the tissue diagnosis of amyloidosis is suggested by hematoxylin-eosin stain and confirmed by Congo red stain. However, false-positive and false-negative results are common with Congo red stain, limiting its sensitivity and specificity. This study showed that Texas Red-filtered fluorescence microscopy (TRFM) can enhance the amyloid-specific congophilia, improving the diagnostic sensitivity and specificity of Congo red-stained tissue sections for detection of amyloid.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Cell Biology
Maria Ioannou, Konstantina Zacharouli, Sotirios G. Doukas, Michael D. Diamantidis, Vaya Tsangari, Konstantinos Karakousis, George K. Koukoulis, Dimitra P. Vageli
Summary: This article reports a case of sHLH diagnosed by trephine biopsy in a living patient after COVID-19, highlighting the diagnostic value of trephine biopsy in preventing life-threatening conditions such as COVID-19.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Medicine, General & Internal
Chao Wang, Zhiqiong Wang, Xiwen Tong, Yi Li, Xian Liu, Lifang Huang
Summary: Metastatic carcinoma of bone marrow (MCBM) often presents with atypical symptoms, leading to potential misdiagnosis. This study investigated the clinical-pathological and hematological characteristics of MCBM patients to aid in early detection and treatment selection. The findings suggest that pain and anemia are common symptoms, and bone marrow biopsy combined with immunohistochemistry is an underappreciated diagnostic method.
Article
Multidisciplinary Sciences
Cherry Greiner, Stephanie Grainger, Samantha Farrow, Alena Davis, Jimmy L. Su, Matthew D. Saybolt, Robert Wilensky, Sean Madden, Stephen T. Sum
Summary: This study demonstrates a novel image acquisition technique and analysis method using linearly polarized light for quantitative analysis of collagen content in tissues. The technique showed high reproducibility and sensitivity in analyzing cap collagen in atherosclerotic plaque, suggesting its potential usefulness for predicting rupture risk.
Article
Cell Biology
Yuzuru Ariga, Shulin Low, Hitomi Hoshino, Tsutomu Nakada, Tomoya O. Akama, Akifumi Muramoto, Mana Fukushima, Takahiro Yamauchi, Yusei Ohshima, Motohiro Kobayashi
Summary: Spi-B plays an important role in B cell differentiation and development of B-cell lymphoma. The expression of Spi-B in B-ALL patients is associated with patient age, serum uric acid and creatinine levels, and shorter overall survival.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lorena M. B. Pereira, Mariana P. Cali, Rafael C. Marchi, Wallance M. Pazin, Rose M. Carlos
Summary: A sensitive and selective strategy using a luminescent complex has been demonstrated as a rapid and low-cost alternative for in vitro detection of fibrillar insulin, showing high sensitivity and binding affinity while minimizing background fluorescence and light scattering.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Review
Hematology
J. L. Vives Corrons, L. Berga Casafont, E. Feliu Frasnedo
Summary: The average lifespan of a human red blood cell is around 120 days. At this point, the cell is usually worn out and undergoes phagocytosis by macrophages in the spleen or liver, where iron is recycled and hem molecule is eliminated as bilirubin.
ANNALS OF HEMATOLOGY
(2021)