☆ 4.3 Article

Epithelioid Sarcoma A Clinicopathologic and Immunohistochemical Analysis of 106 Cases From the French Sarcoma Group

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2009)

Journal

AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Volume 131, Issue 2, Pages 222-227

Publisher

OXFORD UNIV PRESS INC

DOI: 10.1309/AJCPU98ABIPVJAIV

Keywords

Epithelioid sarcoma; INI1; Prognosis

Categories

Pathology

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Abstract

Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported. We report a study of 106 cases with clinical, histologic, and immunohistochemical data, including INI1 expression, and follow-up data. Of the 106 cases, 70,were the conventional subtype and 36 the large cell subtype. INI1 was negative in 86 cases (81.1 %): 57 (81 %) of 70 conventional and 29 (81 %) of 36 large cell subtypes. Treatment modalities were available for 76 and follow-up for 80 patients. Of the 80 patients, 43 (54%) experienced metastasis and 25 (31 %) died of the disease. Univariate analysis indicated that tumor size and mitotic index were significant for metastasis-free survival, whereas proximal location, tumor size and mitotic index were significant for overall survival. Loss of expression of INI1 is frequent in the conventional and large cell subtypes of ES and can be used as a diagnostic marker, but it has no prognostic impact.

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