Article
Medical Laboratory Technology
Pablo Leiva-Salinas, Emilio Flores, Alvaro Blasco, Ruth Torreblanca, Irene Gutierrez, Maite Lopez-Garrigos, Carlos Leiva-Salinas
Summary: This study compared the diagnostic performance of D-dimer for the diagnosis of VTE in the emergency department (ED) using conventional cut-off values versus age-adjusted values. It also investigated the ordering pattern of Doppler ultrasound (US) and computerized tomographic pulmonary angiogram (CTPA) before and after reporting the age-adjusted cut-off value.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medical Laboratory Technology
Lucia M. White, Mayukh K. Sarkar
Summary: This study analyzed the effectiveness of D-dimer assay in ruling out VTE in the Emergency Department. The results showed that D-dimer testing had a moderate effect on ED visit length, but it did not correspond to differences in ED visit length or VTE diagnostic cost.
CLINICAL LABORATORY
(2022)
Article
Hematology
Oskar Steinbrecher, Hana Sinkovec, Lisbeth Eischer, Paul A. Kyrle, Sabine Eichinger
Summary: This study found that D-dimer levels increased over time, were positively correlated with body mass index, and were higher in female patients compared to male patients. The increase in D-dimer levels was associated with a higher risk of recurrent VTE.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Stuart L. Cohen, Eugenia Gianos, Mathew A. Barish, Saurav Chatterjee, Nina Kohn, Martin Lesser, Dimitrios Giannis, Kevin Coppa, Jamie S. Hirsch, Thomas G. McGinn, Mark E. Goldin, Alex C. Spyropoulos
Summary: This study aimed to identify the prevalence and predictors of venous thromboembolism (VTE) or mortality in hospitalized COVID-19 patients. The overall in-hospital VTE rate was 2.9% (4.9% in the ICU) and a VTE or mortality rate of 26.1%. Key predictors of VTE or mortality included advanced age, increasing CCI, history of cardiovascular disease, ICU level of care, and elevated maximum D-dimer with a cutoff at least four times the ULN. Use of prophylactic-dose anticoagulation but not treatment-dose anticoagulation was associated with reduced VTE or mortality.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Fridtjof B. Rinde, Camilla T. J. Jorgensen, Heidi H. Pettersen, John-Bjarne Hansen, Waleed Ghanima, Sigrid K. Braekkan
Summary: This study investigated the impact of D-dimer levels measured at the time of VTE diagnosis on the risk of recurrence in patients with a first-time VTE. The findings showed that patients with lower D-dimer levels at the time of VTE diagnosis had a lower risk of recurrence, suggesting that D-dimer levels measured at diagnosis can be used to identify patients at a low risk of recurrent VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, Research & Experimental
Harish Dharmarajan, Jennifer L. McCoy, Noel Jabbour, Andrew McCormick, Frederico Xavier, Debra Correa, Reema Padia
Summary: This study reviewed the practice of periprocedural anticoagulation for venous malformations in a multidisciplinary vascular anomalies center, and compared the risk of thromboembolic events between head and neck and extremity VM patients. The results showed a low incidence of post-procedure thrombus formation in head and neck patients, regardless of anticoagulation use.
Article
Medical Laboratory Technology
Lucia M. White, Mayukh K. Sarkar
Summary: This study compared the length and cost of emergency department visits with and without D-dimer testing through a retrospective data analysis. The results showed that D-dimer testing did not significantly improve the length and cost of emergency department visits compared to imaging studies.
CLINICAL LABORATORY
(2023)
Article
Hematology
Yan Xu, Faizan Khan, Michael J. Kovacs, Elham Sabri, Marc Carrier, Marc Righini, Susan R. Kahn, Philip S. Wells, David R. Anderson, Isabelle Chagnon, Mark A. Crowther, Richard H. White, Marc Rodger, Gregoire Le Gal
Summary: In this study, researchers examined the potential of serial normal D-dimer levels in predicting recurrent VTE in patients who have ceased oral anticoagulant treatment. They found that patients with normal D-dimer levels at both timepoints may have a lower risk of VTE recurrence, while an elevated D-dimer level was associated with a higher risk of recurrent VTE. Additionally, the study suggested that Delta D-dimer, regardless of baseline value, could also predict recurrent VTE.
THROMBOSIS RESEARCH
(2023)
Article
Medicine, General & Internal
Vitali Koch, Simon S. Martin, Tatjana Gruber-Rouh, Katrin Eichler, Scherwin Mahmoudi, David M. Leistner, Jan-Erik Scholtz, Simon Bernatz, Valentina O. Puntmann, Eike Nagel, Christian Booz, Tommaso D'Angelo, Leona S. Alizadeh, Ibrahim Yel, Nicole S. Ziegengeist, Katerina Torgashov, Tobias Geyer, Stefan E. Hardt, Thomas J. Vogl, Leon D. Gruenewald, Evangelos Giannitsis
Summary: This retrospective study assessed the diagnostic and prognostic features of D-dimers in cancer patients with suspected pulmonary embolism and deep vein thrombosis. The results showed that D-dimer concentrations had high positive and negative predictive values for the diagnosis of VTE and were correlated with recurrence of VTE and mortality.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Hematology
Ellen-Sofie Hansen, Fridtjof B. Rinde, Magnus S. Edvardsen, Kristian Hindberg, Nadezhda Latysheva, Pal Aukrust, Thor Ueland, Annika E. Michelsen, John-Bjarne Hansen, Sigrid K. Braekkan, Vania M. Morelli
Summary: The results of the study suggest that elevated plasma D-dimer levels are associated with an increased risk of incident VTE. However, the risk estimates were slightly attenuated after adjusting for body mass index and C-reactive protein, indicating that D-dimer may partly reflect underlying conditions related to obesity and inflammation.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Ying Chen, Yanchun Wang, Suhong Xie, Hui Zheng, Ying Tong, Xiang Gao, Renquan Lu, Lin Guo
Summary: The study found that an algorithm called RVTA can effectively predict the risk of venous thromboembolism (VTE) in colorectal cancer patients and has prognostic value for cancer. In colorectal cancer patients, those in the low-risk group identified by RVTA had significantly longer progression-free survival than those in the high-risk group.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Review
Medicine, General & Internal
Joel L. Gerber, Anna S. Messmer, Tobias Krebs, Martin Mueller, Debora M. Hofer, Carmen A. Pfortmueller
Summary: This study systematically reviewed and analyzed relevant literature to assess the impact of adjusting D-dimer thresholds based on individual patient factors on the diagnosis of venous thromboembolism (VTE). The findings suggest that adjusting thresholds has the potential to improve safety and reduce unnecessary imaging, but different adjustment strategies vary in terms of robustness, safety, and efficiency.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Hematology
Yupei Shen, Yan Zhang, Ying Xiong, Zhiping Zhang, Baohua Zhang, Aihong Li, Zhaofeng Zhang, Jing Ding, Jing Du, Yan Che
Summary: This study investigated genetic risk factors for venous thromboembolism (VTE) in pregnant women through a large-scale prospective cohort study. The findings suggest that the presence of known pathogenic variants, damaging variants in thrombophilia genes, and rare damaging variants are associated with VTE in pregnancies. Exome-wide association analysis identified several genes related to basement membranes, sterol accumulation, atherosclerosis, lipid metabolism, and coagulation deficiency as potential mechanisms of VTE in pregnancies.
THROMBOSIS RESEARCH
(2022)
Article
Hematology
Fumihiro Ogawa, Yasufumi Oi, Kento Nakajima, Reo Matsumura, Tomoki Nakagawa, Takao Miyagawa, Takeru Abe, Ichiro Takeuchi
Summary: Severe cases of COVID-19 can lead to coagulopathy and thrombosis, which can contribute to high mortality rates. Enhanced CT scans can help detect thrombosis in critical COVID-19 patients. It is important to consider therapeutic dose anticoagulants and closely monitor systemic venous thromboembolism in these cases.
THROMBOSIS JOURNAL
(2021)
Article
Surgery
Jonathan P. Kuriakose, Wenbo Wu, Wenjing Weng, Neil Kamdar, Richard E. Burney
Summary: Based on a retrospective cohort study, this research investigated the effectiveness of eVTEp on pdVTE rates. The results showed that pdVTE was associated with eVTEp and LOS of 5 days or more, but not with other VTE risk factors. Therefore, the current guidelines for eVTEp should include LOS of more than 5 days in the selection criteria.
JOURNAL OF SURGICAL RESEARCH
(2023)
