Article
Thermodynamics
Peng Yu
Summary: This study broke through the traditional model dimensionality and expanded the logging intersection space to three dimensions to predict the hydraulic unit (HU) class. Scheme B showed good prediction performances, and HU #2 and HU #3 were identified as the main targets for future remaining oil exploitation.
Article
Computer Science, Interdisciplinary Applications
Yubing Shen, Luwen Zhang, Peng Wu, Yuguang Huang, Shijie Xin, Qiang Zhang, Shengxiu Zhao, Hong Sun, Guanghua Lei, Taiping Zhang, Wei Han, Zixing Wang, Jingmei Jiang, Xiaochu Yu
Summary: This study constructed an association network among multiple postoperative complications to quantify their possible evolution trajectories, providing a basis for preventing further deterioration in high-risk patients and developing targeted measures.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Jingyu Lei, Zhenzhou Lu, Lu Wang
Summary: An adaptive Kriging nested Importance Sampling (AK-IS) method is proposed to efficiently estimate the effect of input uncertainty on failure probability, by employing an equivalent form of the FP-GS transformed by Bayes' formula to eliminate dimensionality dependence in the calculation, and transforming failure samples to original conditional PDF using Metropolis-Hastings algorithm. The proposed method highly improves the efficiency of estimating the FP-GS, as shown by results in the paper.
ENGINEERING WITH COMPUTERS
(2022)
Article
Hematology
Martina Chiu, Giuseppe Taurino, Erica Dander, Donatella Bardelli, Alessandra Fallati, Roberta Andreoli, Massimiliano G. Bianchi, Cecilia Carubbi, Giulia Pozzi, Laura Galuppo, Prisco Mirandola, Carmelo Rizzari, Saverio Tardito, Andrea Biondi, Giovanna D'Amico, Ovidio Bussolati
Summary: ALL blasts utilize glutamine to exchange amino acids with MSCs, promoting the survival of leukemic cells during treatment.
Article
Computer Science, Interdisciplinary Applications
Xiukai Yuan, Shaolong Liu, Marcos A. Valdebenito, Matthias G. R. Faes, Danko J. Jerez, Hector A. Jensen, Michael Beer
Summary: An efficient framework for reliability-based design optimization of structural systems is proposed, utilizing the failure probability function and posterior distribution for the optimization of design parameters.
ADVANCES IN ENGINEERING SOFTWARE
(2021)
Article
Engineering, Mechanical
Kaixuan Feng, Yixin Lu, Zhenzhou Lu, Pengfei He, Ying Dai
Summary: In this paper, a novel simulation method based on the theorem of Bayes and subset simulation is proposed to efficiently estimate the failure probability-based-global-sensitivity. The method estimates the unconditional failure probability using efficient subset simulation and computes conditional failure probabilities on arbitrary inputs through an equivalent transformation formula. The failure probability-based-global-sensitivity can then be estimated using the unconditional failure probability and conditional failure probabilities.
PROBABILISTIC ENGINEERING MECHANICS
(2022)
Review
Hematology
Yasmina Serroukh, Josee Hebert, Lambert Busque, Francois Mercier, Christopher E. Rudd, Sarit Assouline, Silvy Lachance, Jean-Sebastien Delisle
Summary: In this review, the authors summarize the role of the immune microenvironment in healthy bone marrow and AML development, focusing on T cells and other lymphoid cells. They discuss the types and function of immune cells in the AML microenvironment, as well as their potential role in disease onset and treatment response. The review also examines how the immune context predicts the response to immunotherapy in AML and how these therapies modulate the immune status of the bone marrow. Finally, the authors focus on allogeneic stem cell transplantation and discuss the immune environment in the post-transplant bone marrow, factors associated with immune escape, and strategies to prevent and treat relapse.
Article
Hematology
Kaitlyn M. Dykstra, Hannah R. S. Fay, Ashish C. Massey, Neng Yang, Matthew Johnson, Scott Portwood, Monica L. Guzman, Eunice S. Wang
Summary: This passage discusses the role of autophagy in the survival, mitochondrial function, and cell death of AML cells. The study found that inducing apoptosis in AML cells and preventing the maintenance of AML LSCs can be achieved by using autophagy inhibitors, which also reveals the effectiveness of autophagy inhibitors in inducing AML cell death is related to inducing mitochondrial damage and mitophagy simultaneously.
Article
Pathology
Akira Matsuda, Kazunori Imada, Naoshi Obara, Hiroatsu Iida, Hirohito Yamazaki, Yoshiaki Tomiyama, Koichi Miyamura, Osamu Sasaki, Tetsuo Maeda, Kensuke Ohta, Kensuke Usuki, Yukihiro Tokumine, Kenji Imajo, Yuji Okamoto, Mami Murakami, Shinji Nakao
Summary: This study examined the effect of Eltrombopag on cytomorphologic findings in patients with acquired aplastic anemia (AA) and found that dysmegakaryopoiesis without micromegakaryocytes and a transient increase of less than 5% in bone marrow blast count may be signs of hematologic improvement with Eltrombopag treatment for AA patients.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Oncology
Xueyan Chen, Megan Othus, Brent L. Wood, Roland B. Walter, Pamela S. Becker, Mary-Elizabeth Percival, Janis L. Abkowitz, Frederick R. Appelbaum, Elihu H. Estey
Summary: sAML and MDS-EB share many similarities, including similar mutation distribution and treatment response. This suggests that they may represent different stages or lineages of the same disease.
LEUKEMIA & LYMPHOMA
(2021)
Article
Hematology
Lok Lam Ngai, Connie Y. Ma, Orla Maguire, An D. Do, Alberto Robert, Aaron C. Logan, Elizabeth A. Griffiths, Michael J. Nemeth, Cherie Green, Tony Pourmohamad, Bo J. van Kuijk, Alexander N. Snel, Zinia W. Kwidama, Bianca Venniker-Punt, James Cooper, Markus G. Manz, Bjorn T. Gjertsen, Linda Smit, Gert J. Ossenkoppele, Jeroen J. W. M. Janssen, Jacqueline Cloos, Teiko Sumiyoshi
Summary: This study retrospectively assessed C-lectin-like molecule 1 (CLL-1) bimodal expression on CD34+ blasts in acute myeloid leukemia (AML) patients and explored potential CLL-1 bimodal associations with leukemia and patient-specific characteristics. The study found that bimodal CLL-1 expression was most prevalent in patients with MDS-related AML, ELN adverse risk, NPM1 wild type, FLT3 wild type, and relatively low percentages of leukemia-associated immunophenotypes. Additional immunophenotyping analysis revealed that the CLL-1(-) subpopulation may consist of pre-B cells, immature myeloblasts, and hematopoietic stem cells.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Article
Physics, Mathematical
Soumendu Sundar Mukherjee
Summary: This paper presents elementary and characterization results on Poisson thinning and its free probability analogues. The implications of the characterization results in the context of Cochran's theorem are also discussed.
RANDOM MATRICES-THEORY AND APPLICATIONS
(2022)
Article
Computer Science, Theory & Methods
Hayato Takahashi
Summary: This article examines the variants of conditional randomness and conditional blind randomness defined by ML-randomness on Bayes models. It is shown that variants of conditional blind randomness are ill-defined from the Bayes statistical point of view. The paper also proves the existence of a consistent estimator for the model when the sets of random sequences of uniformly computable parametric models are pairwise disjoint. Furthermore, an algorithmic solution to a classical problem in Bayes statistics is presented, indicating that the posterior distributions converge weakly to almost all parameters if and only if the posterior distributions converge weakly to all ML-random parameters. (c) 2023 Elsevier Inc. All rights reserved.
INFORMATION AND COMPUTATION
(2023)
Article
Hematology
Claire Horgan, Khushnuma Mullanfiroze, Archana Rauthan, Katharine Patrick, Naeem Akram Butt, Oana Mirci-Danicar, Olya O'Connor, Caroline Furness, Akshay Deshpande, Sarah Lawson, Valerie Broderick, Pamela Evans, Brenda Gibson, Wing Roberts, Salah Ali, Sevasti Galani, Amy A. Kirkwood, Jelena Jovanovic, Richard Dillon, Paul Virgo, Beki James, Kanchan Rao, Persis J. Amrolia, Robert F. Wynn
Summary: Stem cell transplant outcomes for high-risk and relapsed/refractory pediatric acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) have historically been poor. Cord blood (CB) transplant with T-cell repletion enables enhanced graft-versus-leukemia effect. This study analyzed data from 367 patients undergoing CB transplant or other cell source transplant for pediatric AML/MDS in the UK and Ireland, showing that CB transplant had improved event-free survival, reduced chronic graft-versus-host disease, and possibly improved overall survival, regardless of measurable residual disease (MRD) status. CB transplant without serotherapy may be the optimal option for children with myeloid malignancies.
Article
Medicine, General & Internal
Meenakshi Balasubramanian, Niyati N. Sangoi
Summary: Bone marrow examination is crucial in the diagnosis and management of various haematological and non-haematological conditions in children. It helps in understanding the underlying pathology, establishing a tissue diagnosis, ruling out haematological malignancies, planning further investigations, and evaluating response to therapy and prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)