Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 132, Issue 1, Pages 50-59Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPBDFR5L5UOAUZ
Keywords
Hodgkin lymphoma; Epstein-Barr virus; Latent membrane protein 1; Aberrant expression; Cyclin A
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Funding
- National Cheng Kung University Hospital [NCKUH-96-004]
- National Science Council, Taiwan [NSC 97-2320-B-006-022-MY3]
- National Health Research Institute, Taiwan
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Reed-Sternberg (RS) cells represent a histopathologic hallmark for Hodgkin lymphoma (HL). Viral proteins may induce aberrant expression of cyclin A and lead to multinucleation in virus-infected cells. We investigated whether Epstein-Barr virus (EBV) latent membrane protein-1 (LMP1) and cyclin A are involved in the morphogenesis of RS cells. We immunohistochemically analyzed individual tumor cells in 34 HLs for the subcellular expression of cyclin A and HL-related markers. In LMP1+ and LMP1- HLs, multinucleated RS cells aberrantly expressed cyclin A in cytoplasm, while the mononuclear Hodgkin cells expressed cyclin A predominantly in nuclei (P < .001). No differential expression of CD 15, CD30, or CD99 in HL cells was found In vitro, EBV-LMP1 increased cytoplasmic cyclin A expression and multinucleation in an HL cell line. Therefore, the aberrant expression of cyclin A is commonly associated with RS cell morphologic features in HL, probably through LMP1 signaling or other similar mechanisms in EBV- cases.
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