Article
Gastroenterology & Hepatology
Ahmed Gabr, Laura Kulik, Samdeep Mouli, Ahsun Riaz, Rehan Ali, Kush Desai, Ronald A. Mora, Daniel Ganger, Haripriya Maddur, Steven Flamm, Justin Boike, Christopher Moore, Bartley Thornburg, Ali Alasadi, Talia Baker, Daniel Borja-Cacho, Nitin Katariya, Daniela P. Ladner, Juan Carlos Caicedo, Robert J. Lewandowski, Riad Salem
Summary: This study presents the long-term outcomes of liver transplantation for HCC patients bridged or downstaged by Y90, demonstrating the effectiveness of Y90 in HCC treatment and the benefit of achieving extensive or complete necrosis for improved recurrence-free survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew M. Chiu, Rohan Savoor, Andrew C. Gordon, Ahsun Riaz, Kent T. Sato, Elias Hohlastos, Riad Salem, Robert J. Lewandowski
Summary: A retrospective study found that yttrium-90 radiation segmentectomy is a safe and effective treatment for oligo-metastatic secondary hepatic malignancies, achieving high disease control rate.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Oncology
Stefano Testa, Nam Q. Bui, David S. Wang, John D. Louie, Daniel Y. Sze, Kristen N. Ganjoo
Summary: Radioembolization may be a safe and effective treatment option for patients with unresectable liver sarcomas. In a retrospective analysis, researchers found that patients with good disease control in the liver and a long liver progression-free interval post-procedure had longer overall survival. Patients with good performance status and normal liver function at baseline also had better survival outcomes.
Article
Cardiac & Cardiovascular Systems
Seth I. Stein, Mohamed M. Soliman, Joseph Sparapani, Raphael Doustaly, Benjamin W. Cobb, Anuj Malhotra, Resmi Charalel, Benjamin J. May, Kyungmouk S. Lee, David C. Madoff, Adam D. Talenfeld
Summary: The study compared the volumes of radioembolization treatment zones using mapping CBCT versus planning CT/MRI, and modeled their impact on dosimetry. Results showed that CBCT-based volumetry may allow more accurate and personalized dosimetry for segmental Y90 radioembolization.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Oncology
Siddharth A. Padia, Guy E. Johnson, Vatche G. Agopian, Joseph DiNorcia, Ravi Srinivasa, James Sayre, David Shin
Summary: Y-90 radiation segmentectomy for hepatic metastases shows high rates of tumor control and minimal toxicity. This treatment should be considered for patients with metastatic hepatic malignancy who are not candidates for surgical resection.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ammar Sarwar, Alexei Kudla, Jeffrey L. Weinstein, Aamir Ali, Raza Malik, Andrea Bullock, Khalid O. Khwaja, Michael Curry, Salomao Faintuch, Muneeb Ahmed
Summary: This study reviewed the technical feasibility of resin microsphere yttrium-90 radioembolization using the MIRD model and found that prescribed activity calculated by MIRD was significantly higher than BSA model. The results indicated that MIRD prescribed activity with target absorbed doses up to 200 Gy can be successfully administered without prophylactic embolization in selected patients.
EUROPEAN RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Luciana Puleo, Laura Agate, Irene Bargellini, Giuseppe Boni, Paolo Piaggi, Claudio Traino, Tommaso Depalo, Giulia Lorenzoni, Francesca Bianchi, Duccio Volterrani, Sandra Brogioni, Valeria Bottici, Maurizia Rossana Brunetto, Barbara Coco, Eleonora Molinaro, Rossella Elisei
Summary: This study aimed to investigate the biochemical parameters and objective response of liver metastases (LM) from medullary thyroid cancer (MTC) to transarterial radioembolization (TARE). The results showed that TARE was effective in reducing calcitonin levels and liver tumor mass in patients with MTC LM. Additionally, TARE had minimal impact on liver function and was well tolerated clinically.
EUROPEAN THYROID JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sander C. Ebbers, Caren van Roekel, Manon N. G. J. A. Braat, Maarten W. Barentsz, Marnix G. E. H. Lam, Arthur J. A. T. Braat
Summary: This study confirms a clear dose-response relationship in patients with neuroendocrine tumor liver metastases treated with Y-90 radioembolization. It is suggested to perform Y-90 radioembolization with a minimum planned tumor-absorbed dose of 150 Gy. No significant dose-toxicity relationship was identified in the study.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Gastroenterology & Hepatology
Ahmad Hamad, Hassan Aziz, Ihab R. Kamel, Dayssy Alexandra Diaz, Timothy M. Pawlik
Summary: Radioembolization (RE) with 90Yttrium (Y90) has shown promising results for patients with HCC, regardless of stage. It can be used as a downstaging treatment for advanced HCC patients and has comparable outcomes to other standard treatments. Radiation lobectomy (RL) can be used to treat the liver lobe with HCC and induce compensatory hypertrophy of the future liver remnant (FLR).
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sen Lu, Jasreman Dhillon, Julie Hallanger Johnson, Ghassan El-Haddad
Summary: Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis, often diagnosed late due to non-specific symptoms. Y-90 radioembolization has been shown to be effective in treating isolated hepatic ACC metastases, with further prospective study needed to establish its efficacy and safety.
Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Mohamed H. Khalaf, Valentina Ferri, Lucia Baratto, Shyam M. Srinivas, Daniel Y. Sze, Andrei Iagaru
Summary: Tc-99m-MAA SPECT/CT showed great accuracy for treatment planning dosimetry. The SiPM-based PET/CT scanner demonstrated good image quality at a 10-min scan time in one bed position. A 5-min PET/CT scan time revealed acceptable image quality, which is sufficient for dosimetry and treatment verification.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hugo Levillain, Oreste Bagni, Christophe M. Deroose, Arnaud Dieudonne, Silvano Gnesin, Oliver S. Grosser, S. Cheenu Kappadath, Andrew Kennedy, Nima Kokabi, David M. Liu, David C. Madoff, Armeen Mahvash, Antonio Martinez de la Cuesta, David C. E. Ng, Philipp M. Paprottka, Cinzia Pettinato, Macarena Rodriguez-Fraile, Riad Salem, Bruno Sangro, Lidia Strigari, Daniel Y. Sze, Berlinda J. de Wit van der Veen, Patrick Flamen
Summary: This study established recommendations for the optimisation of selective internal radiation therapy (SIRT) with yttrium-90 (Y-90)-resin microspheres, based on expert panel discussions and survey responses from leading experts in the field. The recommendations cover various aspects of SIRT, including activity prescription, post-treatment dosimetry, and imaging for treatment verification. It is recommended that a multidisciplinary team define treatment strategy and therapeutic intent, and that a personalised approach using dosimetry be adopted for activity prescription. Additionally, post-SIRT imaging and dosimetry are strongly recommended for treatment verification and assessment.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Oncology
Martin Carl Tammemagi
Summary: Multiple lines of reasoning and evidence, including the study by Meza and colleagues, suggest that the use of the <= 15 quit-years rule for lung cancer screening eligibility should be abandoned.
Review
Oncology
Encarna Gonzalez-Flores, Natalia Zambudio, Pedro Pardo-Moreno, Beatriz Gonzalez-Astorga, Jorge Roldan de la Rua, Eva M. Trivino-Ibanez, Pablo Navarro, Nataly Espinoza-Camac, Miguel Angel Casado, Antonio Rodriguez-Fernandez
Summary: This study provides a comprehensive overview of the management of Y-90 TARE for patients with unresectable lmCRC, offering recommendations based on scientific evidence and insights from a multidisciplinary committee.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Engineering, Biomedical
Stephen F. Mee, Daniel F. Polan, Yuni K. Dewaraja, Kyle C. Cuneo, Joseph J. Gemmete, Joseph R. Evans, Theodore S. Lawrence, Janell S. Dow, Justin K. Mikell
Summary: This study introduces a method for treating underdosed hepatocellular carcinoma lesions using stereotactic body radiation therapy (SBRT) following post-selective internal radiation therapy (SIRT) dosimetry. It demonstrated that selectively targeting these lesions with SBRT could reduce normal tissue toxicity and improve treatment outcomes.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riad Salem, Siddharth A. Padia, Marnix Lam, Carlo Chiesa, Paul Haste, Bruno Sangro, Beau Toskich, Kirk Fowers, Joseph M. Herman, S. Cheenu Kappadath, Thomas Leung, Daniel Y. Sze, Edward Kim, Etienne Garin
Summary: This article presents the updated recommendations from the TheraSphere Global Dosimetry Steering Committee for the treatment of hepatocellular carcinoma (HCC). The recommendations aim to provide a more personalized and effective approach to treatment, taking into account disease presentation, tumor biology, and treatment intent.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jules Gregory, Lambros Tselikas, Caroline Allimant, Thierry de Baere, Irene Bargellini, Jon Bell, Jose Ignacio Bilbao, Antoine Bouvier, Julius Chapiro, Carlo Chiesa, Thomas Decaens, Alban Denys, Rafael Duran, Julien Edeline, Etienne Garin, Julien Ghelfi, Thomas Helmberger, Farah Irani, Marnix Lam, Robert Lewandowski, David Liu, Romaric Loffroy, David C. Madoff, Charles Mastier, Riad Salem, Bruno Sangro, Daniel Sze, Valerie Vilgrain, Michael Vouche, Boris Guiu, Maxime Ronot
Summary: This study aimed to define a textbook outcome (TO) for selective internal radiation therapy (SIRT) of hepatocellular carcinoma. The final TO, determined through expert opinions and an international survey, is a multidimensional standardization tool suitable for routine care, clinical round, and research.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Gastroenterology & Hepatology
Loreto Martin-Navarro, Carlos de Andrea, Bruno Sangro, Josepmaria Argemi
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Brandon M. Caldwell, Ahmed Gabr, Pouya Entezari, Alex Sher, Edward Kim, Guy E. Johnson, Riad Salem, Robert J. Lewandowski
LIVER TRANSPLANTATION
(2023)
Article
Oncology
Thomas Yau, Vittorina Zagonel, Armando Santoro, Mirelis Acosta-Rivera, Su Pin Choo, Ana Matilla, Aiwu Ruth He, Antonio Cubillo Gracian, Anthony B. El-Khoueiry, Bruno Sangro, Tarek E. Eldawy, Jordi Bruix, Giovanni Luca Frassineti, Gina M. Vaccaro, Marina Tschaika, Christian Scheffold, Petra Koopmans, Jaclyn Neely, Fabio Piscaglia
Summary: The study aimed to investigate the safety and efficacy of nivolumab plus cabozantinib with or without ipilimumab in patients with advanced hepatocellular carcinoma. The results showed that this combination therapy had promising antitumor activity and a favorable safety profile in the treatment of advanced hepatocellular carcinoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Courtney Sperry, Asad Malik, Allison Reiland, Bartley Thornburg, Rajesh Keswani, Muhammed Sufyaan Ebrahim Patel, Aziz Aadam, Anthony Yang, Ezra Teitelbaum, Riad Salem, Ahsun Riaz
Summary: The study evaluated the feasibility, effectiveness, and outcomes of percutaneous cholecystostomy drain internalization in patients with calculous cholecystitis who were not surgical candidates. Dual cholecystoduodenal stent placement was attempted in 17 patients, with successful placement in 13 patients. The 1-year patency rate was 77%.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew M. Chiu, Rohan Savoor, Andrew C. Gordon, Ahsun Riaz, Kent T. Sato, Elias Hohlastos, Riad Salem, Robert J. Lewandowski
Summary: A retrospective study found that yttrium-90 radiation segmentectomy is a safe and effective treatment for oligo-metastatic secondary hepatic malignancies, achieving high disease control rate.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Oncology
Daniel Aliseda, Pablo Marti-Cruchaga, Gabriel Zozaya, Macarena Rodriguez-Fraile, Jose I. Bilbao, Alberto Benito-Boillos, Antonio Martinez de la Cuesta, Luis Lopez-Olaondo, Francisco Hidalgo, Mariano Ponz-Sarvise, Ana Chopitea, Javier Rodriguez, Mercedes Inarrairaegui, Jose Ignacio Herrero, Fernando Pardo, Bruno Sangro, Fernando Rotellar
Summary: This retrospective study evaluated the postoperative and long-term survival outcomes of patients with unresectable or high biological risk HCC and ICC treated with radioembolization (RE) and subsequently rescued by liver surgery with curative intent. The results showed that liver resection after RE is safe and feasible, with good short-term outcomes. Moreover, the long-term outcomes after RE and liver resection were optimal, with a 10-year overall survival rate greater than 50% for HCC and ICC patients. The study also highlighted the efficacy of RE in downstaging or bridging to liver transplantation for HCC patients.
Article
Medicine, Research & Experimental
Bruno Sangro, Thomas Yau, Anthony B. El-Khoueiry, Masatoshi Kudo, Yun Shen, Marina Tschaika, Amit Roy, Yan Feng, Ling Gao, Urvi Aras
Summary: This analysis aimed to determine the appropriate dose selection for the combination of nivolumab plus ipilimumab in treating patients with hepatocellular carcinoma. The study found that increased exposure to ipilimumab was associated with improved tumor response and overall survival, while exposure to nivolumab had no significant impact. Adverse events related to liver and immune responses were more common in one treatment arm compared to others. Overall, the regimen of nivolumab 1 mg/kg plus ipilimumab 3 mg/kg followed by nivolumab monotherapy 240 mg q2w showed the most favorable benefit:risk profile in advanced HCC patients.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Gastroenterology & Hepatology
Lorenza Rimassa, Richard S. Finn, Bruno Sangro
Summary: Single-agent immune checkpoint inhibitors (ICIs) have limited efficacy in advanced hepatocellular carcinoma (HCC) patients, and approximately 30% of patients show intrinsic resistance to ICIs. Therefore, researchers are exploring combination therapies, such as anti-angiogenic agents and other ICIs. Some trials have shown promising results and potential for clinical application. However, there are still many unanswered questions that require further research.
JOURNAL OF HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Paloma Sangro, Manuel de la Torre Alaez, Bruno Sangro, Delia D'Avola
Summary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing global health concern due to its association with metabolic syndrome, diabetes, and obesity. This disease encompasses a range of liver damage, from simple steatosis to non-alcoholic steatohepatitis (NASH), which can lead to severe complications such as cirrhosis and liver cancer. The complex pathophysiology and underlying mechanisms have led to the testing of various agents in preclinical and clinical settings over the past two decades. Clinical trials have shown promising results, indicating that multiple drugs may be approved for the treatment of MAFLD at different stages in the near future. This review aims to evaluate the recent advances in pharmacotherapy for NASH by synthesizing the characteristics and results of the most advanced clinical trials.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Gabriel M. Knight, Andrew C. Gordon, Vanessa Gates, Abhinav Talwar, Ahsun Riaz, Riad Salem, Robert Lewandowski
Summary: Yttrium-90 transarterial radioembolization (TARE) has evolved from a salvage or palliative therapy to a versatile and potentially curative treatment for liver cancer patients. Personalized radiation dosimetry has been proven to improve tumor response and overall survival while ensuring patient safety. This review covers the imaging techniques, dosimetry methods, and future developments in TARE.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Bruno Sangro, Josepmaria Argemi
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Frank Kolligs, Dirk Arnold, Rita Golfieri, Maciej Pech, Bora Peynircioglu, Thomas Pfammatter, Maxime Ronot, Bruno Sangro, Niklaus Schaefer, Geert Maleux, Graham Munneke, Helena Pereira, Bleranda Zeka, Niels de Jong, Thomas Helmberger, R. Gol, Maciej Pech, Bora Peynircioglu, Thomas Pfammatter, Maxime Ronot, Bruno Sangro, Niklaus Schaefer, Geert Maleux, Graham Munneke, Helena Pereira, Bleranda Zeka, Thomas Helmberger
Summary: This prospective observational study aimed to evaluate the effectiveness, safety, and prognostic factors of transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC). The use of partition model dosimetry was associated with improved overall survival outcomes compared to body surface area calculations. Factors such as patient health, ascites, and liver function predicted outcomes after TARE.
Editorial Material
Cardiac & Cardiovascular Systems
Riad Salem, Allison Reiland, Bartley Thornburg
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)