Article
Nutrition & Dietetics
Soo Lim, Yoon Ji Kim, Ah Reum Khang, Robert H. Eckel
Summary: This study found that abdominal visceral obesity and low HDL-cholesterol concentrations were associated with increased postprandial triglycerides (TG) and apolipoprotein B (ApoB), and these elevated concentrations were linked with subclinical atherosclerosis.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Salma Fourati, Annick Hamon, Rita Daclat, Joe-Elie Salem, Katell Peoc'h, Johanne Le Beyec, Francisca Joly, Jean-Marc Lacorte
Summary: This study found that ApoB-48 protein could be used as a marker to assess intestinal function in patients with short bowel syndrome. There was a positive correlation between ApoB-48 and residual small bowel length, and lower levels of ApoB-48 were observed in patients dependent on parenteral nutrition.
Article
Nanoscience & Nanotechnology
Joke Deprez, Rein Verbeke, Sofie Meulewaeter, Ilke Aernout, Heleen Dewitte, Tine Decruy, Julie Coudenys, Julie Van Duyse, Gert Van Isterdael, Dan Peer, Roy van der Meel, Stefaan C. C. De Smedt, Peggy Jacques, Dirk Elewaut, Ine Lentacker
Summary: The therapeutic potential of liposomes for drug delivery to inflamed tissue is well-established. The main mechanism of liposomal transport into inflamed joints is believed to be selective extravasation through endothelial gaps at inflammatory sites, known as the enhanced permeation and retention effect. However, the role of blood-circulating myeloid cells in liposome uptake and delivery has been largely overlooked. A study using a collagen-induced arthritis model demonstrates that myeloid cells can transport liposomes to inflammatory sites, and their depletion significantly reduces liposomal accumulation. Contrary to the prevailing theory, the long circulation times of PEGylated liposomes actually favor uptake by myeloid cells, challenging the current understanding of synovial liposomal accumulation and highlighting the potential for alternative delivery pathways in inflammatory diseases.
NATURE NANOTECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Hongen Meng, Li Jiang, Zijun Song, Fudi Wang
Summary: This study used Mendelian randomization to evaluate the genetic causal effects of circulating apolipoproteins and lipoprotein lipids on osteoarthritis (OA) risk. The results showed that genetic predisposition to Apolipoprotein B (APOB) and low-density lipoprotein (LDL) was associated with a decreased risk of OA, providing new insights into the relationship between lipids and OA risk.
Article
Agriculture, Dairy & Animal Science
Shanchuan Cao, Wenjie Tang, Hui Diao, Shuwei Li, Honglin Yan, Jingbo Liu
Summary: This study examined the effects of feeding frequency on growth performance, nutrient digestibility, carcass quality, and lipid metabolism in growing-finishing pigs. The results showed that reducing feeding frequency improved feed conversion ratio and had an impact on fat deposition and carcass composition. This study provides a new approach to feeding and management of growing-finishing pigs.
Article
Microbiology
Shanshan Nan, Min Yao, Xiaoyang Zhang, Hailiang Wang, Jiacheng Li, Junli Niu, Cheng Chen, Wenju Zhang, Cunxi Nie
Summary: This study investigated the effects of feeding fermented grape seed meal (FGSM) on the growth performance and gut microbiota of yellow feather broilers. The results showed that FGSM improved broiler growth performance and serum biochemistry, and reduced fat deposition by regulating gut microbiota structure and short-chain fatty acid content.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongen Meng, Rong Wang, Zijun Song, Fudi Wang
Summary: This study used Mendelian randomization to evaluate the genetic effects of circulating lipids on the risk of epithelial ovarian cancer (EOC). The results showed a negative association between circulating high-density lipoprotein (HDL) and the risk of low malignant potential ovarian cancer (LMPOC), low-grade low malignant ovarian cancer (LGLMSOC), and low malignant serous ovarian cancer (LMSOC). Elevated circulating triglyceride (TG) levels were associated with an increased risk of LGLMSOC and LGSOC. These findings contribute to further research on the impact of lipids on ovarian cancer.
Article
Agriculture, Dairy & Animal Science
Ziyi Pan, Guoqing Du, Guoyu Li, Dongsheng Wu, Xingyong Chen, Zhaoyu Geng
Summary: This study investigated the effects of APOH on fat synthesis in duck myoblasts. Overexpression of APOH resulted in increased triglyceride and cholesterol contents, while knockdown of APOH reduced these lipid levels. APOH affected lipid deposition by regulating the expression of the AKT/AMPK pathway.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Dandan Wang, Menglin Teng, Yangyang Wang, Yuzhu Cao, Weihua Tian, Zhang Wang, Yulong Guo, Hong Li, Zhuanjian Li, Ruirui Jiang, Guoxi Li, Yadong Tian, Xiaojun Liu
Summary: This study reveals the association of GPNMB gene with abdominal fat traits in chickens and investigates its role in adipogenesis. The study also explores the regulatory mechanism of GPNMB gene and identifies genetic markers for breeding selection to improve abdominal fat traits in chicken.
Article
Biochemistry & Molecular Biology
Nadya M. Morrow, Cassandra A. A. Locatelli, Natasha A. Trzaskalski, Chelsea T. Klein, Antonio A. Hanson, Hadeel Alhadi, Ishika Tripathi, Andrew C. Clement, Sara Imran, Ilka Lorenzen-Schmidt, Erin E. Mulvihill
Summary: This study aimed to investigate the effects of dietary composition on lipid metabolism in the small intestines of mice. The results showed that ketogenic diet and Western-style diet had different impacts on lipid metabolism in male and female mice.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Oncology
Sai Ma, Bo Zhou, Qian Yang, Yunzhi Pan, Wei Yang, Stephen J. Freedland, Ling-Wen Ding, Michael R. Freeman, Joshua J. Breunig, Neil A. Bhowmick, Jian Pan, H. Phillip Koeffler, De-Chen Lin
Summary: The study identified a transcriptional feedback loop between MRTF (ELF3, KLF5, GATA6) and fatty acid synthesis in esophageal adenocarcinoma. The findings shed light on the crucial role of this mechanism in the development of the disease, suggesting a potential avenue for prevention and intervention by targeting key factors such as PPARG and ELF3.
Article
Nutrition & Dietetics
Iskandar Azmy Harahap, Maria Madalena C. Sobral, Susana Casal, Susana C. M. Pinho, Miguel A. Faria, Joanna Suliburska, Isabel M. P. L. V. O. Ferreira
Summary: This study evaluated the oxidation process and fatty acid release from the stomach to the duodenum of fatty fish and meat meals under in vitro gastric conditions. The results showed that the fatty fish meal had higher formation of lipid oxidation products (LOPs), but still contained a higher content of unoxidized polyunsaturated fatty acids (PUFAs). For PUFA-rich meals, reducing calorie intake and avoiding prolonged stomach residence time can reduce LOP formation.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Hyo Bin Lee, Ah Young Lee, Yumi Jang, Young Hye Kwon
Summary: This study investigated the distinctive effects of soy protein components on adiposity and circulating miRNA profiles in obese mice. The results showed that soy isoflavones are the main contributor to the health-beneficial effects of soy protein in diet-induced obesity. The dysregulation of circulating miRNAs coincided with obesity.
Article
Biochemistry & Molecular Biology
Wenwen Shen, Lin Yang, Yi Yang, Peng Wang, Xiaofang Tao, Yujun Shen, Sheng Wang, Yuxian Shen
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease characterized by an imbalance of lipogenesis and lipid catabolism. Peroxiredoxin 6 (PRDX6) has been found to play a role in the pathogenesis and progression of NAFLD, but its role in liver lipid catabolism is not well understood.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Agriculture, Dairy & Animal Science
Jiying Liu, Ruilong Song, Shengyan Su, Nannan Qi, Qifa Li, Zhuang Xie, Shali Yu
Summary: Betaine can improve fat distribution and mitochondrial function in goose liver, with a certain repairing effect in a high-glucose culture medium, reducing fatty liver damage.
Article
Biochemistry & Molecular Biology
Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Irene Garcia-Dominguez, Isaac Rosado-Sanchez, Yolanda M. Pacheco, Rosario Moyano, Jose G. Monterde, Jose Luis Venero, Rocio M. de Pablos
Summary: This study investigates the role of galectin-3 (Gal3) in the development of endotoxemia and sepsis. The absence of Gal3 reduces mortality and tissue damage in a murine model of endotoxemia. Gal3 levels decrease in immune cells, particularly monocytes, after LPS injection, and Gal3 is up-regulated in peripheral organs. These findings suggest that Gal3 plays a significant role in systemic inflammation and may provide potential therapeutic options for sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elena Yeregui, Jenifer Masip, Consuelo Vilades, Pere Domingo, Yolanda M. Pacheco, Julia Blanco, Josep Mallolas, Veronica Alba, Montserrat Vargas, Graciano Garcia-Pardo, Eugenia Negredo, Montserrat Olona, Judit Vidal-Gonzalez, Maria Peraire, Anna Marti, Laia Reverte, Frederic Gomez-Bertomeu, Manuel Leal, Francesc Vidal, Joaquim Peraire, Anna Rull
Summary: Low concentrations of adiponectin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) were associated with poor immune recovery in treated PLHIV, indicating potential predictive biomarkers of a discordant immunological response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Salvador Resino, Maria Angeles Jimenez-Sousa, Julia Blanco, Yolanda M. Pacheco, Jorge del Romero, Joaquim Peraire, Ana Virseda-Berdices, Maria Jose Munoz-Gomez, Carlos Galera-Penaranda, Lucio Jesus Garcia-Fraile, Jose M. Benito, Norma Rallon
Summary: The study found that DHCR7 rs3829251 and DBP rs7041 gene polymorphisms are associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Hanieh Motahari-Rad, Alba Subiri, Rocio Soler, Luis Ocana, Juan Alcaide, Jorge Rodriguez-Capitan, Veronica Buil, Hamid el Azzouzi, Almudena Ortega-Gomez, Rosa Bernal-Lopez, Maria Insenser, Francisco J. Tinahones, Mora Murri
Summary: This study analyzed the impact of sex, obesity, and their interactions on the gene expression of two lipid flippases in visceral adipose tissue (VAT). The results showed that obesity had a significant influence on the gene expression of these flippases, with a stronger effect in men for one of the flippases. The study also found associations between these flippases and microRNAs, which were also affected by sex.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Infectious Diseases
Maria del Mar Pozo-Balado, Angel Bulnes-Ramos, Vanesa Garrido-Rodriguez, Israel Olivas-Martinez, Carmen Lozano, Maria Francisca Gonzalez-Escribano, Manuel Leal, Yolanda M. Pacheco
JOURNAL OF INFECTION
(2023)
Editorial Material
Nutrition & Dietetics
Lourdes M. M. Varela
Article
Clinical Neurology
Gonzalo Revilla-Gonzalez, Lourdes Maria Varela, Zaida Ruiz de Azua-Lopez, Rosario Amaya-Villar, Maria Rosa Pezzotti, Maria Jose Castro, Juan Urena, Maria del Carmen Gonzalez-Montelongo, Antonio Castellano
Summary: Aneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease caused by blood leakage into the subarachnoid space after rupture of cerebral vessels. This study analyzed the changes in peripheral blood mononuclear cells (PBMCs) and their interaction with endothelium in aSAH patients, with a focus on adhesion and expression of adhesion molecules. The study found increased adhesion of PBMCs, particularly monocytes, in patients with aSAH, especially those who developed vasospasm. The expression of several adhesion molecules in T lymphocytes and monocytes was altered, providing insights for predicting vasospasm and improving treatment.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Geriatrics & Gerontology
Maria del Mar Pozo-Balado, Angel Bulnes-Ramos, Israel Olivas-Martinez, Vanesa Garrido-Rodriguez, Carmen Lozano, Ana I. alvarez-Rios, Berta Sanchez-Sanchez, Encarnacion Sanchez-Bejarano, Isabel Maldonado-Calzado, Jose Manuel Martin-Lara, Juan Antonio Santamaria, Rafael Bernal, Maria Francisca Gonzalez-Escribano, Manuel Leal, Yolanda M. Pacheco
Summary: Older people have lower antibody titers and declining humoral immunity over time after Covid-19 vaccination due to immune system aging. However, the factors that predict the waning immune response have been poorly explored. This study measured antibody levels and various markers in a cohort of nursing home residents and healthcare workers who received the BNT162b2 vaccine. Thymosin-alpha 1 levels were found to be associated with the durability of the vaccine response, suggesting its potential as a biomarker for predicting vaccine response in older individuals.
Editorial Material
Pharmacology & Pharmacy
Lourdes M. M. Varela, Elena Meseguer, Almudena Ortega-Gomez
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Angel Bulnes-Ramos, Maria Mar Pozo-Balado, Israel Olivas-Martinez, Vanesa Garrido-Rodriguez, Gabriel Bernal-Blanco, Alejandro Suarez-Benjumea, Ana Isabel Alvarez-Rios, Carmen Lozano, Carmen Gonzalez-Corvillo, Marta Suner-Poblet, Francisco Manuel Gonzalez-Roncero, Berta Sanchez, Isabel Maldonado-Calzado, Jose Manuel Lara-Ruiz, Maria Francisca Gonzalez-Escribano, Yolanda Maria Pacheco
Summary: Despite receiving three doses of the mRNA COVID-19 vaccine, kidney transplant recipients have a weak humoral response, indicating the need for new approaches to enhance their protective immunity. A longitudinal study found that immunosuppressive therapy, worse kidney function, higher inflammatory status, and older age are associated with a reduced response, while immune cell counts, thymosin-a1 plasma concentration, and thymic output are associated with a stronger humoral response. Further research on thymosin-a1 as a potential adjuvant for vaccine boosters is warranted.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Zaida Ruiz de Azua-Lopez, M. Rosa Pezzotti, Angela Gonzalez-Diaz, Olivier Meilhac, Juan Urena, Rosario Amaya-Villar, Antonio Castellano, Lourdes M. Varela
Summary: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality rates. Patients with aSAH exhibit structural alterations in their high-density lipoproteins (HDL), resulting in loss of anti-inflammatory function. This study highlights the importance of investigating HDL in the pathophysiology of aSAH and suggests that functional HDL supplementation could be a novel therapeutic approach for the inflammatory response following aSAH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Javier Benitez-Porres, Francisco J. Tinahones, Almudena Ortega-Gomez, Mora Murri
Summary: The increasing prevalence of metabolic syndrome has significant health and socioeconomic consequences. Exercise, along with dietary interventions, is currently the main treatment for obesity and related metabolic complications. However, the potential effects of exercise timing on metabolic health are yet to be fully understood. This article reviews the role of exercise timing in metabolic health and discusses the potential mechanisms behind its benefits.
Meeting Abstract
Cardiac & Cardiovascular Systems
Z. Ruiz De Azua, M. R. Pezzotti, G. Revilla-Gonzalez, J. Navarro-Rodriguez, O. Meilhac, J. Urena, R. Amaya Villar, A. Castellano, L. M. Varela
Article
Food Science & Technology
Almudena Ortega-Gomez, Sergio Lopez, Lourdes M. Varela, Sara Jaramillo, Francisco J. G. Muriana, Rocio Abia
Summary: This study investigated the effects of different fatty acids on the migration of neutrophils from bone marrow to blood in mice. The results showed that a high-fat diet enriched in saturated fatty acids promoted neutrophil migration and was associated with neutrophil apoptosis and bone marrow inflammation. In contrast, monounsaturated fatty acids were found to preserve bone marrow health and ensure proper neutrophil migration.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2022)