Review
Pharmacology & Pharmacy
Giovana Nakanishi, Laisa S. Bertagnolli, Murilo Pita-Oliveira, Mariana M. Scudeler, Sabrina Torres-Loureiro, Thais Almeida-Dantas, Maria Laura C. Alves, Heithor S. Cirino, Fernanda Rodrigues-Soares
Summary: GSTM1 and GSTT1 deletions show significant frequency differences among distinct ethnic groups, with East Asians having the highest frequencies and Sub-Saharan Africans having the lowest, indicating a strong influence of ethnicity. Further studies on the impact of admixture on the frequency values of these genes are needed.
DRUG METABOLISM REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Maria Manuel Casteleiro Alves, Micaela Almeida, Antonio Helio Oliani, Luiza Breitenfeld, Ana Cristina Ramalhinho
Summary: Oxidative stress is an important factor in the development of conditions such as infertility. This study examined the role of CYP19A1, GSTM1, and GSTT1 in female infertility risk. The results showed that carriers of specific genotypes in these genes had a significantly increased risk of female infertility. Furthermore, the risk was even higher when both GSTs were deleted, regardless of the CYP19A1 genotype.
Article
Oncology
Abozer Y. Elderdery, Hadeil M. E. Idris, Entesar M. Tebien, Nada Abdalfatah Diab, Siddiqa M. A. Hamza, Bandar A. Suliman, Abdulaziz H. Alhamidi, Nawal Eltayeb Omer, Jeremy Mills
Summary: The study found a strong correlation between GSTT1 polymorphism and the development of Ph-ve CML, while GSTM1 polymorphism did not play a role in the initial development of the disease. Further research is needed to clarify the roles of other genes in disease development.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Environmental Sciences
Mohammad H. Rahbar, Maureen Samms-Vaughan, Sepideh Saroukhani, Jan Bressler, Manouchehr Hessabi, Megan L. Grove, Sydonnie Shakspeare-Pellington, Katherine A. Loveland, Compton Beecher, Wayne McLaughlin
Summary: The study revealed significant interactions between GSTP1 and ASD status in relation to blood Hg concentrations, suggesting different levels of BHC based on genotype in ASD cases and typically developing controls. Further replication studies in other populations are needed to confirm the role of GSTP1 in detoxification of Hg.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Hyun-Ki Kim, Hye Jin Chung, Huong Giang Le, Byoung-Kuk Na, Min-Chul Cho
Summary: This study investigated the values of 24,25(OH)(2)D and VMR in healthy Koreans for the first time, comparing them with other vitamin D biomarkers. The results showed a close correlation between 25(OH)D concentration and 24,25(OH)(2)D as well as bioavailable 25(OH)D, but no significant effects of these markers on PTH and BMD prediction were observed.
Article
Dermatology
Amal Maouia, Nadia Leban, Monia Youssef, Ahmed Noureddine Helal, Asma Kassab
Summary: This study investigated the efficacy of desloratadine in Tunisian patients with CSU and found associations between GSTM1 and GSTT1 genotypes and susceptibility to the disease.
INDIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Anthropology
Sanaa Nassereddine, Rachida Habbal, Yaya Kassogue, Ait Boujmia Oum Kaltoum, Korchi Farah, Haraka Majda, Abou Elfath Rhizlane, Sellama Nadifi, Hind Dehbi
Summary: This study found that the GSTT1-null genotype alone or in combination with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null genotype seems to be associated with the age of onset of hypertension.
ANNALS OF HUMAN BIOLOGY
(2021)
Article
Medicine, General & Internal
Corina Iulia Cornean, Andreea Catana, Alma Aurelia Maniu
Summary: This study investigated the association between smoking status and single-nucleotide polymorphisms in candidate genes associated with smoking-related tumors. Results showed that the GSTT1-null genotype and the mutant heterozygote variant of TERTRs2736100 genes may play a significant role in laryngeal cancer susceptibility. However, there may be no association between laryngeal carcinoma susceptibility and the GSTM1 polymorphism. The study could not confirm the carcinogenic influence of smoking on laryngeal cancer development for the studied polymorphisms.
MEDICINA-LITHUANIA
(2022)
Review
Medicine, General & Internal
Yi Zhu, Jian-Hua Yang, Jun-Ping Hu, Ming Qiao
Summary: This study revealed that the GSTM1 null, GSTT1 null and GSTP1-Val genotypes might be related to increased NAFLD susceptibility.
Article
Veterinary Sciences
Lorena Franco-Martinez, Luis Pardo-Marin, Laura Sanchez-Mateos, Alberto Munoz-Prieto, Juan Diego Garcia-Martinez, Jose J. Ceron, Silvia Martinez-Subiela, Camila P. Rubio, Asta Tvarijonaviciute
Summary: The study found higher levels of ferritin in overweight/obese dogs compared to lean/normal weight dogs, which may indicate tissue hypoxia. Additionally, obese dogs exhibited higher haematocrit and erythrocyte mean corpuscular volume. These findings contribute to our understanding of the mechanisms causing complications in obese dogs.
VETERINARY SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shidong Yang, Wentao Lin, Mengmeng Jia, Haichun Chen
Summary: This study aimed to assess athletic performance indicators of Chinese youth male football players with different ACE and ACTN3 gene profiles. The results indicate that ACE I/D and ACTN3 R577x polymorphisms are not associated with muscle power in Chinese elite and sub-elite players, while the XX genotype of ACTN3 is associated with the aerobic endurance of elite players.
Article
Medical Laboratory Technology
Mengmeng Du, Shengnan Wu, Chang Su, Xiaohong Wang, Bingbing Li, Yifan Lin, Shuxian Yuan, Yongxing Chen, Changlian Zhu, Haiyan Wei
Summary: This study investigated whether serum Vitamin B12 levels could be used as an early diagnostic biomarker for MMA. The results showed that serum Vitamin B12 levels were significantly increased in MMA patients, and serum Vitamin B12 combined with other biomarkers could be used to distinguish different types of MMA. Additionally, elevated Vitamin B12 was found to be an independent predictor of MMA clinical onset.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Stephanie Fryar-Williams, Joerg Strobel, Peter Clements, Karen K. Szumlinski
Summary: This review investigates the role of the MTHFR gene in schizophrenia and explores the pathways affected by its activity. The findings suggest that these pathways may be potential markers for the diagnosis and treatment of mental illnesses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nan Zheng, Mengxi Niu, Yannan Zang, Hongyan Zhuang, Fei Jia, Shuang Bao, Shanshan Liu
Summary: Drug therapy for depression varies greatly in its outcomes, ranging from beneficial effects to adverse effects. Genetic variations in drug metabolism enzymes and pharmacodynamic molecules contribute to interindividual differences in response to antidepressants. Personalized treatment focusing on interindividual gene differences has been the main approach for improving the use of antidepressants. This study comprehensively reviews the literature on the clinical applications of pharmacogenomics in antidepressant therapy. Polymorphisms in drug metabolism enzymes such as CYP2D6 and CYP2C19 are potential predictors of side effects or treatment failure, and clinical recommendations based on functional diplotypes of these enzymes have been made for a wide selection of psychopharmacological agents. The relationship between pharmacodynamic genes and clinical outcomes varies across different races.
CURRENT DRUG METABOLISM
(2023)
Article
Endocrinology & Metabolism
Cora M. Best, Leila R. Zelnick, Kenneth E. Thummel, Simon Hsu, Christine Limonte, Ravi Thadhani, Howard D. Sesso, JoAnn E. Manson, Julie E. Buring, Samia Mora, I-Min Lee, Nancy R. Cook, Georgina Friedenberg, Heike Luttmann-Gibson, Ian H. de Boer, Andrew N. Hoofnagle
Summary: Vitamin D-3 supplementation increases total serum vitamin D and 25(OH) D concentrations with variation according to baseline 25(OH)D, which suggests that 25-hydroxylation of vitamin D-3 is more efficient when serum 25(OH)D concentration is low.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Gladys Block, Kristen M. J. Azar, Robert J. Romanelli, Torin J. Block, Donald Hopkins, Heather A. Carpenter, Marina S. Dolginsky, Mark L. Hudes, Latha P. Palaniappan, Clifford H. Block
JOURNAL OF MEDICAL INTERNET RESEARCH
(2015)
Article
Nutrition & Dietetics
Amanda W. Singer, Suzan L. Carmichael, Steve Selvin, Cecilia Fu, Gladys Block, Catherine Metayer
BRITISH JOURNAL OF NUTRITION
(2016)
Article
Oncology
Amanda W. Singer, Steve Selvin, Gladys Block, Carla Golden, Suzan L. Carmichael, Catherine Metayer
CANCER CAUSES & CONTROL
(2016)
Article
Food Science & Technology
Weihong Guo, Karen Huen, June-Soo Park, Myrto Petreas, Sabrina Crispo Smith, Gladys Block, Nina Holland
FOOD AND CHEMICAL TOXICOLOGY
(2016)
Article
Endocrinology & Metabolism
G. Block, K. M. J. Azar, R. J. Romanelli, T. J. Block, L. P. Palaniappan, M. Dolginsky, C. H. Block
NUTRITION & DIABETES
(2016)
Article
Gastroenterology & Hepatology
Ai Kubo, Gladys Block, Charles P. Quesenberry, Patricia Buffler, Douglas A. Corley
BMC GASTROENTEROLOGY
(2014)
Article
Oncology
Catherine Metayer, Ghislaine Scelo, Anand P. Chokkalingam, Lisa F. Barcellos, Melinda C. Aldrich, Jeffrey S. Chang, Neela Guha, Kevin Y. Urayama, Helen M. Hansen, Gladys Block, Vincent Kiley, John K. Wiencke, Joseph L. Wiemels, Patricia A. Buffler
CANCER CAUSES & CONTROL
(2011)
Article
Nutrition & Dietetics
Kamyar Kalantar-Zadeh, Csaba P. Kovesdy, Rachelle Bross, Debbie Benner, Nazanin Noori, Sameer B. Murali, Torin Block, Jean Norris, Joel D. Kopple, Gladys Block
JOURNAL OF RENAL NUTRITION
(2011)
Article
Multidisciplinary Sciences
Gertrude Case Buehring, Hua Min Shen, Hanne M. Jensen, Diana L. Jin, Mark Hudes, Gladys Block
Article
Substance Abuse
Lyndsay Ammon Avalos, Sarah C. M. Roberts, Lee Ann Kaskutas, Gladys Block, De-Kun Li
SUBSTANCE USE & MISUSE
(2014)
Article
Oncology
Raheem J. Paxton, Richard Hajek, Patricia Newcomb, Megha Dobhal, Sujana Borra, Wendell C. Taylor, Deborah Parra-Medina, Shine Chang, Kerry S. Courneya, Gladys Block, Torin Block, Lovell A. Jones
Meeting Abstract
Endocrinology & Metabolism
Gladys Block, Kristen M. J. Azar, Torin J. Block, Robert J. Romanelli, Latha Palaniappan, Clifford H. Block
Article
Health Care Sciences & Services
Gladys Block, Kristen M. J. Azar, Torin J. Block, Robert J. Romanelli, Heather Carpenter, Donald Hopkins, Latha Palaniappan, Clifford H. Block
JMIR RESEARCH PROTOCOLS
(2015)
Meeting Abstract
Biochemistry & Molecular Biology
Gladys Block, Kristen Azar, Torin Block, Clifford Block, Latha Palaniappan
Meeting Abstract
Environmental Sciences
W. Guo, K. Huen, J. Park, C. Jensen, G. Block, N. Holland
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2013)