Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 93, Issue 3, Pages 644-651Publisher
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.110.004176
Keywords
-
Categories
Funding
- Direction Generale de la Sante (Ministry of Health)
- Mederic
- Ipsen
- Mutuelle Generale de l'Education Nationale
- SODEXHO
- Pierre Fabre
- Agence Nationale de la Recherche [ANR-05-PNRA-010]
- European Union [FOOD-CT-2005-007034]
- Universidad Politecnica de Madrid [CH/018/2008]
- Axis-Shield Diagnostics Ltd (Oslo, Norway)
- Abbot Cientifica SA (Spain)
- Spanish Ministry of Education [EX-2007-1124]
- Cognis GmbH (Germany)
Ask authors/readers for more resources
Background: Blood vitamin E concentrations are modulated by dietary, metabolic, and genetic factors. CD36 (cluster of differentiation 36), a class B scavenger receptor, might be involved in tissue vitamin E uptake and thus would influence blood vitamin E concentrations. Objective: The goal of the study was to assess the association between CD36 single nucleotide polymorphisms (SNPs) and plasma alpha-tocopherol concentrations in humans. Design: A subsample from the adult SU.VI.MAX (SUpplementation en VItamines et Mineraux AntioXydants) cohort (n = 621) and the adolescent cross-sectional HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study (n = 993) were genotyped for CD36 SNPs (4 and 10 SNPs, respectively). Fasting plasma alpha-tocopherol concentrations were assayed by using HPLC. Associations were determined by haplotype analyses and by general linear regression models. Results: In the SU.VI.MAX subsample, haplotype analyses showed that some haplotypes of SNPs rs1984112, rs1527479, rs7755, and rs1527483 tended to be associated with plasma alpha-tocopherol concentrations (P = 0.08 and P = 0.09 for haplotypes 1222 and 1122, respectively). We then investigated the whole known common genetic variability (10 SNPs) of CD36 in the HELENA Study. Three SNPs were associated with lower plasma a-tocopherol concentrations (rs1984112: -3.2%, P = 0.053; rs1761667: -2.9%, P = 0.046; rs1527479: -3.7%, P = 0.0061). After correction for multiple testing, the association between rs1527479 and alpha-tocopherol concentrations remained significant. This association was modulated by concentrations of fasting serum triglycerides (P for interaction = 0.006) and long-chain polyunsaturated fatty acids (P for interaction = 0.005). Conclusion: Our results suggest that CD36 can modulate blood alpha-tocopherol concentrations and may therefore be involved in the intestinal absorption or tissue uptake of vitamin E. Am J Clin Nutr 2011;93:644-51.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available