Article
Food Science & Technology
Gabriela Grassmann Roschel, Tayse Ferreira Ferreira da Silveira, Leticia Maeda Cajaiba, Roseli Aparecida Ferrari, Inar Alves Castro
Summary: By reducing temperature and adding a mixture of antioxidants, the oxidative stability of echium seed oil can be significantly improved. This study provides a feasible method to enhance the shelf-life of echium oil for the oil industry and consumers worldwide.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Ji-Ling Su, Juan Wang, Xiao-Na Fu, Li Hou, Ping Zhu, Kai Zhang, Huo-Wang Li, Ying Hou, Xiang-Yi Liu, Juan Xu
Summary: This study investigated the properties, fatty acid compositions, and thermal characteristics of Malania oleifera seed oil (MOSO). It found that MOSO is a rich source of essential fatty acids and nervonic acid (NA), making it a potential resource for health supplements and medicines.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Article
Agricultural Engineering
Roque L. Evangelista, Terry A. Isbell, Jim Todd, Steven C. Cermak
Summary: This study evaluated the effect of starting seed moisture content and heating temperature on the oil extraction from Euphorbia lagascae seeds. The results showed that seeds with 5% moisture content and heated at 104 degrees C produced press cake suitable for solvent extraction. Pre-pressing without flaking adequately prepared the pressed cake for solvent extraction, recovering 99.8% of the total oil. The combined press- and hexane-extracted oils had lower contents of free fatty acids, diacylglycerides, and phospholipids. The vernolic acid content and fatty acid composition of the extracted oils remained practically the same. Oil refining is necessary to reduce the free fatty acid content and improve the oil color for the intended application.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Cell Biology
Fabien Miart, Jean-Xavier Fontaine, Gaelle Mongelard, Christopher Wattier, Michelle Lequart, Sophie Bouton, Roland Molinie, Nelly Dubrulle, Francoise Fournet, Herve Demailly, Romain Roulard, Loic Dupont, Arezki Boudaoud, Brigitte Thomasset, Laurent Gutierrez, Olivier Van Wuytswinkel, Francois Mesnard, Karine Pageau
Summary: This study demonstrated a positive relationship between seed oil production and seed coat mucilage extrusion in flax. Transcriptome analysis revealed significant changes in the seed coat during the mid-phase of seed development, potentially involving genes related to mucilage chemical modification and oil synthesis. This integrative biology approach suggests that transcriptional regulations of seed oil and fatty acid metabolism occur in the seed coat during the mid-stage of seed development.
Article
Plant Sciences
Lihang Xie, Jiayuan Hu, Zhenguo Yan, Xinyao Li, Sailong Wei, Ruilin Xu, Weizong Yang, Huihui Gu, Qingyu Zhang
Summary: In this study, a new member of the WRI1 family, named PrWRI1, was isolated from tree peony and found to be highly expressed in immature seeds. Overexpression of PrWRI1 significantly increased fatty acid content, particularly unsaturated fatty acids, in plants. The up-regulation of genes related to fatty acid synthesis and triacylglycerol assembly was also observed.
Article
Biochemistry & Molecular Biology
Nadia Raboanatahiry, Yongtai Yin, Kang Chen, Jianjie He, Longjiang Yu, Maoteng Li
Summary: The study revealed the characteristics of desaturase genes in Camelina sativa, providing a basis for further research and potential genetic engineering strategies for seed oil modification. Overexpression of omega 3-fatty acid desaturases affected oil content, seed weight, and phenotypes in transgenic lines, highlighting the potential for improving Camelina sativa through manipulation of fatty acid composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yuzhou Yang, Que Kong, Wan Ting Tee, Yuqing Li, Pui Man Low, Barunava Patra, Liang Guo, Ling Yuan, Wei Ma
Summary: bZIP52 physically interacts with and represses the transcriptional activity of WRINKLED1 to negatively regulate seed oil accumulation in Arabidopsis. bZIP52 acts by inhibiting the transcriptional activity of AtWRI1 and thereby reducing the expression of fatty acid biosynthetic genes in Arabidopsis, resulting in a reduction in oil production.
Article
Biochemistry & Molecular Biology
Zhikun Wang, Yuanzhuo Wang, Ping Shang, Chao Yang, Mingming Yang, Jinxiu Huang, Baizheng Ren, Zhaohui Zuo, Qingyan Zhang, Wenbin Li, Bo Song
Summary: In this study, GmWRI1a was successfully overexpressed and contributed to a stable increase in seed oil content in soybean. The transgenic plants exhibited significant upregulation of GmWRI1a and bar genes at different developmental stages. Transcriptome sequencing analysis revealed distinct differences in gene expression between the transgenic lines and the wild type. The field trial demonstrated that the transgenic lines had a consistent increase in seed oil content without affecting protein content and yield. Overexpression of GmWRI1a altered the fatty acid composition by increasing linoleic acid content and decreasing palmitic acid content in seeds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Bibi Marzieh Razavizadeh, Parvaneh Tabrizi
Summary: The study found that fortified chocolates containing microcapsules with chia seed oil did not show significant differences in taste, texture, and overall acceptance compared to control chocolates. After storage for 120 days, sensory evaluations revealed lower scores but were not significant. The physicochemical properties analysis showed that the hardness of fortified chocolate was lower than the control, but not significantly.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Zhen Li, Hui Chi, Caiyue Liu, Tianbao Zhang, Lida Han, Liang Li, Xinwu Pei, Yan Long
Summary: This study identified 50 LEA genes in the flax genome using bioinformatics approaches, revealing uneven distribution among different flax chromosomes and late-stage expression during seed development. Functional analysis showed that LuLEA1 gene reduced seed size and fatty acid contents in transgenic Arabidopsis, providing valuable insights for improving seed development related genes.
Article
Plant Sciences
Weizong Yang, Jiayuan Hu, Jyoti R. Behera, Aruna Kilaru, Yanping Yuan, Yuhui Zhai, Yanfeng Xu, Lihang Xie, Yanlong Zhang, Qingyu Zhang, Lixin Niu
Summary: The study identified a key transcription factor, PrASIL1, in tree peony seed oil accumulation, which represses oil accumulation by down-regulating numerous key genes during biosynthesis. Silencing the PrASIL1 gene led to up-regulation of oil biosynthesis genes and an increase in total lipids and major fatty acids. These findings provide new insights into controlling seed oil accumulation.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Food Science & Technology
Giovanna Calixto Garcia Carlini, Gabriela Grassmann Roschel, Roseli Aparecida Ferrari, Severino Mathias Alencar, Helton Cherubim Ota, Tayse Ferreira Ferreira da Silveira, Inar Alves Castro
Summary: By comparing three different extraction methods, it was found that the pressing method significantly affected the content of beta-sitosterol and gamma-tocopherol in echium oil, while the solvent method was more conducive to extracting higher concentrations of minor compounds. The different extraction methods resulted in some changes in the chemical composition of echium oil, but did not affect its nutritional quality or sensory acceptability.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Plant Sciences
Grace Q. Chen, Kumiko Johnson, Tara J. Nazarenus, Grisel Ponciano, Eva Morales, Edgar B. Cahoon
Summary: Through RNA interference technology, transgenic Lesquerella lines with high levels of 18:1OH have been successfully developed, providing a new approach for the development of alternative industrial oilseeds to replace castor. The study revealed the impact of different genes on 18:1OH accumulation, while also discussing potential avenues for further increasing 18:1OH production.
Article
Energy & Fuels
Berhanu Sugebo, Zerihun Demrew, Sisay Feleke, Mikias Biazen
Summary: This study optimized oil yield from rubber tree seed, determined its physicochemical properties, and synthesized biodiesel from the oil. The biodiesel had a maximum yield of 81.55% and met the fuel standards of ASTM6751 and EN590. Rubber seed oil was found to be a suitable feedstock for biodiesel production.
BIOMASS CONVERSION AND BIOREFINERY
(2021)
Article
Multidisciplinary Sciences
Asli Inal, Hande Yenipazar, Nese Sahin-Yesilcubuk
Summary: The study focuses on investigating the bioaccessibility of curcumin in simulated intestinal digestion conditions and the release behavior of fatty acids from echium oil nanoemulsions, showing that curcumin-containing nanoemulsions have higher radical scavenging activity and a 35.5% bioaccessibility of curcumin after digestion. Gas chromatography results suggest that curcumin addition affects the release of fatty acids in the nanoemulsions.
Article
Biochemistry & Molecular Biology
Ashley J. Snider, Michael C. Seeds, Laurel Johnstone, Justin M. Snider, Brian Hallmark, Rahul Dutta, Cristina Moraga Franco, John S. Parks, Jeannette T. Bensen, Corey D. Broeckling, James L. Mohler, Gary J. Smith, Elizabeth T. H. Fontham, Hui-Kuan Lin, William Bresette, Susan Sergeant, Floyd H. Chilton
Article
Biochemistry & Molecular Biology
Ya Pei, Dammah Otieno, Inah Gu, Sun-Ok Lee, John S. Parks, Keith Schimmel, Hye Won Kang
Summary: The study found that quercetin supplementation in high-fat diet-fed mice attenuated obesity by promoting browning of white adipose tissue and increasing nonshivering thermogenesis in brown adipose tissue.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biology
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S. Parks, Cristina Furdui, Peter W. Stacpoole, Jennifer Martinez, Charles E. McCall, Matthew A. Quinn
Summary: Metabolic reprogramming occurs in the immune system during sepsis, particularly in the liver, with changes in lipid metabolism, mitochondrial energy, and redox balance. Targeting mitochondrial energy metabolism can rebalance the transcriptional and metabolic manifestations of sepsis in the liver.
Article
Hematology
Srividya Velagapudi, Lucia Rohrer, Francesco Poti, Renate Feuerborn, Damir Perisa, Dongdong Wang, Grigorios Panteloglou, Anton Potapenko, Mustafa Yalcinkaya, Andreas J. Hulsmeier, Bettina Hesse, Alexander Lukasz, Mingxia Liu, John S. Parks, Christina Christoffersen, Markus Stoffel, Manuela Simoni, Jerzy-Roch Nofer, Arnold von Eckardstein
Summary: The study revealed that ApoM and S1P(1) play a role in promoting the endothelial barrier function and facilitating the transport of HDL. The findings suggest that HDL crosses the endothelial barrier through specific mechanisms rather than passive filtration.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Parag Anilkumar Chevli, Barry I. Freedman, Fang-Chi Hsu, Jianzhao Xu, Megan E. Rudock, Lijun Ma, John S. Parks, Nicholette D. Palmer, Michael D. Shapiro
Summary: Distinct metabolic signatures associated with subclinical coronary atherosclerosis were identified in African American and European American participants of the Diabetes Heart Study.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniel C. Parker, Ma Wan, Kurt Lohman, Li Hou, Anh Tram Nguyen, Jingzhong Ding, Alain Bertoni, Steve Shea, Gregory L. Burke, David R. Jacobs, Wendy Post, David Corcoran, Ina Hoeschele, John S. Parks, Yongmei Liu
Summary: miRNAs play a role in the occurrence and development of type 2 diabetes (T2D) and are also associated with lipid levels.
Article
Multidisciplinary Sciences
L. Madison Kirk, Charlotte Mae K. Waits, Alexander C. Bashore, Beverly Dosso, Allison K. Meyers, Antonio C. Renaldo, Thomas J. DePalma, Kelli N. Simms, Nathaniel Hauser, Chia-Chi Chuang Key, Charles E. McCall, John S. Parks, Susan Sergeant, Carl D. Langefeld, Aleksander Skardal, Elaheh Rahbar
Summary: The Modern Western Diet is associated with the increase in metabolic and inflammatory diseases. Dietary omega-6 polyunsaturated fatty acids (PUFAs), specifically linoleic acid (LA) and arachidonic acid (ARA), are believed to contribute to these diseases by being metabolized into pro-inflammatory compounds. Genetic variants near the fatty acid desaturase (FADS) haplotype block, particularly single nucleotide polymorphism rs174537, regulate the conversion of LA to ARA. This study used a three-dimensional human hepatic culture to investigate PUFA metabolism and gene-diet interactions.
Article
Food Science & Technology
Ya Pei, John S. Parks, Hye Won Kang
Summary: Quercetin improves obesity-induced inflammation in BAT by suppressing the NF kappa B pathway through activation of SIRT1.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cardiac & Cardiovascular Systems
Qingxia Zhao, Zhan Wang, Allison K. Meyers, Jennifer Madenspacher, Manal Zabalawi, Qianyi Zhang, Elena Boudyguina, Fang-Chi Hsu, Charles E. McCall, Cristina M. Furdui, John S. Parks, Michael B. Fessler, Xuewei Zhu
Summary: Macrophages play a central role in atherosclerosis pathogenesis, and SLC37A2 deficiency can accelerate atherosclerosis development by affecting macrophage inflammatory responses rather than blood lipid levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Meeting Abstract
Endocrinology & Metabolism
Jingzhong Ding, Kurt Lohman, Stephen B. Kritchevsky, John S. Parks, Ina Hoeschele, Barb J. Nicklas, Jamehl Demons, Yongmei Liu
Article
Biochemistry & Molecular Biology
Ya Pei, Olugbenga Balogun, Dammah Otieno, John S. Parks, Hye Won Kang
Summary: This study found that supplementation of 30% BSG in a high-fat diet can alleviate obesity-induced NAFLD in mice by regulating liver metabolism and bile acid synthesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Kylie Kavanagh, Alexander C. Bashore, Matthew A. Davis, Matthew J. Jorgensen, Christopher J. McClouth, Daniel A. Beavers, John S. Parks
Summary: This study demonstrates the efficacy of early time-restricted feeding (eTRF) in increasing high-density lipoprotein (HDL) cholesterol efflux capacity (CEC) in nonhuman primates (NHPs). eTRF induces larger-sized HDL particles, increases HDL apolipoprotein A-1 content, lowers triglyceride concentrations, and increases plasma CEC primarily to HDL particles.
Article
Oncology
Zhiwei Ji, Jade Moore, Nelmi O. Devarie-Baez, Joshua Lewis, Hanzhi Wu, Kirtikar Shukla, Elsa I. Silva Lopez, Victor Vitvitsky, Chia-Chi Chuang Key, Mercedes Porosnicu, Melissa L. Kemp, Ruma Banerjee, John S. Parks, Allen W. Tsang, Xiaobo Zhou, Cristina M. Furdui
Summary: Redox metabolism is an important regulator in cancer, affecting tumor progression, response to therapies, and patients' quality of life. However, the ability to integrate redox information across signaling and metabolic networks is currently limited, hindering the advancement of new cancer therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pedersen, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri
Summary: This study reveals that Apolipoprotein M (ApoM) is inversely associated with mortality in heart failure patients and is reduced by anthracyclines like doxorubicin. In the presence of Dox stress, ApoM can sustain myocardial autophagic flux through post-transcriptional regulation, attenuate Dox cardiotoxicity, and prevent lysosomal injury.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Parag Anilkumar Chevli, Nicholette Allred, Fang-Chi Hsu, John Parks, Barry Freedman, Michael Shapiro
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)