Scutellarin Ameliorates Learning and Memory Deficit via Suppressing β-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion

Effects of Hypoperfusion in Alzheimer's Disease

(2018) Benjamin P. Austin et al.   JOURNAL OF ALZHEIMERS DISEASE

The BACE1-PSEN-AβPP Regulatory Axis has an Ancient Role in Response to Low Oxygen/Oxidative Stress

(2018) Seyyed Hani Moussavi Nik et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy

(2017) Edith G. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice

(2016) Lingxi Wang et al.   EXPERIMENTAL NEUROLOGY

Scutellarin promotes microglia-mediated astrogliosis coupled with improved behavioral function in cerebral ischemia

(2016) Ming Fang et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor

(2016) Wenjuan Wang et al.   PLoS One

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats

(2015) Ming Fang et al.   BMC NEUROSCIENCE

Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

(2015) Yun Yuan et al.   Journal of Neuroinflammation

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia

(2014) Yun Yuan et al.   BMC NEUROSCIENCE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both  -Amyloid Production and Clearance

(2013) Z. Zhu et al.   JOURNAL OF NEUROSCIENCE

The neurotoxicity of β-amyloid peptide toward rat brain is associated with enhanced oxidative stress, inflammation and apoptosis, all of which can be attenuated by scutellarin

(2012) Li-Li Guo et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Synthesis and Protective Effect of Scutellarein on Focal Cerebral Ischemia/Reperfusion in Rats

(2012) Lihua Qian et al.   MOLECULES

Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase

(2011) Li-li Guo et al.   ACTA PHARMACOLOGICA SINICA

Vascular risk factor detection and control may prevent Alzheimer's disease

(2010) Jack C. de la Torre   AGEING RESEARCH REVIEWS

Changing perspectives regarding late-life dementia

(2009) Majid Fotuhi et al.   Nature Reviews Neurology

Upregulation of BACE1 and β-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer’s Disease

(2009) Cai Zhiyou et al.   NEUROCHEMICAL RESEARCH

Estrogenic and Neuroprotective Properties of Scutellarin fromErigeron breviscapus: A Drug against Postmenopausal Symptoms and Alzheimer's Disease

(2009) Judy Zhu et al.   PLANTA MEDICA

Detection of changed regional cerebral blood flow in mild cognitive impairment and early Alzheimer's dementia by perfusion-weighted magnetic resonance imaging

(2008) Christian Luckhaus et al.   NEUROIMAGE

Protective Effects of Scutellarin Against Cerebral Ischemia in Rats: Evidence for Inhibition of the Apoptosis-Inducing Factor Pathway

(2008) Hua-Feng Zhang et al.   PLANTA MEDICA