Effects of Berberine in the Gastrointestinal Tract — A Review of Actions and Therapeutic Implications

Moringa Fruit Inhibits LPS-InducedNO/iNOSExpression through Suppressing theNF-κBActivation in RAW264.7 Cells

(2013) Hyo-Jin Lee et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Berberine Reduces Rat Intestinal Tight Junction Injury Induced by Ischemia–Reperfusion Associated with the Suppression of Inducible Nitric Oxide Synthesis

(2013) Lili Gu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of berberine on rat jejunal motility

(2013) Da-Peng Chen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Metabolomic Mining of the Botanical Dietary Supplement Wild Yam (Dioscorea villosa L.)

(2013) SH Dong et al.   PLANTA MEDICA

Berberine Inhibits Proliferation and Down-Regulates Epidermal Growth Factor Receptor through Activation of Cbl in Colon Tumor Cells

(2013) Lihong Wang et al.   PLoS One

Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth

(2013) Ya-Yun Hsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antinociceptive effect of berberine on visceral hypersensitivity in rats

(2013) Qing-Lin Tang   WORLD JOURNAL OF GASTROENTEROLOGY

Eucommiae Cortex Inhibits TNF-α and IL-6 Through the Suppression of Caspase-1 in Lipopolysaccharide-Stimulated Mouse Peritoneal Macrophages

(2012) Min-Cheol Kim et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Upregulating Reverse Cholesterol Transport With Cholesteryl Ester Transfer Protein Inhibition Requires Combination With the LDL-Lowering Drug Berberine in Dyslipidemic Hamsters

(2012) François Briand et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells

(2012) Kotamballi N. Chidambara Murthy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell

(2012) Ning Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials

(2012) Giuseppe Derosa et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model

(2012) Yongguo Zhang et al.   FITOTERAPIA

Anti-hyperglycemic effects and mechanism of traditional Chinese medicine Huanglian Wan in streptozocin-induced diabetic rats

(2012) Yuan-xiong Deng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Berberine acutely inhibits the digestion of maltose in the intestine

(2012) Zeng-Qiang Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

(2012) Lihong Wang et al.   PLoS One

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

(2012) Xu Zhang et al.   PLoS One

Sensing of energy and nutrients by AMP-activated protein kinase

(2011) D Grahame Hardie   AMERICAN JOURNAL OF CLINICAL NUTRITION

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice

(2011) Fang Yan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes

(2011) Pravinkumar Bhutada et al.   BEHAVIOURAL BRAIN RESEARCH

Berberine acutely activates the glucose transport activity of GLUT1

(2011) Alexandra Cok et al.   BIOCHIMIE

Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells

(2011) Keqiang Yan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine Ameliorates Pro-inflammatory Cytokine-Induced Endoplasmic Reticulum Stress in Human Intestinal Epithelial Cells In Vitro

(2011) Xianhua Hao et al.   INFLAMMATION

Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia

(2011) Ai-Wen Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

(2011) Wen Tan et al.   International Journal of Nanomedicine

Berberine, an Isoquinoline Alkaloid in Herbal Plants, Protects Pancreatic Islets and Serum Lipids in Nonobese Diabetic Mice

(2011) Wei-Han Chueh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus

(2011) BeiBei Zhang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Berberine Chloride Mediates Its Anti-Leishmanial Activity via Differential Regulation of the Mitogen Activated Protein Kinase Pathway in Macrophages

(2011) Piu Saha et al.   PLoS One

Enhancement of Sodium Caprate on Intestine Absorption and Antidiabetic Action of Berberine

(2010) Xiao-Yan Lv et al.   AAPS PHARMSCITECH

Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation

(2010) In-Ah Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid

(2010) Min Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat

(2010) Lingying Niu et al.   FITOTERAPIA

Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides

(2010) Qian Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

(2010) Maren Amasheh et al.   JOURNAL OF CELL SCIENCE

Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats

(2010) Yanwen Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study

(2010) Li Liu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Increased Plasma Exposures of Five Protoberberine Alkaloids from Coptidis Rhizoma in Streptozotocin-Induced Diabetic Rats: Is P‐GP Involved?

(2010) Sen Yu et al.   PLANTA MEDICA

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

(2009) Yiyi Sun et al.   ANTI-CANCER DRUGS

Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters

(2009) Yanwen Wang et al.   ATHEROSCLEROSIS

The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells

(2009) Lili Gu et al.   FITOTERAPIA

Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2in LPS-induced rat intestinal microvascular endothelial cells

(2009) Yiyi Hu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine

(2009) Yoko Watanabe-Fukuda et al.   JOURNAL OF GASTROENTEROLOGY

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

(2009) Hao Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Palmatine, a protoberberine alkaloid, inhibits both Ca2+- and cAMP-activated Cl− secretion in isolated rat distal colon

(2008) D Z Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats

(2008) Chandragiri Janakiraman Thirupurasundari et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

(2008) N. Turner et al.   DIABETES

Berberine promotes glucagon-like peptide-1 (7–36) amide secretion in streptozotocin-induced diabetic rats

(2008) Shou-Si Lu et al.   JOURNAL OF ENDOCRINOLOGY

Efficacy of berberine in patients with type 2 diabetes mellitus

(2008) Jun Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL