Article
Plant Sciences
Feng Xiao, Yang Zhao, Xiurong Wang, Yanan Sun
Summary: This study investigated the growth and development of G. sinensis thorn (Zao Jiao Ci) by measuring the content of soluble sugar and starch and performing transcriptome sequencing. The results showed changes in the sugar and starch content during thorn formation, and identified several genes that may be related to thorn maintenance and growth. Gene Ontology enrichment analysis revealed terms related to development regulation and photomorphogenesis. The study also validated the transcriptome data using real-time quantitative PCR. Overall, this research provides a comprehensive understanding of G. sinensis thorn development.
Article
Plant Sciences
Yangang Cao, Zhiyou Hao, Yanli Zhang, Hongwei Li, Man Qi, Yingjie Ren, Yanling Liu, Xu Chen, Chen He, Xiaoke Zheng, Weisheng Feng
Summary: Two new flavonoids were isolated from Gleditsia sinensis thorns, with their structures determined by spectroscopic data and absolute configurations deduced through interpretation of ECD spectra. In vitro studies showed that these new compounds exhibited moderate cytoprotective effects against LPS-induced apoptosis.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Minjie Zhang, Jiaxi Qu, Zhiwei Gao, Qi Qi, Hong Yin, Ling Zhu, Yichen Wu, Wei Liu, Jian Yang, Xuefeng Huang
Summary: TAIII induces DNA damage and activates the ATM/Chk2 and p38 MAPK pathways, leading to G2/M phase arrest and apoptosis in breast cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jih-Tung Pai, Ming-Wei Hsu, Yann-Lii Leu, Kuo-Ting Chang, Meng-Shih Weng
Summary: This study evaluated the anticancer activity of bavachinin on non-small cell lung cancer (NSCLC). Bavachinin induced G2/M cell cycle arrest in NSCLC cells by regulating cell cycle regulators and p21(Waf1/Cip1), which was reversed by inhibiting p38 MAPK activation.
Article
Biochemistry & Molecular Biology
Ya He, Maohong Luo, Shan Lei, Zhirui Zeng, Tengxiang Chen, Yingmin Wu, Dongyan Wang, Long Wang, Lu Wang
Summary: Luteoloside has exhibited anti-inflammatory, antiviral, and antitumor properties. Its effect on neuroblastoma cells was investigated in this study. Luteoloside inhibited the proliferation of neuroblastoma cells by activating the p38 MAPK pathway, indicating its potential as an anticancer drug for treating neuroblastoma.
Article
Cell Biology
Caili Bi, Xue Zhang, Yueyue Chen, Yushuo Dong, Yixin Shi, Yunshen Lei, Dan Lv, Xiaowei Cao, Wei Li, Hongcan Shi
Summary: MAGT1 plays a crucial role in cell proliferation and cell cycle regulation, impacting the expression of multiple key genes and being associated with the MAPK signaling pathway. Down-regulation of MAGT1 results in restricted cell proliferation, indicating its potential as a novel target for anticancer research.
Article
Chemistry, Medicinal
Zhuo Han, Xingming Zhao, E. Zhang, Jiahui Ma, Hao Zhang, Jianjiang Li, Weidong Xie, Xia Li
Summary: The study elucidated the mechanism of resistomycin in promoting apoptosis and cell cycle arrest in human hepatocellular carcinoma, indicating that the p38 MAPK signaling pathway may play an important role in this process.
Article
Pharmacology & Pharmacy
Shuaishuai Huang, Gulimire Tuergong, Hangjie Zhu, Xue Wang, Guobin Weng, Yu Ren
Summary: Norcantharidin (NCTD) exhibits anti-tumor activity in renal cell carcinoma cells by inducing apoptosis and G2/M phase cell cycle arrest through the activation of JNK and ERK signaling pathways, showing promising therapeutic potential for RCC treatment.
ACTA PHARMACEUTICA
(2021)
Article
Engineering, Environmental
Liang Zhang, Lilai Shen, Yizhou Huang, Shixuan Cui, Qiming Zhao, Chunlong Zhang, Shulin Zhuang, Guibin Jiang
Summary: This study identified the key signaling cascades involved in oxidative stress in zebrafish larvae and evaluated the cell cycle arrests and associated developmental alterations caused by UV-328 exposure. UV-328 inhibited the p38 MAPK/p53/Gadd45a regulatory circuit, leading to G1 phase cell cycle arrest and abnormal embryo hatching and heart rate.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Oncology
Huocong He, Keyu Lin, Changyan Zou, Jianru Pan, Wankai Fu, Yan Zhou, Huamei Lin, Chao Chen, Ying Su
Summary: Annexin A2 (ANXA2) is associated with prognosis in nasopharyngeal carcinoma (NPC), with high expression leading to radioresistance. Knockdown of ANXA2 enhances radiosensitivity in NPC cells by inducing G2/M phase arrest, apoptosis, and activating the p38 MAPK-HSP27 pathway. ANXA2 may be a promising therapeutic target for overcoming radioresistance in NPC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yan Xiao, Chenglei Su, Guozhen Zhang, Lian Liang, Tao Jin, Jennifer Bradley, Joseph P. Ornato, Wanchun Tang
Summary: Vitamin C improves the recovery of myocardial and cerebral functions, reduces post-resuscitation inflammatory response and oxidative stress, and protects the integrity of the vascular endothelium.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Wei Zhao, Yongxia Lao, Yang Liu, Jiqin Niu, Zhihui Xiao, Palanisamy Arulselvan, Jian Shen
Summary: This study demonstrated that escin possesses potent antioxidant capacity and inhibits the viability of OC A2780 cells by increasing lipid peroxidation, promoting ROS accumulation and apoptotic cell death, while suppressing the p38 MAPK/ERK signaling pathway.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zeyang Sun, Wenwen Sun, Baoping Pan, Yuan Yao, Chuncai Yan
Summary: A novel p38 MAPK gene, Csp38 MAPK, was identified in Cyclina sinensis and found to be ubiquitously expressed in various tissues, potentially playing a role in response to bacterial invaders.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Medicinal
Je-Chiuan Ye, Yih-Shou Hsieh, Pei-Ni Chen, Jer-Yuh Liu, Yi-Hsien Hsieh
Summary: Our study shows that PKCa regulates the PA and MMPs systems in liver cancer cells through the p38 MAPK signaling pathway, promoting cell progression. MMP-1 and u-PA play critical roles in this pathway, and targeting these genes may be a potential treatment approach for liver cancer.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Chemistry, Medicinal
Zi-Wei Cai, Ting Ye, Pei-Wen Jiang, Yu-Jiao Liao, Lin Wang, Qing-Liang Zhang, Wen-Qian Du, Min Huang, Ping Yang, Min-Hui Li
Summary: This study aimed to investigate the inhibitory effect of alpha-momorcharin on the proliferation of multiple myeloma MM.1S cells. The results showed that alpha-momorcharin can inhibit the proliferation of MM.1S cells and induce cell death through cell cycle regulation and mitochondrial pathway-dependent apoptosis.