Article
Biochemistry & Molecular Biology
Magdalena Chelchowska, Justyna Jurczewska, Joanna Gajewska, Joanna Mazur, Dorota Szostak-Wegierek, Ewa Rudnicka, Jadwiga Ambroszkiewicz
Summary: Metabolic disorders in women with PCOS may lead to increased oxidative stress and reproductive failure. This study evaluated the levels of antioxidant parameters and proteins involved in cellular redox in the serum of PCOS patients. It found that abdominal obesity, as indicated by the VAT/SAT ratio and WHR, was associated with higher concentrations of oxidative markers and lower cellular redox index. The study suggests that oxidative stress associated with abdominal obesity may disrupt cellular processes and activate antioxidant enzymes. Further research is needed to confirm these associations in a larger group of PCOS patients.
Article
Biochemistry & Molecular Biology
Sou Hyun Kim, Minwoo Kim, Doyoung Kwon, Jae Sung Pyo, Joo Hyun Kim, Jae-Hwan Kwak, Young-Suk Jung
Summary: Substituted N-phenyl cinnamamide derivatives were synthesized to activate the Nrf2 pathway via introducing electronic effect on Michael acceptor. Compound 1g showed desirable luciferase activity without toxicity in HepG2 cells and upregulated Nrf2/ARE target genes. Treatment with 1g resulted in increased endogenous antioxidant glutathione and exhibited a cytoprotective effect in a concentration-dependent manner, suggesting its potential as an Nrf2/ARE activator in antioxidative therapy.
Article
Oncology
Yanqiong Liu, Qiulian Wu, Fuyong Zhang, Xue Qin
Summary: This study provides evidence for the first time that the NRF2 gene rs6721961 variation is a potential genetic marker for susceptibility to hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Omayma A. Eldahshan, Yasmine M. Abdelkhalek, Magdy El Dahshan, Eman A. Ahmed, Jean-Marc Sabatier, Gaber E. -S. Batiha
Summary: COVID-19 is caused by SARS-CoV-2 and results in pulmonary and extra-pulmonary manifestations due to oxidative stress and hyperinflammation. The Nrf2 pathway plays a crucial role in mitigating viral toxicity and inflammation in COVID-19, and Nrf2 activators could be a potential therapeutic strategy for managing the disease.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shuang Zhao, Tianyu Song, Yue Gu, Yihua Zhang, Siyi Cao, Qing Miao, Xiyue Zhang, Hongshan Chen, Yuanqing Gao, Lei Zhang, Yi Han, Hong Wang, Jun Pu, Liping Xie, Yong Ji
Summary: The study suggests that H2S alleviates liver damage by activating Keap1 S-sulfhydration and promoting the activation of Nrf2, leading to increased expression of antioxidant proteins, which may have potential therapeutic benefits for liver diseases.
Article
Critical Care Medicine
Eilise M. Ryan, Pranvera Sadiku, Patricia Coelho, Emily R. Watts, Ailiang Zhang, Andrew J. M. Howden, Manuel A. Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J. McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, James F. Callahan, George Cooper, Nicholas Parkinson, Kenneth Baillie, Doreen A. Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and impaired macrophage function. This study found that COPD alveolar macrophages (AMs) and peripheral monocyte-derived macrophages (MDMs) exhibit metabolic deficiencies and impairments in redox balance. Activation of the NRF2 pathway can rescue these defects and improve macrophage function in COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Cell Biology
David Rysanek, Pavla Vasicova, Jayaprakash Narayana Kolla, David Sedlak, Ladislav Andera, Jiri Bartek, Zdenek Hodny
Summary: The accumulation of senescent cells in aging tissues contributes to age-associated diseases. Inhibiting the anti-apoptotic machinery of senescent cells through BCL-2 protein family inhibitors can eliminate these cells. Combination therapy with BCL-2 inhibitors shows synergistic effects in eliminating senescent cells and overcoming resistance to monotherapy.
Article
Environmental Sciences
Yuan-yuan Wei, Hui-ru Wang, Yi-meng Fan, Jin-hua Gu, Xiu-ying Zhang, Xu-hao Gong, Zhi-hui Hao
Summary: The study evaluated the effect and underlying mechanism of GDK aqueous extract in alleviating acute liver injury caused by CCl4. The results showed that GDK effectively inhibited liver damage and restored the structure and function of the liver. It achieved this by suppressing liver fibrosis, blocking the NFicB pathway, inhibiting hepatic inflammatory response, reducing oxidative stress, inhibiting ferroptosis, and alleviating hepatocyte injury caused by CCl4. In conclusion, this study provides insights into the potential complex mechanism of GDK against acute liver injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li
Summary: This study found that 15, 16-Dihydrotanshinone I (DHT) can protect against ferroptosis and ischemic stroke by activating the Nrf2 signaling pathway.
Article
Fisheries
Yun Wang, Yafei Duan, Jianhua Huang, Jun Wang, Chuanpeng Zhou, Shigui Jiang, Heizhao Lin, Zhe Zhang
Summary: PmNrf2, a member of CNC-bZIP transcription factor family, is constitutively expressed in various tissues of shrimp and responds to bacterial challenge. Knockdown of PmNrf2 results in decreased expression of PmGPx gene, indicating its role in regulating the transcription of antioxidant enzyme genes in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Huiyan Deng, Miaojian Wan, Huaping Li, Quan Chen, Runxiang Li, Bihua Liang, Huilan Zhu
Summary: The study demonstrates that curcumin can protect the skin from UV damage by regulating the Nrf2 pathway. UV irradiation leads to cell apoptosis and oxidative stress, which can be reversed by adding curcumin. Additionally, curcumin induces Nrf2 nuclear accumulation in Hacat cells to provide protection against UV exposure-induced photodamage.
Article
Nutrition & Dietetics
Hai Jia, Yunchang Zhang, Xuemeng Si, Yuhang Jin, Da Jiang, Zhaolai Dai, Zhenlong Wu
Summary: This study demonstrates that quercetin can alleviate diquat-induced cell injury in enterocytes by upregulating the protein abundance of Nrf2 and regulating GSH-related redox homeostasis.
Article
Clinical Neurology
Xin-Jiang Yan, Cheng-Peng Zhan, Yao Lv, Dan-Dan Mao, Ri-Cheng Zhou, Yong-Min Xv, Guo-Feng Yu
Summary: This study found that increased serum Nrf2 levels in severe traumatic brain injury (sTBI) patients are associated with traumatic severity and prognosis. Serum Nrf2 levels may serve as an important prognostic marker for sTBI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Plant Sciences
Keisuke Yaku, Isao Matsui-Yuasa, Akiko Kojima-Yuasa
Article
Cell Biology
Maryam Gulshan, Keisuke Yaku, Keisuke Okabe, Arshad Mahmood, Tsutomu Sasaki, Masashi Yamamoto, Keisuke Hikosaka, Isao Usui, Tadahiro Kitamura, Kazuyuki Tobe, Takashi Nakagawa
Article
Biochemical Research Methods
Keisuke Yaku, Keisuke Okabe, Takashi Nakagawa
BIOMEDICAL CHROMATOGRAPHY
(2018)
Article
Biochemistry & Molecular Biology
Keisuke Okabe, Isao Usui, Keisuke Yaku, Yoshio Hirabayashi, Kazuyuki Tobe, Takashi Nakagawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura
NATURE COMMUNICATIONS
(2018)
Review
Oncology
Keisuke Yaku, Keisuke Okabe, Keisuke Hikosaka, Takashi Nakagawa
FRONTIERS IN ONCOLOGY
(2018)
Article
Neurosciences
Keisuke Hikosaka, Keisuke Yaku, Keisuke Okabe, Takashi Nakagawa
Summary: NAD is a crucial coenzyme involved in energy metabolism, DNA repair, gene expression, and stress response. Studies have shown that dysregulated NAD metabolism is implicated in neurodegenerative diseases, highlighting the importance of maintaining appropriate NAD levels for mitochondrial function.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kai Yasukawa, Daisuke Kinoshita, Keisuke Yaku, Takashi Nakagawa, Takumi Koshiba
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Keisuke Yaku, Keisuke Okabe, Maryam Gulshan, Kiyoshi Takatsu, Hiroshi Okamoto, Takashi Nakagawa
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Miki Hanasaki, Keisuke Yaku, Motohiro Yamauchi, Takashi Nakagawa, Hiroshi Masumoto
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Keisuke Okabe, Allah Nawaz, Yasuhiro Nishida, Keisuke Yaku, Isao Usui, Kazuyuki Tobe, Takashi Nakagawa
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Taiji Yamamoto, Keisuke Yaku, Takashi Nakagawa
Summary: A new quantification method for amino acid enantiomers was developed, identifying multiple chiral amino acids through derivatization and liquid chromatography-tandem mass spectrometry. The study found that aging affects amino acid levels in specific brain regions.
Article
Multidisciplinary Sciences
Keisuke Yaku, Sailesh Palikhe, Hironori Izumi, Tomoyuki Yoshida, Keisuke Hikosaka, Faisal Hayat, Mariam Karim, Tooba Iqbal, Yasuhito Nitta, Atsushi Sato, Marie E. Migaud, Katsuhiko Ishihara, Hisashi Mori, Takashi Nakagawa
Summary: Nicotinamide riboside increases NAD(+) levels through two pathways, directly generating NAD(+) via the NR salvage pathway and contributing to NAD(+) production through the Preiss-Handler pathway after being hydrolyzed by BST1.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Keisuke Okabe, Keisuke Yaku, Yoshiaki Uchida, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Kazuyuki Tobe, Takashi Nakagawa
Summary: Nicotinamide mononucleotide (NNM), an orally bioavailable NAD(+) precursor, has shown beneficial effects against aging and aging-associated diseases. In a trial with healthy subjects, oral supplementation of NMN for 12 weeks caused no adverse effects and significantly increased NAD(+) levels in whole blood.
FRONTIERS IN NUTRITION
(2022)
Review
Cell Biology
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe, Takashi Nakagawa
JOURNAL OF BIOMEDICAL SCIENCE
(2019)
