Journal
AMERICAN JOURNAL OF CHINESE MEDICINE
Volume 36, Issue 1, Pages 141-148Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X08005655
Keywords
lipopolysaccharide (LPS); Pentoxifylline (PXF); interleukin 10 (IL-10); Chinese; herbal medicine; abortion
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In the present study, lipopolysaccharide (LPS) was injected i.v. via the tail vein (0.1 mu g per mouse) to induce abortion (embryo resorption) in Kunming mice. The interleukin 10 (IL-10) contents in the uterus were assayed by ELISA. The results revealed that the IL-10 level was significantly decreased in the LPS-induced abortion group of mice compared to the controls. Use of Pentoxifylline (PXF), or a combination of Radix scutellariae and Rhizoma atractylodis reversed the LPS effects: bringing down the fetal resorption rate, and increasing the IL-10 level significantly. The study indicates that the anti-abortive effects of PXF and the combination of Radix scutellariae and Rhizoma atractylodis are closely related to up-regulation of the Th2 cytokine IL-10 at the maternal fetal interface.
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