Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Obaid Afzal, Waleed Hassan Almalki, Imran Kazmi, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Monica Gulati, Sachin Kumar Singh, Niraj Kumar Jha, Piyush Kumar Gupta, Dinesh Kumar Chellappan, Brian George Oliver, Kamal Dua, Gaurav Gupta
Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Neeraj Kumar Fuloria, Shivkanya Fuloria, Sk Batin Rahman, Waleed Hassan Al-Malki, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Sachin K. Singh, Venkata Sita Rama Raju Allam, Niraj Kumar Jha, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: NF-xB is a crucial transcription factor involved in inflammation, immune response, and various physiological processes, playing a key role in many respiratory disorders.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Plant Sciences
Li Yuan, Lingming Zhang, Na Yao, Lingna Wu, Jianming Liu, Fanglan Liu, Hong Zhang, Xiao Hu, Yuqing Xiong, Chunhua Xia
Summary: The study reveals that PKC/NF-kappa B signaling downregulates UGT1A1 expression, while UA and OA promote the expression of UGT1A1 in HepG2 cells by inhibiting the PKC/NF-kappa B signaling pathway.
Article
Pharmacology & Pharmacy
Suizhi Cheng, Li Che, Qingqing Yang, Rongjing Sun, Yuhong Nie, Haoyue Shi, Yiwen Ding, Li Wang, Zuo Du, Zhenzhong Liu
Summary: In this study, it was found that folic acid (FA) effectively protected esophageal cells in the MNNG-induced esophageal inflammation model by inhibiting the NF-kappa B pathway and down-regulating the expression of inflammatory molecules IL-6, IL-8, and TNF-alpha. These findings are of great significance for further research and development of therapeutic strategies for preventing esophageal inflammation.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ziqi Zhou, Ji-Won Choi, Joon Yeon Shin, Dong-Uk Kim, Bitna Kweon, Hyuncheol Oh, Youn-Chul Kim, Ho-Joon Song, Gi-Sang Bae, Sung-Joo Park
Summary: Acute pancreatitis (AP) is an inflammatory disorder, and research shows that Betulinic acid (BA) has prophylactic and therapeutic effects on AP. BA can reduce the severity of pancreatitis, decrease inflammation, and inhibit the NF-κ B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yongjie Jin, Eun Nim Kim, Ji Hee Lim, Hyung Duk Kim, Tae Hyun Ban, Chul Woo Yang, Cheol Whee Park, Bum Soon Choi
Summary: Cellular senescence and aging are closely related, with chronic inflammation playing a key role in cellular senescence. There is a positive feedback loop between LPAR1 and NF-kappa B, exacerbating the inflammatory response, and blocking LPAR1 may alleviate renal aging.
Article
Biochemistry & Molecular Biology
Mehtap Savran, Halil Asci, Yalcin Erzurumlu, Ozlem Ozmen, Ilter Ilhan, M. Cem Sirin, Nasif Fatih Karakuyu, Adnan Karaibrahimoglu
Summary: This study aims to evaluate the potential protective effects of Theranekron (TH) on acetic acid (AA)-induced colonic damage and describe the possible mechanisms of TH.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Eiichi Kusagawa, Chiharu Okuda, Rikako Yamaguchi, Kaori Nakano, Yasunobu Miyake, Takao Kataoka
Summary: Cucurbitacin B down-regulates TNF-alpha-induced ICAM-1 expression and inhibits the inflammatory response in lung adenocarcinoma cells by modulating the TNF-R1 expression in the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Abeer A. Al-Masri, Fuad Ameen
Summary: Banana is an important fruit crop worldwide. In this study, an anthocyanin-rich extract from banana bract (BBA) was prepared and characterized. BBA showed antioxidant and anti-inflammatory activity in LPS-stimulated macrophage-like cells. The presence of phenolic compounds, flavonoids, and anthocyanin in BBA was identified. BBA increased endogenous antioxidants and inhibited the nuclear translocation of NF-kappaB under LPS-stimulated conditions, indicating its potential as an anti-inflammatory agent.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Dan Wang, Zhenzhen Tan, Jing Yang, Longfei Li, Haoran Li, Huaxing Zhang, Heqiong Liu, Yi Liu, Lei Wang, Qian Li, Huicai Guo
Summary: This study aimed to investigate the effects of PFOS exposure on atherosclerosis progression and the underlying mechanisms. The results showed that PFOS increased pulse wave velocity, intima-media thickness, aortic plaque burden, and levels of serum lipids and inflammatory cytokines. PFOS promoted M1 macrophage polarization and suppressed M2 macrophage polarization, leading to inflammation. NF-κB activation in macrophages was associated with this process. These findings highlight the role of PFOS in accelerating atherosclerosis progression through NF-κB-mediated inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Yahong Zheng, Chengcheng Yue, Hui Zhang, Haoran Chen, Yanyan Liu, Jiabin Li
Summary: The study revealed that secondary bile acids (SBAs) protect the liver and inhibit inflammation in Klebsiella pneumoniae-induced liver abscess and bacteremia by modulation of the NF-κB inflammatory signaling pathway via TGR5.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Kehinde S. Olaniyi, Stephanie E. Areloegbe
Summary: This study investigated the effects of acetate on cardiometabolic abnormalities associated with polycystic ovarian syndrome (PCOS) in a rat model. The results suggest that acetate protects against cardiac inflammation by suppressing PCSK9 and NF-kB-dependent mechanisms.
Article
Dentistry, Oral Surgery & Medicine
Shaohua Cong, Qian Peng, Liou Cao, Qingqing Yi, Yi Liu, Linhui Li, Qingchun Tong, Dongyu Liang
Summary: This study investigated the effects of diosgenin on periodontitis and found that it inhibited inflammatory responses and the activation of NF-kappa B pathway while promoting osteogenesis. Administering diosgenin to periodontitis rats also reduced the levels of inflammatory factors and NF-kappa B in gingival tissue, and promoted the expression of osteoblast-related genes. These findings suggest that diosgenin may be a potential therapeutic strategy for treating periodontitis in the future.
Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)