Pharmacokinetic–Pharmacodynamic Relationships of Macitentan, a New Endothelin Receptor Antagonist, After Multiple Dosing in Healthy Korean Subjects

Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial

(2013) Ganesh Raghu et al.   EUROPEAN RESPIRATORY JOURNAL

Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertension

(2013) Jasper Dingemanse et al.   Expert Opinion On Drug Safety

Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension

(2013) Tomás Pulido et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacokinetics of Macitentan in Caucasian and Japanese Subjects: The Influence of Ethnicity and Sex

(2013) Shirin Bruderer et al.   PHARMACOLOGY

Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan

(2012) G.W. Don et al.   INTERNAL MEDICINE JOURNAL

The Discovery of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist

(2012) Martin H. Bolli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans

(2012) Shirin Bruderer et al.   XENOBIOTICA

Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist

(2011) Shirin Bruderer et al.   AAPS Journal

Race and Sex Differences in Response to Endothelin Receptor Antagonists for Pulmonary Arterial Hypertension

(2011) Nicole B. Gabler et al.   CHEST

Macitentan: entry-into-humans study with a new endothelin receptor antagonist

(2011) Patricia N. Sidharta et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Liver toxicity of sitaxentan in pulmonary arterial hypertension

(2011) N. Galie et al.   EUROPEAN RESPIRATORY JOURNAL

Pharmacotherapeutic Management of Pulmonary Arterial Hypertension

(2010) Joe R. Anderson et al.   Cardiology in Review

Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentan

(2009) Oliver Kummer et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Endothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism

(2009) Terence K. Trow et al.   RESPIRATORY MEDICINE

Endothelin Receptor Antagonists for Pulmonary Arterial Hypertension

(2008) Laura C Price et al.   American Journal of Cardiovascular Drugs

Role of Endothelin-1 in Clinical Hypertension

(2008) Neeraj Dhaun et al.   HYPERTENSION

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

(2008) M. Iglarz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS