Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor

The P-Glycoprotein Transport System and Cardiovascular Drugs

(2013) Jeffrey D. Wessler et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Edoxaban for the long-term treatment of venous thromboembolism: rationale and design of the Hokusai-venous thromboembolism study - methodological implications for clinical trials

(2013) G. Raskob et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pharmacokinetics of the Direct Factor Xa Inhibitor Edoxaban and Digoxin Administered Alone and in Combination

(2012) Jeanne Mendell et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Edoxaban administration following enoxaparin: A pharmacodynamic, pharmacokinetic, and tolerability assessment in human subjects

(2012) Nobuko Matsushima et al.   THROMBOSIS AND HAEMOSTASIS

Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation

(2012) Jeanne Mendell et al.   THROMBOSIS AND HAEMOSTASIS

A Thorough Electrocardiogram Study of Edoxaban, a Novel Factor Xa Inhibitor

(2011) J. Mendell et al.   JOURNAL OF CLINICAL PHARMACOLOGY

In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux

(2011) Meyer Michel Samama et al.   THROMBOSIS RESEARCH

Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: Design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation–Thrombolysis In Myocardial Infarction study 48 (ENGAGE AF–TIMI 48)

(2010) Christian T. Ruff et al.   AMERICAN HEART JOURNAL

Novel Oral Factor Xa and Thrombin Inhibitors in the Management of Thromboembolism

(2010) Bengt I. Eriksson et al.   Annual Review of Medicine

Clinical Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Factor Xa Inhibitor Edoxaban in Healthy Volunteers

(2010) Koichiro Ogata et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effects of Food on the Pharmacokinetics of Edoxaban, an Oral Direct Factor Xa Inhibitor, in Healthy Volunteers

(2010) Jeanne Mendell et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation

(2010) Stuart Connolly et al.   THROMBOSIS AND HAEMOSTASIS