Article
Oncology
Cara Reiter-Brennan, Omar Dzaye, Mouaz H. Al-Mallah, Zeina Dardari, Clinton A. Brawner, Lois E. Lamerato, Steven J. Keteyian, Jonathan K. Ehrman, Michael J. Blaha, Kala Visvanathan, Catherine H. Marshall
Summary: The study found that men with high fitness are more likely to undergo PSA screening and have a higher incidence of prostate cancer. However, men with high fitness have a lower risk of death after a prostate cancer diagnosis.
Article
Cardiac & Cardiovascular Systems
Erik H. Van Iterson, Leslie Cho, Adriano Tonelli, J. Emanuel Finet, Luke J. Laffin
Summary: In patients with HFrEF, demonstrating a restrictive pattern on spirometry yields the severest mortality risk associated with (V) over dotO(2peak). Using spirometry to screen patients with HFrEF for ventilatory defects has a potential role in improving risk stratification based on (V) over dotO(2peak).
Article
Medicine, General & Internal
Daniel J. Chu, Amjad M. Ahmed, Waqas T. Qureshi, Clinton A. Brawner, Steven J. Keteyian, Khurram Nasir, Roger S. Blumenthal, Michael J. Blaha, Jonathan K. Ehrman, Miguel Cainzos-Achirica, Kershaw Patel, Mahmoud Al Rifai, Mouaz H. Al-Mallah
Summary: The study found that improving cardiorespiratory fitness can reduce all-cause mortality among patients with chronic kidney disease. Cardiorespiratory fitness provides additional prognostic information when added to traditional risk factors, which may help guide treatment options for patients with renal dysfunction.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah Gorgis, Jonathan K. Ehrman, Michael J. Blaha, Waqas T. Qureshi, Steven J. Keteyian, Mouaz H. Al Mallah, Clinton A. Brawner
Summary: The study found that among patients with coronary heart disease but no history of heart failure, exercise capacity is independently and inversely related to the risk of future heart failure.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hongliang Feng, Lulu Yang, Yannis Yan Liang, Sizhi Ai, Yaping Liu, Yue Liu, Xinyi Jin, Binbin Lei, Jing Wang, Nana Zheng, Xinru Chen, Joey W. Y. Chan, Raymond Kim Wai Sum, Ngan Yin Chan, Xiao Tan, Christian Benedict, Yun Kwok Wing, Jihui Zhang
Summary: There is increasing interest in the role of timing of physical activity (PA) in improving health. A large-scale study shows that engaging in moderate-to-vigorous PA at the optimal time of day can significantly reduce mortality risk and maximize the benefits of PA.
NATURE COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Atsushi Takayama, Taro Takeshima, Hajime Yamazaki, Tsukasa Kamitani, Sayaka Shimizu, Shunichi Fukuhara, Yosuke Yamamoto
Summary: This study investigated the association between resting respiratory rate (RRR) and all-cause mortality among older outpatients. The results showed that RRR was independently associated with all-cause mortality. This suggests that RRR may be a simple and important predictor, deserving further study in older populations and different settings.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Yang Zhao, Haohang Sun, Ranran Qie, Minghui Han, Ming Zhang, Xuezhong Shi, Yongli Yang, Jie Lu, Dongsheng Hu, Liang Sun
Summary: This study aimed to evaluate the risk of all-cause, cardiovascular disease (CVD), cancer, and other-cause mortality in Chinese adults using estimated cardiorespiratory fitness (eCRF). The results showed that eCRF was inversely associated with all-cause, CVD, and other-cause mortality.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Geriatrics & Gerontology
Mengyi Liu, Zhuxian Zhang, Chun Zhou, Ziliang Ye, Panpan He, Yuanyuan Zhang, Huan Li, Chengzhang Liu, Xianhui Qin
Summary: This study explores the association between predicted fat mass and lean mass with mortality in the US general population, finding that both fat mass and lean mass are independent predictors of overall and cause-specific mortality. Age was found to significantly modify the associations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cardiac & Cardiovascular Systems
Dong Hoon Lee, Leandro F. M. Rezende, Hee-Kyung Joh, NaNa Keum, Gerson Ferrari, Juan Pablo Rey-Lopez, Eric B. Rimm, Fred K. Tabung, Edward L. Giovannucci
Summary: Engaging in moderate or vigorous physical activities for an appropriate amount of time can reduce the risk of mortality.
Article
Medicine, Research & Experimental
Chen-An Liu, Tong Liu, Yi-Zhong Ge, Meng-Meng Song, Guo-Tian Ruan, Shi-Qi Lin, Hai-Lun Xie, Jin-Yu Shi, Xin Zheng, Yue Chen, Liuyi Shen, Li Deng, Han-Ping Shi
Summary: According to the COX regression analysis, the distribution of muscle mass across different body parts, such as upper limbs, lower limbs, trunk, gynoid, and total lean mass, is positively associated with the survival rate of participants. Changes in the lean mass ratio and android-gynoid ratio attenuate the protective effect of lean mass. Age and sex act as potential modifiers, and the relationship between lean mass and prognosis is more significant in men and middle-aged participants. The impact of lean mass on prognosis is more substantial in the near-term rather than the long-term.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Jonathan K. Ehrman, Steven J. Keteyian, Michelle C. Johansen, Michael J. Blaha, Mouaz H. Al-Mallah, Clinton A. Brawner
Summary: The study aimed to investigate the association between changes in cardiorespiratory fitness (CRF) and incident ischemic stroke. The results showed that improvement in CRF was inversely associated with the risk of ischemic stroke. Therefore, encouraging regular exercise to improve CRF may reduce the risk of ischemic stroke.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Public, Environmental & Occupational Health
K. He, X. Chen, Z. Shi, S. Shi, Q. Tian, X. Hu, R. Song, K. Bai, W. Shi, J. Wang, H. Li, J. Ding, S. Geng, X. Sheng
Summary: The study revealed associations between resting heart rate and blood pressure with all-cause and cardiovascular disease mortality, especially fast heart rate combined with high systolic blood pressure increasing the risk of mortality.
Article
Engineering, Civil
Rui Yue, Guangchuan Yang, Yichen Zheng, Zong Tian
Summary: All-way stop-controlled intersections are commonly used for low traffic demand roads. This research investigates the impact of pedestrian crossings on the capacity of AWSC intersections, finding that the effects vary depending on pedestrian activities and vehicle directions.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Nutrition & Dietetics
Moniek van Zutphen, Hendriek C. Boshuizen, Marlou-Floor Kenkhuis, Evertine Wesselink, Anne J. M. R. Geijsen, Johannes H. W. de Wilt, Henk K. van Halteren, Ernst Jan Spillenaar Bilgen, Eric T. P. Keulen, Maryska L. G. Janssen-Heijnen, Stephanie O. Breukink, Martijn J. L. Bours, Dieuwertje E. Kok, Renate M. Winkels, Matty P. Weijenberg, Ellen Kampman, Franzel J. B. van Duijnhoven
Summary: The study found that having a healthy lifestyle and improving lifestyle after a colorectal cancer diagnosis does not increase the risk of cancer recurrence, but significantly reduces the risk of all-cause mortality.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Niels A. Stens, Esmee A. Bakker, Asier Manas, Laurien M. Buffart, Francisco B. Ortega, Duck-chul Lee, Paul D. Thompson, Dick H. J. Thijssen, Thijs M. H. Eijsvogels
Summary: According to the meta-analysis, daily step counts of approximately 2,600 and 2,800 already yield significant benefits in terms of reducing mortality and cardiovascular disease. Further increasing the step count up to approximately 8,800 and 7,200 steps per day leads to progressive risk reductions. There are additional mortality benefits from moderate to high step cadences.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Alka M. Kanaya, Namratha R. Kandula, Jaideep Patel, Mouaz H. Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H. Criqui, Salim S. Virani
Summary: Individuals of South Asian ancestry have a higher risk of atherosclerotic cardiovascular disease. Coronary artery calcium volume and density can identify unique plaque characteristics in this population, providing important prognostic information. Cardiovascular risk factors are associated with CAC density and volume.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Maan Malahfji, Mouaz H. Al-Mallah
Summary: This study aimed to determine the prognostic value of positron emission tomography (PET) derived left ventricular mass (LVM) in addition to clinical variables and myocardial flow reserve (MFR). The results showed that LVM was not independently associated with outcomes and had no incremental prognostic value over MFR and clinical variables.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maan Malahfji, Valentina Crudo, Ahmed Ibrahim Ahmed, Mujtaba Saeed, Jean Michel Saad, William A. Zoghbi, Mouaz H. Al-Mallah
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sun Young Jeong, Christina C. Wee, Lara C. Kovell, Timothy B. Plante, Edgar R. Miller, Lawrence J. Appel, Kenneth J. Mukamal, Stephen P. Juraschek
Summary: Compared with a typical American diet, both the DASH and fruits and vegetables (F/V) diets can reduce 10-year ASCVD risk scores by about 10% over 8 weeks.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Sankar D. Navaneethan, Sophia Zoungas, M. Luiza Caramori, Juliana C. N. Chan, Hiddo J. L. Heerspink, Clint Hurst, Adrian Liew, Erin D. Michos, Wasiu A. Olowu, Tami Sadusky, Nikhil Tandon, Katherine R. Tuttle, Christoph Wanner, Katy G. Wilkens, Jonathan C. Craig, David J. Tunnicliffe, Marcello Tonelli, Michael Cheung, Amy Earley, Peter Rossing, Ian H. de Boer, Kamlesh Khunti
Summary: The KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease is an update of the 2020 guideline. The guideline was updated based on reviewing new evidence and using the GRADE approach to assess evidence and develop consensus practice points. The recommendations were updated in the areas of comprehensive care and glucose-lowering therapies, while recommendations in the areas of glycemic monitoring, lifestyle interventions, and management approaches remained unchanged.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Rishi Rikhi, Harpreet S. Bhatia, Christopher L. Schaich, Nicklaus Ashburn, Michael Y. Tsai, Erin D. Michos, Parag A. Chevli, David M. Herrington, Sotirios Tsimikas, Michael D. Shapiro
Summary: This study examined the relationship between Lp(a) and hypertension with cardiovascular outcomes in a large multiethnic cohort. The results showed that individuals with elevated Lp(a) and hypertension had a significantly increased risk for cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Luke J. Laffin, Dennis Bruemmer, Michelle Garcia, Danielle M. Brennan, Ellen McErlean, Douglas S. Jacoby, Erin D. Michos, Paul M. Ridker, Tracy Y. Wang, Karol E. Watson, Howard G. Hutchinson, Steven E. Nissen
Summary: This study compared the efficacy of a low-dose statin with placebo and 6 common supplements in impacting lipid and inflammatory biomarkers. The results showed that rosuvastatin significantly lowered LDL-C compared to placebo and each supplement. None of the dietary supplements demonstrated a significant decrease in LDL-C compared to placebo.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Geriatrics & Gerontology
Stephen P. Juraschek, Lawrence J. Appel, Lewis A. Lipsitz, Edgar R. Miller
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Letter
Peripheral Vascular Disease
Stephen P. Juraschek, Natalie A. Bello, Alexander R. Chang, Jennifer L. Cluett, Karen A. Griffin, Alan Hinderliter, Kenneth J. Mukamal, Long H. Ngo, Ruth-Alma N. Turkson-Ocran, Raven Voora, Wanpen Vongpatanasin
Article
Geriatrics & Gerontology
Caitlin W. Hicks, Dan Wang, Natalie Daya, Stephen P. Juraschek, Kunihiro Matsushita, B. Gwen Windham, Elizabeth Selvin
Summary: This study found that peripheral neuropathy (PN) detected by monofilament testing is common in older adults, even in the absence of diabetes. These individuals have an increased risk of falls and fractures. Therefore, screening with monofilament testing may help identify older adults at high risk for falls.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Jennifer A. Schrack, Yurun Cai, Jacek K. Urbanek, Amal A. Wanigatunga, Christine M. Mitchell, Edgar R. Miller III, Jack M. Guralnik, Stephen P. Juraschek, Erin D. Michos, David L. Roth, Lawrence J. Appel
Summary: This study aimed to assess whether vitamin D-3 supplementation could attenuate the decline in daily physical activity in low-functioning older adults. The results showed that supplementation with 1000 IU/day or higher of vitamin D-3 did not attenuate the decline in physical activity compared to 200 IU/day. Individuals with baseline serum 25(OH)D levels < 20 ng/mL experienced accelerated declines in physical activity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Cardiac & Cardiovascular Systems
Michael J. Wilkinson, Norman E. Lepor, Erin D. Michos
Summary: Management of elevated low-density lipoprotein cholesterol (LDL-C) is crucial for preventing atherosclerotic cardiovascular disease (ASCVD) and reducing ASCVD events. Statins are recommended as the first-line therapy for LDL-C reduction, while nonstatin lipid-lowering therapy can be added for intensive LDL-C lowering in high-risk patients. However, many high-risk patients fail to meet LDL-C thresholds despite guideline recommendations. This review explores the challenges of LDL-C lowering and proposes a new approach to ASCVD risk assessment and treatment.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Noelle Castilla-Ojo, Ruth-Alma Turkson-Ocran, Paul R. Conlin, Lawrence J. Appel, Edgar R. Miller III, Stephen P. Juraschek
Summary: The DASH diet significantly decreased serum urate levels in participants with higher urate at baseline, while losartan significantly reduced serum urate, especially among younger adults.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Review
Obstetrics & Gynecology
Brigitte Kazzi, Bairavi Shankar, Petal Elder-Odame, Lale S. Tokgoezoglu, Lilia M. Sierra-Galan, Erin D. Michos
Summary: Mid-life in women is marked by changes in cardiometabolic risk factors, making it a critical time for cardiovascular disease (CVD) risk assessment. It is important to evaluate traditional risk factors and reproductive history to identify female-specific factors that contribute to CVD risk. In cases of uncertainty, measuring a coronary artery calcium score can help refine risk assessment. Additionally, there is a need to improve the recognition of ischemic heart disease in women and incorporate novel risk factors into CVD assessment. This review provides an approach to CVD screening and risk assessment in middle-aged women.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)