Review
Pharmacology & Pharmacy
Qi Jin, Dandan Chen, Xiaochun Zhang, Feng Zhang, Dongxiang Zhong, Dawei Lin, Lihua Guan, Wenzhi Pan, Daxin Zhou, Junbo Ge
Summary: Pulmonary arterial hypertension (PAH) is a malignant pulmonary vascular syndrome characterized by progressive pulmonary vascular resistance and pressure increase, leading to right heart failure and death. Although the exact mechanisms of PAH are not fully understood, vasoconstriction, remodeling, immune responses, and thrombosis are implicated. Over the past 30 years, PAH-specific therapies targeting three classical signaling pathways have significantly improved hemodynamics, function, and prognosis but have limited effects on pulmonary arterial pressure and right ventricular afterload. Current targeted agents can delay progression but cannot reverse vascular remodeling. New therapeutic drugs like sotatercept have emerged, injecting new vitality. This review summarizes general treatments and elaborates on specific drugs and combination strategies, highlighting the progress in finding new therapeutic targets for PAH.
Review
Biochemistry & Molecular Biology
Aangi J. Shah, Taylor Beckmann, Mounica Vorla, Dinesh K. Kalra
Summary: Pulmonary arterial hypertension (PAH) is a chronic and progressive disorder that affects the pulmonary vasculature and leads to pulmonary and cardiac remodeling. Despite improved life expectancy through targeted therapies, PAH still remains a progressive disease with significant morbidity and mortality. Current vasodilator therapies do not target the underlying pathogenesis of the disease, highlighting the need for the development of new drugs and interventional therapies. This review focuses on newer targets, drugs, and interventional therapies that modify various pathways involved in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ruiqi Liu, Tianyi Yuan, Ranran Wang, Difei Gong, Shoubao Wang, Guanhua Du, Lianhua Fang
Summary: This paper reviews the regulation of endothelin receptors and their pathways in normal physiological processes and disease processes, and describes the mechanistic roles of ET receptor antagonists that are currently approved and used in clinical studies. Current clinical researches on ET are focused on the development of multi-target combinations and novel delivery methods to improve efficacy and patient compliance while reducing side effects. Future research directions and trends of ET targets, including monotherapy and precision medicine, are also described in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yoichi Sugiyama, Hiromi Matsubara, Hiroto Shimokawahara, Aiko Ogawa
Summary: Lowering mean pulmonary arterial pressure (mPAP) has a favorable impact on the prognosis of patients with pulmonary arterial hypertension (PAH), and it has become a therapeutic goal. By following a treatment algorithm, a significant number of patients achieved the target mPAP, and the survival rate of patients who achieved the therapeutic goal was significantly better than those who did not.
JOURNAL OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rebecca R. Vanderpool, Anastasia Gorelova, Yiran Ma, Mohammad Alhamaydeh, Jeffrey Baust, Sruti Shiva, Stevan P. Tofovic, Jian Hu, Seyed Mehdi Nouraie, Mark T. Gladwin, Maryam Sharifi-Sanjani, Imad Al Ghouleh
Summary: The study demonstrates that the prostacyclin analogue treprostinil can reduce right ventricular hypertrophy and improve right ventricular function in severe PAH models, leading to decreased pulmonary arterial pressure and fibrotic responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Shuang Hua, Yong Yang, Danqi Zou, Jufei Li, Kaixuan Yan, Ying Xu, Xue Jiang, Xianglu Rong, Dewei Ye
Summary: Metabolic complications such as type 2 diabetes, obesity, and hypertension play a crucial role in the morbidity and mortality of COVID-19 patients. Treatment decisions for COVID-19 patients with such comorbidities should be made cautiously based on emerging evidence.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Respiratory System
Johannes M. Douwes, Willemijn M. H. Zijlstra, Erika B. Rosenzweig, Mark-Jan Ploegstra, Usha S. Krishnan, Meindina G. Haarman, Marcus T. R. Roofthooft, Douwe Postmus, Hans L. Hillege, D. Dunbar Ivy, Rolf M. F. Berger
Summary: This study retrospectively analyzed data from 275 children with PAH and found that early initiation and higher doses of IV/SC prostanoid therapy, as well as combination with other targeted drugs, were associated with better outcomes. Transition from IV/SC prostanoid therapy to oral or inhaled therapies was found to be safe in selected patients who met specific hemodynamic criteria.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Medicine, General & Internal
Abdullah A. Alqarni, Abdulelah M. Aldhahir, Heba M. Bintalib, Jaber S. Alqahtani, Rayan A. Siraj, Mansour Majrshi, Abdulkareem A. Algarni, Abdallah Y. Naser, Sara A. Alghamdi, Hassan Alwafi
Summary: Inhaled prostaglandin I2 analogue does not improve lung function and exercise capacity in patients with COPD-related pulmonary hypertension. However, short-term use of inhaled prostaglandin I2 analogue has the potential to reduce mean pulmonary artery pressure and pulmonary vascular resistance without impairing ventilation-perfusion mismatch. Further studies with larger sample sizes are warranted.
FRONTIERS IN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Hehua Guo, Jiazheng Sun, Siyu Zhang, Yalan Nie, Sirui Zhou, Yulan Zeng
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with an unknown cause and poorly understood pathogenesis. The transformation of fibroblasts into myofibroblasts, triggered by injury to the alveolar epithelial cells, and the excessive accumulation of extracellular matrix (ECM) components, such as collagen, play crucial roles in IPF progression. Two novel anti-fibrotic medications, pirfenidone and nintedanib, have shown efficacy in slowing down lung function decline and reducing hospitalization risk in IPF patients. However, lung transplantation remains the only potential curative measure for IPF, and various innovative therapeutic strategies are currently being investigated.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Pengwei Wang, Jiaxin Deng, Quanying Zhang, Hongyan Feng, Yongheng Zhang, Yizhong Lu, Lizhu Han, Pengfei Yang, Zhijian Deng
Summary: This study investigated the additional benefits of prostacyclin analogs in combination therapy for PAH patients. The results showed that prostacyclin analog treatment significantly improved clinical worsening, exercise capacity, functional class, mean pulmonary artery pressure, and cardiac index compared to the control group. However, it was also associated with increased risk of adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Eben G. Estell, Clifford J. Rosen
Summary: The mainstay treatment for osteoporosis has traditionally been antiresorptive agents, but declining adherence has led to a plateau in fracture rates reduction. The approval of anabolic agents in the past two decades represents a new approach to improving bone quality and reducing fracture risk, potentially leading to a new clinical paradigm.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Constanza E. Martinez-Olivares, Leonardo Del Valle-Mondragon, Fernando Cortes-Camacho, Oscar R. Zambrano-Vasquez, Rogelio Hernandez-Pando, Fausto Sanchez-Munoz, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: In this study, we evaluated the effects of allicin on vascular remodeling, endothelial function, and oxidative stress in experimental pulmonary arterial hypertension (PAH). Allicin administration improved body weight, survival rate, and prevented wall thickness and right ventricle hypertrophy. Allicin also maintained normal levels of angiotensin II and its receptors, increased nitric oxide and other beneficial molecules, and prevented oxidative stress and hypoxia response. These effects of allicin contribute to preventing endothelial dysfunction, remodeling of the pulmonary arteries, and heart failure in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew Constantine, Konstantinos Dimopoulos, Petra Jenkins, Robert M. R. Tulloh, Robin Condliffe, Katrijn Jansen, Natali A. Y. Chung, James Oliver, Helen Parry, Samantha Fitzsimmons, Niki Walker, Stephen John Wort, Vasilios Papaioannou, Kate von Klemperer, Paul Clift
Summary: The Fontan circulation is a surgical strategy for treating congenital heart disease with single ventricle physiology, and Fontan failure is a major cause of poor quality of life and mortality. This study assessed the use of PAH therapies in adult patients with Fontan physiology in specialist centers in the United Kingdom, targeting individuals with more advanced disease or complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Aleksandra Gasecka, Marta Banaszkiewicz, Rienk Nieuwland, Edwin van der Pol, Najat Hajji, Hubert Mutwil, Sylwester Rogula, Wiktoria Rutkowska, Kinga Pluta, Ceren Eyileten, Marek Postula, Szymon Darocha, Zenon Huczek, Grzegorz Opolski, Krzysztof J. Filipiak, Adam Torbicki, Marcin Kurzyna
Summary: The study showed that PAH patients treated with prostacyclin analogues had impaired platelet reactivity, EV release, and thrombus formation compared to those not receiving prostacyclin analogues.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Marta Banaszkiewicz, Pawel Kurzyna, Nina Kubikowska, Magda Mucha, Aleksander Rudnik, Aleksandra Gasecka, Arkadiusz Pietrasik, Marcin Grabowski, Milosz J. Jaguszewski, Piotr Kasprzyk, Piotr Kedzierski, Dariusz Ciecwierz, Grzegorz Zuk, Piotr Szwed, Michal Pilka, Michal Florczyk, Marcin Kurzyna, Szymon Darocha
Summary: In this article, the authors discuss the role of balloon pulmonary angioplasty (BPA) in the treatment of chronic thromboembolic pulmonary disease (CTEPD). They describe the pathophysiology of CTEPD and highlight the poor prognosis of the chronic thromboembolic pulmonary hypertension (CTEPH) subpopulation. The article outlines a multimodal approach to treating CTEPH, including pulmonary endarterectomy (PEA), BPA, and pharmacological therapies, and emphasizes that BPA serves as a complementary treatment option. The authors summarize the efficacy and treatment goals of BPA, including improvements in functional and biochemical parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Mariana Faria-Urbina, Rudolf K. F. Oliveira, Manyoo Agarwal, Aaron B. Waxman
Editorial Material
Cardiac & Cardiovascular Systems
John J. Ryan, Aaron B. Waxman
Article
Critical Care Medicine
Paul B. Dieffenbach, Christina Mallarino Haeger, Rakhshinda Rehman, Alexis M. Corcoran, Anna Maria F. Coronata, Shamsudheen K. Vellarikkal, Izabela Chrobak, Aaron B. Waxman, Sally H. Vitali, Lynette M. Sholl, Robert F. Padera, David Lagares, Francesca Polverino, Caroline A. Owen, Laura E. Fredenburgh
Summary: MMP-8 is upregulated in the pulmonary vasculature during PAH pathogenesis and acts as a protective factor by altering matrix composition and disrupting integrin-beta 3/FAK and YAP/TAZ-dependent mechanical signaling in PASMCs.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Steven D. Nathan, Victor F. Tapson, Jean Elwing, Franz Rischard, Jinesh Mehta, Shelley Shapiro, Eric Shen, Chunqin Deng, Peter Smith, Aaron Waxman
Summary: The study showed that patients treated with inhaled treprostinil had better outcomes in terms of 6-minute walk distance and fewer clinical worsening events. There were fewer occurrences of multiple disease progression events in the inhaled treprostinil group, indicating a lower risk of further disease progression in these patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Respiratory System
Aaron B. Waxman, Davide Elia, Yochai Adir, Marc Humbert, Sergio Harari
Summary: Pulmonary hypertension complicates interstitial lung disease and is associated with poor prognosis. Diagnosis of PH-ILD can be challenging but can be accurately determined through appropriate tests and equipment. Research on treatment options, particularly drugs for pulmonary arterial hypertension, has shown promising results.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Respiratory System
Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Janethe de Oliveira Pena, David B. Badesch
Summary: In participants with pulmonary arterial hypertension, 24 weeks of sotatercept resulted in a significant reduction in pulmonary vascular resistance. This study reports the longer-term safety and efficacy of sotatercept in the PULSAR open-label extension, showing that sotatercept has good safety and efficacy in patients with pulmonary arterial hypertension.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Critical Care Medicine
Phillip Joseph, Inderjit Singh, Rudolf Oliveira, Christine A. Capone, Mary P. Mullen, Dane B. Cook, Mary Catherine Stovall, Johanna Squires, Kristine Madsen, Aaron B. Waxman, David M. Systrom
Summary: This review highlights the exercise pathophysiologic commonalities between PASC and ME/CFS, which can guide future diagnostics and treatment.
Article
Respiratory System
Aaron Waxman, Ricardo Restrepo-Jaramillo, Thenappan Thenappan, Peter Engel, Abubakr Bajwa, Ashwin Ravichandran, Jeremy Feldman, Amy Hajari Case, Rahul G. Argula, Victor Tapson, Peter Smith, Chunqin Deng, Eric Shen, Steven D. Nathan
Summary: This study evaluated the long-term effects of inhaled treprostinil in patients with pulmonary hypertension due to interstitial lung disease. The results support the long-term safety and efficacy of inhaled treprostinil in these patients.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Critical Care Medicine
Steven D. Nathan, Aaron B. Waxman
Article
Respiratory System
Rogerio Souza, David B. Badesch, H. Ardeschir Ghofrani, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Vallerie V. Mclaughlin, Ioana R. Preston, Aaron B. Waxman, Ekkehard Gruenig, Grzegorz Kope, Gisela Meyer, Karen M. Olsson, Stephan Rosenkranz, Jianxin Lin, Amy O. Johnson-Levonas, Janethe de Oliveira Pena, Marc Humbert, Marius M. Hoeper
Summary: Sotatercept demonstrated significant improvements in pulmonary artery pressure and right heart function in pre-treated patients with pulmonary arterial hypertension (PAH).
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Respiratory System
Steven D. Nathan, Boris Medarov, Lawrence Ho, John Kingrey, Taekwon Hong, Youlan Rao, Eric Shen, Peter Smith, Chunqin Deng, Aaron Waxman
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Tilo Winkler, Puja Kohli, Vanessa J. Kelly, Ekaterina G. Kehl, Alison S. Witkin, Josanna M. Rodriguez-Lopez, Kathryn A. Hibbert, Mamary T. Kone, David M. Systrom, Aaron B. Waxman, Jose G. Venegas, Richard N. Channick, R. Scott Harris
Summary: Perfusion imaging during O2 + iNO showed significant differences in the heterogeneity associated with the vertical gradient in perfusion, distinguishing PAH subjects from controls in this small cohort study.
RESPIRATORY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew J. Schissler, Robert J. Gylnn, Piotr S. Sobieszczyk, Aaron B. Waxman
PULMONARY CIRCULATION
(2018)
Article
Cardiac & Cardiovascular Systems
Mariana Faria-Urbina, Rudolf K. F. Oliveira, Sergio A. Segrera, Laurie Lawler, Aaron B. Waxman, David M. Systrom
PULMONARY CIRCULATION
(2018)
Article
Cardiac & Cardiovascular Systems
Yuchi Han, Paul R. Forfia, Anjali Vaidya, Jeremy A. Mazurek, Myung H. Park, Gautam Ramani, Stephen Y. Chan, Aaron B. Waxman
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)