Article
Cardiac & Cardiovascular Systems
Clive R. Pullinger, Patricia M. O'Connor, Josefina M. Naya-Vigne, Steven T. Kunitake, Irina Movsesyan, Philip H. Frost, Mary J. Malloy, John P. Kane
Summary: The study demonstrated a strong association between prebeta-1 HDL levels and a history of CHD or MI, independent of traditional risk factors. Addition of prebeta-1 HDL significantly improved the clinical assessment of the risk of CHD and MI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Hayato Tada, Kan Yamagami, Kenji Sakata, Soichiro Usui, Masa-aki Kawashiri, Masayuki Takamura
Summary: Healthy lifestyle is associated with a lower risk of coronary artery disease regardless of Lp(a) levels.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Hiroshi Ito
Summary: This study found that high serum malondialdehyde low-density lipoprotein (MDA-LDL) levels are associated with the prevalence of high-risk plaques (HRP). High MDA-LDL levels independently predict the presence of HRP, which may lead to cardiovascular events in statin-treated patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Hiroki Nishiyama, Takehiro Funamizu, Hiroshi Iwata, Hirohisa Endo, Yuichi Chikata, Shinichiro Doi, Hideki Wada, Ryo Naito, Manabu Ogita, Yoshiteru Kato, Iwao Okai, Tomotaka Dohi, Takatoshi Kasai, Kikuo Isoda, Shinya Okazaki, Katsumi Miyauchi, Tohru Minamino
Summary: This study aimed to evaluate the prognostic impact of preprocedural ApoA1 on cancer mortality in patients undergoing PCI. The results showed that patients with lower levels of ApoA1 had higher mortality rates for total, gastrointestinal, and lung cancer, while HDL-C levels had no significant impact on any type of cancer mortality. Multivariable analysis confirmed that elevated ApoA1 levels independently predicted a lower risk of total and gastrointestinal cancer. Therefore, preprocedural ApoA1 levels have prognostic implications for predicting cancer mortality in PCI patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Endocrinology & Metabolism
Changwei Zheng, Yi Lin, Bingcai Jiang, Xiaomin Zhu, Qianyi Lin, Wangdu Luo, Min Tang, Lin Xie
Summary: Through a two-sample Mendelian randomization (MR) analysis, the study found that an increase in levels of high-density lipoprotein-cholesterol (HDL-C) was associated with a decreased risk of retinal vascular occlusion (RVO), suggesting that a low HDL-C level may be an independent risk factor for RVO. However, there was no evidence to support a causal association between low-density lipoprotein-cholesterol (LDL-C), total cholesterol, or triglycerides and RVO.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah Leatherman, Ryan Ferguson, Cynthia Hau, Kelly Harrington, Craig Granowitz, Sephy Philip, Peter Paul Toth, Deepak Bhatt, William Boden
Summary: This study examined the association between elevated triglyceride (TG) levels and cardiovascular (CV) risks in a large cohort of US veterans with well-controlled LDL-C levels. The results showed that elevated TG levels were associated with a modest increase in CV events, especially in patients with established cardiovascular disease and diabetes alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Keishi Ichikawa, Toru Miyoshi, Kazuhiko Kotani, Kazuhiro Osawa, Mitsutaka Nakashima, Takahiro Nishihara, Hiroshi Ito
Summary: The study revealed a significant association between high levels of oxidized HDL (oxHDL) and increased pericoronary inflammation. This association may explain the link between impaired HDL function and the development of coronary atherosclerosis.
JOURNAL OF CARDIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Evangelia Zvintzou, Dimitra Sotiria Karampela, Aggeliki Vakka, Eva Xepapadaki, Eleni A. Karavia, Aikaterini Hatziri, Panagiota C. Giannopoulou, Kyriakos E. Kypreos
Summary: Recent epidemiological studies suggest a U-shaped relationship between HDL-C levels and CVD risk, with optimal range for men 40-70 mg/dl and for women 50-70 mg/dl. HDL particles have different attributes and may be antiatherogenic or proatherogenic based on their structural and functional characteristics. Pharmacological successes in mice may not translate to humans due to important differences between the two species.
VASCULAR PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Gregory G. Schwartz, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Maja Bujas-Bobanovic, Rafael Diaz, Sergio Fazio, Zlatko Fras, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Garen Manvelian, Robert Pordy, Kausik K. Ray, Michel Scemama, Harvey D. White, Ph Gabriel Steg
Summary: Long-term placebo-controlled trials have shown clinical benefits that persist after the end of the trial. This study aims to investigate whether similar effects can be seen with short-term very low low-density lipoprotein cholesterol (LDL-C) levels achieved using statin and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor therapy.
EUROPEAN HEART JOURNAL
(2023)
Article
Nutrition & Dietetics
Mengyun Tian, Teng Hu, Jiajun Ying, Hanbin Cui, Huangfu Ning
Summary: This study aimed to explore the causal association between genetically predicted concentrations of micronutrients and coronary artery disease (CAD) in patients with diabetes. The findings suggest that genetically predicted selenium levels are associated with an increased risk of CAD in diabetic patients, while genetically predicted iron concentrations are associated with a decreased risk. These results highlight the necessity of micronutrient monitoring and application in these patients.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Nathaniel L. Baker, Samar M. Hammad, Kelly J. Hunt, Andrea Semler, Richard L. Klein, Maria F. Lopes-Virella
Summary: This study found that plasma apoM levels are associated with the development of diabetic kidney disease. Higher apoM levels are associated with increased risk of progression to macroalbuminuria and chronic kidney disease in patients with type 1 diabetes, suggesting that alterations in apoM may play a role in the development of nephropathy.
Article
Medicine, General & Internal
Shiva Ganjali, Elahe Mahdipour, Seyed Hamid Aghaee-Bakhtiari, Majid Ghayour-Mobarhan, Sara Saffar Soflaei, Maciej Banach, Anatol Kontush, Amirhossein Sahebkar
Summary: This study aimed to evaluate the compositional and functional alterations of high-density lipoprotein (HDL) in patients with in-stent restenosis (ISR). The capacity of HDL to efflux cholesterol from lipid-loaded macrophages and to take up free cholesterol from triglyceride-rich lipoproteins during lipolysis was assessed. The results showed that the functional capacity of HDL was not associated with ISR.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Elizabeth A. Ellins, Daniel E. Harris, Arron Lacey, Ashley Akbari, Fatemeh Torabi, Dave Smith, Geraint Jenkins, Daniel Obaid, Alex Chase, Ann John, Michael B. Gravenor, Julian P. Halcox
Summary: This study found that coronary patients with prior depression were less likely to have their lipids monitored and achieve guideline targets within 1 year. Females with depression were particularly at risk, as they were the least likely to be tested and achieve lipid targets. Improving care for these patients could greatly reduce their risk of future events.
Article
Microbiology
Luis A. Marcos, Charles Kyriakos Vorkas, Inderjit Mann, Evan Garry, Pooja Lamba, Sophia K. Pham, Rachel Spector, Aikaterini Papamanoli, Sara Krivacsy, Michael Lum, Aleena Zahra, Wei Hou, Eric D. Spitzer
Summary: This study aimed to describe the cholesterol levels in patients with acute babesiosis in New York and investigate the correlation between high-density lipoprotein (HDL) levels and infection severity. The results showed that LDL and HDL levels were significantly reduced during acute babesiosis, suggesting that cholesterol depletion may predict disease severity.
Article
Endocrinology & Metabolism
Pei Yang, DongDong Li, Xiaokang Li, Zongbiao Tan, Huan Wang, Xiaona Niu, Yang Han, Cheng Lian
Summary: This study investigated the relationship between HDL-C levels and intertrochanter bone mineral density. The results showed a negative correlation between HDL-C and intertrochanter BMD. Subgroup analysis revealed negative correlations among 60-70-year-olds, non-Hispanic whites, and obese individuals. The relationship between HDL-C and intertrochanter BMD was an inverted U-shaped curve in men and hormone users, and a U-shaped curve in other Hispanic and premenopausal individuals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)