Article
Clinical Neurology
Fjola D. Sigurdardottir, Caroline Tonje Overby, Sami Nikkonen, Tuomas Karhu, Toril Dammen, Inger Hilde Nordhus, Thea Thorshov, Gunnar Einvik, Samu Kainulainen, Timo Leppanen, Erna Sif Arnardottir, Juha Toyras, Torbjorn Omland, Harald Hrubos-Strom
Summary: This study assessed the association between novel desaturation parameters and elevated cardiac troponin I and T levels. The results showed that these parameters can predict the elevation of cardiac troponin levels.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Engineering, Biomedical
Marika Rissanen, Henri Korkalainen, Brett Duce, Saara Sillanmaki, Henna Pitkanen, Aaron Suni, Sami Nikkonen, Antti Kulkas, Juha Toyras, Timo Leppanen, Samu Kainulainen
Summary: This study aimed to examine the effects of atrial arrhythmias on the severity and characteristics of desaturation in patients with obstructive sleep apnea. Retrospective analysis was conducted on 520 suspected patients, and various parameters were calculated from polysomnographic recordings. The results showed that patients with a previous atrial arrhythmia diagnosis had greater desaturation recovery area and more gradual recovery slopes compared to those without a diagnosis. Patients with atrial fibrillation also exhibited more gradual oxygen saturation fall and recovery slopes than patients with sinus rhythm. These findings suggest that considering the desaturation recovery section could provide valuable information about OSA severity.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Philipp Hegner, Simon Lebek, Benedikt Schaner, Florian Ofner, Mathias Gugg, Lars Siegfried Maier, Michael Arzt, Stefan Wagner
Summary: Left ventricular contractile dysfunction and arrhythmias frequently occur in patients with sleep-disordered breathing. This study examined a mouse model of obstructive sleep apnea (OSA) and found that inhibition of the oxidative activation of CaMKII provided cardioprotection, suggesting therapeutic implications. The study demonstrated the association between OSA and contractile dysfunction as well as pro-arrhythmic activity, and shed light on the underlying mechanisms.
Review
Cardiac & Cardiovascular Systems
Julio Marti-Almor, Jesus Jimenez-Lopez, Benjamin Casteigt, Javier Conejos, Ermengol Valles, Nuria Farre, Miquel Felez Flor
Summary: OSAS has a high prevalence in western countries and is related to cardiac arrhythmias, while early diagnosis and treatment can reduce cardiovascular morbidity and mortality.
CURRENT CARDIOLOGY REPORTS
(2021)
Article
Neurosciences
Dominika Urbanik, Pawel Gac, Helena Martynowicz, Maciej Podgorski, Malgorzata Poreba, Grzegorz Mazur, Rafal Poreba
Summary: The study found that patients with OSA have increased abnormalities in 24-hour ECG Holter monitoring, which are positively correlated with higher AHI levels, with more frequent occurrences of SVT and VPC.
Article
Medicine, General & Internal
Akram Khan, Ryan D. Clay, Asha Singh, Chitra Lal, Larisa G. Tereshchenko
Summary: Patients with pre-existing cardiac disease and high risk of obstructive sleep apnea (OSA) have increased burden of non-sustained ventricular tachycardia (NSVT).
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Hiwa Mohammadi, Ardalan Aarabi, Mohammad Rezaei, Habibolah Khazaie, Serge Brand
Summary: The study found that individuals with OSAS have significantly lower spindle density in N3 and shorter spindle duration in N2 compared to healthy controls. Furthermore, individuals with mild OSAS showed sleep spindle characteristics more similar to healthy controls, unlike those with moderate and severe OSAS.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Balint Laczay, Michael D. Faulx
Summary: Obstructive sleep apnea (OSA) is a highly prevalent disorder closely associated with cardiovascular diseases, including cardiac rhythm disorders. Recognizing and treating OSA in a timely manner is crucial to reducing the burden of cardiovascular diseases such as arrhythmias, which can greatly impact health outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hui Gong, Xing Lyu, Lini Dong, Shengyu Tan, Shizhen Li, Jieting Peng, Yang Liu, Xiangyu Zhang
Summary: The severity of OSA is significantly associated with cardiac injury and remodeling in patients with DCM, potentially through altering autophagy levels. This study provides new clues for the treatment of heart failure caused by OSA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Otorhinolaryngology
Diogo Raposo, Marco Menezes, Joao Rito, Mafalda Trindade-Soares, Cristina Adonis, Helena Cristina Loureiro, Filipe Freire
Summary: DISE findings varied between surgically naive children and those with persistent obstructive sleep apnea after adenotonsillectomy. Increased obstruction at the tongue base and multilevel obstruction predicted a lower saturation nadir in children with persistent obstructive sleep apnea after adenotonsillectomy.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Clinical Neurology
Yi Cai, Hailey M. Juszczak, Emily K. Cope, Andrew N. Goldberg
Summary: Recent evidence suggests a bidirectional relationship between obstructive sleep apnea and microbiota composition, where sleep quality and microbiota alterations influence each other. Animal model studies support the idea that the microbiome mediates disease states associated with obstructive sleep apnea, and potential treatment options include probiotics, prebiotics, and microbiota transplantation.
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Silvia Conde, Fatima O. Martins, Sara S. Dias, Paula Pinto, Cristina Barbara, Emilia C. Monteiro
Summary: This study investigated the effect of caffeine consumption on patients with obstructive sleep apnea (OSA) and found that higher caffeine consumption does not alter the variables related to the disease.
Article
Critical Care Medicine
Samuel T. Kuna, David M. Reboussin, Elsa S. Strotmeyer, Richard P. Millman, Gary Zammit, Michael P. Walkup, Thomas A. Wadden, Rena R. Wing, F. Xavier Pi-Sunyer, Adam P. Spira, Gary D. Foster
Summary: Intensive lifestyle intervention for weight loss can lead to reduced severity of obstructive sleep apnea in individuals with type 2 diabetes mellitus, and this improvement can be sustained over a 10-year period. The amount of weight loss is related to the improvement in OSA severity, and ILI may play a significant role in this improvement.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Engineering, Biomedical
Xin-Xue Lin, Phone Lin, En-Hau Yeh, Gi-Ren Liu, Wan-Ching Lien, Yuguang Fang
Summary: In this paper, an AI-based framework called RAPIDEST is proposed to detect OSA. The framework only requires EEG signals, simplifying the signal collection process and reducing the complexity of severity determination for apnea and hypopnea.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Torbjorn Omland, Anna Randby, Harald Hrubos-Strom, Helge Rosjo, Gunnar Einvik
AMERICAN JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Julia Brox Skranes, Gunnar Einvik, Silje Kjeka Namtvedt, Anna Randby, Harald Hrubos-Strom, Jon Brynildsen, Tor-Arne Hagve, Virend K. Somers, Helge Rosjo, Torbjorn Omland
BMC CARDIOVASCULAR DISORDERS
(2016)
Article
Clinical Neurology
Maria Pedersen, Mirjam Ekstedt, Milada C. Smastuen, Vegard B. Wyller, Dag Sulheim, Even Fagermoen, Anette Winger, Edvard Pedersen, Harald Hrubos-Strom
JOURNAL OF SLEEP RESEARCH
(2017)
Article
Clinical Neurology
Maria Varendh, Morgan Andersson, Erla Bjornsdottir, Harald Hrubos-Strom, Arne Johannisson, Erna S. Arnardottir, Thorarinn Gislason, Sigurdur Juliusson
JOURNAL OF SLEEP RESEARCH
(2018)
Article
Otorhinolaryngology
Maria Varendh, Arne Johannisson, Harald Hrubos-Strom, Morgan Andersson
Article
Respiratory System
Nina F. Caspersen, Helge Rosjo, Allan Flyvbjerg, Mette Bjerre, Anna Randby, Harald Hrubos-Strom, Torbjorn Omland, Gunnar Einvik
BMC PULMONARY MEDICINE
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Benjamin Gardner, Anders Brostrom, Per Nilsen, Harald Hrubos Strom, Martin Ulander, Bengt Fridlund, Janna Skagerstrom, Peter Johansson
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2014)
Article
Clinical Neurology
Maria Varendh, Morgan Andersson, Erla Bjornsdottir, Erna S. Arnardottir, Thorarinn Gislason, Allan Pack, Harald Hrubos-Strom, Arne Johannisson, Sigurdur Juliusson
JOURNAL OF SLEEP RESEARCH
(2019)
Article
Clinical Neurology
Fjola D. Sigurdardottir, Magnus N. Lyngbakken, Kristian Hveem, Harald Hrubos Strom, Helge Rosjo, Susan Redline, Torbjorn Omland
Summary: Insomnia symptoms are associated with increased risk of heart failure and cardiovascular mortality. However, there is no direct association between insomnia symptoms and subclinical myocardial injury based on biochemical evidence from cTnI levels. Further research is needed to understand the relationship between insomnia symptoms and cardiac biomarkers.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Sport Sciences
Cameron McIntosh, Hege H. Clemm, Nicola Sewry, Harald Hrubos-Strom, Martin P. Schwellnus
Summary: Protecting the respiratory health of athletes is crucial for their overall performance, with nasal conditions potentially impacting their quality of life and athletic abilities. Athletes are more prone to mucosal inflammation in the nose compared to the general population, highlighting the importance of addressing nasal health for improved athlete well-being and sports performance.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2021)
Article
Clinical Neurology
Thorarinn Arnar Olafsson, Eivind Andreas Steinsvik, Gregor Bachmann-Harildstad, Harald Hrubos-Strom
Summary: This study aimed to validate the automatically scored results of an esophageal probe-based polygraph system against manually scored polysomnography results. The ApneaGraph Spiro performed acceptably when OSA was defined by an AHI of 15, although it tended to overestimate mild OSA and underestimate severe OSA compared to polysomnography.
SLEEP AND BREATHING
(2022)
Article
Clinical Neurology
Ilona Merikanto, Yves Dauvilliers, Frances Chung, Brigitte Holzinger, Luigi De Gennaro, Yun Kwok Wing, Maria Korman, Markku Partinen
Summary: This protocol paper outlines the second survey conducted by the International Covid Sleep Study (ICOSS) group, aiming to investigate the associations between SARS-CoV-2 infection and sleep, sleepiness, and circadian problems as potential predisposing factors for more severe COVID-19 and Long-COVID in the general population. The survey will include 47 questions covering various aspects related to sleep, health, and socio-economic status, and will be administered online in multiple countries from May to November 2021. Data collected from the survey will provide valuable insights into COVID-19 risk factors, symptomatology, evolution of Long-COVID, and other long-term consequences of the pandemic.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Fjola D. Sigurdardottir, Caroline Tonje Overby, Sami Nikkonen, Tuomas Karhu, Toril Dammen, Inger Hilde Nordhus, Thea Thorshov, Gunnar Einvik, Samu Kainulainen, Timo Leppanen, Erna Sif Arnardottir, Juha Toyras, Torbjorn Omland, Harald Hrubos-Strom
Summary: This study assessed the association between novel desaturation parameters and elevated cardiac troponin I and T levels. The results showed that these parameters can predict the elevation of cardiac troponin levels.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Purbanka Pahari, Henri Korkalainen, Tuomas Karhu, Marika Rissanen, Erna Sif Arnardottir, Harald Hrubos-Strom, Brett Duce, Juha Toyras, Timo Leppanen, Sami Nikkonen
Summary: Intermittent hypoxaemia related to obstructive sleep apnea (OSA) can increase the risk of OSA comorbidities, such as cardiovascular disease. However, it is unclear whether intermittent hypoxaemia is associated with impaired vigilance. This study aimed to compare the desaturation characteristics between non-impaired vigilance and impaired vigilance patient groups and evaluate the association with traditional OSA severity parameters.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Harald Hrubos-Strom, Joel Bergqvist, Ding Zou
Summary: This article reviews the literature on the management of treatment-resistant OSA and proposes a management plan for this patient group, focusing on reducing cardiovascular risk and relieving symptoms. Future diagnostic trends in OSA and a decision-aid tool are also discussed.
CURRENT SLEEP MEDICINE REPORTS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)