Article
Biochemistry & Molecular Biology
Marta Pelczynska, Aniceta Ada Mikulska, Krystyna Czyzewska, Pawel Bogdanski, Teresa Grzelak
Summary: The study suggests that lower NPQ concentration may be associated with obesity-related metabolic syndrome, while CHEM shows no significant correlations with cardiometabolic risk factors. Total muscle mass has an impact on NPQ concentration in the population.
Article
Endocrinology & Metabolism
Antonietta Maio, Maria Ida Maiorino, Miriam Longo, Lorenzo Scappaticcio, Vlenia Pernice, Paolo Cirillo, Paola Caruso, Vanda Amoresano Paglionico, Giuseppe Bellastella, Katherine Esposito
Summary: The study compared the levels of EPCs and sexual function changes during the menstrual cycle in women with T1DM and healthy women, finding lower EPCs levels and sexual function scores in diabetic women, particularly in the ovulatory phase.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Serap Ozer Yaman, Fulya Balaban Yucesan, Cihan Orem, Birgul Vanizor Kural, Asim Orem
Summary: This study aimed to investigate the circulating levels of endocan in PPL subjects and determine its association with endothelial and inflammatory factors. The results showed that the levels of endocan were significantly higher in PPL subjects and positively correlated with other endothelial and inflammation factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V. Baker, Marta Catalfamo
Summary: This study examines the impact of HIV infection on endothelial inflammation and repair by evaluating cell phenotypes and subsets in the blood of HIV-infected individuals. The researchers found that infection-induced phenotypic changes were associated with inflammatory biomarkers, suggesting that HIV infection may affect endothelial inflammation and repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lin-Zhen Xia, Jun Tao, Yan-Jun Chen, Ling-Li Liang, Gui-fang Luo, Ze-Min Cai, Zuo Wang
Summary: The vascular endothelium plays a crucial role in maintaining normal blood vessel function, with endothelial damage leading to vascular lesions. Endothelial repair process (re-endothelialization) is important in inhibiting neointimal hyperplasia, but is inevitably influenced by promoting and inhibiting factors.
DNA AND CELL BIOLOGY
(2021)
Article
Medicine, General & Internal
Nasser M. Al-Daghri, Kaiser Wani, Hind AlHarthi, Amani Alghamdi, Abdullah M. Alnaami, Sobhy M. Yakout
Summary: The study revealed a gender disparity in circulating NLRP3 levels among Saudi patients, with a positive correlation between circulating NLRP3 levels and the number of MetS components observed in females and influenced primarily by the adiposity and dyslipidemia components of MetS. Longitudinal studies with larger sample sizes and investigation into sex-specific hormones are needed to establish a causal relationship between NLRP3 and MetS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Olga Tura-Ceide, Isabel Blanco, Jessica Garcia-Lucio, Roberto del Pozo, Agustin Roberto Garcia, Elisabet Ferrer, Isabel Crespo, Diego A. Rodriguez-Chiaradia, Carmen Pilar Simeon-Aznar, Manuel Lopez-Meseguer, Clara Martin-Ontiyuelo, Victor I. Peinado, Joan Albert Barbera
Summary: The study found that the levels and ratio of circulating endothelial microvesicles (EMVs) and progenitor cells (PCs) in patients with PAH were altered, and these changes were not restored with PAH therapy. Combined measurement of circulating EMVs and PCs could be a potential biomarker of endothelial dysfunction in PAH.
Article
Neurosciences
Xue Han, Li Zhou, Yu Tu, Jiajia Wei, Jiajia Zhang, Guojun Jiang, Qiaojuan Shi, Huazhong Ying
Summary: The study found that circulating exosome miR-154-5p was upregulated in patients with VaD, and inhibiting miR-154-5p in EPCs improved EPC functions and angiogenesis in VaD rat model. This suggests that miR-154-5p could be a promising biomarker and therapeutic target for VaD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Maria Vazquez-Reza, Antia Custodia, Iria Lopez-Dequidt, Marta Aramburu-Nunez, Daniel Romaus-Sanjurjo, Alberto Ouro, Joao Botelho, Vanessa Machado, Ramon Iglesias-Rey, Juan Manuel Pias-Peleteiro, Rogelio Leira, Juan Blanco, Jose Castillo, Tomas Sobrino, Yago Leira
Summary: This study investigates the relationship between periodontitis and an increased number of circulating endothelial progenitor cells (EPCs) (CD34(+)/CD133(+)/KDR+). The results show that periodontitis patients have a higher concentration of EPCs compared to non-periodontitis patients, and there is a significant increase in EPCs over time in patients with periodontitis. These findings suggest a potential link between periodontitis and endothelial dysfunction.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Clinical Neurology
Ying-Jay Liou, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Po-Hsun Huang, Ya-Mei Bai
Summary: This study found that dysfunction in circulating endothelial progenitor cells (cEPCs) is associated with manic symptom severity and cognitive deficits in patients with bipolar disorder (BPD).
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Min Joo Seon, So Yoon Hwang, Yujeong Son, Juhyun Song, Oh Yoen Kim
Summary: Circulating GLP-1 levels may serve as a potential early indicator of MetS risk in women without diagnosed diseases. The levels of GLP-1 positively correlated with adiposity, HOMA-IR, blood pressure, and hs-CRP, and increased proportionally with the number of MetS risk factors.
Article
Behavioral Sciences
Ying-Jay Liou, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Po-Hsun Huang, Ya-Mei Bai
Summary: This study found that the numbers of cEPCs are associated with clinical symptoms in patients with BPD, and are inversely correlated with the severity of manic and positive symptoms.
BRAIN AND BEHAVIOR
(2022)
Article
Geriatrics & Gerontology
Arunima Kapoor, Aimee Gaubert, Anisa Marshall, Irene B. Meier, Belinda Yew, Jean K. Ho, Anna E. Blanken, Shubir Dutt, Isabel J. Sible, Yanrong Li, Jung Yun Jang, Adam M. Brickman, Kathleen Rodgers, Daniel A. Nation
Summary: The study found that elevated levels of circulating EPCs and VEGF-D are associated with greater cerebral SVD burden in older adults. This suggests that activation of systemic angiogenic growth factors and EPCs may represent an early attempt to rescue the vascular endothelium and repair damage in SVD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Physiology
Zerbu Yasar, Mark D. D. Ross, Christopher J. J. Gaffney, Ruth D. D. Postlethwaite, Russell Wilson, Lawrence D. D. Hayes
Summary: Older adults have reduced levels of CD34 + circulating progenitor cells (CPC), which is a risk factor for cardiovascular disease. This study investigated the effect of age and exercise on CPC levels in aerobically trained adults. The study found that older adults have lower resting CPC counts compared to younger adults, but exercise increased CPC levels in both age groups.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Oncology
Heba Abdel Razik Sayed, Helal F. Hetta, Engy A. Shafik, Asmaa M. Zahran
Summary: The study found that pediatric patients with solid tumors have significantly higher levels of CECs and EPCs at diagnosis and even higher levels after chemotherapy; the increase in CECs levels on day 7 after chemotherapy may be an early predictor of treatment response and outcome.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Cardiac & Cardiovascular Systems
Andrea Cignarella, Gian Paolo Fadini, Chiara Bolego, Lucia Trevisi, Carlotta Boscaro, Viola Sanga, Teresa Maria Seccia, Antonio Rosato, Gian Paolo Rossi, Matthias Barton
Summary: This review discusses the challenges clinicians face in angiogenesis inhibitor therapy, including the need to consider sex differences in clinical efficacy and safety, and proposes future research directions.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mattia Albiero, Marianna D'Anna, Benedetta Maria Bonora, Gaia Zuccolotto, Antonio Rosato, Marco Giorgio, Elisabetta Iori, Angelo Avogaro, Gian Paolo Fadini
Summary: For the first time, this study explores the hematopoietic and nonhematopoietic roles of p66Shc in regulating HSPC traffic and ischemic responses. Hematopoietic deletion of p66Shc is sufficient to rescue HSPC mobilization and homing in diabetes after ischemia and improves blood flow recovery. Inhibiting p66Shc in blood cells may be a novel strategy to counter PAD in diabetes.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Endocrinology & Metabolism
Gian Paolo Fadini, Stefano Del Prato, Angelo Avogaro, Anna Solini
Summary: With the increasing global population aging and prevalence of type 2 diabetes, prevention of diabetic complications remains a major challenge. SGLT2 inhibitors have been proven to reduce DKD progression and improve cardiovascular outcomes, but critical challenges such as channelling bias and database heterogeneity need to be addressed in research studies.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
G. P. Fadini, F. Boscari, D. Falaguasta, S. Ferretto, A. Maran, A. Avogaro, D. Bruttomesso
Summary: In routine care, patients with type 1 diabetes who switched to faster insulin aspart (FIA) experienced a reduction in the time spent in hyperglycemia > 250 mg/dl during daytime and an increase in time in range. These improvements were particularly significant for patients with higher baseline HbA1c levels.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Editorial Material
Endocrinology & Metabolism
Gian Paolo Fadini
Article
Endocrinology & Metabolism
Francesca Mannucci, Giacomo Vitturi, Luca Benacchio, Luca Gino Sbrogio, Francesca Bano, Annunziata Lapolla, Francesco Piarulli, Maria Cecilia Giron, Angelo Avogaro, Gian Paolo Fadini
Summary: Diabetes does not appear to significantly modify the risk of SARS-CoV-2 infection, but it does increase the rates of hospitalization and death. Insulin use is associated with worse outcomes, while metformin use is associated with lower mortality.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Mario Luca Morieri, Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Angelo Avogaro, Gian Paolo Fadini
Summary: This observational study found that managing patients with T2D according to international standards for pharmacological management based on a treat-to-benefit approach was associated with a lower risk of major adverse cardiovascular events, heart failure, and mortality. These results provide ex-post validation of the ADA/EASD treatment algorithm.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Mattia Albiero, Stefano Ciciliot, Anna Rodella, Ludovica Migliozzi, Francesco Ivan Amendolagine, Carlotta Boscaro, Gaia Zuccolotto, Antonio Rosato, Gian Paolo Fadini
Summary: Innate immune cells infiltrate and spread inflammatory signals in growing adipose tissue, leading to glucose intolerance and insulin resistance in distant tissues. Oncostatin M (OSM), a cytokine, is debated for its role in the metabolic consequences of overfeeding. Through this study, it was found that OSM is required during obesity development, as its concentrations are dynamically regulated during a high-fat diet. Osm(-/-) mice showed glucose intolerance, impaired muscle glucose uptake, and worsened liver inflammation and damage, demonstrating the importance of OSM in adapting to overfeeding.
Editorial Material
Cardiac & Cardiovascular Systems
Gian Paolo Fadini, Mario Luca Morieri
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
M. L. Morieri, I. Raz, A. Consoli, M. Rigato, A. Lapolla, F. Broglio, E. Bonora, A. Avogaro, G. P. Fadini
Summary: This study compared the effectiveness of dapagliflozin to DPP-4 inhibitors in achieving individualized HbA1c targets and extra-glycaemic endpoints in elderly patients with type 2 diabetes. The results showed that patients initiating dapagliflozin had a lower likelihood of reaching individualized HbA1c targets compared to those initiating DPP-4 inhibitors. However, they experienced greater improvements in body weight and blood pressure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Gian Paolo Fadini, Cristobal Morales, Irene Caballero, Beatriz Gonzalez, Nikolaos Tentolouris, Agostino Consoli
Summary: This study extends a previous analysis of real-world data in patients with type 2 diabetes initiating dapagliflozin in Italy, Greece, and Spain. The results confirm the efficacy of dapagliflozin in reducing HbA1c in diverse real-world settings, with similar effects across countries and baseline characteristics.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
B. M. Bonora, R. Cappellari, M. Albiero, L. Prevedello, M. Foletto, R. Vettor, A. Avogaro, G. P. Fadini
Summary: This study examined adipose tissue-derived stem cells (ASCs) in individuals with metabolic syndrome traits and found that these cells can enter the systemic circulation and establish ectopic adipose depots, leading to insulin resistance. This phenomenon, previously observed in mice, has been confirmed in humans, highlighting the importance of further investigation.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Mauro Rigato, Gian Paolo Fadini, Angelo Avogaro
Summary: This study aimed to assess the safety of SGLT2 inhibitors (SGLT2is) in elderly patients with type 2 diabetes. A meta-analysis of randomized controlled trials (RCTs) showed that SGLT2is were well tolerated in the elderly, but older patients were underrepresented in clinical trials.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Jonathan Golledge, Shivshankar Thanigaimani, Kristen S. Barratt, Gian Paolo Fadini
Summary: Diabetes is a major risk factor for ischaemic foot disease, which can lead to severe complications such as tissue loss and amputation. Current treatment options focus on revascularisation, but there are limitations in both surgical eligibility and success rates. Recent research in animal models and clinical trials have identified potential novel medical targets for ischaemia, aiming to improve wound healing and enhance blood supply recovery. However, translating these findings to human patients remains challenging due to limitations in clinically relevant animal models. Promising results have been reported in small clinical trials with certain therapies, but further research and larger clinical trials are needed to determine their broader applicability.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Benedetta Maria Bonora, Mario Luca Morieri, Marella Marassi, Roberta Cappellari, Angelo Avogaro, Gian Paolo Fadini
Summary: This study aimed to investigate whether measuring circulating levels of haematopoietic stem/progenitor cells (HSPCs) can improve the prediction of long-term kidney outcomes in individuals with type 2 diabetes. The results showed that HSPC levels are associated with worsening kidney function and can enhance the identification of adverse kidney outcomes in individuals with type 2 diabetes.
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
