Article
Cardiac & Cardiovascular Systems
A. M. Saguner, D. Lunk, M. Mohsen, Sven Knecht, Deniz Akdis, S. Costa, A. Gasperetti, F. Duru, V. A. Rossi, C. B. Brunckhorst
Summary: This study investigated the use of contact-force sensing catheters (CFSC) in endocardial electroanatomical mapping (EAM) to diagnose arrhythmogenic right ventricular cardiomyopathy (ARVC). The results showed that ARVC patients had lower RV voltage amplitudes compared to controls, particularly in the subtricuspid region and RV apex. EAM using CFSC was found to be a promising tool for diagnosing ARVC.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Emergency Medicine
Leen Alblaihed, Christine Kositz, William J. Brady, Tareq Al -Salamah, Amal Mattu
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder of the myocardium that can cause ventricular arrhythmia and sudden cardiac death. Early recognition of the disease by emergency clinicians is crucial to prevent subsequent death, as it is a significant cause of arrhythmic death among young people and athletes. This publication reviews the pathophysiology, classification, clinical presentations, and appropriate approach to diagnosis and management of ARVC.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hubert Delasnerie, Estelle Gandjbakhch, Romain Sauve, Maxime Beneyto, Guillaume Domain, Quentin Voglimacci-Stephanopoli, Franck Mandel, Nicolas Badenco, Xavier Waintraub, Pierre Mondoly, Veronique Fressart, Anne Rollin, Philippe Maury
Summary: This study investigated the correlation between endocardial voltage mapping and the genetic background of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). The presence of scar areas on voltage mapping was significantly associated with ARVC diagnosis and the presence of a pathogenic variant. 3-dimensional endocardial mapping may have an important role in refining ARVC diagnosis and detecting minor forms with insufficient criteria for diagnosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Nadine Molitor, Firat Duru
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease characterized by fibro-fatty replacement of the right ventricle, which can lead to ventricular tachyarrhythmias and sudden cardiac death. Diagnosis is challenging due to its variable expressivity, incomplete penetrance, and lack of specific diagnostic criteria. Other cardiac diseases may mimic the clinical phenotypes of ARVC, leading to misdiagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Paloma Jorda, Laurens P. Bosman, Alessio Gasperetti, Andrea Mazzanti, Jean-Baptiste Gourraud, Brianna Davies, Tanja Charlotte Frederiksen, Zoraida Moreno Weidmann, Andrea Di Marco, Jason D. Roberts, Ciorsti MacIntyre, Colette Seifer, Antoine Deliniere, Wael Alqarawi, Deni Kukavica, Damien Minois, Alessandro Trancuccio, Marine Arnaud, Mattia Targetti, Annamaria Martino, Giada Oliviero, Daniel C. Pipilas, Corrado Carbucicchio, Paolo Compagnucci, Antonio Dello Russo, Iacopo Olivotto, Leonardo Calo, Steven A. Lubitz, Michael J. Cutler, Philippe Chevalier, Elena Arbelo, Silvia Giuliana Priori, Jeffrey S. Healey, Hugh Calkins, Michela Casella, Henrik Kjaerulf Jensen, Claudio Tondo, Rafik Tadros, Cynthia A. James, Andrew D. Krahn, Julia Cadrin-Tourigny
Summary: This study validated a 5-year risk prediction model for ARVC patients, demonstrating its superior performance in guiding ICD implantation decisions compared to other published guidelines and consensus statements. The findings support the use of this model for shared decision making in the primary prevention of SCD in ARVC patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas Rolland, Nicolas Badenco, Carole Maupain, Guillaume Duthoit, Xavier Waintraub, Mikael Laredo, Caroline Himbert, Robert Frank, Francoise Hidden-Lucet, Estelle Gandjbakhch
Summary: The combination of flecainide and beta-blockers is complementary in treating ventricular arrhythmias (VA) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), and it is safe and effective in reducing the burden of premature ventricular contractions and preventing sustained VA.
Article
Cardiac & Cardiovascular Systems
Shehab Anwer, Francesca Guastafierro, Ladina Erhart, Sarah Costa, Deniz Akdis, Manuel Schuermann, Sara Hosseini, Neria E. Winkler, Nazar Kuzo, Alessio Gasperetti, Corinna Brunckhorst, Firat Duru, Ardan M. Saguner, Felix C. Tanner
Summary: This study examines right atrial (RA) deformation in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and its association with cardiovascular (CV) outcomes. The results show that ARVC patients exhibit impaired RA strain, and reservoir and pump strain are associated with an increased risk of CV events.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Bernard Belhassen, Mikael Laredo, Rob W. Roudijk, Giovanni Peretto, Guy Zahavi, Srijita Sen-Chowdhry, Nicolas Badenco, Anneline S. J. M. Te Riele, Simone Sala, Guillaume Duthoit, J. Peter van Tintelen, Gabriele Paglino, Jean-Marc Sellal, Alessio Gasperetti, Elena Arbelo, Antoine Andorin, Sandro Ninni, Anne Rollin, Petr Peichl, Xavier Waintraub, Laurens P. Bosman, Bertrand Pierre, Eyal Nof, Chris Miles, Jacob Tfelt-Hansen, Alexandros Protonotarios, Carla Giustetto, Frederic Sacher, Jean-Sylvain Hermida, Stepan Havranek, Leonardo Calo, Ruben Casado-Arroyo, Giulio Conte, Konstantinos P. Letsas, Esther Zorio, Francisco J. Bermudez-Jimenez, Elijah R. Behr, Roy Beinart, Laurent Fauchier, Josef Kautzner, Philippe Maury, Dominique Lacroix, Vincent Probst, Josep Brugada, Firat Duru, Christian de Chillou, Paolo Della Bella, Estelle Gandjbakhch, Richard Hauer, Anat Milman
Summary: The study found that RBBB-VT accounts for a significant proportion of sustained VTs in ACM patients. Sex and type of pathogenic mutations are associated with VT type, with female sex associated with LBBB + RBBB-VT and DSP mutation associated with RBBB-VT.
Article
Cardiac & Cardiovascular Systems
Remco de Brouwer, Laurens P. Bosman, Sophia Gripenstedt, Arthur A. M. Wilde, Maarten P. van den Berg, J. Peter van Tintelen, Rudolf A. de Boer, Anneline S. J. M. Te Riele
Summary: This study investigates the value of genetic testing in diagnosing arrhythmogenic right ventricular cardiomyopathy (ARVC) and its relation to the occurrence of first malignant ventricular arrhythmia (VA). The results show that ignoring the genetic criterion in the diagnostic criteria causes loss or delay of diagnosis in 10% of ARVC patients, and the occurrence rate of malignant VA is 1%.
Article
Cardiac & Cardiovascular Systems
Karima Addetia, Andrea Mazzanti, Riccardo Maragna, Lorenzo Monti, Megan Yamat, Deni Kukavica, Eleonora Pagan, Kanako Kishiki, Aldo Prado, Maira Marino, Vincenzo Bagnardi, Silvia Priori, Roberto M. Lang
Summary: This study aimed to compare the diagnostic value of 2D echocardiography and 3D echocardiography in arrhythmogenic right ventricular cardiomyopathy (ARVC). The results showed a high concordance between the two approaches, and 3D echocardiography had a unique advantage in detecting right ventricular regional wall-motion abnormalities.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Oyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A. M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. van der Heijden, Harikrishna Tandri, Jan D. H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N. W. Hauer, Hugh Calkins, Anneline S. J. M. te Riele, Cynthia A. James
Summary: We developed a prediction model for incident VA/SCD in ARVC patients using readily available clinical parameters, which accurately distinguished patients with and without events and showed superior clinical benefit compared to current ICD placement algorithms.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Sayed Al-Aidarous, Alexandros Protonotarios, Perry M. Elliott, Pier D. Lambiase
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterized by myocardial fibrofatty replacement due to specific mutations, resulting in ventricular arrhythmias and sudden cardiac death. Treating this condition is challenging due to fibrosis progression, phenotypic variations, and limited clinical trials. While beta-blockers are theoretically effective, their efficacy in reducing arrhythmic risk is not strong. Emerging evidence suggests that combining flecainide and bisoprolol may be effective. Radiofrequency ablation and stereotactic radiotherapy show potential in disrupting ventricular circuits and modifying myocardial fibrosis. Future therapies, such as adenoviruses and GSk3b modulation, are still in early-stage research. Implantable cardioverter-defibrillator implantation reduces arrhythmic death but comes with risks.
Article
Cardiac & Cardiovascular Systems
Tarek Zghaib, Anneline S. J. M. Te Riele, Cynthia A. James, Neda Rastegar, Brittney Murray, Crystal Tichnell, Marc K. Halushka, David A. Bluemke, Harikrishna Tandri, Hugh Calkins, Ihab R. Kamel, Stefan Loy Zimmerman
Summary: Among patients with ARVD/C according to the 2010 Task Force Criteria, CMR evidence for LV abnormalities are seen in half of patients, typically manifesting as fibrofatty infiltration in the subepicardium, and are not associated with arrhythmic outcomes.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Genetics & Heredity
Jia Chen, Yuting Ma, Hong Li, Zhuo Lin, Zhe Yang, Qin Zhang, Feng Wang, Yanping Lin, Zebing Ye, Yubi Lin
Summary: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a condition associated with ventricular arrhythmia, heart failure, and sudden death. Thromboembolism is also a serious complication of ARVC/D. This study identified a Chinese Han family with ARVC/D and characterized their genetic mutations. The LMNA and LAMA4 gene variants were found to be potentially pathogenic and associated with the manifestation of ARVC/D and related symptoms.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Marit Kristine Smedsrud, Monica Chivulescu, Marianne Inngjerdingen Forsa, Isotta Castrini, Eivind Westrum Aabel, Christine Rootwelt-Norberg, Martin Proven Bogsrud, Thor Edvardsen, Nina Eide Hasselberg, Andreas Fruh, Kristina Hermann Haugaa
Summary: The study aimed to investigate the incidence of severe cardiac events in paediatric arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and the ARVC penetrance in paediatric relatives. The results showed a high incidence of severe cardiac events in paediatric ARVC cohort, with half occurring in children aged 12 or below. Additionally, the ARVC penetrance in genotype positive paediatric relatives was 18%.
EUROPEAN HEART JOURNAL
(2022)
Article
Pathology
Katarzyna Michaud, Christina Jacobsen, Cristina Basso, Jytte Banner, Britt M. Blokker, Hans H. de Boer, Fabrice Dedouit, Chris O'Donnell, Carla Giordano, Virginie Magnin, Silke Grabherr, S. Kim Suvarna, Krzysztof Wozniak, Sarah Parsons, Allard C. van der Wal
Summary: Postmortem imaging (PMI) is an increasingly used alternative to conventional autopsies, particularly in sudden cardiac deaths (SCD). However, PMI has limitations when compared to clinical imaging, which impacts the diagnosis of myocardial injuries, coronary occlusion, and other SCD-related cardiac lesions. Emerging minimally invasive techniques in PMI show promising results and require further investigation. The field of postmortem imaging is rapidly developing and will require detailed knowledge of both radiology and pathology for the diagnosis of sudden death due to cardiovascular diseases.
Review
Pathology
Joseph J. J. Maleszewski, Cristina Basso, Allen Burke, Mathieu Castonguay, Charles Leduc, Fabio Tavora, Mary Sheppard, Rakesh Suri, Meagan Judge, Wendy A. A. Cooper
Summary: The International Collaboration on Cancer Reporting (ICCR) was established to develop internationally standardized datasets for pathologists' reporting of cancer, aiming to improve cancer patient outcomes worldwide and advance international benchmarking in cancer management. The ICCR datasets are aligned with the revisions of the WHO Classification of Tumours and are regularly updated. The dataset for neoplasms of the heart, pericardium, and great vessels has been revised to align with the 2021 WHO Blue Book series.
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Marrone, Cristina Basso, Gaetano Thiene
EUROPEAN HEART JOURNAL
(2023)
Biographical-Item
Cardiac & Cardiovascular Systems
Gaetano Thiene, Gianfranco Buja, Barbara Bauce, Domenico Corrado, Cristina Basso, Jeffrey Saffitz
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Patrizio Sarto, Alessandro Zorzi, Laura Merlo, Teresina Vessella, Cinzia Pegoraro, Flaviano Giorgiano, Francesca Graziano, Cristina Basso, Jonathan A. Drezner, Domenico Corrado
Summary: This study aimed to report the long-term findings of the Italian programme of cardiovascular preparticipation screening (PPS) in young, competitive athletes. The study assessed the diagnostic yield for diseases at risk of sudden cardiac death (SCD), the costs of serial evaluations, and the long-term outcomes of PPS in a large population of Italian children. Over an 11-year study period, 69 children (0.3%) were identified with cardiovascular diseases at risk of SCD, and one child with normal PPS findings experienced an episode of resuscitated cardiac arrest during sports activity.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Domenico Corrado, Alessandro Zorzi, Alberto Cipriani, Barbara Bauce, Riccardo Bariani, Giulia Brunetti, Francesca Graziano, Manuel De Lazzari, Giulia Mattesi, Federico Migliore, Kalliopi Pilichou, Ilaria Rigato, Stefania Rizzo, Gaetano Thiene, Martina Perazzolo Marra, Cristina Basso
Summary: The term 'arrhythmogenic cardiomyopathy' now includes both right ventricular (ARVC) and left ventricular (LV) involvement, with different phenotypic variants. The disease is characterized by the loss of myocardium and the formation of scar tissue, leading to lethal ventricular arrhythmias and impaired ventricular function. The new 'Padua criteria' incorporate cardiac magnetic resonance imaging findings to improve the diagnosis of S/ACM. Risk stratification and treatment mainly focus on arrhythmic burden and ventricular dysfunction, with implantable cardioverter defibrillator being the most effective life-saving therapy.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Monica De Gaspari, Stefania Rizzo, Gaetano Thiene, Cristina Basso
Summary: Sudden cardiac death (SCD) can be caused by either mechanical or electrical factors. Mechanical causes include pulmonary thromboembolism and cardiac tamponade, while electrical causes include primary electrical diseases and cardiomyopathies in young people, and coronary atherosclerosis and degenerative valve diseases in adult-elderly populations. It is important to differentiate these causes as treatment options vary based on the underlying rhythm.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Neurosciences
Aron Emmi, Stefania Rizzo, Luisa Barzon, Michele Sandre, Elisa Carturan, Alessandro Sinigaglia, Silvia Riccetti, Mila Della Barbera, Rafael Boscolo-Berto, Patrizia Cocco, Veronica Macchi, Angelo Antonini, Monica De Gaspari, Cristina Basso, Raffaele De Caro, Andrea Porzionato
Summary: Neurological manifestations are common in COVID-19 patients, and this study found evidence of SARS-CoV-2 infection in the central nervous system. The researchers observed viral RNA and SARS-CoV-2-immunoreactive neurons in specific regions of the brain in COVID-19 patients. In addition, inflammation was observed in affected brainstem regions, indicating a role of brainstem inflammation in COVID-19. Further investigations are needed to understand the potential implications for neurodegenerative diseases like Parkinson's.
NPJ PARKINSONS DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Andrea Silvio Giordani, Anna Baritussio, Cristina Vicenzetto, Maria Grazia Peloso-Cattini, Elena Pontara, Elisa Bison, Chiara Fraccaro, Cristina Basso, Sabino Iliceto, Renzo Marcolongo, Alida Linda Patrizia Caforio
Summary: Fulminant myocarditis is not a distinct form of myocarditis but rather a unique clinical presentation. The definition of fulminant myocarditis has been inconsistent over the past 20 years, leading to conflicting reports on prognosis and treatment strategies due to variations in inclusion criteria. This review highlights the importance of diagnosing and treating fulminant myocarditis based on its histotypes and underlying causes through endomyocardial biopsy. Management should include short-term interventions such as mechanical circulatory support, inotropic and antiarrhythmic treatment, as well as long-term follow-up due to recent findings suggesting a worsened prognosis.
EUROPEAN CARDIOLOGY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Elena Arbelo, Alexandros Protonotarios, Juan R. Gimeno, Eloisa Arbustini, Roberto Barriales-Villa, Cristina Basso, Connie R. Bezzina, Elena Biagini, Nico A. Blom, Rudolf A. de Boer, Tim De Winter, Perry M. Elliott, Marcus Flather, Pablo Garcia-Pavia, Kristina H. Haugaa, Jodie Ingles, Ruxandra Oana Jurcut, Sabine Klaassen, Giuseppe Limongelli, Bart Loeys, Jens Mogensen, Iacopo Olivotto, Antonis Pantazis, Sanjay Sharma, J. Peter Van Tintelen, James S. Ware, Juan Pablo Kaski
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Gaetano Thiene, Cristina Basso, Kalliopi Pilichou, Maria Bueno Marinas
Summary: Arrhythmogenic cardiomyopathy (AC) is a genetically determined desmosomal disease, which was discovered in a four-generation family in 1728. At the University of Padua, further research on AC was conducted, leading to the identification of specific diagnostic methods and the discovery of the genes responsible for the disease. The advancements in knowledge have also resulted in the prevention of sudden cardiac death and the identification of asymptomatic carriers through genetic screening.
Article
Cardiac & Cardiovascular Systems
Giovanni Peretto, Giacomo De Luca, Andrea Villatore, Chiara Di Resta, Simone Sala, Anna Palmisano, Davide Vignale, Corrado Campochiaro, Davide Lazzeroni, Monica De Gaspari, Stefania Rizzo, Elena Busnardo, Paola Ferro, Luigi Gianolli, Cristina Basso, Lorenzo Dagna, Antonio Esposito, Sara Benedetti, Paolo Della Bella
Summary: This article presents a clinical report on the overlap between myocarditis and genetic cardiomyopathies. Through extensive baseline characterization and prospective reassessment of 25 patients, the authors demonstrated that multimodal imaging can distinguish specific genotypes and identify myocardial inflammation. Additionally, they showed that immunomodulatory therapy was beneficial for most patients.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Peretto, Michela Casella, Marco Merlo, Sara Benedetti, Stefania Rizzo, Chiara Cappelletto, Chiara Di Resta, Paolo Compagnucci, Monica De Gaspari, Antonio Dello Russo, Giorgio Casari, Cristina Basso, Simone Sala, Gianfranco Sinagra, Paolo Della Bella, Leslie T. Cooper Jr
Summary: This study aimed to investigate the prognostic value of genetic testing and histology in a cohort of patients with undefined left ventricular arrhythmogenic cardiomyopathy (ULVACM). The study found that malignant ventricular arrhythmias and active myocardial inflammation were closely associated with the occurrence of major adverse cardiovascular events (MACE). Furthermore, immunosuppressive therapy was found to be negatively associated with MACE at 60 months.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michela Casella, Alessio Gasperetti, Paolo Compagnucci, Maria Lucia Narducci, Gemma Pelargonio, Valentina Catto, Corrado Carbucicchio, Gianluigi Bencardino, Edoardo Conte, Nicolo Schicchi, Daniele Andreini, Gianluca Pontone, Andrea Giovagnoni, Stefania Rizzo, Frediano Inzani, Cristina Basso, Andrea Natale, Claudio Tondo, Antonio Dello Russo, Filippo Crea
Summary: This study aims to characterize and compare clinical and electrophysiological characteristics of different biopsy-proven LM phases. The study found that different phases of LM are characterized by diverse clinical, morphological, and electrophysiological features. Further research is required to identify electroanatomical markers of inflammation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Letter
Medicine, General & Internal
Andreas Schuster, Sebastian Kelle
Summary: In the review article on myocarditis by Basso, the author suggests invasive coronary angiography for diagnostic workup in patients with suspected myocarditis to rule out underlying coronary artery disease. However, strong evidence suggests that noninvasive coronary computed tomographic angiography has similar diagnostic accuracy and lower incidence of adverse events compared to invasive coronary angiography. In fact, recent guidelines on chest pain management and prevention of sudden cardiac death recommend coronary computed tomographic angiography as a class I indication.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
