4.4 Article

Comparison of 600 Versus 300-mg Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Coronary Angioplasty

Journal

AMERICAN JOURNAL OF CARDIOLOGY
Volume 106, Issue 9, Pages 1208-1211

Publisher

EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2010.06.044

Keywords

-

Funding

  1. Meijer Lavino Foundation for Cardiovascular Research Aalst Belgium

Ask authors/readers for more resources

The aim of the present study was to compare 600- and 300-mg clopidogrel loading doses in patients with ST-segment elevation myocardial infarctions who underwent primary percutaneous coronary intervention (PCI) Two hundred fifty-five consecutive patients presenting with ST-segment elevation myocardial infarctions who underwent primary PCI were enrolled Patients were divided into 2 groups on the basis of the loading dose of clopidogrel received before the procedure (600 vs 300 mg) Procedural angiographic end points and 1-year major adverse cardiac events were compared between the 2 groups Major adverse cardiac events were defined as death, nonfatal myocardial infarction, and target vessel revascularization There were no significant differences in baseline clinical and angiographic features between the 2 groups 157 (62%) m the clopidogrel 600 mg group and 98 (38%) m the 300 mg group Patients receiving 600-mg loading dose of clopidogrel showed a significantly lower incidence of post-PCI myocardial blush grade 0 or 1 (odds ratio 0 64, 95% confidence interval 0 43 to 0 96, p = 0 03) and significantly less common no-reflow phenomenon (odds m 0 38, 95% confidence interval 0 15 to 098, p = 0 04) compared to those in the 300-mg g) up Propensity-adjusted Cox analysis showed significantly higher survival free of major adverse cardiac events in patients receiving 600-mg loading dose of clopidogrel compared to those receiving the lower dose (hazard ratio 0 57, 95% confidence interval 0 33 to 0 98, p = 0 04) In conclusion, a 600-mg loading dose of clopidogrel is associated with improvements m procedural angiographic end points and 1-year clinical outcomes m patients with ST-segment elevation myocardial infarction who undergo primary PCI compared to a 300-mg dose (C) 2010 Elsevier Inc All rights reserved (Am J Cardiol 2010,106 1208-1211)

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Cardiac & Cardiovascular Systems

Predictive value of post-percutaneous coronary intervention fractional flow reserve: a systematic review and meta-analysis

Birgitte Krogsgaard Andersen, Daixin Ding, Lone Juul Hune Mogensen, Shengxian Tu, Niels Ramsing Holm, Jelmer Westra, William Wijns

Summary: This systematic review and study-level meta-analysis investigated the relationship between post-PCI FFR and the rate of major adverse cardiac events (MACE) including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). The results showed no clear continuous association between post-PCI FFR and clinical outcomes, but in studies comparing high vs. low post-PCI FFR, high FFR was associated with better clinical outcomes.

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES (2023)

Article Cardiac & Cardiovascular Systems

Electrocardiographic and echocardiographic predictors of greater carotid intima-media thickness in tactical athletes: The CHIEF atherosclerosis study

Yen-Po Lin, Yi-Chiung Hsu, Kun-Zhe Tsai, Wei-Chun Huang, Chih-Lu Han, Gen-Min Lin

Summary: This study found differences in the associations between electrocardiographic and echocardiographic left ventricular hypertrophy (LVH) with carotid intima-media thickness (cIMT) in physically fit young adults. Higher physical fitness may cause cardiac muscle hypertrophy and reduce the severity of atherosclerosis, leading to this paradoxical echocardiographic finding.

ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (2023)

Article Cardiac & Cardiovascular Systems

Diagnostic performance of angiography-derived fractional flow reserve in patients with NSTEMI

Ioannis Skalidis, David Meier, Bernard De Bruyne, Carlos Collet, Jeroen Sonck, Thabo Mahendiran, David Rotzinger, Salah Dine Qanadli, Eric Eeckhout, Olivier Muller, Stephane Fournier

Summary: Noninvasive methods of estimating invasively measured fractional flow reserve (FFRinvasive) are actively being explored, aiming to avoid invasive procedures and drugs. This study evaluates the diagnostic performance of coronary angiography-derived FFR (FFRangio) in NSTEMI patients, demonstrating its sensitivity, specificity, and accuracy. FFRangio can precisely estimate FFRinvasive in NSTEMI patients and guide treatment decisions for coronary artery lesions without invasive procedures or drugs.

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2023)

Article Cardiac & Cardiovascular Systems

Comparison of the prognostic value of impaired stress myocardial blood flow, myocardial flow reserve, and myocardial flow capacity on low-dose Rubidium-82 SiPM PET/CT

Matthieu Dietz, Christel H. Kamani, Gilles Allenbach, Vladimir Rubimbura, Stephane Fournier, Vincent Dunet, Giorgio Treglia, Marie Nicod Lalonde, Niklaus Schaefer, Eric Eeckhout, Olivier Muller, John O. Prior

Summary: Using low-dose silicon photomultipliers (SiPM) technology with Rb-82 cardiac PET/CT, impaired global stress MBF, global MFR, and regional MFC were found to be powerful predictors of major adverse cardiovascular events (MACE), outperforming traditional risk factors. However, only reduced global stress MBF independently predicted MACE.

JOURNAL OF NUCLEAR CARDIOLOGY (2023)

Article Cardiac & Cardiovascular Systems

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Roxane de La Harpe, Christian W. Thorball, Claire Redin, Stephane Fournier, Olivier Mueller, Davide Strambo, Patrik Michel, Peter Vollenweider, Pedro Marques-Vidal, Jacques Fellay, Julien Vaucher

Summary: This study aimed to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores. The results showed that combining a polygenic risk score with clinical risk scores significantly improved risk reclassification for patients with intermediate risk for cardiovascular disease.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2023)

Article Endocrinology & Metabolism

Hepatic and Systemic Inflammation for Left Ventricular Mass in Physically Fit Adults: CHIEF Heart Study

Yi-Ting Chou, Kai-Wen Chen, Pang-Yen Liu, Kun-Zhe Tsai, Yen-Po Lin, Gen-Min Lin

Summary: This study found that in physically active young males, hepatic inflammation was associated with a higher risk of left ventricular hypertrophy (LVH) compared to low-grade systemic inflammation.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2023)

Article Cardiac & Cardiovascular Systems

Deep learning-based prediction of future myocardial infarction using invasive coronary angiography: a feasibility study

Thabo Mahendiran, Dorina Thanou, Ortal Senouf, David Meier, Nicolas Dayer, Fahrang Aminfar, Denise Auberson, Omar Raita, Pascal Frossard, Mattia Pagnoni, Stephane Cook, Bernard De Bruyne, Olivier Muller, Emmanuel Abbe, Stephane Fournier

Summary: This study compared the ability of humans, angiographic parameters, and deep learning to predict the lesion responsible for future myocardial infarction. The results showed that deep learning outperformed other parameters and human visual assessment in predicting future culprit lesions.

OPEN HEART (2023)

Editorial Material Cardiac & Cardiovascular Systems

High-Intensity Lipid-Lowering Therapies: An Opportunity for Improving Cardiovascular Outcomes in Postmenopausal Women?

Martine Gilard, William Wijns

CIRCULATION-CARDIOVASCULAR IMAGING (2023)

Editorial Material Cardiac & Cardiovascular Systems

The POT-PUFF sign: an angiographic mark of stent malapposition during proximal optimisation

Farhang Aminfar, Vladimir Rubimbura, Luc Maillard, Stephane Noble, Gregoire Range, Loic Belle, Francois Derimay, Anne Bellemain-Appaix, Alexis Al Karaky, Jean-Francois Morelle, Georgios Sideris, Pascal Motreff, Olivier Muller, Julien Adjedj

EUROINTERVENTION (2023)

Article Physiology

Estimated power output for a distance run and maximal oxygen uptake in young adults

Gen-Min Lin, Kun-Zhe Tsai, Xuemei Sui, Carl J. Lavie

Summary: This study examined the correlations between time and estimated power output (EPO) for a run field test and VO2 max obtained from cardiopulmonary exercise testing (CPET). The results showed that EPO had a stronger correlation with VO2 max compared to time.

FRONTIERS IN PHYSIOLOGY (2023)

Article Endocrinology & Metabolism

Insulin Resistance Indices and Carotid Intima-media Thickness in Physically Fit Adults: CHIEF Atherosclerosis Study

Yen-Po Lin, Yi-Chiung Hsu, Kun-Zhe Tsai, Younghoon Kwon, Gen-Min Lin

Summary: This study aimed to examine the associations between various non-insulin-based insulin resistance indices and subclinical atherosclerosis assessed by carotid intima-media thickness in young adults. The findings suggest that serum triglycerides and related indices are positively associated with carotid intima-media thickness in overweight/obese individuals and those without hyperuricemia.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2023)

Article Cardiac & Cardiovascular Systems

Clinical outcomes in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary interventions later than 48 h after symptom onset

Miklos Rohla, Fabrice Temperli, George C. M. Siontis, Roland Klingenberg, Baris Gencer, Nicolas Rodondi, Sarah Bar, David Nanchen, Francois Mach, Jonas D. Haner, Thomas Pilgrim, Olivier Muller, Christian M. Matter, Thomas Luscher, Marco Roffi, Dik Heg, Stephan Windecker, Lorenz Raber

Summary: This study compared the outcomes of STEMI patients undergoing PCI according to total ischemic time. The results showed that PCI performed within 12 hours of symptom onset had better outcomes, while PCI performed later than 12 hours was associated with higher mortality and target lesion failure rates. However, there was no significant difference in outcomes between PCI performed later than 48 hours and PCI performed between 12-48 hours.

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE (2023)

Editorial Material Cardiac & Cardiovascular Systems

Editorial: Insights in cardiovascular epidemiology and prevention: 2022

Gen-Min Lin

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

Article Cardiac & Cardiovascular Systems

Integrated Assessment of Computational Coronary Physiology From a Single Angiographic View in Patients Undergoing TAVI

Simone Fezzi, Daixin Ding, Roberto Scarsini, Jiayue Huang, Paolo Alberto Del Sole, Qiang Zhao, Gabriele Pesarini, Andrew Simpkin, William Wijns, Flavio Ribichini, Shengxian Tu

Summary: This study demonstrated that angiography-derived physiology can provide a reliable assessment of coronary circulation in patients with severe aortic stenosis, showing good accuracy in predicting FFR and stable evaluation results.

CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2023)

Article Cardiac & Cardiovascular Systems

Validation of a multiple-lead smartphone-based electrocardiograph with automated lead placement for layman use in patients with hypertrophic cardiomyopathy

Niccolo Maurizi, Carlo Fumagalli, Ioannis Skalidis, Jacopo F. Imberti, Alessandro Faragli, Mattia Targetti, Henri Lu, Pierre Monney, Olivier Muller, Niccolo Marchionni, Franco Cecchi, Iacopo Olivotto

Summary: This study validated the accuracy of the D-Heart ECG device, a smartphone 8/12-Lead electrocardiograph with an image processing algorithm, for diagnosing ECG abnormalities in patients with hypertrophic cardiomyopathy. The results showed that the D-Heart ECG device had high accuracy and concordance with standard 12-Lead ECG, and the image processing algorithm provided accurate electrode placement, standardizing the quality of the examination.

JOURNAL OF ELECTROCARDIOLOGY (2023)

Editorial Material Cardiac & Cardiovascular Systems

Toward Optimizing Antiplatelet Therapy for Patients at High Bleeding Risk

Jose E. Exaire, Timothy A. Mixon

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Influence of the Type of Disability and Sporting Discipline on Lipid Profile in a Cohort of Italian Paralympic Athletes

Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia

Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Can GRACE Risk Score Predict Mortality and the Need for Thrombolytic Treatment in Acute Pulmonary Embolism?

Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan

Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Echocardiography Versus Magnetic Resonance Imaging Quantification and Novel Algorithm for Isolated Severe Tricuspid Regurgitation

Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai

Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Editorial Material Cardiac & Cardiovascular Systems

Social Vulnerability and Hemopericardial Cardiovascular Death: Insight from the Centers for Disease Control and Prevention Databases

Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Coronary Angiography and Chronic Total Occlusion Angioplasty in a Patient With Situs Inversus from the Right Radial Approach

Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg

Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Editorial Material Cardiac & Cardiovascular Systems

Major Adverse Cardiac Events After Fractional Flow Reserve, Instantaneous Wave-Free Ratio, or Angiography-Guided Revascularization in Atrial Fibrillation: A Retrospective Study

Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Pericardial Adipose Tissue Thrombospondin-1 Associates With Antiangiogenesis in Ischemic Heart Disease

Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce

Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Evaluation of MADIT-II Risk Stratification Score Among Nationwide Registry of Heart Failure Patients With Primary Prevention Implantable Cardiac Defibrillators or Resynchronization Therapy Devices

Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson

Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Electromechanical Window and Spontaneous Ventricular Tachyarrhythmias in Takotsubo Syndrome

Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin

Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Socioclinical Phenotyping in Patients With Atherosclerotic Cardiovascular Disease: A Latent Class Analysis

Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir

Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Pericardiocentesis Outcomes in Patients With Pulmonary Hypertension: A Nationwide Analysis from the United States

Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis

Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Echocardiographic Characteristics of Left and Right Ventricular Longitudinal Function in Patients With a History of Cardiac Surgery

Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota

Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Understanding the Burden of 30-Day Readmission in Patients With Both Primary and Secondary Diagnoses of Heart Failure: Causes, Timing, and Impact of Co-Morbidities

Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai

Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.

AMERICAN JOURNAL OF CARDIOLOGY (2024)

Article Cardiac & Cardiovascular Systems

Reversed Septal Curvature Is Associated With Nonsustained Ventricular Tachycardia in Hypertrophic

Ya He, Jianzhong Zhou

Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.

AMERICAN JOURNAL OF CARDIOLOGY (2024)