Article
Medicine, General & Internal
Ying-Ching Huang, Hsiao-Huang Chang, Po-Lin Chen, Chi-Ming Chu, Jen-Chen Tsai, Kwua-Yun Wang
Summary: This study investigated the correlation between preoperative NT-pro-BNP levels and outcomes in older adults undergoing TAVR. Results showed that higher NT-pro-BNP levels (> 4853 ng/L) were associated with worse postoperative outcomes and 1-year mortality.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Seong Chan Gong, Hoon Ryu, Ji Young Jang
Summary: Our study showed that postoperative Delta Neutrophil Index (DNI) can serve as an essential early predictive biomarker for complications after esophagectomy, with DNI on postoperative day 2 being significantly associated with increased risk of complications.
Article
Surgery
Giovanni Scotton, Antonio La Greca, Chiara Lirusso, Diego Mariani, Mauro Zago, Massimo Chiarugi, Dario Tartaglia, Nicolo de Manzini, Alan Biloslavo
Summary: This study validated the predictive value of the American College of Surgeons NSQIP surgical risk calculator in the Italian emergency setting. The calculator was found to be a reliable predictor of adverse postoperative outcomes, specifically mortality. Therefore, the use of the surgical risk calculator is recommended in the multidisciplinary care of patients undergoing emergency abdominal surgery.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Medicine, General & Internal
Pang-Yen Liu, Chin Lin, Chin-Sheng Lin, Wen-Hui Fang, Chia-Cheng Lee, Chih-Hung Wang, Dung-Jang Tsai
Summary: The study aimed to develop an AI-ECG system to predict BNP/pBNP values in patients with cardiovascular diseases (CVDs) and compare their values for future mortality. The results showed that the AI-ECG accurately predicted BNP/pBNP values, and pBNP was a better predictor of future mortality.
Review
Cardiac & Cardiovascular Systems
Pamela Nogueira Cavalcante, Gabriel Kanhouche, Vitor Emer Egypto Rosa, Carlos M. Campos, Mariana Pezzute Lopes, Maria Antonieta Albanez A. de M. Lopes, Roney Orismar Sampaio, Fabio Sandoli de Brito Jr, Flavio Tarasoutchi, Alexandre Antonio Cunha Abizaid
Summary: B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro BNP) are cardiac biomarkers released in response to increased ventricular and atrial wall stress. Studies have shown that elevated levels of these biomarkers are correlated with the severity of aortic stenosis (AS) and can predict the need for intervention. They play a crucial role in risk stratification and predicting cardiovascular outcomes of patients with severe AS. This paper aims to summarize the evidence of the role of BNP and NT-pro BNP in AS, before and after intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Urology & Nephrology
Takaya Sasaki, Emi Oishi, Takuya Nagata, Satoko Sakata, Sanmei Chen, Yoshihiko Furuta, Takanori Honda, Daigo Yoshida, Jun Hata, Nobuo Tsuboi, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya
Summary: The study found that higher serum NT-proBNP levels were associated with increased risks of developing chronic kidney disease (CKD) and a more rapid decline in estimated glomerular filtration rate (eGFR). In the general Japanese population, serum NT-proBNP could serve as a useful biomarker for assessing the future risk of CKD.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Peripheral Vascular Disease
Charles D. Nicoli, Timothy B. Plante, D. Leann Long, Suzanne E. Judd, Leslie A. McClure, Pankaj Arora, Mary Cushman
Summary: The REGARDS study found that NT-proBNP was not associated with incident hypertension, with consistent results across different demographic groups.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Arom Choi, Incheol Park, Hye Sun Lee, Jinseok Chung, Min Joung Kim, Yoo Seok Park
Summary: This study developed a novel prognostic nomogram using qSOFA score and mean platelet volume to predict 28-day mortality and serious medical complications in cancer patients with febrile neutropenia. The nomogram showed good discrimination and provides rapid patient evaluation, especially applicable in the emergency department.
ANNALS OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hsin-Chia Lin, Shu-Chien Huang, Mei-Hwan Wu, Jou-Kou Wang, Ming-Tai Lin, Chun-An Chen, Chun-Wei Lu, Yih-Sharng Chen, Shuenn-Nan Chiu
Summary: The role of preoperative N-terminal pro-brain natriuretic peptide level in patient outcomes after the Fontan operation was investigated in this study. The results showed that high preoperative N-terminal pro-brain natriuretic peptide was associated with poor outcomes after the operation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Caitlin Sok, Sameer Sandhu, Hardik Shah, Pranay S. Ajay, Maria C. Russell, Kenneth Cardona, Felipe Maegawa, Shishir K. Maithel, Juan Sarmiento, Subir Goyal, David A. Kooby, Mihir M. Shah
Summary: The study aimed to identify features on preoperative CT imaging that correlate with an increased risk of postoperative pancreatic fistula (POPF). The results showed that patients with a thick pancreatic neck and increased intra-abdominal girth have a heightened risk of CR-POPF after pancreatoduodenectomy, and they experience more serious postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Rheumatology
Karim Sacre, Evelyne Vinet, Christian A. Pineau, Arielle Mendel, Fares Kalache, Louis-Pierre Grenier, Thao Huynh, Sasha Bernatsky
Summary: NT-proBNP is associated with cardiovascular damage in SLE patients and could serve as a biomarker for cardiovascular damage. NT-proBNP levels are associated with hypertension, dyslipidemia, age, smoking history, reduced eGFR, prior pericarditis/pleuritis, and aPL antibodies.
Article
Cardiac & Cardiovascular Systems
Stefanie Reynen, Michael Schlossbauer, Ute Hubauer, Julian Hupf, Arno Mohr, Evelyn Orso, Markus Zimmermann, Andreas Luchner, Lars S. Maier, Stefan Wallner, Carsten G. Jungbauer
Summary: This study found that urinary NT-proBNP provides significant predictive value in patients with acute chest pain and ACS, with a strong positive correlation with plasma NT-proBNP. Additionally, both urinary and plasma NT-proBNP were significant predictors for mortality and major adverse cardiac events in the entire study cohort and ACS subgroup.
Article
Cardiac & Cardiovascular Systems
James L. Januzzi, Xi Tan, Lingfeng Yang, Joanne E. Brady, Mei Yang, Puja Banka, Dominik Lautsch
Summary: The study found that NT-proBNP testing was not frequently performed in patients with heart failure with reduced ejection fraction (HFrEF) in US clinical practice, and the concentrations varied across different data sources and subgroups within HFrEF.
Article
Cardiac & Cardiovascular Systems
Farnaz Khatami, Taulant Muka, Dion Groothof, Martin H. de Borst, Chepkoech Buttia, Gaston van Hassel, Iris Baumgartner, Daan Kremer, Stephan J. L. Bakker, Arjola Bano, Michele F. Eisenga
Summary: The study found that iron biomarkers marginally explain sex differences in levels of NT-proBNP, with ferritin and hepcidin playing a larger role in this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Geriatrics & Gerontology
Julius M. Nagaratnam, Sifat Sharmin, Aaron Diker, Wen Kwang Lim, Andrea B. Maier
Summary: The study found that MMSE scores decline with age, especially between the ages of 84 and 105.
CLINICAL GERONTOLOGIST
(2022)
Correction
Biochemistry & Molecular Biology
Judy Savige, Helen Storey, Elizabeth Watson, Jens Michael Hertz, Constantinos Deltas, Alessandra Renieri, Francesca Mari, Pascale Hilbert, Pavlina Plevova, Peter Byers, Agne Cerkauskaite, Martin Gregory, Rimante Cerkauskiene, Danica Galesic Ljubanovic, Francesca Becherucci, Carmela Errichiello, Laura Massella, Valeria Aiello, Rachel Lennon, Louise Hopkinson, Ania Koziell, Adrian Lungu, Hansjorg Martin Rothe, Julia Hoefele, Miriam Zacchia, Tamara Nikuseva Martic, Asheeta Gupta, Albertien van Eerde, Susie Gear, Samuela Landini, Viviana Palazzo, Laith al-Rabadi, Kathleen Claes, Anniek Corveleyn, Evelien Van Hoof, Micheel van Geel, Maggie Williams, Emma Ashton, Hendica Belge, Elisabeth Ars, Agnieszka Bierzynska, Concetta Gangemi, Beata S. Lipska-Zietkiewicz
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Correction
Immunology
Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Anesthesiology
Tim G. Coulson, Lachlan F. Miles, Alex Zarbock, Louise M. Burrell, Sheila K. Patel, Thilo von Groote, David Pilcher, Laurence Weinberg, Giovanni Landoni, Rinaldo Bellomo
Summary: Compared with norepinephrine, angiotensin II infusion can suppress renin release while maintaining aldosterone levels, providing a potential treatment for vasoplegia after cardiac surgery. Plasma renin concentration before surgery is associated with vasopressor requirement for norepinephrine but not angiotensin II.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Genetics & Heredity
Gefei Yang, Heather Mack, Philip Harraka, Deb Colville, Judy Savige
Summary: This study examined the tubulopathy-causing genes and found that some genes were associated with ocular features. Ocular abnormalities, including structural features, refractive errors, crystal deposition, and sclerochoroidal calcification, were more common in the genes affected in proximal tubulopathies. The study suggests that ocular features may help recognize genetic diseases, and early identification is important to monitor and treat visual complications.
OPHTHALMIC GENETICS
(2023)
Review
Genetics & Heredity
Kieran Gooley, Peter Williams, Heather Mack, Victor Zhu, David Langsford, Tim Pianta, David Barit, Khalid Mahmood, Judy Savige
Summary: This study describes the ocular features in an individual with a homozygous LAMB2 pathogenic variant and compares the reported abnormalities in Pierson syndrome with those in Alport syndrome. The findings suggest that mutations in LAMB2 and COL4A5 have similar effects on basement membranes and the pathogenesis of ocular damage.
OPHTHALMIC GENETICS
(2023)
Review
Pediatrics
Omar Salehi, Heather Mack, Deb Colville, Debbie Lewis, Judy Savige
Summary: This study reviewed the ocular associations of renal ciliopathies, a common cause of kidney failure in children and adults. Genes affected in renal ciliopathies were identified and their ocular expression and phenotype were examined. It was found that most pediatric-onset renal ciliopathies have ocular manifestations, but ocular abnormalities are uncommon in adult-onset cystic kidney diseases.
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
Victor Zhu, Tess Huang, David Wang, Deb Colville, Heather Mack, Judy Savige
Summary: This study examined FSGS-associated genes for ocular abnormalities and found that a significant proportion of these genes are associated with ocular features in human disease or in animal models. The presence of ocular manifestations suggests a genetic basis for FSGS and can help identify the affected gene. Ocular abnormalities require early evaluation and sometimes treatment to prevent visual loss, and the patient should also be examined for other syndromic features.
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
James Virth, Heather G. Mack, Deb Colville, Emma Crockett, Judy Savige
Summary: Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects worldwide, which can lead to kidney failure in children. This study investigated the ocular features associated with CAKUT-associated genes and found that a significant number of these genes also have ocular abnormalities. These findings suggest a genetic basis for both CAKUT and ocular anomalies in affected individuals.
PEDIATRIC NEPHROLOGY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Sheila K. Patel, Carolina Restrepo, Mohamed Khlif, Emilio Werden, Jay Ramchand, Piyush M. Srivastava, Richard J. MacIsaac, Elif I. Ekinci, Louise M. Burrell, Amy Brodtmann
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nicholas Alexander Doumtsis, Sheila Patel, Jay Ramchand, Ken Lu, Piyush Srivastava, Louise Burrell
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Lebo F. Gafane-Matemane, Louise M. Burrell, Sheila K. Patel, Ruan Kruger, Aletta E. Schutte
JOURNAL OF HYPERTENSION
(2023)
Article
Chemistry, Analytical
John A. Adegoke, Callum Gassner, Varun J. Sharma, Sheila K. Patel, Louise Jackett, Isaac O. Afara, Jaishankar Raman, Louise M. Burrell, Bayden R. Wood
Summary: This study demonstrates that a portable handheld near-infrared spectrometer coupled with machine learning algorithms can effectively differentiate between kidney and cardiac fibrosis in a rat model of kidney failure, providing a potential intraoperative surgical tool for detecting and quantifying fibrosis in the heart and kidney.
ANALYSIS & SENSING
(2023)
Article
Medicine, General & Internal
Meg J. Jardine, Sradha S. Kotwal, Abhinav Bassi, Carinna Hockham, Mark Jones, Arlen Wilcox, Carol Pollock, Louise M. Burrell, James McGree, Vinay Rathore, Christine R. Jenkins, Lalit Gupta, Angus Ritchie, Ashpak Bangi, Sanjay D'Cruz, Andrew J. McLachlan, Simon Finfer, Michelle M. Cummins, Thomas Snelling, Vivekanand Jha
Summary: The study aimed to determine whether using angiotensin receptor blockers could improve clinical outcomes in people with covid-19. The results showed no evidence of benefit when using telmisartan, predominantly at a dose of 40 mg/day, as an angiotensin receptor blocker in hospitalized patients with mild covid-19.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)