Article
Medicine, General & Internal
Patrizia Amadio, Nicola Cosentino, Sonia Eligini, Simone Barbieri, Calogero Claudio Tedesco, Leonardo Sandrini, Marta Zara, Franco Fabiocchi, Giampaolo Niccoli, Giulia Magnani, Francesco Fracassi, Filippo Crea, Fabrizio Veglia, Giancarlo Marenzi, Silvia Stella Barbieri
Summary: This study found that plasma BDNF levels are associated with the clinical severity and plaque vulnerability of coronary artery disease patients. Specifically, in both acute myocardial infarction (AMI) and stable angina (SA) patients, BDNF is related to the characteristics of coronary plaques.
Article
Medicine, Research & Experimental
Hui-Hui Liu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou, Jian-Jun Li
Summary: This study evaluated the combined impact of remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation on the prognosis of statin-treated patients with chronic coronary syndrome (CCS). The results showed that elevated levels of RC and Lp(a) were significantly associated with an increased risk of major adverse cardiovascular events (MACEs), while high levels of high-sensitivity C-reactive protein (hsCRP) were slightly but not significantly associated with increased MACEs risk. Furthermore, patients with high levels of RC, Lp(a), and hsCRP had a significantly higher risk of MACEs, especially in those with low-density lipoprotein cholesterol (LDL-C) levels below 2.6 mmol/L.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Weili Pan, Hui Dong, Rong Sun, Linlin Zhao, Meng Sun, Longyan Li, Xianghao Yu, Jinxin Liu, Jianjun Wu, Fan Yang, Bo Yu
Summary: The study found an association between plasma ceramides and culprit plaque vulnerability evaluated using optical coherence tomography, supporting the proatherogenic role of ceramides.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Shuping Li, Ling Yi, Xiqing Wei, Jinguo Zhang, Xiaojue Wang, Chang Jiang, Zhuohong Yan, Liwei Song, Bin Yang, Panjian Wei, Xiang Gao, Jinghui Wang, Hongtao Zhang, Jian Zhang
Summary: The study found that plasma sPD-L1 levels were significantly increased in CAD patients, especially those with ACS. sPD-L1 was independently associated with ACS and correlated with inflammatory cytokines in ACS patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nlandu Roger Ngatu, Mitsunori Ikeda, Daniel Kuezina Tonduangu, Severin Luzitu Nangana, Tomohiro Hirao
Summary: This study investigates the effects of NBF1, a formula rich in algal fiber, on CRP, APN, and diabetes markers. It also explores the associations between dietary nutrients, CRP, and APN. The results demonstrate that NBF1 improves metabolic health and that the intake of algal fiber and n-3 PUFA is positively associated with APN increase.
Article
Nutrition & Dietetics
Tianyu Li, Peizhi Wang, Xiaozeng Wang, Zhenyu Liu, Zheng Zhang, Yongzhen Zhang, Zhifang Wang, Yingqing Feng, Qingsheng Wang, Xiaogang Guo, Xiaofang Tang, Jingjing Xu, Ying Song, Yan Chen, Na Xu, Yi Yao, Ru Liu, Pei Zhu, Yaling Han, Jinqing Yuan
Summary: Limited evidence suggests that systemic inflammation mediates the relationship between insulin resistance and cardiovascular events in patients with diabetes and chronic coronary syndrome. A secondary analysis of a prospective cohort study involving 4419 patients found that high levels of triglyceride-glucose index (TyG) and high-sensitivity C-reactive protein (hsCRP) were associated with the highest risk of major adverse cardiac events (MACE). HsCRP partially mediated the association between TyG and MACE, accounting for 14.37% of the relationship.
Article
Medicine, General & Internal
Dorota Diakowska, Rafal Wyderka, Malgorzata Krzystek-Korpacka, Lukasz Osuch, Anna Leskow, Alicja Soltowska, Marta Stanek, Joanna Rosinczuk, Joanna Jaroch
Summary: This study investigated the levels of AP, ELA, and APJ receptor in patients with coronary artery diseases. Researchers found that levels of AP-17 and ELA were significantly lower in CCS patients compared to healthy controls and ACS patients, indicating a compensatory up-regulation mechanism in ACS patients. Additionally, there is a relationship between circulating ELA and AP-17 levels and classical markers of ischemia and left ventricular ejection fraction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hyun Suk Yang, Gun-Hyuk Lee, Donghwan Kim, Kyeong Ryong Lee, Mina Hur
Summary: Adiponectin could be a potential biomarker for multi-MetSC in general health checkup subjects with extremely high HDL-C levels, and there are sex differences in the manifestation of metabolic risk factors.
Review
Biochemistry & Molecular Biology
Marko Kumric, Josip A. Borovac, Dinko Martinovic, Tina Ticinovic Kurir, Josko Bozic
Summary: Despite advancements in mitigating ACS complications, it remains a global health burden. Most vulnerable plaques leading to ACS are due to sudden disruption rather than gradual narrowing of vessel lumen. Current imaging modalities for vulnerable plaque detection are invasive, leading to the search for biomarkers from lipid and inflammation processes.
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Vijaykumar Subban, Michele Russo, Krzysztof L. Bryniarski, Osamu Kurihara, Makoto Araki, Yoshiyasu Minami, Tsunenari Soeda, Taishi Yonetsu, Filippo Crea, Masamichi Takano, Takumi Higuma, Tsunekazu Kakuta, Tom Adriaenssens, Niklas F. Boeder, Holger M. Nef, Owen C. Raffel, Iris McNulty, Hang Lee, Sunao Nakamura, Jabir Abdullakutty, Rony Mathew, Mullasari Ajit Sankardas, Ik-Kyung Jang
Summary: South Asians with ACS were younger and more frequently presented with ST-segment elevation myocardial infarction compared to East Asians and Whites. Plaque erosion was the predominant pathology for ACS in South Asians and their culprit lesions had more features of plaque vulnerability.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chananikan Makmool, Burabha Pussadhamma, Wit Leuangwatthananon, Songpol Howhan, Nantarat Komanasin
Summary: The study showed that high fibrinogen and hs-CRP levels are associated with clinical risk assessment of acute coronary syndrome (ACS) in patients. Combining these two parameters can enhance the prediction accuracy of ACS risk assessment in patients.
Article
Cardiac & Cardiovascular Systems
Tom Adriaenssens, Marc P. Allard-Ratick, Vikas Thondapu, Tomoyo Sugiyama, O. Christopher Raffel, Peter Barlis, Eric K. W. Poon, Makoto Araki, Akihiro Nakajima, Yoshiyasu Minami, Masamichi Takano, Osamu Kurihara, Valentin Fuster, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: The development of optical coherence tomography (OCT) technology has significantly impacted our understanding of coronary artery disease by revealing unique mechanisms of plaque growth and stability through the study of different hemodynamic factors. Recent research has introduced a new concept of plaque healing, changing the way we perceive coronary artery disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medical Laboratory Technology
Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Qian Dong, Jing Sun, Ke- Fei Dou, Jian-Jun Li
Summary: The level of low-density lipoprotein-triglyceride (LDL-TG) is associated with cardiovascular events (CVEs) in patients with chronic coronary syndrome (CCS) receiving percutaneous coronary intervention (PCI), especially in combination with high-sensitivity C-reactive protein (hs-CRP) concentrations.
CLINICA CHIMICA ACTA
(2023)
Article
Cardiac & Cardiovascular Systems
Zhao Wang, Binhao Wang, Xintao Li, Shengmin Zhang, Shouling Wu, Yunlong Xia
Summary: This study investigated the association of metabolic syndrome (MS) and high-sensitivity C-reactive protein (hs-CRP) levels with the risk of atrial fibrillation (AF) in a large community-based population. The results showed that MS combined with a high hs-CRP level is associated with an increased risk for AF in the Chinese population, indicating a potential combined effect of these conditions on AF risk.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Physiology
Lingfang Zhuang, Yulong Ge, Xiao Zong, Qian Yang, Ruiyan Zhang, Qin Fan, Rong Tao
Summary: In patients with ACS, serum DCN levels were elevated and independently associated with the condition after adjusting for other cardiovascular factors. The increased serum DCN level was positively correlated with white blood cell count and high-sensitivity C-reactive protein level, suggesting a role in promoting inflammatory response in ischemic heart disease by potentially suppressing anti-inflammatory genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)