Review
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Francesco Saverio Dioguardi
Summary: Chronic heart failure (CHF) remains a major health problem in industrialized countries, despite therapeutic improvements. Malnutrition, especially protein energy malnutrition, is present in more than half of CHF patients and is an independent predictor of prognosis. Nutritional supplementation and exercise training have been used to treat this condition, but their effectiveness is inconclusive. This paper discusses the molecular mechanisms of specific nutritional supplementation and exercise training that may improve anabolic pathways, particularly focusing on the relationship between exercise and the mTOR complex subunit as Deptor and/or related signaling proteins.
Article
Nutrition & Dietetics
Jan Mieszkowski, Paulina Brzezinska, Blazej Stankiewicz, Andrzej Kochanowicz, Katarzyna Zolodkiewicz, Bartlomiej Niespodzinski, Joanna Reczkowicz, Tomasz Kowalik, Tomasz Waldzinski, Jedrzej Antosiewicz
Summary: This study investigates the effect of single high-dose vitamin D supplementation on serum amino acid levels in ultramarathon runners. The results show that vitamin D can impact exercise-induced changes in serum amino acids and methylated arginine metabolites, potentially affecting the body's ability to synthesize NO.
Review
Cardiac & Cardiovascular Systems
Xuewen Duan, Xingguang Liu, Zhenzhen Zhan
Summary: Mortality from heart diseases, especially ischemic cardiomyopathy, remains the highest in the world. While adult mammalian hearts have limited regenerative capacity, early neonatal hearts possess stronger regenerative ability. Promoting endogenous regeneration of adult mammalian cardiomyocytes is crucial for improving the prognosis of heart failure patients and finding effective therapeutic strategies. This review focuses on the role of energy metabolism in cardiac regeneration to provide insights into manipulating heart regeneration and promoting heart repair after injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Haihong Chen, Qixing Nie, Jielun Hu, Xiaojun Huang, Junyi Yin, Shaoping Nie
Summary: Glucomannan extracts can improve branched-chain amino acid metabolism in type 2 diabetic rats by modulating intestinal microbiota. Glucomannan with higher molecular weight and lower mannose/glucose ratio exhibits better antidiabetic effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Fisheries
Abdullateef Yusuf, Xuxiong Huang, Naisong Chen, Songlin Li, Andrews Apraku, Weilong Wang, Micah Adekunle David
Summary: The study showed that AMP100, AMP125, and AMP150 significantly improved the growth, survival rate, and digestive enzyme activity of largemouth bass juveniles, as well as positively influenced the expression levels of related genes. Dietary vitamin C supplementation levels also affected tissue vitamin C content, body composition, and enzyme activity in the fish.
Article
Multidisciplinary Sciences
Maryam Khoshnejat, Ali Mohammad Banaei-Moghaddam, Ali Akbar Moosavi-Movahedi, Kaveh Kavousi
Summary: Type 2 diabetes mellitus (T2DM) is a challenging and progressive metabolic disease caused by insulin resistance. Skeletal muscle dysfunction is implicated in the disturbance of glucose homeostasis and the development of insulin resistance. Understanding metabolism reprogramming in newly diagnosed patients provides opportunities for early diagnosis and treatment.
Article
Multidisciplinary Sciences
Lijun Wu, Jiayi Wang, Xiuhui Cao, Yue Tian, Jia Li
Summary: This study aimed to explore the effects of acute high-intensity exercise on rat myocardial metabolism and evaluate its diagnostic potential for sports injuries. It was found that acute high-intensity exercise caused changes in myocardial metabolism, including disorders in complex lipids and fatty acids, an increase in purine degradation products, and signs of impaired glucose metabolism. Additionally, amino acids were enhanced and exerted a protective effect on the myocardium.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Noura B. Younes, Omnia Ahmed Mohamed, Nasser M. Rizk
Summary: This study demonstrates that DHA has the potential to mitigate obesity by reducing the secretion of inflammatory adipokines, oxidative stress, lipolysis, and apoptosis in adipocytes exposed to low O-2 tension-induced hypoxia.
Article
Food Science & Technology
Rongrong He, Qiuping Zhong, Weijun Chen, Ming Zhang, Jianfei Pei, Haiming Chen, Wenxue Chen
Summary: This study investigated the antibacterial mechanism of linalool and its application in chicken breast preservation using transcriptomics and proteomics. The results showed that linalool exerted antibacterial effect by damaging cellular structure, impairing energy metabolism, activating specific amino acid metabolism, and DNA repair. Additionally, linalool effectively prevented the growth of L. monocytogenes in chicken breast during storage without affecting sensory acceptability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Shuiya Sun, Dongjuan He, Cheng Luo, Xihua Lin, Jiahua Wu, Xueyao Yin, Chengfang Jia, Qianqian Pan, Xuehong Dong, Fenping Zheng, Hong Li, Jiaqiang Zhou
Summary: Recent studies have shown that plasma amino acid levels are associated with visceral obesity, insulin resistance, and future development of diabetes and cardiovascular diseases. This study aimed to examine the association between amino acid profile and metabolic syndrome in the Chinese Han population. The results indicated that MetS patients exhibit an abnormal amino acid profile, with certain amino acids showing significant differences between MetS and non-MetS groups. Additionally, decreased taurine levels may be linked to the future development of MetS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shereen M. Aleidi, Lina A. Dahabiyeh, Xinyun Gu, Mohammed Al Dubayee, Awad Alshahrani, Hicham Benabdelkamel, Muhammad Mujammami, Liang Li, Ahmad Aljada, Anas M. Abdel Rahman
Summary: Metformin has metabolic effects in T2DM and obesity, with 30 dysregulated metabolites in obese diabetic patients restored to control levels by metformin. Interestingly, 9 metabolites were significantly dysregulated between lean and obese cohorts due to T2DM and metformin regardless of obesity status, providing insight into potential molecular targets of metformin in T2DM and obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jakob Vowinckel, Johannes Hartl, Hans Marx, Martin Kerick, Kathrin Runggatscher, Markus A. Keller, Michael Muelleder, Jason Day, Manuela Weber, Mark Rinnerthaler, Jason S. L. Yu, Simran Kaur Aulakh, Andrea Lehmann, Diethard Mattanovich, Bernd Timmermann, Nianshu Zhang, Cory D. Dunn, James MacRae, Michael Breitenbach, Markus Ralser
Summary: The study reveals that petite cells suffer from an insufficient capacity to synthesize glutamate, glutamine, leucine and arginine, negatively impacting their growth rate. Fast growth overcomes these amino acid deficiencies by alleviating a perturbation in mitochondrial iron metabolism and restoring a defect in the mitochondrial tricarboxylic acid cycle.
Review
Nutrition & Dietetics
Luokun Liu, Jingge Xu, Zhiyu Zhang, Dongwen Ren, Yuzheng Wu, Dan Wang, Yi Zhang, Shuwu Zhao, Qian Chen, Tao Wang
Summary: Diabetic kidney disease (DKD) affects a significant percentage of diabetic patients and poses a high risk of kidney failure. Current treatments focusing on glucose lowering and blood pressure control have shown no beneficial impact on preventing progression to kidney failure. This review explores the relationship between kidney dysfunction and the metabolic homeostasis of specific amino acids, and highlights the regulation effects of certain metabolites on DKD progression. The paper suggests an optimized protein diet strategy to manage amino acid homeostasis and reduce the risks of DKD in hyperglycemic conditions.
Article
Food Science & Technology
Mariaurea Matias Sarandy, Silvania Mol Pelinsari, Lorena Miranda de Souza, Romulo Dias Novaes, Virginia Vinha Zanuncio, Reggiani Vilela Goncalves
Summary: We evaluated the healing of cutaneous wounds in male wild type (WT) and knockout (KO) mice (iNOS) after supplementation with L-citrulline (CIT) and L-arginine (ARG). The wound area was smaller and the contraction rate was higher with ARG and CIT in WT and KO. ARG and CIT accelerated healing and tissue repair at morphological, histological and biochemical levels.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Kang Chen, Lai Yee Cheong, Yuan Gao, Yaming Zhang, Tianshi Feng, Qin Wang, Leigang Jin, Eric Honore, Karen S. L. Lam, Weiping Wang, Xiaoyan Hui, Aimin Xu
Summary: This study demonstrates that targeted delivery of thyroid hormone to adipose tissue with liposomes is a safe and efficient strategy for treating obesity and its related complications.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Lorenza Brocca, Maira Rossi, Monica Canepari, Roberto Bottinelli, Maria Antonietta Pellegrino
Summary: Endurance exercise before disuse can protect against disuse-induced muscle atrophy by enhancing PGC1 alpha expression and preventing mitochondrial dysfunction and AMPK activation. Moderate treadmill exercise can protect muscles from atrophy during the early stages of disuse.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Annamaria Tisi, Darin Zerti, Germano Genitti, Maria Teresa Vicentini, Mariangela Baccante, Vincenzo Flati, Rita Maccarone
Summary: Recent studies have identified the eye as an additional entry route for the SARS-CoV-2 virus, with the expression of entry factors on the ocular surface potentially being modulated in an age-dependent manner. The study also found a relationship between the expression of TMPRSS proteases and the activation state of limbal cells in 80-year-old donors.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Biology
Catarina N. Matias, Francesco Campa, Giuseppe Cerullo, Giuseppe D'Antona, Rita Giro, Joao Faleiro, Joana F. Reis, Cristina P. Monteiro, Maria J. Valamatos, Filipe J. Teixeira
Summary: This study demonstrates the usefulness of bioelectrical impedance vector analysis (BIVA) in discriminating fitness levels in professional futsal players. Fat mass and bioelectrical phase angle were identified as valid predictors for aerobic power.
Article
Cell Biology
Jacopo Di Gregorio, Sabrina Petricca, Roberto Iorio, Elena Toniato, Vincenzo Flati
Summary: Metabolic alterations, including enhanced aerobic glycolysis, oxidative phosphorylation, gluconeogenesis, and fatty acid beta-oxidation, play crucial roles in the development and survival of cancers.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Giovanni Corsetti, Claudia Romano, Silvia Codenotti, Evasio Pasini, Alessandro Fanzani, Francesco S. Dioguardi
Summary: A diet rich in essential amino acids can reduce fat accumulation in mice and promote thermogenesis.
Editorial Material
Physiology
Giuseppe D'Antona, Martin Burtscher
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Annamaria Tisi, Fanny Pulcini, Giulia Carozza, Vincenzo Mattei, Vincenzo Flati, Maurizio Passacantando, Cinzia Antognelli, Rita Maccarone, Simona Delle Monache
Summary: The study demonstrates that cerium oxide nanoparticles can counteract retinal neovascularization induced by oxidative damage, suggesting a potential new therapeutic strategy for wet AMD treatment.
Article
Biochemistry & Molecular Biology
Giulia Carozza, Annamaria Tisi, Annamaria Capozzo, Benedetta Cinque, Aldo Giovannelli, Marco Feligioni, Vincenzo Flati, Rita Maccarone
Summary: This study reveals the dose-dependent mechanisms of action of Cur in ARPE-19 cells. Cur at 0.01 mM promotes cell proliferation, while Cur at 0.05 mM and 0.1 mM blocks cell proliferation and induces S-phase cell cycle arrest. Furthermore, Cur at 0.05 mM and 0.1 mM activates autophagy in the cells. These findings have significant implications for the treatment of ocular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Annamaria Tisi, Dyan Ramekers, Vincenzo Flati, Huib Versnel, Rita Maccarone
Summary: This study investigated the localization of mTOR signaling proteins in the cochlea of guinea pigs and their modulation by exogenous BDNF. The results showed that mTOR signaling proteins are expressed in the organ of Corti, particularly in supporting cells. BDNF treatment increased mTOR immunostaining, suggesting a potential protective mechanism in the degenerating organ of Corti.
Article
Nutrition & Dietetics
Giovanni Corsetti, Claudia Romano, Evasio Pasini, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi
Summary: A diet rich in essential amino acids can protect cardiomyocytes from Doxorubicin-induced damage by increasing mitochondrial generation and reducing oxidative stress, thereby promoting cell survival.
Review
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Francesco Saverio Dioguardi
Summary: Chronic heart failure (CHF) remains a major health problem in industrialized countries, despite therapeutic improvements. Malnutrition, especially protein energy malnutrition, is present in more than half of CHF patients and is an independent predictor of prognosis. Nutritional supplementation and exercise training have been used to treat this condition, but their effectiveness is inconclusive. This paper discusses the molecular mechanisms of specific nutritional supplementation and exercise training that may improve anabolic pathways, particularly focusing on the relationship between exercise and the mTOR complex subunit as Deptor and/or related signaling proteins.
Article
Chemistry, Medicinal
Ivana Cacciatore, Sonia Spalletta, Annalisa Di Rienzo, Vincenzo Flati, Erika Fornasari, Laura Pierdomenico, Piero Del Boccio, Silvia Valentinuzzi, Erica Costantini, Elena Toniato, Stefano Martinotti, Carmela Conte, Antonio Di Stefano, Iole Robuffo
Summary: This study synthesized a series of carvacrol derivatives and found that one derivative, CD3, exhibited anti-obesity and anti-inflammatory effects.
Editorial Material
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Francesco S. S. Dioguardi
Review
Sport Sciences
Roberto Cannataro, Erika Cione, Diego A. Bonilla, Giuseppe Cerullo, Fabrizio Angelini, Giuseppe D'Antona
Summary: The loss of muscle mass and strength in the elderly is a public health problem, affecting their quality of life. While cardiovascular and low-intensity exercises are beneficial, strength-based resistance training is more effective in increasing muscle strength and hypertrophy, reducing sarcopenia-related problems.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jose E. Exaire, Timothy A. Mixon
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Giuseppe Di Gioia, Federica Coletti, Lorenzo Buzzelli, Viviana Maestrini, Sara Monosilio, Andrea Segreti, Maria Rosaria Squeo, Erika Lemme, Antonio Nenna, Antonio Pelliccia
Summary: Dyslipidemia is common in Paralympic athletes, with lipid levels influenced by the type of disability and sporting discipline.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Esra Donmez, Sevgi Ozcan, Irfan Sahin, Murat Ziyrek, Ertugrul Okuyan
Summary: This study aimed to evaluate the predictive value of the GRACE risk score in acute pulmonary embolism (PE) patients for 30-day mortality and the need for thrombolytic treatment. The study found that the GRACE risk score, along with the PESI score, were independent risk factors associated with 30-day mortality and the need for thrombolytic treatment. The GRACE risk score showed high sensitivity and specificity in predicting mortality, and its combination with the PESI score helped define high-risk PE patients and predict poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Reza Reyaldeen, Kevser Akyuz, Zoran B. Popovic, A. Marc Gillinov, Bo Xu, Brian P. Griffin, Milind Y. Desai
Summary: Transthoracic echocardiography (TTE) is commonly used to evaluate isolated tricuspid regurgitation (TR), but there is limited research comparing its quantification with magnetic resonance imaging (MRI). In this study, a novel TTE algorithm was developed to identify severe TR based on TTE parameters. The algorithm had a higher accuracy than the current guidelines' criteria in detecting severe TR by MRI.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Enkhtsogt Sainbayar, Ramzi Ibrahim, Hoang Nhat Pham, Wisam Beauti, Mahek Shahid, Natalie Hickerson, Mohammed Salih, Joao Paulo Ferreira, Mamas A. Mamas
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Richard E. Casazza, Hymie Chera, Carlos Adolfo Rodriguez, Sergey Ayzenberg
Summary: This article presents a case of a patient with known situs inversus who underwent cardiac catheterization and was found to have chronic total occlusion in the right coronary artery. Situs inversus is a rare congenital abnormality characterized by the inverted position of chest and abdominal organs. Cardiac catheterization is uncommon in patients with this particular abnormality, highlighting the importance of customizing techniques to engage coronary arteries and optimize guide support for percutaneous coronary intervention if needed.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Editorial Material
Cardiac & Cardiovascular Systems
Georgiana Pintea Bentea, Brahim Berdaoui, Sophie Samyn, Marielle Morissens, Philippe van de Borne, Jose Castro Rodriguez
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bulbul Ahmed, Melissa G. Farb, Shakun Karki, Sophia D'Alessandro, Niloo M. Edwards, Noyan Gokce
Summary: This study evaluated the angiogenic capacity of adipose tissue in patients undergoing cardiac surgeries and found that patients with coronary artery disease (CAD) had reduced angiogenic capacity in their pericardial adipose tissue. Gene expression analysis revealed upregulated expression of the anti-angiogenic gene TSP-1 in CAD patients, with no significant differences in other angiogenic factors. Additionally, inhibiting TSP-1 expression significantly improved angiogenic deficiency in CAD patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moshe Rav-Acha, Orli Wube, Oholi Tovia Brodie, Yoav Michowitz, Michael Ilan, Tal Ovdat, Robert Klempfner, Mahmud Suleiman, Ilan Goldenberg, Michael Glikson
Summary: The current guidelines recommend prophylactic implantable cardioverter-defibrillator (ICD) for patients with symptomatic heart failure (HF) and low left ventricular ejection fraction. However, not all patients will benefit from ICD treatment. This study evaluated the feasibility of using the MADIT-II-based Risk Stratification Score (MRSS) to predict the survival benefit of prophylactic ICDs in patients with HF. The results showed that different risk subgroups had varying levels of ICD survival benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ariel Banai, Rachel Retsky, Lior Lupu, Erez Levi, David Zahler, Omri Feder, Roei Merin, Yan Topilsky, Raphael Rosso, Shmuel Banai, Sami Viskin, Ehud Chorin
Summary: This study aims to evaluate the association between electromechanical window (EMW) and ventricular tachyarrhythmias in patients with Takotsubo syndrome (TTS). The study found that TTS patients had a lower EMW value, which was associated with an increased risk of ventricular tachyarrhythmias.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Harun Kundi, Kobina Hagan, Tamer Yahya, Garima Sharma, Sadeer Al-Kindi, Zulqarnain Javed, Khurram Nasir
Summary: Using latent class analysis (LCA), the study identified clinical, demographic, and social subphenotypes in ASCVD population and assessed the risk of all-cause and cardiovascular mortality across different socioclinical classes. The results showed that the younger, female, non-Hispanic Black or Hispanic individuals with a high burden of co-morbidities and unfavorable social determinants of health had the highest risk of mortality in the identified latent classes.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Moises A. Vasquez, Mina Iskander, Mohammed Mustafa, Juan A. Quintero-Martinez, Antonio Luna, Joel Mintz, Jose Noy, Juan Uribe, Ivan Mijares, Eduardo de Marchena, Yiannis S. Chatzizisis
Summary: The benefits of pericardiocentesis (PC) in patients with pulmonary hypertension (PH) and pericardial effusions are unclear. The study found that PC in PH patients is associated with higher in-hospital mortality and rates of cardiovascular complications.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ken Kuwajima, Mana Ogawa, Irving Ruiz, Hiroko Hasegawa, Nobuichiro Yagi, Florian Rader, Robert J. Siegel, Takahiro Shiota
Summary: After cardiac surgery, the longitudinal function of the right ventricle and left ventricle is reduced, despite preserved global functions. In particular, tricuspid annular plane systolic excursion (TAPSE) remains decreased after surgery.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Min -Jung Kim, Robert H. Aseltine Jr, Sara R. Tabtabai
Summary: This study evaluated the rates and causes of 30-day readmissions after discharge for heart failure (HF) as a primary and secondary diagnosis. The findings indicate that efforts to reduce readmission rates should include patients with secondary HF diagnosis, and surveillance should extend to 2 weeks postdischarge to identify at-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Ya He, Jianzhong Zhou
Summary: This study aimed to examine the relation between reverse septal curvature (RSC) and nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). The study found that patients with RSC were younger and had a higher incidence of NSVT, and RSC was identified as a strong independent risk factor for NSVT.
AMERICAN JOURNAL OF CARDIOLOGY
(2024)
