Editorial Material
Veterinary Sciences
Sheri Ann Hild, Michael C. Chang, Stephanie J. Murphy, Franziska B. Grieder
Summary: The COVID-19 pandemic has led to a significant increase in demand for nonhuman primates (NHPs) and biocontainment laboratory spaces, requiring skilled personnel to work in these facilities.
Article
Zoology
Elyse L. Morin, Kristie M. Garza, Hadj Aoued, Soma Sannigrahi, Erin R. Siebert, Brittany R. Howell, Hasse Walum, Mar M. Sanchez, Brian G. Dias
Summary: The study found that exposure to naturally occurring adverse caregiving of infant rhesus macaques can affect RNA in the male germline, with the top 100 identified transcripts related to germline biology and reproduction. While definitive assessment of stress-induced alterations of RNA in the male germline of rhesus macaques that experienced ELS was not possible due to small sample sizes, this research sets the foundation for future investigations into how early adversity may alter male germline across species.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nadege Sarrazin, Estelle Chavret-Reculon, Corinne Bachelin, Mehdi Felfli, Rafik Arab, Sophie Gilardeau, Elena Brazhnikova, Elisabeth Dubus, Lydia Yaha-Cherif, Jean Lorenceau, Serge Picaud, Serge Rosolen, Pierre Moissonnier, Pierre Pouget, Anne Baron-Van Evercooren
Summary: This study focuses on the long-term effects of toxin-induced demyelination of the macaque optic nerve and its impact on remyelination, axon preservation, and visual functions. The findings reveal visual impairment, including damage to the optic nerve and retina. This nonhuman primate model replicates key features of multiple sclerosis lesions, making it valuable for studying new therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Behavioral Sciences
Rachel A. Harrison, Erica van de Waal
Summary: Studies of wild non-human primates have provided groundbreaking insights into social learning and social cognition, taking advantage of their natural and diverse social and environmental contexts. Recent advances in statistical techniques and technologies have enabled studies of social learning in wild primates that were previously unattainable. Controlled experiments with wild populations also offer the opportunity to compare cognitive abilities between wild and captive individuals.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2022)
Review
Cell Biology
Ov D. Slayden, Fangzhou Luo, Cecily Bishop
Summary: Therapies targeting progesterone action have potential for contraception and managing gynecological disorders. Steroid hormones play a role in regulating the mammalian oviduct, with estrogen stimulating epithelial differentiation and progesterone suppressing ciliation and secretion. Nonhuman primates exhibit different hormonal patterns, with progesterone driving fallopian tube cycles. Synthetic progesterone receptor modulators disrupt the normal cyclic regulation of the tube, affecting various factors including receptor expression and cilia activity. Understanding progesterone's role in NHP oviduct is crucial for advancing PRMs as pharmaceutical therapies.
Review
Biochemistry & Molecular Biology
Elena S. B. Campbell, Melanie M. Goens, Wenguang Cao, Brad Thompson, Leonardo Susta, Logan Banadyga, Sarah K. Wootton
Summary: Monoclonal antibodies (mAbs) are crucial in preventing and treating infectious diseases, especially when vaccines or therapies are lacking. Recent developments in mAb gene cloning have resulted in highly potent mAbs against various pathogens. Adeno-associated virus (AAV) vectors have been explored as a platform for delivering mAb genes, but further optimization is needed for improved therapeutic efficacy. This review summarizes the current landscape of AAV vectored immunoprophylaxis (VIP) in nonhuman primate (NHP) models and discusses major obstacles and implications for clinical translation.
Article
Immunology
Julie Sartoretti, Christiane S. Eberhardt
Summary: Early life immunity research still has gaps in knowledge, especially regarding maternal antibody transfer and the impact on infant vaccine responses. While murine models are commonly used, nonhuman primate models show potential for addressing these research questions effectively.
Review
Multidisciplinary Sciences
Mei Huang, Jiao Yang, Peng Li, Yongchang Chen
Summary: Nonhuman primate models play an increasingly indispensable role in translational medicine research, with unique advantages in mimicking clinical patients, although there is still a remaining gap between basic research of NHP models and translational medicine.
Review
Zoology
Eliza Bliss-Moreau, Rama R. Amara, Elizabeth A. Buffalo, Ricki J. Colman, Monica E. Embers, John H. Morrison, Ellen E. Quillen, Jonah B. Sacha, Charles T. Roberts
Summary: Nonhuman primates (NHPs) play a critical role in translational/preclinical biomedical research due to their strong similarities to human physiology and disease pathology, serving as the most appropriate or even the only animal model for complex metabolic, neurological, and infectious diseases. Enhancing rigor and reproducibility in NHP research is essential for maximizing the utility of these valuable research subjects in the face of increasing demand and limited availability.
AMERICAN JOURNAL OF PRIMATOLOGY
(2021)
Article
Neurosciences
David J. Marmion, Angela A. Rutkowski, Diptaman Chatterjee, Benjamin M. Hiller, Milton H. Werner, Erwan Bezard, Deniz Kirik, Thomas McCown, Steven J. Gray, Jeffrey H. Kordower
Summary: Multiple system atrophy (MSA) is a progressive neurodegenerative disease with unclear pathogenesis. Studies using large animal models have successfully reproduced some pathological features of the disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Materials Science, Multidisciplinary
Qiang Liu, Wei Huang, Hongbing Chen
Summary: This study presents a versatile methodology to simulate and forecast the radiochemical damage of polydimethylsiloxane (PDMS) foam. By conducting multiscale simulations with experimental verification, the radiolytic kinetics of PDMS foam in radiation-thermal environments are studied. A radiolytic kinetic model of PDMS is then developed using material informatics gained from experiments, reactive force field simulations, and density functional theory calculations.
ACS MATERIALS LETTERS
(2023)
Article
Neurosciences
Cristina Banuelos, Joshua R. Kittleson, Katherine H. Lanasa, Christina S. Galiano, Stephanie M. Roth, Evelyn J. Perez, Jeffrey M. Long, Mary T. Roberts, Sania Fong, Peter R. Rapp
Summary: This study found that the GABAergic component of the primate basal forebrain is more vulnerable to aging, leading to a potential loss of inhibitory drive to cortical circuitry. Adaptive reorganization of the GABAergic circuitry may contribute to successful neurocognitive outcomes in aging.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha Rossano, Takuya Toyonaga, Eric Berg, Isabella Lorence, Krista Fowles, Nabeel Nabulsi, Jim Ropchan, Songye Li, Yunpeng Ye, Zachary Felchner, David Kukis, Yiyun Huang, Helene Benveniste, Alice F. Tarantal, Stephanie Groman, Richard E. Carson
Summary: This study assessed synaptic density changes in the developing fetal brain using positron emission tomography (PET) radioligands. The results showed an increase in SV2A concentration during the third trimester, with lower levels in cortical regions. Furthermore, the post-mortem quantification of SV2A density correlated significantly with the PET measurements.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Anesthesiology
Nir Samuel, Eilat Kahana, Aryeh Taub, Tamar Reitich-Stolero, Rony Paz, Aeyal Raz
Summary: The study found that nonhuman primates under sedation with ketamine and midazolam showed signs of memory formation in response to aversive stimuli. By measuring neural responses during acquisition, it was discovered that activity in the amygdala and dorsal anterior cingulate cortex could predict memory retention.
Article
Neurosciences
Nakul Aggarwal, Jason F. Moody, Douglas C. Dean III, Do P. M. Tromp, Steve R. Kecskemeti, Jonathan A. Oler, Andy L. Alexander, Ned H. Kalin
Summary: The study investigates the early white matter (WM) growth in nonhuman primates by imaging 34 rhesus monkeys longitudinally during the first year of life. The results show a rapid WM development in the initial 10 weeks followed by a decline in growth rates, with distinct gradients observed in WM maturation. Individual differences in WM microstructure at 3 weeks of age were found to be significantly related to those at 1 year of age.
