Journal
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
Volume 29, Issue 3, Pages 222-235Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317513517045
Keywords
Alzheimer's disease; diabetes; APOE4; healthy aging; white matter
Categories
Funding
- National Institute of Neurologic Disorders and Stroke [K23NS062148]
- National Institute of Nursing Research [R01NR010827]
- National Institute on Aging [P60AG08812, P01AG004390]
- American Psychological Association Division [40]
- The Rosalind and Arthur Gilbert Foundation/AFAR New Investigator Award in Alzheimer's Disease
- Medical Research Service VA Merit Review Awards
Ask authors/readers for more resources
Possession of the apolipoprotein E4 (APOE4) allele and diabetes risk are independently related to reduced white matter (WM) integrity that may contribute to the development of Alzheimer's disease (AD). The purpose of this study is to examine the interactive effects of APOE4 and diabetes risk on later myelinating WM regions among healthy elderly individuals at risk of AD. A sample of 107 healthy elderly (80 APOE4-/27 APOE4+) individuals underwent structural magnetic resonance imaging/diffusion tensor imaging (DTI). Data were prepared using Tract-Based Spatial Statistics, and a priori regions of interest (ROIs) were extracted from T1-based WM parcellations. Regions of interest included later myelinating frontal/temporal/parietal WM regions and control regions measured by fractional anisotropy (FA). There were no APOE group differences in DTI for any ROI. Within the APOE4 group, we found negative relationships between hemoglobin A(1c)/fasting glucose and APOE4 on FA for all later myelinating WM regions but not for early/middle myelinating control regions. Results also showed APOE4/diabetes risk interactions for WM underlying supramarginal, superior temporal, precuneus, superior parietal, and superior frontal regions. Results suggest interactive effects of APOE4 and diabetes risk on later myelinating WM regions, which supports preclinical detection of AD among this particularly susceptible subgroup.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available