Journal
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
Volume 28, Issue 2, Pages 120-125Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317512473193
Keywords
Alzheimer's disease; vitamin C; oxidative stress
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Funding
- National Research Foundation of Korea (NRF)
- Korea government (MEST) [2011-0018267, 20120005823]
- National Research Foundation of Korea [2009-0080348] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Oxidative stress is suggested to play a major role in the pathogenesis of Alzheimer's disease (AD). Among the antioxidants, vitamin C has been regarded as the most important one in neural tissue. It also decreases beta-amyloid generation and acetylcholinesterase activity and prevents endothelial dysfunction by regulating nitric oxide, a newly discovered factor in the pathogenesis and progression of AD. However, clinical trials using antioxidants, including vitamin C, in patients with AD yielded equivocal results. The current article discusses the relevance of vitamin C in the cellular and molecular pathogenesis of AD and explores its therapeutic potential against this neurodegenerative disorder.
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