Article
Clinical Neurology
Kevin Kuo, Ya-Ru Zhang, Shi-Dong Chen, Xiao-Yu He, Shu-Yi Huang, Bang-Sheng Wu, Yue-Ting Deng, Liu Yang, Ya-Nan Ou, Yu Guo, Rui-Qi Zhang, Yi Zhang, Lan Tan, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: This study analyzed data from the UK Biobank and found that a 5 kg increment in grip strength was associated with lower risks of all types of dementia, while a slow walking pace was associated with increased risks of all types of dementia. These findings highlight the importance of grip strength and walking pace in estimating the risks of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Xuewen Xiao, Tianyan Xu, Hui Liu, Xixi Liu, Xinxin Liao, Yafang Zhou, Lu Zhou, Xin Wang, Yuan Zhu, Qijie Yang, Xiaoli Hao, Yingzi Liu, Hong Jiang, Jifeng Guo, Junling Wang, Beisha Tang, Jinchen Li, Lu Shen, Bin Jiao
Summary: Through screening the CYLD gene in the Chinese population, we found that rare damaging variants of CYLD may be implicated in the pathogenesis of Alzheimer's disease and frontotemporal dementia.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Editorial Material
Neurosciences
Mathieu Maltais
Summary: Over the past two decades, systematic reviews and meta-analyses have yielded conflicting results regarding the impact of exercise on fall reduction in individuals with dementia. A recent systematic review published in the Journal of Alzheimer's Disease identified positive outcomes in only two studies, suggesting insufficient data to support the effectiveness of exercise interventions in reducing falls. This commentary highlights the importance of interdisciplinary approaches in reducing falls among this vulnerable population.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Rosanna Squitti, Mariacarla Ventriglia, Ilaria Simonelli, Cristian Bonvicini, Alfredo Costa, Giulia Perini, Giuliano Binetti, Luisa Benussi, Roberta Ghidoni, Giacomo Koch, Barbara Borroni, Alberto Albanese, Stefano L. Sensi, Mauro Rongioletti
Summary: Evidence suggests that patients with Alzheimer's dementia exhibit disturbances in copper homeostasis. A meta-analysis of studies on copper biomarkers in brain specimens and serum/plasma samples revealed decreased copper in AD brains, increased copper and nonbound ceruloplasmin in serum/plasma, with excess copper associated with a higher risk of AD. Replication study confirmed these findings and indicated a subset of AD patients carrying a genetic haplotype associated with copper imbalance and elevated nonbound ceruloplasmin.
Article
Neurosciences
Fang Yu, David M. Vock, Lin Zhang, Dereck Salisbury, Nathaniel W. Nelson, Lisa S. Chow, Glenn Smith, Terry R. Barclay, Maurice Dysken, Jean F. Wyman
Summary: The study found that for older adults with mild-to-moderate Alzheimer's disease, exercise may help reduce the decline in global cognition. However, aerobic exercise did not show superior cognitive effects compared to stretching, possibly due to the lack of power in the pilot trial.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Fang Yu, Dereck Salisbury, Michelle A. Mathiason
Summary: Inter-individual differences in aerobic fitness and cognitive responses to aerobic exercise were found in older adults with mild-to-moderate dementia due to AD, highlighting the potential impact on treatment outcomes.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2021)
Article
Clinical Neurology
Valeria Isella, Cinzia Crivellaro, Anna Formenti, Monica Musarra, Sara Pacella, Sabrina Morzenti, Francesca Ferri, Cristina Mapelli, Francesca Gallivanone, Luca Guerra, Ildebrando Appollonio, Carlo Ferrarese
Summary: The aim of this study was to investigate the extent to which reduced glucose uptake in specific brain regions can distinguish amyloid-positive from amyloid-negative patients with non-classical AD phenotypes. Three rating methods were applied and the results showed good sensitivity and accuracy, but lower specificity. The qualitative visual interpretation method had the highest sensitivity but also had a higher proportion of unclassified cases.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Kristian Steen Frederiksen, Camilla Steen Jensen, Peter Hogh, Robert Gergelyffy, Gunhild Waldemar, Birgitte Bo Andersen, Hanne Gottrup, Karsten Vestergaard, Lene Wermuth, Helle Bach Sondergaard, Finn Sellebjerg, Steen Gregers Hasselbalch, Anja Hviid Simonsen
Summary: This study aimed to investigate whether a 16-week aerobic exercise program could reduce serum NfL in patients with mild Alzheimer's disease. The results showed that the exercise intervention did not have a significant effect on neurodegeneration. Further studies are needed to explore other types and durations of exercise as well as other measures of neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Health Care Sciences & Services
Vasileios Papatsimpas, Sotiria Vrouva, Marianna Papadopoulou, George Papathanasiou, Daphne Bakalidou
Summary: The study aims to investigate the effect of different exercise programs on cognitive functions and functionality of individuals with mild Alzheimer's disease. A randomized controlled trial will be conducted involving aerobic and resistance exercise interventions. Participants will be assessed at baseline and after 12 weeks. The primary outcome will measure the effect of exercise programs on cognitive functions using various cognitive tests. The secondary outcomes will assess the effect on functionality, depression, physical activity, and compliance with the intervention. Exercise is a low-cost and low-risk intervention.
Review
Neurosciences
Alexandra Saude, Raquel Bouca-Machado, Mariana Leitao, Andrea Benedetti, Joaquim J. Ferreira
Summary: This study summarized and appraised the effects of physiotherapy interventions in dementia. The most frequently used interventions, including aerobic training, strength training, balance training, and stretching, were found to have positive effects on motor and cognitive outcomes. The study also highlighted the need for future research to establish physiotherapy prescription protocols for different stages of dementia and individuals with mild cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Nicole L. Spartano, Ruiqi Wang, Qiong Yang, Ariel Chernofsky, Joanne M. Murabito, Daniel Levy, Ramachandran S. Vasan, Charles DeCarli, Pauline Maillard, Sudha Seshadri, Alexa S. Beiser
Summary: The study found that cardiometabolic risk factors and epigenetic patterns mediate the association between physical inactivity and unfavorable brain morphology. The findings suggest that cardiometabolic risk factors and epigenetic patterns partially explain the relationship between physical inactivity and lower brain volume, higher white matter diffusivity, and aggregation of free water in the brain.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Michael G. Slee, Stephanie R. Rainey-Smith, Victor L. Villemagne, James D. Doecke, Hamid R. Sohrabi, Kevin Taddei, David Ames, Vincent Dore, Paul Maruff, Simon M. Laws, Colin L. Masters, Christopher C. Rowe, Ralph N. Martins, Kirk I. Erickson, Belinda M. Brown
Summary: The study found no significant relationship between habitual physical activity and brain amyloid beta levels in cognitively unimpaired older adults, nor did apolipoprotein E (APOE) ε4 carrier status moderate this relationship.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Kelly N. H. Nudelman, Trever Jackson, Malia Rumbaugh, Ani Eloyan, Marco Abreu, Jeffrey L. Dage, Casey Snoddy, Kelley M. Faber, Tatiana Foroud, Dustin B. Hammers, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Laurel Beckett, Joel Kramer, Robert Koeppe, Walter A. Kukull, Melissa E. Murray, Arthur W. Toga, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J. Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova
Summary: The Longitudinal Early-onset Alzheimer's Disease Study aims to investigate the genetic causes of early onset cognitive impairment. The study found that the participants had a low frequency of common pathogenic variants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Anita Korpioja, Johanna Kruger, Susanna Koivuluoma, Katri Pylkas, Virpi Moilanen, Seppo Helisalmi, Mikko Hiltunen, Anne M. Remes
Summary: This study evaluated the role of SORL1 variants among Finnish patients with early-onset Alzheimer's disease (EOAD) and found that several variants were more common in these patients, strengthening previous findings that rare variants in SORL1 are associated with EOAD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
