Article
Cardiac & Cardiovascular Systems
Antonino Tuttolomondo, Carlo Maida, Alessandra Casuccio, Domenico Di Raimondo, Roberto Fonte, Valerio Vassallo, Maria Grazia Puleo, Tiziana Di Chiara, Alba Mogavero, Alessandro Del Cuore, Mario Daidone, Antonella Ortello, Antonio Pinto
Summary: Comparing the effects of furosemide + hypertonic saline solution treatment and furosemide alone in patients with acute decompensated heart failure, along with the response after an acute saline load, showed similar reductions in serum heart failure biomarkers. However, treatment with furosemide + HSS may have a higher efficacy in modulating stretching and fibrosis mechanisms.
Review
Cardiac & Cardiovascular Systems
Carlos Diaz-Arocutipa, Jack Denegri-Galvan, Lourdes Vicent, Marcos Pariona, Mamas A. Mamas, Adrian V. Hernandez
Summary: We evaluated the effects of hypertonic saline solution (HSS) plus furosemide compared to furosemide alone in patients with acute decompensated heart failure (ADHF). Ten randomized controlled trials involving 3013 patients were included in our study. HSS plus furosemide significantly reduced hospital stay, weight, serum creatinine, and type-B natriuretic peptide compared to furosemide alone. HSS plus furosemide also significantly increased urine output, serum Na+, and urine Na+ compared to furosemide alone.
CLINICAL CARDIOLOGY
(2023)
Review
Critical Care Medicine
Chang Liu, Zhiyong Peng, Xiaolan Gao, Ognjen Gajic, Yue Dong, Larry J. Prokop, M. Hassan Murad, Kianoush B. Kashani, Juan Pablo Domecq
Summary: A meta-analysis of 11 randomized controlled trials found that the simultaneous use of hypertonic saline solution and intravenous furosemide (HSS+Fx) for treating acute decompensated heart failure patients with fluid overload resulted in lower mortality, reduced heart failure-related readmission rates, shorter hospital stays, increased daily diuresis and 24-hour urine sodium excretion, as well as improved weight loss and serum creatinine compared to intravenous furosemide alone (Fx).
CRITICAL CARE MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Adrian Covic, Sidar Copur, Laura Tapoi, Baris Afsar, Carina Ureche, Dimitrie Siriopol, Ionut Nistor, Mehmet Kanbay
Summary: Combination therapy with hypertonic saline solution (HSS) and furosemide in patients with acute decompensated heart failure (ADHF) shows superiority in preserving kidney function, improving diuresis, promoting natriuresis, inducing weight loss, reducing hospital stay duration, readmissions, and mortality, with no effect on BNP levels. Further randomized controlled trials are needed to confirm these effects and investigate potential mechanisms.
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2021)
Article
Ophthalmology
Pia Inborr, Mika Harju, Tero T. Kivela
Summary: This study compared the effects of single versus split bolus of intravenous hypertonic saline on intraocular pressure and pain, finding that splitting the bolus did not reduce pain associated with IVHTS. Therefore, a single bolus is recommended.
ACTA OPHTHALMOLOGICA
(2022)
Review
Medicine, General & Internal
Jomana Madieh, Bashar Hasan, Iman Khamayseh, Alaa Hrizat, Tareq Salah, Tarek Nayfeh, Kamel Gharaibeh, Abdurrahman Hamadah
Summary: This article presents a systematic review and meta-analysis of the complications associated with peripheral infusion of 3% hypertonic saline (3% HTS). The study found that peripheral administration of 3% HTS has a low rate of complications and is considered a safe and possibly preferred option.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Mathematical & Computational Biology
Zuoqing Li, ZuanJin Wang, Nanchao Liu, Haili Li
Summary: This meta-analysis examines the efficacy of hypertonic saline solution (HSS) combined with furosemide for the treatment of acute heart failure. The results suggest that the combination of HSS and furosemide is associated with lower readmission and mortality rates, as well as increased 24-hour urine volume and weight loss. However, the study has heterogeneity and bias, and further research is needed for confirmation.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Physiology
Stergios Gatzoflias, Shoujin Hao, Nicholas R. Ferreri
Summary: Administration of hypertonic saline in combination with diuretics has shown improved outcomes in patients with acute decompensated heart failure, but the underlying mechanisms are not yet fully understood and require further study for more widespread adoption.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Clinical Neurology
Yingying Su, Yifei Liu, Zhongyun Chen, Lili Cui
Summary: This study compared the efficacy and safety of 10 % hypertonic saline and 20 % mannitol in reducing intracranial pressure in patients with large hemispheric infarction. Both treatments were equally effective in reducing ICP, but differences were seen in heart rate and serum chloride levels.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicolas Girerd, Matthieu Aubry, Pierre Lantelme, Olivier Huttin, Patrick Rossignol
Summary: Intravenous mineralocorticoid receptor antagonists (MRAs) have been successfully used as a rescue procedure in patients with acutely decompensated heart failure (ADHF) and diuretic resistance. Further trials evaluating the effects of this therapeutic strategy in ADHF could be promising.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Mohammad Parsa Mahjoob, Farnaz Barzi, Amirahmad Nassiri, Alireza Kaveh, Mahshid Haghi, Mahshad Ghoddusi, Mohammad Sistanizad
Summary: In this study, the effectiveness of hypertonic saline solution administration in weight loss of hospitalized patients with diuretic-resistant edema due to heart failure was evaluated through a randomized double-blinded clinical trial. The results showed that hypertonic saline solution administration could lead to a significant decrease in body weight and provide a safe and effective treatment for increasing urine output in patients with heart failure.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Veterinary Sciences
Seyed Hesamaddin Banihashemi, Amir Saeed Samimi, Kamyab Samimi, Javad Tajik
Summary: The effects of double intravenous administration of furosemide at different doses on clinical variables, electrocardiographic indices, and serum electrolytes levels in miniature donkeys were evaluated. The results showed no significant changes in these parameters after furosemide administration.
VETERINARY RESEARCH FORUM
(2023)
Article
Anesthesiology
Georgia G. Tsaousi, Ioakeim Pezikoglou, Anastasia Nikopoulou, Nicolaos G. Foroglou, Aikaterina Poulopoulou, Timoleon-Achilleas Vyzantiadis, Dimitrios Vasilakos
Summary: This study investigates the effects of 7.5% hypertonic saline and 20% mannitol on cerebral oxygenation and metabolic status during craniotomy. The results show that 7.5% hypertonic saline has a more beneficial effect on cerebral oxygenation, but neither solution demonstrates clear clinical superiority.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2023)
Review
Neurosciences
Theodorus Kevin Putra Johansyah, Jeremy Jonathan, I. G. A. A. Andra Yusari, John Nolan, Alif Hakim Alamsyah, Geizar Arsika Ramadhana
Summary: Hypertonic saline is associated with better brain relaxation and increased blood sodium level compared to mannitol in patients undergoing elective craniotomy. Mannitol, on the other hand, is associated with increased fluid input and urine output. There was no significant difference in serum osmolality and hemodynamic parameters between the two agents.
EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY
(2022)
Article
Pharmacology & Pharmacy
Neelesh Bhatnagar, Saurabh Bhateja, Lalita Jeenger, Govind Mangal, Sunanda Gupta
Summary: The study aimed to compare the effects of two different doses of 3% hypertonic saline with mannitol during decompressive craniectomy in traumatic brain injury. The addition of 3% hypertonic saline to mannitol was found to provide better intraoperative brain relaxation and improve GCS in severe TBI patients. The results suggest that increasing osmotic load by adding 3% hypertonic saline to mannitol can be beneficial for patients undergoing decompressive craniectomy.
JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Gaspare Parrinello, Daniele Torres, Jeffrey M. Testani, Piero Luigi Almasio, Michele Bellanca, Giuseppina Pizzo, Francesco Cuttitta, Antonio Pinto, Javed Butler, Salvatore Paterna
INTERNAL AND EMERGENCY MEDICINE
(2015)
Article
Emergency Medicine
Francesco Massari, Filippo Mastropasqua, Massimo Iacoviello, Vincenzo Nuzzolese, Daniele Torres, Gaspare Parrinello
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2012)
Article
Emergency Medicine
Daniele Torres, Gaspare Parrinello, Mauro Cardillo, Marina Pomilla, Caterina Trapanese, Bellanca Michele, Umberto Lupo, Caterina Schimmenti, Francesco Cuttitta, Rossella Pietrantoni, Danai Vogiatzis, Giuseppe Licata
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2012)
Article
Medicine, General & Internal
F. Cuttitta, D. Torres, D. Vogiatzis, C. Butta, M. Bellanca, D. Gueli, U. Lupo, C. Schimmenti, G. Virzi, R. Petrantoni, F. Balistreri, S. Paterna, G. Parrinello
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2014)
Article
Cardiac & Cardiovascular Systems
Gaspare Parrinello, Stephen J. Greene, Daniele Torres, Michael Alderman, Joseph Vincent Bonventre, Pietro Di Pasquale, Luna Gargani, Anju Nohria, Gregg C. Fonarow, Muthiah Vaduganathan, Javed Butler, Salvatore Paterna, Lynne Warner Stevenson, Mihai Gheorghiade
HEART FAILURE REVIEWS
(2015)
Article
Gastroenterology & Hepatology
Salvatore Petta, Daniele Torres, Giovanni Fazio, Calogero Camma, Daniela Cabibi, Vito Di Marco, Anna Licata, Giulio Marchesini, Alessandra Mazzola, Gaspare Parrinello, Salvatore Novo, Giuseppe Licata, Antonio Craxi
Editorial Material
Medicine, General & Internal
Gaspare Parrinello, Daniele Torres, Giuseppe Licata
INTERNAL AND EMERGENCY MEDICINE
(2011)
Editorial Material
Medicine, General & Internal
Daniele Torres, Gaspare Parrinello, Caterina Trapanese, Mauro Cardillo, Giuseppe Licata
INTERNAL AND EMERGENCY MEDICINE
(2011)
Article
Medicine, General & Internal
Gaspare Parrinello, Daniele Torres, Salvatore Paterna
INTERNAL AND EMERGENCY MEDICINE
(2011)
Article
Medicine, General & Internal
Gaspare Parrinello, Daniele Torres, Salvatore Paterna, Pietro Di Pasquale, Caterina Trapanese, Mauro Cardillo, Michele Bellanca, Sergio Fasullo, Giuseppe Licata
INTERNAL AND EMERGENCY MEDICINE
(2013)
Article
Cardiac & Cardiovascular Systems
Gaspare Parrinello, Salvatore Paterna, Pietro Di Pasquale, Daniele Torres, Manuela Mezzero, Mauro Cardillo, Sergio Fasullo, Gabriella La Rocca, Giuseppe Licata
JOURNAL OF CARDIAC FAILURE
(2011)
Letter
Medicine, General & Internal
Daniele Torres, Gaspare Parrinello, Mauro Cardillo, Michele Bellanca, Giuseppe Licata
LIBYAN JOURNAL OF MEDICINE
(2013)
Article
Multidisciplinary Sciences
Salvatore Petta, Luca Valenti, Giulio Marchesini, Vito Di Marco, Anna Licata, Calogero Camma, Maria Rosa Barcellona, Daniela Cabibi, Benedetta Donati, Anna Fracanzani, Stefania Grimaudo, Gaspare Parrinello, Rosaria Maria Pipitone, Daniele Torres, Silvia Fargion, Giuseppe Licata, Antonio Craxi
Letter
Peripheral Vascular Disease
G. Avellone, V. Di Garbo, V. Guarnotta, R. Scaglione, G. Parrinello, L. Purpura, D. Torres, D. Campisi
INTERNATIONAL ANGIOLOGY
(2011)
Article
Cardiac & Cardiovascular Systems
Xiaoxi Yao, Zachi I. Attia, Emma M. Behnken, Melissa S. Hart, Shealeigh A. Inselman, Kayla C. Weber, Fan Li, Nikki H. Stricker, John L. Stricker, Paul A. Friedman, Peter A. Noseworthy
Summary: This study aims to explore whether Apple Watch, used as a long-term monitoring device, is effective in the early diagnosis of atrial fibrillation (AF) and the prevention of cognitive function decline in older adults. By using AI-ECG to screen high-risk patients and record electrocardiograms, the effectiveness of Apple Watch will be evaluated. If successful, this approach could have significant implications on how future clinical practice leverages consumer devices for early diagnosis and disease prevention.
AMERICAN HEART JOURNAL
(2024)