Article
Medicine, General & Internal
John E. Brush, Alexandra M. Hajduk, Erich J. Greene, Rachel P. Dreyer, Harlan M. Krumholz, Sarwat Chaudhry
Summary: This study investigates the symptom phenotypes of acute myocardial infarction in older patients and their distribution in women and men. The results show significant variation in symptom phenotypes in older patients with acute myocardial infarction, with women reporting more symptoms and having significantly more symptom phenotypes than men.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Maurizio Bertaina, Nuccia Morici, Simone Frea, Laura Garatti, Martina Briani, Carlotta Sorini, Luca Villanova, Elena Corrada, Alice Sacco, Marco Moltrasio, Amelia Ravera, Michele Tedeschi, Letizia Bertoldi, Maddalena Lettino, Francesco Saia, Anna Corsini, Rita Camporotondo, Costanza Natalia Julia Colombo, Stephanie Bertolin, Matteo Rota, Fabrizio Oliva, Mario Iannaccone, Serafina Valente, Matteo Pagnesi, Marco Metra, Alessandro Sionis, Marco Marini, Gaetano Maria De Ferrari, Navin K. Kapur, Federico Pappalardo, Guido Tavazzi
Summary: The present analysis compares the clinical features, in-hospital course, and management of cardiogenic shock complicating acutely decompensated heart failure (ADHF-CS) with that complicating acute myocardial infarction (AMI-CS). ADHF-CS patients have a higher prevalence of end-organ and biventricular dysfunction at presentation, longer hospital length of stay, and a higher need for heart replacement therapies compared to AMI-CS patients. In-hospital mortality is similar between the two etiologies. The findings suggest the need for new management protocols focused on the etiology of cardiogenic shock.
Article
Medicine, General & Internal
Susanne Bendesgaard Pedersen, Jens Cosedis Nielsen, Hans Erik Botker, Aparna Udupi, Jeffrey J. Goldberger
Summary: This study aimed to investigate the association between beta-blocker dose and mortality following acute myocardial infarction. A nationwide cohort study in Denmark was conducted, and the results showed that any dose of beta-blocker was associated with a significant reduction in mortality compared to no treatment. The largest reduction in mortality was observed within the first year after acute myocardial infarction for doses >25%-50% of the recommended target dose, suggesting that higher doses are unnecessary.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Maximiliano de Abreu, Marcelo Zylberman, Natalia Vensentini, Ricardo Villarreal, Ezequiel Zaidel, Laura Antonietti, Javier Mariani, Juan Gagliardi, Hernan Doval, Carlos Tajer
Summary: The clinical presentation of acute coronary syndromes (ACS) differs between women and men, with women more commonly having non-ST-elevation ACS (NSTEACS), especially non-obstructive coronary artery ACS in young women. There is no significant difference in the clinical presentation between sexes in patients with obstructive coronary heart disease.
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Article
Medicine, General & Internal
M. Alexandra Hajduk, S. Jane Saczynski, Sui Tsang, E. Mary Geda, A. John Dodson, M. Gregory Ouellet, J. Robert Goldberg, I. Sarwat Chaudhry
Summary: The study found that 11% of older acute myocardial infarction patients had mild cognitive impairment, and 6% had moderate/severe impairment. Cognitive impairment was associated with an increased risk of readmission and death, with a significant association between moderate/severe impairment and death persisting after adjustment for multiple factors. Routine cognitive screening may help identify high-risk patients who could benefit from closer monitoring and support post-discharge.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew G. L. Williams, Amardeep Dastidar, Kate Liang, Thomas W. Johnson, Anna Baritussio, Julian Strange, Nikhil Joshi, Stephen Dorman, Estefania De Garate, Lucrezia Spagnoli, Emiliano Fiori, Christopher Lawton, Giovanni Biglino, Sven Plein, Chiara Bucciarelli-Ducci
Summary: This study evaluates the impact of sex on clinical presentation and outcome in patients with suspected ACS and non-obstructive coronary arteries. The results show that sex does not have a significant effect on all-cause mortality, but men are more likely to have non-ischemic causes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jonathan D. Knott, Laura De Michieli, Olatunde Ola, Ashok Akula, Ramila A. Mehta, David O. Hodge, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe, Yader Sandoval
Summary: This observational cohort study examined emergency department patients and classified them into type 2 myocardial infarction (MI), myocardial injury, and myocardial ischemia. The study found that patients with objective evidence of myocardial ischemia (type 2 MI) had significantly higher mortality risk.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Sidong Li, Xiaojin Gao, Jingang Yang, Haiyan Xu, Yang Wang, Yanyan Zhao, Lu Yin, Chao Wu, Yi Wang, Yang Zheng, Bao Li, Xuan Zhang, Yunqing Ye, Rui Fu, Qiuting Dong, Hui Sun, Xinxin Yan, Yuan Wu, Jun Zhang, Chen Jin, Wei Li, Yuejin Yang
Summary: A study in China on acute myocardial infarction patients found an inverse association between the number of standard modifiable risk factors (SMuRFs) and all-cause mortality within 30 days, but after multivariate adjustment, a higher number of SMuRFs were associated with poor prognosis, especially among patients admitted beyond 12 hours from onset.
Article
Cardiac & Cardiovascular Systems
Jeppe K. Petersen, Abdulrahman N. Shams-Eldin, Emil L. Fosbol, Rasmus Rorth, Rikke Sorensen, Reza Jabbari, Thomas Engstrom, Lene Holmvang, Frants Pedersen, Amna Alhakak, Johanna Kroll, Christian Torp-Pedersen, Lars Kober, Jawad H. Butt
Summary: Employment status prior to acute myocardial infarction is associated with long-term risk of mortality and recurrent MI. Patients who were not part of the workforce had a higher risk of death and new heart attacks following discharge compared to those who were part of the workforce.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Xuexue Zhang, Miaoran Wang, Zhengchuan Zhu, Hua Qu, Jiyu Gu, Tian Ni, Yi Wang, Xujie Wang, Rui Zhang, Qiuyan Li
Summary: Among patients with acute myocardial infarction in the intensive care unit (ICU), the risk of in-hospital mortality is lowest in those with mean serum potassium levels between 3.5 and 4.5 mmol/L or minimal potassium variability.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Shashank S. Sinha, Carolyn M. Rosner, Behnam N. Tehrani, Aneel Maini, Alexander G. Truesdell, Seiyon Ben Lee, Pramita Bagchi, James Cameron, Abdulla A. Damluji, Mehul Desai, Shashank S. Desai, Kelly C. Epps, Christopher deFilippi, M. Casey Flanagan, Leonard Genovese, Hala Moukhachen, James J. Park, Mitchell A. Psotka, Anika Raja, Palak Shah, Matthew W. Sherwood, Ramesh Singh, Daniel Tang, Karl D. Young, Timothy Welch, Christopher M. O'Connor, Wayne B. Batchelor
Summary: Patients with HF-CS were younger and less likely to receive vasopressors or temporary mechanical circulatory support compared to AMI-CS patients, resulting in lower in-hospital and 1-year mortality rates.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, Jose M. de Miguel-Yanes, Romana Albaladejo-Vicente, Rosa Villanueva-Orbaiz, David Carabantes-Alarcon, Jose J. Zamorano-Leon, Marta Lopez-Herranz, Javier de Miguel-Diez
Summary: In Spain, patients with T2DM had higher incidence rates of both STEMI and NSTEMI, with men having higher rates than women. Women with T2DM were less likely to undergo revascularization procedures and had a higher risk of mortality compared to men with T2DM.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Amalie Lykkemark Moller, Elisabeth Helen Anna Mills, Filip Gnesin, Britta Jensen, Nertila Zylyftari, Helle Collatz Christensen, Stig Nikolaj Fasmer Blomberg, Fredrik Folke, Kristian Hay Kragholm, Gunnar Gislason, Emil Fosbol, Lars Kober, Thomas Alexander Gerds, Christian Torp-Pedersen
Summary: The study found that patients with acute myocardial infarction presenting with atypical symptoms have a reduced chance of receiving an emergency dispatch and increased 30-day mortality compared to patients with chest pain symptoms when calling for help.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Article
Cardiac & Cardiovascular Systems
Jiachen Luo, Baoxin Liu, Hongqiang Li, Siling Xu, Mengmeng Gong, Zhiqiang Li, Xiaoming Qin, Beibei Shi, Chuanzhen Hao, Ji Zhang, Yidong Wei
Summary: This study found that symptomatic NOAF in patients with AMI is associated with in-hospital mortality, while asymptomatic NOAF is linked to poorer long-term survival. Both types of NOAF episodes were associated with heart failure, but only symptomatic NOAF was associated with a higher risk of stroke. Patients with asymptomatic high-burden NOAF were identified as the highest-risk population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Jose M. de Miguel-Yanes, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, Javier de Miguel-Diez, Nuria Munoz-Rivas, Manuel Mendez-Bailon, Napoleon Perez-Farinos, Marta Lopez-Herranz, Ana Lopez-de-Andres
Summary: The study found that men had higher incidence rates of myocardial infarction than women in Spain from 2016 to 2018. Women were less likely to undergo invasive procedures and had a higher in-hospital mortality when admitted for an ST elevation myocardial infarction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Samaah Sullivan, An Young, Mariana Garcia, Zakaria Almuwaqqat, Kasra Moazzami, Brad Pearce, Allison Hankus, Emily G. Driggers, Lisa Elon, Oleksiy Levantsevych, Mhmtjamil Alkhalaf, Mohamad N. Jajeh, Amit J. Shah, Tene T. Lewis, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Article
Psychology, Biological
Erick A. Perez Alday, Giulia Da Poian, Oleksiy Levantsevych, Nancy Murrah, Lucy Shallenberger, Mhmtjamil Alkhalaf, Ammer Haffar, Belal Kaseer, Yi-An Ko, Jack Goldberg, Nicholas Smith, Rachel Lampert, J. Douglas Bremner, Gari D. Clifford, Viola Vaccarino, Amit J. Shah
Summary: Post-traumatic stress disorder (PTSD) may be associated with cardiovascular disease (CVD), though the exact mechanisms are unclear. This study examined the physiological changes in real-time associated with PTSD, finding that traumatic reminders can lead to autonomic dysregulation, suggesting a potential causal mechanism for increased CVD risk.
Article
Psychology, Biological
Shafa-at Ali Sheikh, Erick A. Perez Alday, Ali Bahrami Rad, Oleksiy Levantsevych, Mhmtjamil Alkhalaf, Majd Soudan, Rami Abdulbaki, Ammer Haffar, Nicholas L. Smith, Jack Goldberg, J. Douglas Bremner, Viola Vaccarino, Omer T. Inan, Gari D. Clifford, Amit J. Shah
Summary: Post-traumatic stress disorder (PTSD) is an independent risk factor for incident heart failure, and impedance cardiography (ICG) can help understand the underlying mechanisms. This study found an association between PTSD and lower contractility metrics (PEP and HI) measured through ICG, indicating a potential risk for heart failure.
Article
Cardiac & Cardiovascular Systems
Duygu Islek, Mohammed K. Ali, Amita Manatunga, Alvaro Alonso, Viola Vaccarino
Summary: This study investigated whether there are racial and ethnic differences in the risk of being discharged home among patients who received a diagnostic code of acute coronary syndrome (ACS) in the emergency department (ED). The results showed that Black and Hispanic patients had a higher risk of being discharged home compared to White patients, while Asian/Pacific Islander patients had a relatively lower risk. The association between race and ethnicity and discharge home was marginally mediated by health insurance status.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Shabatun J. Islam, Jeong Hwan Kim, Xiaona Li, Yi-An Ko, Peter Baltrus, Gary F. Mitchell, Ervin R. Fox, Mahasin S. Mujahid, Viola Vaccarino, Tene T. Lewis, Herman A. Taylor, Mario Sims, Arshed A. Quyyumi
Summary: The quality of neighborhood environments is connected to arterial stiffness in Black adults, who experience significant health disparities in cardiovascular disease. Improving social characteristics in neighborhoods is associated with better vascular health among Black adults.
Article
Public, Environmental & Occupational Health
Izraelle I. McKinnon, Dayna A. Johnson, Raphiel J. Murden, Christy L. Erving, Rachel Parker, Miriam E. Van Dyke, Viola Vaccarino, Bianca Booker, Renee H. Moore, Tene T. Lewis
Summary: This study examines the impact of violent racism-related events on sleep quality and finds that direct violent racism-related events are associated with poor sleep quality, while indirect events witnessed via social media do not have a significant impact on sleep quality.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Duygu Islek, Alvaro Alonso, Wayne Rosamond, Cameron S. Guild, Kenneth R. Butler, Mohammed K. Ali, Amita Manatunga, Ashley I. Naimi, Viola Vaccarino
Summary: Black patients have higher rates of fatal coronary heart disease than their White counterparts. Racial differences in out-of-hospital fatal coronary heart disease might explain the increased risk among Black patients. This study examines the racial disparities in in-and out-of-hospital fatal coronary heart disease among participants with no history of heart disease, and explores the potential role of socio-economic status in this association.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Hematology
Samaah Sullivan, An Young, Mariana Garcia, Zakaria Almuwaqqat, Kasra Moazzami, Muhammad Hammadah, Bruno B. Lima, Yingtian Hu, Mohamad Nour Jajeh, Ayman Alkhoder, Lisa Elon, Tene T. Lewis, Amit J. Shah, Puja K. Mehta, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Summary: Microvascular dysfunction during acute mental stress is an important determinant of major adverse cardiovascular events (MACE), particularly among younger and middle-aged women survivors of a heart attack. In this study, microvascular response to stress and transient endothelial dysfunction were measured using reactive hyperemia index and flow-mediated dilation, respectively. The results showed that worse microvascular response to stress was associated with higher risk of MACE among women, while endothelial dysfunction was related to MACE in both men and women.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zakaria Almuwaqqat, Ernest V. Garcia, C. David Cooke, Mariana Garcia, Amit J. Shah, Lisa Elon, Yi-An Ko, Samaah Sullivan, Jonathon Nye, Marly Van Assen, Carlo De Cecco, Paolo Raggi, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Summary: Microcirculatory dysfunction during psychological stress may result in diffuse myocardial ischemia. A novel quantification method for diffuse ischemia during mental stress (dMSI) was developed and its relationship with outcomes after a myocardial infarction (MI) was examined. The study found that higher levels of dMSI were associated with an increased risk of adverse events, particularly in women.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Psychiatry
Alexis K. Okoh, An Young, Mariana Garcia, Samaah Sullivan, Zakaria Almuwaqqat, Yingtian Hu, Chang Liu, Kasra Moazzami, Irina Uphoff, Bruno B. Lima, Yi-An Ko, Lisa Elon, Nour Jajeh, Pratik Rout, Shishir Gupta, Amit J. Shah, J. Douglas Bremner, Tene Lewis, Arshed Quyyumi, Viola Vaccarino
Summary: This study aimed to investigate differences in transient endothelial dysfunction (TED) with mental stress in Black and non-Black individuals with coronary heart disease (CHD), and their potential impact on cardiovascular outcomes. The results showed that Black patients had lower prestress endothelial dysfunction and a higher occurrence of TED with mental stress compared to non-Black patients. TED with mental stress explained a substantial portion of the excess risk of adverse cardiovascular events in Black individuals.
PSYCHOSOMATIC MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Zakaria Almuwaqqat, Ernest V. Garcia, C. David Cooke, Amit J. Shah, Jonathon Nye, Samaah Sullivan, Carlo Nicola De Cecco, Marly Van Assen, Arshed A. Quyyumi, Viola Vaccarino
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Maggie Wang, Chang Liu, Anish Shah, Yi-An Ko, Yan Sun, Rachel J. Lampert, Mariana Garcia, Kasra Moazzami, Zakaria Almuwaqqat, Laura Ward, Samaah Sullivan, Paolo Raggi, Doug Bremner, Arshed A. Quyyumi, Viola Vaccarino, Alanna A. Morris, Amit J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anish Shah, Viola Vaccarino, Yi-An Ko, Zakaria Almuwaqqat, Mariana Garcia, Kasra Moazzami, Maggie Wang, Oleksiy Levantsevych, an Young, Laura Ward, Jonathon Nye, Paolo Raggi, David S. Sheps, Rachel J. Lampert, Doug Bremner, Ernest V. Garcia, Arshed A. Quyyumi, Amit J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Brian Cheung, Zakaria Almuwaqqat, Jeong Hwan Kim, Muhammad Hammadah, Amit J. Shah, Yi-An Ko, Lisa Elon, Samaah Sullivan, Anish Shah, Ayman Alkhoder, Bruno B. Lima, Brad Pearce, Laura Ward, Michael Kutner, Yingtian Hu, Tene T. Lewis, Ernest V. Garcia, Jonathon A. Nye, David Sheps, Paolo Raggi, James Douglas Bremner, Viola Vaccarino, Arshed A. Quyyumi
Meeting Abstract
Cardiac & Cardiovascular Systems
Matthew R. Deshotels, Mahmoud Al Rifai, Ali Agha, Caroline Sun, Elizabeth Selvin, B. Gwen Windham, Viola Vaccarino, Erin D. Michos, Hani Jneid, Glenn N. Levine, Salim S. Virani, Christie M. Ballantyne, Vijay Nambi