Article
Emergency Medicine
Kemal Gokcek, Aysel Gokcek, Birdal Yildirim, Ethem Acar, Omer Dogan Alatas, Ahmet Demir
Summary: In this study, the ACUTE HF score was found to be an independent predictor of in-hospital mortality in patients with AHF. Patients were categorized into low, intermediate, and high-risk groups based on the score, with a significant association between the score and mortality rate observed. More validation studies in different regions with diverse AHF populations are needed to determine the generalizability of the ACUTE HF score.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Joyce N. Njoroge, John R. Teerlink
Summary: ADHF is a leading admission diagnosis worldwide, with incompletely understood pathophysiology and limited therapeutic options. Patients often experience high in-hospital morbidity and mortality due to suboptimal medical management leading to persistent congestion upon hospital discharge and inadequate initiation of life-saving therapies before discharge. There has been no new therapy approved for ADHF in decades, highlighting the need for expanding available therapies for these high-risk patients.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Chia-Te Liao, Jin-Long Huang, Huai-Wen Liang, Fa-Po Chung, Ying-Hsiang Lee, Po-Lin Lin, Wei-Ru Chiou, Wen-Yu Lin, Chien-Yi Hsu, Hung-Yu Chang
Summary: The study investigated the effects of ivabradine among patients with acute decompensated heart failure with reduced ejection fraction before discharge using real-world multicentre database. The results showed that ivabradine treatment was associated with reduced risks of cardiovascular mortality, all-cause mortality, and heart failure rehospitalization within 1 year among these patients.
Article
Cardiac & Cardiovascular Systems
Alberto Cordero, Belen Alvarez-Alvarez, David Escribano, Jose Ma Garcia-Acuna, Belen Cid-Alvarez, Moises Rodriguez-Manero, M. Amparo Quintanilla, Rosa Agra-Bermejo, Pilar Zuazola, Jose R. Gonzalez-Juanatey
Summary: Elevated remnant cholesterol is commonly found in ACS patients and is negatively correlated with age and positively correlated with body mass index. Remnant cholesterol is not associated with higher risk of in-hospital mortality, but it is associated with higher long-term risk of mortality and heart failure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Teng-Yao Yang, Meng-shu Tsai, Jeng-Yu Jan, Jung-Jung Chang, Chang-Ming Chung, Ming-Shyan Lin, Hui-Ming Chen, Yu-Sheng Lin
Summary: Ivabradine is effective in controlling heart rate when initiated in patients with acute heart failure, but it does not seem to provide significant benefits in reducing heart failure hospitalization, all-cause hospitalization, and mortality after one year.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Masafumi Ono, Atsushi Mizuno, Shun Kohsaka, Yasuyuki Shiraishi, Takashi Kohno, Yuji Nagatomo, Ayumi Goda, Shintaro Nakano, Nobuyuki Komiyama, Tsutomu Yoshikawa
Summary: This study retrospectively analyzed the relationship between Geriatric Nutritional Risk Index (GNRI) at hospital admission and discharge and long-term survival in patients with acute decompensated heart failure (ADHF). The results suggest that evaluating GNRI at hospital discharge is more accurate in predicting the long-term prognosis of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Qing Zhou, Jie Yang, Wenyao Wang, Chunli Shao, Xinwei Hua, Yi-Da Tang
Summary: This study investigated the associations between stress hyperglycemia and mortality and rehospitalization rates among acute decompensated heart failure (ADHF) patients with diabetes. The findings showed that both elevated and reduced stress hyperglycemia are associated with an unfavorable long-term prognosis in ADHF patients with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yodo Tamaki, Hidenori Yaku, Takeshi Morimoto, Yasutaka Inuzuka, Neiko Ozasa, Erika Yamamoto, Yusuke Yoshikawa, Makoto Miyake, Hirokazu Kondo, Toshihiro Tamura, Takeshi Kitai, Moritake Iguchi, Kazuya Nagao, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Mitsunori Kawato, Mamoru Toyofuku, Yukihito Sato, Koichiro Kuwahara, Yoshihisa Nakagawa, Takao Kato, Takeshi Kimura
Summary: The study found that the use of beta-blockers at hospital admission in patients with acute decompensated heart failure is associated with lower in-hospital mortality rates. Patients receiving beta-blockers also had lower cardiovascular and noncardiovascular mortality risks.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Abhigna Kolupoti, Marat Fudim, Ambarish Pandey, Anna Kucharska-Newton, Michael E. Hall, Muthiah Vaduganathan, Robert J. Mentz, Melissa C. Caughey
Summary: The prevalence of obesity has increased from 2005 to 2014 for both HF types, affecting the physical examination findings related to congestion. Detected edema increased with higher obesity category, while jugular venous distension decreased. The combination of physical examination findings is more predictive of 28-day mortality for patients with HFpEF than HFrEF.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Pilar Lopez-Diez, Aitor Alquezar-Arbe, Javier Jacob, Pere Llorens, Lluis Llauger, Pablo Herrero, Victor Gil, Julio Nunez, Francisco Javier Martin-Sanchez, Oscar Miro
Summary: This study investigated whether the existence of heart failure units (HFU) and link nurse units (LNU) in the hospital improve short-term outcomes of acute heart failure (AHF) episodes. The results showed that the complete development of these follow-up units was not associated with 30-day mortality but was associated with less prolonged hospitalization and fewer post-discharge adverse events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maurizio Bertaina, Nuccia Morici, Simone Frea, Laura Garatti, Martina Briani, Carlotta Sorini, Luca Villanova, Elena Corrada, Alice Sacco, Marco Moltrasio, Amelia Ravera, Michele Tedeschi, Letizia Bertoldi, Maddalena Lettino, Francesco Saia, Anna Corsini, Rita Camporotondo, Costanza Natalia Julia Colombo, Stephanie Bertolin, Matteo Rota, Fabrizio Oliva, Mario Iannaccone, Serafina Valente, Matteo Pagnesi, Marco Metra, Alessandro Sionis, Marco Marini, Gaetano Maria De Ferrari, Navin K. Kapur, Federico Pappalardo, Guido Tavazzi
Summary: The present analysis compares the clinical features, in-hospital course, and management of cardiogenic shock complicating acutely decompensated heart failure (ADHF-CS) with that complicating acute myocardial infarction (AMI-CS). ADHF-CS patients have a higher prevalence of end-organ and biventricular dysfunction at presentation, longer hospital length of stay, and a higher need for heart replacement therapies compared to AMI-CS patients. In-hospital mortality is similar between the two etiologies. The findings suggest the need for new management protocols focused on the etiology of cardiogenic shock.
Article
Cardiac & Cardiovascular Systems
Marija Polovina, Milenko Tomic, Mihajlo Viduljevic, Natasa Zlatic, Andrea Stojicevic, Danka Civric, Aleksandra Milosevic, Gordana Krljanac, Ratko Lasica, Milika Asanin
Summary: This study found a high incidence of HAP in AHF patients admitted to the ICU, and it was associated with de novo AHF, mitral regurgitation, higher levels of NT proB-type natriuretic peptide, pleural effusion on chest x-ray, as well as a history of stroke, diabetes, and chronic kidney disease. Patients with HAP had longer lengths of stay, and a higher likelihood of requiring inotropic or ventilatory support. HAP was also associated with increased in-hospital mortality and a lower likelihood of receiving HF medications at discharge.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Renata R. T. Castro, Luka Lechnewski, Alan Homero, Denilson Campos de Albuquerque, Luis Eduardo Rohde, Dirceu Almeida, Joao David, Salvador Rassi, Fernando Bacal, Edimar Bocchi, Lidia Moura
Summary: The study found that AHI can independently predict in-hospital mortality in patients with acute decompensated HF, with a low AHI value being associated with a higher risk of death.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
P. Christian Schulze, Juergen Bogoviku, Julian Westphal, Pawel Aftanski, Franz Haertel, Sissy Grund, Stephan von Haehling, Ulrike Schumacher, Sven Moebius-Winkler, Martin Busch
Summary: This study suggests that early addition of empagliflozin to standard diuretic therapy can increase urine output in patients with acute decompensated heart failure without affecting renal function.
Article
Medicine, General & Internal
Wei-Chieh Lee, Po-Jui Wu, Hsiu-Yu Fang, Yen-Nan Fang, Huang-Chung Chen, Meng-Shen Tong, Pei-Hsun Sung, Chieh-Ho Lee, Wen-Jung Chung
Summary: This study compared the clinical outcomes of levosimendan therapy for ADHF patients with ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM). The NICM patients had lower cardiovascular and all-cause mortality rates during the 30-day follow-up period. Additionally, the NICM subgroup had significantly lower all-cause mortality rates at the 180-day and 1-year follow-ups. NICM and the use of extracorporeal membrane oxygenation (ECMO) were significant predictors of 30-day all-cause mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Aymen Ahmed, Stephen J. Greene, Mona Fiuzat, Michelle M. Kittleson, Javed Butler, George L. Bakris, Gregg C. Fonarow
Summary: Heart failure and end-stage kidney disease often coexist and worsen each other's prognosis. Patients on dialysis are at high risk, but they have been excluded from major clinical trials on heart failure, resulting in a lack of data and reliance on observational evidence. In clinical practice, heart failure treatment is often reduced or discontinued in patients with end-stage kidney disease undergoing dialysis due to safety concerns. This review discusses the available evidence, challenges, and future directions for optimizing heart failure management in these high-risk patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Amgad Mentias, Eric D. Peterson, Neil Keshvani, Dharam J. Kumbhani, Clyde W. Yancy, Alanna A. Morris, Larry A. Allen, Saket Girotra, Gregg C. Fonarow, Randall C. Starling, Paulino Alvarez, Milind Y. Desai, Peter Cram, Ambarish Pandey
Summary: This study found that using race-specific risk adjustment models can more accurately represent hospital performance for patients of Black and other races in terms of heart failure hospitalization and 30-day risk-standardized readmission rate and risk-standardized mortality rate.
Editorial Material
Cardiac & Cardiovascular Systems
Javed Butler, Khawaja M. Talha, Gregg C. Fonarow
Editorial Material
Cardiac & Cardiovascular Systems
Brian R. Lindman, Gregg C. Fonarow, Gary Myers, Heather M. Alger, Christine Rutan, Katie Troll, Angeline Aringo, Melanie Shahriary, Mariell Jessup, Suzanne V. Arnold, Pinak B. Shah, Wilson Y. Szeto, Clyde W. Yancy, Catherine M. Otto
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Jie-Lena Sun, Gregg C. Fonarow, Stephen B. Heitner, Punag H. Divanji, Gary Binder, Larry A. Allen, Brooke Alhanti, Clyde W. Yancy, Nancy M. Albert, Adam D. DeVore, G. Michael Felker, Stephen J. Greene
Summary: This study investigated the clinical profile and healthcare costs of US patients with heart failure who do not meet the threshold for advanced therapies. The majority of these patients have severely reduced ejection fraction (≤30%) and face increased risk of death and heart failure hospitalization despite receiving guideline-directed medical therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hubert B. Haywood, Gregg C. Fonarow, Muhammad Shahzeb Khan, Michael E. Nassif, Javed Butler, Stephen J. Greene
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Sumitabh Singh, Matthew W. Segar, Muhammad Shariq Usman, Neil Keshvani, Andrew P. Ambrosy, Mona Fiuzat, Harriette G. C. Van Spall, Gregg C. Fonarow, Faiez Zannad, G. Michael Felker, James L. Januzzi, Christopher O'Connor, Javed Butler, Ambarish Pandey
Summary: This study aimed to evaluate the impact of polypharmacy on the receipt of optimal guideline-directed medical therapy (GDMT) among patients with heart failure with reduced ejection fraction (HFrEF) over time.
JACC-HEART FAILURE
(2023)
Article
Health Care Sciences & Services
Boshu Ru, Xi Tan, Yu Liu, Kartik Kannapur, Dheepan Ramanan, Garin Kessler, Dominik Lautsch, Gregg Fonarow
Summary: This study aimed to compare different machine learning prediction models and feature construction methods to predict readmissions and worsening heart failure events (WHFEs) in patients with heart failure with reduced ejection fraction (HFrEF). The results showed that the XGBoost model with the frequency of clinical codes as features had the best discriminative ability for predicting these events.
JMIR FORMATIVE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Neil Keshvani, Vinayak Subramanian, Christopher A. Wrobel, Nicole Solomon, Brooke Alhanti, Stephen J. Greene, Adam D. DeVore, Clyde W. Yancy, Larry A. Allen, Gregg C. Fonarow, Ambarish Pandey
Summary: This study aimed to investigate the referral and participation rates in cardiac rehabilitation (CR) among patients with heart failure with reduced ejection fraction and evaluate the impact on survival and readmission. The results showed that referral rates have increased from 2010 to 2020, but only one in four patients were referred to CR. The participation rate in CR was low. Patients referred to CR had a lower risk of 1-year death compared to those not referred.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Hubert B. Haywood, Gregg C. Fonarow, Muhammad Shahzeb Khan, Harriette G. C. Van Spall, Alanna A. Morris, Michael E. Nassif, Michelle M. Kittleson, Javed Butler, Stephen J. Greene
Summary: Hospital at home is an innovative care model that is particularly suitable for heart failure patients. It provides a patient-centered and effective alternative to traditional outpatient and inpatient care. Current research supports its safety and cost-effectiveness, and new payment structures are being introduced to support its development.
CIRCULATION-HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Stephen J. Greene, Gregg C. Fonarow
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Nicholas K. Brownell, Gregg C. Fonarow
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Anping Cai, Congyi Zheng, Jiayuan Qiu, Gregg C. Fonarow, Gregory Y. H. Lip, Yingqing Feng, Zengwu Wang
Summary: The burden of heart failure (HF) in China is expected to increase due to population ageing. However, there is limited knowledge about the prevalence of HF stages in China. Therefore, this study aimed to evaluate the prevalence of HF stages in the general Chinese population and the specific prevalence by age, sex, and urbanity. The study found that both pre-clinical and clinical HF burdens are high in China and vary by age, sex, and urbanity.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: In a large cohort of adults with type 2 diabetes, the study found a significant association between cardiac autonomic neuropathy (CAN) and the risk of silent myocardial infarction (SMI). Low heart rate variability was significantly associated with an increased risk of incident SMI. Participants with CAN had a 1.9-fold greater risk of SMI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Revanth S. Kosaraju, Gregg C. Fonarow, Michael K. Ong, Paul A. Heidenreich, Donna L. Washington, Xiaoyan Wang, Boback Ziaeian
Summary: The burden of heart failure is increasing, and there is geographic variation in the quality of care for heart failure with reduced ejection fraction. This study evaluates the prescription of guideline-directed medical therapies (GDMT) within the Veterans Health Administration and finds significant variation across regions. Targeted strategies are needed to improve GDMT prescription in lower-performing regions, especially those affected by income inequality and poverty.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoxi Yao, Zachi I. Attia, Emma M. Behnken, Melissa S. Hart, Shealeigh A. Inselman, Kayla C. Weber, Fan Li, Nikki H. Stricker, John L. Stricker, Paul A. Friedman, Peter A. Noseworthy
Summary: This study aims to explore whether Apple Watch, used as a long-term monitoring device, is effective in the early diagnosis of atrial fibrillation (AF) and the prevention of cognitive function decline in older adults. By using AI-ECG to screen high-risk patients and record electrocardiograms, the effectiveness of Apple Watch will be evaluated. If successful, this approach could have significant implications on how future clinical practice leverages consumer devices for early diagnosis and disease prevention.
AMERICAN HEART JOURNAL
(2024)